dbPTM

NOLC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NOLC1_HUMAN
UniProt AC	Q14978
Protein Name	Nucleolar and coiled-body phosphoprotein 1 {ECO:0000305}
Gene Name	NOLC1 {ECO:0000312\|HGNC:HGNC:15608}
Organism	Homo sapiens (Human).
Sequence Length	699
Subcellular Localization	Nucleus, nucleolus . Cytoplasm . Shuttles between the nucleolus and the cytoplasm. At telophase it begins to assemble into granular-like pre-nucleolar bodies which are subsequently relocated to nucleoli at the early G1-phase.
Protein Description	Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. [PubMed: 10567578]
Protein Sequence	MADAGIRRVVPSDLYPLVLGFLRDNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVADNSFDAKRGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQVNSIKFDSE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Methylation	-MADAGIRRVVPSDL -CCCCCCCCCCCHHH	25.15	115485301
28	Phosphorylation	FLRDNQLSEVANKFA HHCCCHHHHHHHHHH	21.91	21815630
33	Acetylation	QLSEVANKFAKATGA HHHHHHHHHHHHHCC	36.64	19608861
33	Ubiquitination	QLSEVANKFAKATGA HHHHHHHHHHHHHCC	36.64	21890473
33 (in isoform 1)	Ubiquitination	-	36.64	21890473
33 (in isoform 2)	Malonylation	-	36.64	26320211
33 (in isoform 2)	Ubiquitination	-	36.64	21890473
33 (in isoform 3)	Ubiquitination	-	36.64	21890473
36	Acetylation	EVANKFAKATGATQQ HHHHHHHHHHCCCHH	50.00	21466224
36	Ubiquitination	EVANKFAKATGATQQ HHHHHHHHHHCCCHH	50.00	-
38	Phosphorylation	ANKFAKATGATQQDA HHHHHHHHCCCHHCC	27.00	24043423
41	Phosphorylation	FAKATGATQQDANAS HHHHHCCCHHCCCHH	28.27	24043423
48	Phosphorylation	TQQDANASSLLDIYS CHHCCCHHHHHHHHH	22.71	24043423
49	Phosphorylation	QQDANASSLLDIYSF HHCCCHHHHHHHHHH	30.46	24043423
54	Phosphorylation	ASSLLDIYSFWLKSA HHHHHHHHHHHHHHC	9.47	24043423
55	Phosphorylation	SSLLDIYSFWLKSAK HHHHHHHHHHHHHCC	15.41	24043423
59	Ubiquitination	DIYSFWLKSAKVPER HHHHHHHHHCCCCHH	38.68	-
60 (in isoform 3)	Methylation	-	31.02	-
67	Sumoylation	SAKVPERKLQANGPV HCCCCHHHHHHCCHH	43.20	-
67	Sumoylation	SAKVPERKLQANGPV HCCCCHHHHHHCCHH	43.20	28112733
76	Acetylation	QANGPVAKKAKKKAS HHCCHHHHHHHHHHC	54.20	23749302
76	Sumoylation	QANGPVAKKAKKKAS HHCCHHHHHHHHHHC	54.20	28112733
80	Methylation	PVAKKAKKKASSSDS HHHHHHHHHHCCCCC	59.43	23748837
83	Phosphorylation	KKAKKKASSSDSEDS HHHHHHHCCCCCCCC	38.97	25159151
84	Phosphorylation	KAKKKASSSDSEDSS HHHHHHCCCCCCCCH	42.92	23927012
85	Phosphorylation	AKKKASSSDSEDSSE HHHHHCCCCCCCCHH	42.53	23927012
85 (in isoform 2)	Phosphorylation	-	42.53	21406692
87	Phosphorylation	KKASSSDSEDSSEEE HHHCCCCCCCCHHHH	45.30	23927012
87 (in isoform 2)	Phosphorylation	-	45.30	21406692
90	Phosphorylation	SSSDSEDSSEEEEEV CCCCCCCCHHHHHHH	35.28	25159151
90 (in isoform 2)	Phosphorylation	-	35.28	21406692
91	Phosphorylation	SSDSEDSSEEEEEVQ CCCCCCCHHHHHHHC	62.44	25159151
110	Acetylation	KKAAVPAKRVGLPPG HHCCCCHHHHCCCCC	41.36	25953088
118	Acetylation	RVGLPPGKAAAKASE HHCCCCCHHHHHHCC	40.40	25953088
124	Phosphorylation	GKAAAKASESSSSEE CHHHHHHCCCCCCCC	36.99	20873877
126	Phosphorylation	AAAKASESSSSEESS HHHHHCCCCCCCCCC	32.78	20873877
127	Phosphorylation	AAKASESSSSEESSD HHHHCCCCCCCCCCC	33.56	20873877
128	Phosphorylation	AKASESSSSEESSDD HHHCCCCCCCCCCCC	51.56	20873877
129	Phosphorylation	KASESSSSEESSDDD HHCCCCCCCCCCCCC	47.53	20873877
132	Phosphorylation	ESSSSEESSDDDDEE CCCCCCCCCCCCCHH	34.71	20873877
133	Phosphorylation	SSSSEESSDDDDEED CCCCCCCCCCCCHHH	48.62	21815630
166	Phosphorylation	APPKKAKSSDSDSDS CCCCCCCCCCCCCCC	44.21	30177828
167	Phosphorylation	PPKKAKSSDSDSDSS CCCCCCCCCCCCCCC	40.19	30576142
169	Phosphorylation	KKAKSSDSDSDSSSE CCCCCCCCCCCCCCC	40.75	30576142
171	Phosphorylation	AKSSDSDSDSSSEDE CCCCCCCCCCCCCCC	43.26	21815630
173	Phosphorylation	SSDSDSDSSSEDEPP CCCCCCCCCCCCCCC	39.45	30576142
174	Phosphorylation	SDSDSDSSSEDEPPK CCCCCCCCCCCCCCC	42.61	30576142
175	Phosphorylation	DSDSDSSSEDEPPKN CCCCCCCCCCCCCCC	53.68	29888752
186	Sumoylation	PPKNQKPKITPVTVK CCCCCCCCCCCEEEC	67.27	28112733
188	Phosphorylation	KNQKPKITPVTVKAQ CCCCCCCCCEEECEE	20.17	30266825
188 (in isoform 2)	Phosphorylation	-	20.17	21406692
191	Phosphorylation	KPKITPVTVKAQTKA CCCCCCEEECEECCC	19.93	30266825
193	Sumoylation	KITPVTVKAQTKAPP CCCCEEECEECCCCC	25.97	-
193	Acetylation	KITPVTVKAQTKAPP CCCCEEECEECCCCC	25.97	25953088
193	Sumoylation	KITPVTVKAQTKAPP CCCCEEECEECCCCC	25.97	28112733
193	Ubiquitination	KITPVTVKAQTKAPP CCCCEEECEECCCCC	25.97	-
197	Acetylation	VTVKAQTKAPPKPAR EEECEECCCCCCCCC	46.98	25953088
197	Ubiquitination	VTVKAQTKAPPKPAR EEECEECCCCCCCCC	46.98	-
216	Phosphorylation	IANGKAASSSSSSSS CCCCCCCCCCCCCCC	35.30	23312004
217	Phosphorylation	ANGKAASSSSSSSSS CCCCCCCCCCCCCCC	29.52	23312004
218	Phosphorylation	NGKAASSSSSSSSSS CCCCCCCCCCCCCCC	31.57	23312004
219	Phosphorylation	GKAASSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	21712546
220	Phosphorylation	KAASSSSSSSSSSSS CCCCCCCCCCCCCCC	35.87	23312004
221	Phosphorylation	AASSSSSSSSSSSSD CCCCCCCCCCCCCCC	35.87	21712546
222	Phosphorylation	ASSSSSSSSSSSSDD CCCCCCCCCCCCCCC	35.87	29888752
223	Phosphorylation	SSSSSSSSSSSSDDS CCCCCCCCCCCCCCH	35.87	29888752
224	Phosphorylation	SSSSSSSSSSSDDSE CCCCCCCCCCCCCHH	35.87	29888752
225	Phosphorylation	SSSSSSSSSSDDSEE CCCCCCCCCCCCHHH	35.49	29888752
226	Phosphorylation	SSSSSSSSSDDSEEE CCCCCCCCCCCHHHH	39.47	29888752
227	Phosphorylation	SSSSSSSSDDSEEEK CCCCCCCCCCHHHHH	47.59	26657352
230	Phosphorylation	SSSSSDDSEEEKAAA CCCCCCCHHHHHHHC	52.47	26657352
238	Phosphorylation	EEEKAAATPKKTVPK HHHHHHCCCCCCCCH	30.80	30576142
238 (in isoform 2)	Phosphorylation	-	30.80	28985074
242	Phosphorylation	AAATPKKTVPKKQVV HHCCCCCCCCHHHEE	48.44	20068231
244 (in isoform 2)	Phosphorylation	-	43.27	20068231
246 (in isoform 2)	Phosphorylation	-	42.10	26434776
247 (in isoform 2)	Phosphorylation	-	40.83	26434776
251	Acetylation	PKKQVVAKAPVKAAT CHHHEEECCCCCCCC	41.43	26822725
251	Ubiquitination	PKKQVVAKAPVKAAT CHHHEEECCCCCCCC	41.43	-
255	Acetylation	VVAKAPVKAATTPTR EEECCCCCCCCCCCC	31.11	25953088
258	Phosphorylation	KAPVKAATTPTRKSS CCCCCCCCCCCCCCC	37.86	25072903
259	Phosphorylation	APVKAATTPTRKSSS CCCCCCCCCCCCCCC	20.24	25072903
261	Phosphorylation	VKAATTPTRKSSSSE CCCCCCCCCCCCCCC	48.95	20068231
264	Phosphorylation	ATTPTRKSSSSEDSS CCCCCCCCCCCCCCC	31.96	21955146
265	Phosphorylation	TTPTRKSSSSEDSSS CCCCCCCCCCCCCCC	40.70	30108239
266	Phosphorylation	TPTRKSSSSEDSSSD CCCCCCCCCCCCCCH	44.85	30108239
267	Phosphorylation	PTRKSSSSEDSSSDE CCCCCCCCCCCCCHH	47.58	30108239
270	Phosphorylation	KSSSSEDSSSDEEEE CCCCCCCCCCHHHHH	27.91	20068231
271	Phosphorylation	SSSSEDSSSDEEEEQ CCCCCCCCCHHHHHH	54.88	20068231
272	Phosphorylation	SSSEDSSSDEEEEQK CCCCCCCCHHHHHHH	53.66	21955146
285	Acetylation	QKKPMKNKPGPYSSV HHCCCCCCCCCCCCC	45.92	26051181
285	Ubiquitination	QKKPMKNKPGPYSSV HHCCCCCCCCCCCCC	45.92	-
289	Phosphorylation	MKNKPGPYSSVPPPS CCCCCCCCCCCCCCC	21.35	16997485
290	Phosphorylation	KNKPGPYSSVPPPSA CCCCCCCCCCCCCCC	28.17	16997485
291	Phosphorylation	NKPGPYSSVPPPSAP CCCCCCCCCCCCCCC	32.57	28796482
296	Phosphorylation	YSSVPPPSAPPPKKS CCCCCCCCCCCCCCC	60.21	28555341
299 (in isoform 2)	Phosphorylation	-	53.73	27642862
301	Acetylation	PPSAPPPKKSLGTQP CCCCCCCCCCCCCCC	61.85	26051181
303	Phosphorylation	SAPPPKKSLGTQPPK CCCCCCCCCCCCCCH	37.85	25159151
306	Phosphorylation	PPKKSLGTQPPKKAV CCCCCCCCCCCHHHH	43.10	29396449
306 (in isoform 2)	Phosphorylation	-	43.10	27642862
321	Phosphorylation	EKQQPVESSEDSSDE HCCCCCCCCCCCCCC	38.98	29888752
322	Phosphorylation	KQQPVESSEDSSDES CCCCCCCCCCCCCCC	31.73	24505115
325	Phosphorylation	PVESSEDSSDESDSS CCCCCCCCCCCCCCC	35.32	29888752
326	Phosphorylation	VESSEDSSDESDSSS CCCCCCCCCCCCCCC	58.69	29888752
329	Phosphorylation	SEDSSDESDSSSEEE CCCCCCCCCCCCHHH	48.02	27174698
331	Phosphorylation	DSSDESDSSSEEEKK CCCCCCCCCCHHHHC	45.07	24505115
332	Phosphorylation	SSDESDSSSEEEKKP CCCCCCCCCHHHHCC	46.92	21712546
333	Phosphorylation	SDESDSSSEEEKKPP CCCCCCCCHHHHCCC	53.64	26657352
341	Phosphorylation	EEEKKPPTKAVVSKA HHHHCCCCCHHHCCC	39.91	27174698
342	Sumoylation	EEKKPPTKAVVSKAT HHHCCCCCHHHCCCC	44.98	28112733
347	Acetylation	PTKAVVSKATTKPPP CCCHHHCCCCCCCCC	37.84	25953088
347	Sumoylation	PTKAVVSKATTKPPP CCCHHHCCCCCCCCC	37.84	28112733
349	Phosphorylation	KAVVSKATTKPPPAK CHHHCCCCCCCCCCH	38.80	28348404
351	Acetylation	VVSKATTKPPPAKKA HHCCCCCCCCCCHHH	51.69	25953088
356	Acetylation	TTKPPPAKKAAESSS CCCCCCCHHHHHCCC	49.03	30584347
361	Phosphorylation	PAKKAAESSSDSSDS CCHHHHHCCCCCCCC	30.34	23663014
362	Phosphorylation	AKKAAESSSDSSDSD CHHHHHCCCCCCCCC	29.66	28355574
363	Phosphorylation	KKAAESSSDSSDSDS HHHHHCCCCCCCCCC	51.28	23927012
365	Phosphorylation	AAESSSDSSDSDSSE HHHCCCCCCCCCCCC	37.68	23927012
366	Phosphorylation	AESSSDSSDSDSSED HHCCCCCCCCCCCCC	46.23	23927012
368	Phosphorylation	SSSDSSDSDSSEDDE CCCCCCCCCCCCCCC	41.14	23663014
370	Phosphorylation	SDSSDSDSSEDDEAP CCCCCCCCCCCCCCC	39.31	23663014
371	Phosphorylation	DSSDSDSSEDDEAPS CCCCCCCCCCCCCCC	50.46	26657352
378	Phosphorylation	SEDDEAPSKPAGTTK CCCCCCCCCCCCCCC	59.32	23663014
383	Phosphorylation	APSKPAGTTKNSSNK CCCCCCCCCCCCCCC	36.38	23663014
384	Phosphorylation	PSKPAGTTKNSSNKP CCCCCCCCCCCCCCC	27.58	23663014
387	Phosphorylation	PAGTTKNSSNKPAVT CCCCCCCCCCCCCEE	36.52	24732914
388	Phosphorylation	AGTTKNSSNKPAVTT CCCCCCCCCCCCEEC	59.26	24732914
390	Acetylation	TTKNSSNKPAVTTKS CCCCCCCCCCEECCC	35.98	23749302
390	Sumoylation	TTKNSSNKPAVTTKS CCCCCCCCCCEECCC	35.98	28112733
394	Phosphorylation	SSNKPAVTTKSPAVK CCCCCCEECCCCCCC	30.52	24732914
395	Phosphorylation	SNKPAVTTKSPAVKP CCCCCEECCCCCCCC	23.95	20201521
396	Acetylation	NKPAVTTKSPAVKPA CCCCEECCCCCCCCC	45.11	25953088
396	Sumoylation	NKPAVTTKSPAVKPA CCCCEECCCCCCCCC	45.11	28112733
397	Phosphorylation	KPAVTTKSPAVKPAA CCCEECCCCCCCCCC	18.92	29255136
397 (in isoform 2)	Phosphorylation	-	18.92	21406692
401	Acetylation	TTKSPAVKPAAAPKQ ECCCCCCCCCCCCCC	30.92	23749302
401	Sumoylation	TTKSPAVKPAAAPKQ ECCCCCCCCCCCCCC	30.92	28112733
407	Acetylation	VKPAAAPKQPVGGGQ CCCCCCCCCCCCCCC	63.61	26051181
407	Sumoylation	VKPAAAPKQPVGGGQ CCCCCCCCCCCCCCC	63.61	28112733
407 (in isoform 2)	Phosphorylation	-	63.61	21406692
415	Acetylation	QPVGGGQKLLTRKAD CCCCCCCEEEEEECC	49.06	19608861
415	Sumoylation	QPVGGGQKLLTRKAD CCCCCCCEEEEEECC	49.06	25114211
416	Acetylation	PVGGGQKLLTRKADS CCCCCCEEEEEECCC	4.54	19608861
423	Phosphorylation	LLTRKADSSSSEEES EEEEECCCCCCCCCC	36.66	23401153
424	Phosphorylation	LTRKADSSSSEEESS EEEECCCCCCCCCCC	38.13	23401153
425	Phosphorylation	TRKADSSSSEEESSS EEECCCCCCCCCCCC	45.80	23401153
426	Phosphorylation	RKADSSSSEEESSSS EECCCCCCCCCCCCC	51.48	23401153
430	Phosphorylation	SSSSEEESSSSEEEK CCCCCCCCCCCHHHH	38.51	23401153
431	Phosphorylation	SSSEEESSSSEEEKT CCCCCCCCCCHHHHH	40.96	23401153
432	Phosphorylation	SSEEESSSSEEEKTK CCCCCCCCCHHHHHH	51.56	20873877
433	Phosphorylation	SEEESSSSEEEKTKK CCCCCCCCHHHHHHH	51.48	21815630
438	Phosphorylation	SSSEEEKTKKMVATT CCCHHHHHHHHHHCC	38.89	29888752
440	Sumoylation	SEEEKTKKMVATTKP CHHHHHHHHHHCCCC	43.78	28112733
446	Acetylation	KKMVATTKPKATAKA HHHHHCCCCHHHHHH	39.92	23749302
452	Acetylation	TKPKATAKAALSLPA CCCHHHHHHHHCCCH	29.82	25953088
452	Sumoylation	TKPKATAKAALSLPA CCCHHHHHHHHCCCH	29.82	28112733
456	Phosphorylation	ATAKAALSLPAKQAP HHHHHHHCCCHHHCC	27.81	25159151
466	Phosphorylation	AKQAPQGSRDSSSDS HHHCCCCCCCCCCCC	27.89	28192239
469	Phosphorylation	APQGSRDSSSDSDSS CCCCCCCCCCCCCCC	30.54	20873877
470	Phosphorylation	PQGSRDSSSDSDSSS CCCCCCCCCCCCCCC	42.31	20873877
471	Phosphorylation	QGSRDSSSDSDSSSS CCCCCCCCCCCCCCC	45.12	23312004
473	Phosphorylation	SRDSSSDSDSSSSEE CCCCCCCCCCCCCHH	41.14	20873877
475	Phosphorylation	DSSSDSDSSSSEEEE CCCCCCCCCCCHHHH	35.75	20873877
476	Phosphorylation	SSSDSDSSSSEEEEE CCCCCCCCCCHHHHH	42.76	20873877
477	Phosphorylation	SSDSDSSSSEEEEEK CCCCCCCCCHHHHHH	45.80	20873877
478	Phosphorylation	SDSDSSSSEEEEEKT CCCCCCCCHHHHHHH	51.48	24275569
485	Phosphorylation	SEEEEEKTSKSAVKK CHHHHHHHCHHHHHH	44.67	23312004
486	Phosphorylation	EEEEEKTSKSAVKKK HHHHHHHCHHHHHHC	35.36	23312004
504	Phosphorylation	VAGGAAPSKPASAKK CCCCCCCCCCCCCCC	46.69	30266825
505	Acetylation	AGGAAPSKPASAKKG CCCCCCCCCCCCCCC	43.47	23749302
505	Sumoylation	AGGAAPSKPASAKKG CCCCCCCCCCCCCCC	43.47	28112733
508	Phosphorylation	AAPSKPASAKKGKAE CCCCCCCCCCCCCCC	49.50	29255136
510	Acetylation	PSKPASAKKGKAESS CCCCCCCCCCCCCCC	60.61	23749302
511	Acetylation	SKPASAKKGKAESSN CCCCCCCCCCCCCCC	66.42	7338259
514 (in isoform 2)	Phosphorylation	-	30.49	21406692
516	Phosphorylation	AKKGKAESSNSSSSD CCCCCCCCCCCCCCC	39.41	28192239
517	Phosphorylation	KKGKAESSNSSSSDD CCCCCCCCCCCCCCC	32.03	30108239
518 (in isoform 2)	Phosphorylation	-	56.01	21406692
519	Phosphorylation	GKAESSNSSSSDDSS CCCCCCCCCCCCCCC	33.28	30108239
520	Phosphorylation	KAESSNSSSSDDSSE CCCCCCCCCCCCCCH	37.80	30108239
521	Phosphorylation	AESSNSSSSDDSSEE CCCCCCCCCCCCCHH	37.29	30108239
522	Phosphorylation	ESSNSSSSDDSSEEE CCCCCCCCCCCCHHH	47.59	30108239
525	Phosphorylation	NSSSSDDSSEEEEEK CCCCCCCCCHHHHHH	44.64	30108239
526	Phosphorylation	SSSSDDSSEEEEEKL CCCCCCCCHHHHHHH	56.90	26657352
538	Phosphorylation	EKLKGKGSPRPQAPK HHHCCCCCCCCCCCC	22.63	20201521
548 (in isoform 2)	Phosphorylation	-	26.38	21406692
549	Phosphorylation	QAPKANGTSALTAQN CCCCCCCCCCCHHCC	15.61	26074081
550	Phosphorylation	APKANGTSALTAQNG CCCCCCCCCCHHCCC	23.76	26074081
553	Phosphorylation	ANGTSALTAQNGKAA CCCCCCCHHCCCCCC	26.39	26074081
558	Acetylation	ALTAQNGKAAKNSEE CCHHCCCCCCCCCHH	53.36	25953088
563	Phosphorylation	NGKAAKNSEEEEEEK CCCCCCCCHHHHHHH	45.75	29255136
572	Sumoylation	EEEEEKKKAAVVVSK HHHHHHHHHEEEECC	53.28	25114211
573 (in isoform 2)	Phosphorylation	-	17.86	21406692
578	Phosphorylation	KKAAVVVSKSGSLKK HHHEEEECCCCHHHH	14.97	21712546
579	Acetylation	KAAVVVSKSGSLKKR HHEEEECCCCHHHHH	47.42	25953088
579	Sumoylation	KAAVVVSKSGSLKKR HHEEEECCCCHHHHH	47.42	28112733
580	Phosphorylation	AAVVVSKSGSLKKRK HEEEECCCCHHHHHH	26.55	26055452
582	Phosphorylation	VVVSKSGSLKKRKQN EEECCCCHHHHHHHH	44.07	26055452
593	Acetylation	RKQNEAAKEAETPQA HHHHHHHHHCCCHHH	65.59	26051181
597	Phosphorylation	EAAKEAETPQAKKIK HHHHHCCCHHHHHCC	27.96	28176443
601	Acetylation	EAETPQAKKIKLQTP HCCCHHHHHCCCCCC	50.19	23749302
602	Acetylation	AETPQAKKIKLQTPN CCCHHHHHCCCCCCC	48.35	25953088
604	Sumoylation	TPQAKKIKLQTPNTF CHHHHHCCCCCCCCC	43.34	-
604	Acetylation	TPQAKKIKLQTPNTF CHHHHHCCCCCCCCC	43.34	25953088
604	Sumoylation	TPQAKKIKLQTPNTF CHHHHHCCCCCCCCC	43.34	28112733
607	Phosphorylation	AKKIKLQTPNTFPKR HHHCCCCCCCCCCCC	29.01	22167270
610	Phosphorylation	IKLQTPNTFPKRKKG CCCCCCCCCCCCCCC	42.38	19664994
613	Sumoylation	QTPNTFPKRKKGEKR CCCCCCCCCCCCCCC	73.06	28112733
617 (in isoform 2)	Phosphorylation	-	49.01	21406692
620 (in isoform 2)	Phosphorylation	-	35.09	21406692
622	Phosphorylation	KKGEKRASSPFRRVR CCCCCCCCCCCCHHH	42.44	22167270
623	Phosphorylation	KGEKRASSPFRRVRE CCCCCCCCCCCHHHH	27.37	12167624
632 (in isoform 2)	Phosphorylation	-	39.43	21406692
633 (in isoform 2)	Phosphorylation	-	7.66	21406692
637	Phosphorylation	EEEIEVDSRVADNSF HHHCEECCHHHCCCC	33.55	25159151
638	Methylation	EEIEVDSRVADNSFD HHCEECCHHHCCCCC	24.15	115485317
643	Phosphorylation	DSRVADNSFDAKRGA CCHHHCCCCCHHCCC	25.67	29255136
647	Acetylation	ADNSFDAKRGAAGDW HCCCCCHHCCCCCCH	53.89	23749302
647	Sumoylation	ADNSFDAKRGAAGDW HCCCCCHHCCCCCCH	53.89	28112733
647	Ubiquitination	ADNSFDAKRGAAGDW HCCCCCHHCCCCCCH	53.89	2190698
647 (in isoform 1)	Ubiquitination	-	53.89	21890473
648	Methylation	DNSFDAKRGAAGDWG CCCCCHHCCCCCCHH	41.52	115485309
648 (in isoform 3)	Ubiquitination	-	41.52	21890473
653 (in isoform 2)	Phosphorylation	-	45.54	21406692
657 (in isoform 2)	Ubiquitination	-	34.59	21890473
663	Sumoylation	ERANQVLKFTKGKSF HHHHHHHHHHCCCCC	52.73	-
663	Acetylation	ERANQVLKFTKGKSF HHHHHHHHHHCCCCC	52.73	19608861
663	Methylation	ERANQVLKFTKGKSF HHHHHHHHHHCCCCC	52.73	22638443
663	Sumoylation	ERANQVLKFTKGKSF HHHHHHHHHHCCCCC	52.73	28112733
663	Ubiquitination	ERANQVLKFTKGKSF HHHHHHHHHHCCCCC	52.73	-
664	Acetylation	RANQVLKFTKGKSFR HHHHHHHHHCCCCCC	8.15	19608861
665	Phosphorylation	ANQVLKFTKGKSFRH HHHHHHHHCCCCCCC	36.98	30576142
669	Phosphorylation	LKFTKGKSFRHEKTK HHHHCCCCCCCCCCC	35.86	26074081
675	Phosphorylation	KSFRHEKTKKKRGSY CCCCCCCCCCCCCCC	45.15	-
681	Phosphorylation	KTKKKRGSYRGGSIS CCCCCCCCCCCCCEE	18.71	25159151
682	Phosphorylation	TKKKRGSYRGGSISV CCCCCCCCCCCCEEE	18.99	21712546
683	Methylation	KKKRGSYRGGSISVQ CCCCCCCCCCCEEEE	44.70	24129315
686	Phosphorylation	RGSYRGGSISVQVNS CCCCCCCCEEEEEEE	17.95	23401153
688	Phosphorylation	SYRGGSISVQVNSIK CCCCCCEEEEEEEEE	14.27	23927012
693	Phosphorylation	SISVQVNSIKFDSE- CEEEEEEEEEECCC-	28.44	22167270
695	Sumoylation	SVQVNSIKFDSE--- EEEEEEEEECCC---	42.83	28112733
696 (in isoform 2)	Phosphorylation	-	13.73	21406692
698	Phosphorylation	VNSIKFDSE------ EEEEEECCC------	48.62	22167270
698 (in isoform 2)	Phosphorylation	-	48.62	21406692
708 (in isoform 2)	Phosphorylation	-		21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
607	T	Phosphorylation	Kinase	CDK1	P06493	PSP
610	T	Phosphorylation	Kinase	CDK1	P06493	PSP
623	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
623	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NOLC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NOLC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COIL_HUMAN	COIL	physical	9679133
RPA1_HUMAN	POLR1A	physical	10567578
CEBPB_HUMAN	CEBPB	physical	9553145
A4_HUMAN	APP	physical	21832049
RS14_HUMAN	RPS14	physical	22939629
NOP56_HUMAN	NOP56	physical	22939629
RL1D1_HUMAN	RSL1D1	physical	22939629
RL15_HUMAN	RPL15	physical	22939629
RL23A_HUMAN	RPL23A	physical	22939629
RL18A_HUMAN	RPL18A	physical	22939629
RL19_HUMAN	RPL19	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
RL11_HUMAN	RPL11	physical	22939629
NOP58_HUMAN	NOP58	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS23_HUMAN	RPS23	physical	22939629
RL5_HUMAN	RPL5	physical	22939629
RL4_HUMAN	RPL4	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RRP7A_HUMAN	RRP7A	physical	22939629
UT14A_HUMAN	UTP14A	physical	22939629
CAVN1_HUMAN	PTRF	physical	22939629
RED_HUMAN	IK	physical	22939629
NOP16_HUMAN	NOP16	physical	22939629
RAI3_HUMAN	GPRC5A	physical	22939629
RRS1_HUMAN	RRS1	physical	22939629
SAP18_HUMAN	SAP18	physical	22939629
TF3C1_HUMAN	GTF3C1	physical	22939629
BRX1_HUMAN	BRIX1	physical	26344197
SSRP1_HUMAN	SSRP1	physical	26344197
WDR36_HUMAN	WDR36	physical	26344197
TCOF_HUMAN	TCOF1	physical	26399832
KBTB8_HUMAN	KBTBD8	physical	26399832
ARRB1_HUMAN	ARRB1	physical	26399832
ARRB2_HUMAN	ARRB2	physical	26399832
RPA1_HUMAN	POLR1A	physical	26399832
RPA2_HUMAN	POLR1B	physical	26399832
DKC1_HUMAN	DKC1	physical	26399832
NHP2_HUMAN	NHP2	physical	26399832
NOP58_HUMAN	NOP58	physical	26399832
NOP56_HUMAN	NOP56	physical	26399832
CSK21_HUMAN	CSNK2A1	physical	26399832
GT2D1_HUMAN	GTF2IRD1	physical	28514442
RPA43_HUMAN	TWISTNB	physical	28514442
HXB9_HUMAN	HOXB9	physical	28514442
AP3B1_HUMAN	AP3B1	physical	27173435
EAF1_HUMAN	EAF1	physical	27173435
DPOD1_HUMAN	POLD1	physical	27173435
CC154_HUMAN	CCDC154	physical	27173435
MFAP1_HUMAN	MFAP1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NOLC1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33; LYS-415 AND LYS-663, ANDMASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-607; THR-610; SER-643AND SER-698, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-188; THR-607; THR-610;SER-623 AND SER-698, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-563, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-85; SER-87;SER-90; SER-91; SER-366; SER-397; SER-508; SER-580; SER-582; THR-607;THR-610; SER-622; SER-623; SER-643; SER-686 AND SER-698, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-698, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397; SER-508; SER-538AND SER-643, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538, AND MASSSPECTROMETRY.	17287340 [Abstract]
"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction."; Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.; Mol. Cell. Proteomics 6:1952-1967(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-698, AND MASSSPECTROMETRY.	17693683 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-397; SER-508; SER-538;THR-607; THR-610 AND SER-643, AND MASS SPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-607; THR-610; SER-643AND SER-698, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-84; SER-85;SER-87; SER-90; SER-91; SER-538; SER-563; THR-607; THR-610 ANDSER-698, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-698, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Robust phosphoproteomic profiling of tyrosine phosphorylation sitesfrom human T cells using immobilized metal affinity chromatography andtandem mass spectrometry."; Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M.,Peters E.C.; Anal. Chem. 76:2763-2772(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-607 AND THR-610, ANDMASS SPECTROMETRY.	15144186 [Abstract]