dbPTM

EAF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	EAF1_HUMAN
UniProt AC	Q96JC9
Protein Name	ELL-associated factor 1
Gene Name	EAF1
Organism	Homo sapiens (Human).
Sequence Length	268
Subcellular Localization	Nucleus speckle . Nucleus, Cajal body .
Protein Description	Acts as a transcriptional transactivator of ELL and ELL2 elongation activities..
Protein Sequence	MNGTANPLLDREEHCLRLGESFEKRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVTITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSKIQARMEQQPTRPPQTSQPPPPPPPMPFRAPTKPPVGPKTSPLKDNPSPEPQLDDIKRELRAEVDIIEQMSSSSGSSSSDSESSSGSDDDSSSSGGEDNGPASPPQPSHQQPYNSRPAVANGTSRPQGSNQLMNTLRNDLQLSESGSDSDD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	25.55	30622161
10 (in isoform 2)	Phosphorylation	-	64.72	30622161
15 (in isoform 2)	Phosphorylation	-	2.40	30622161
21	Phosphorylation	HCLRLGESFEKRPRA HHHHHCHHHHHCCCC	36.59	23401153
24	Ubiquitination	RLGESFEKRPRASFH HHCHHHHHCCCCEEE	66.74	29967540
29	Phosphorylation	FEKRPRASFHTIRYD HHHCCCCEEEEEEEC	20.88	20068231
32	Phosphorylation	RPRASFHTIRYDFKP CCCCEEEEEEECCCC	12.73	23186163
49	Acetylation	IDTSCEGELQVGKGD CCCCCCCEEEECCCC	17.46	-
68	Phosphorylation	TLPHIPGSTPPMTVF ECCCCCCCCCCEEEE	32.17	25627689
69	Phosphorylation	LPHIPGSTPPMTVFK CCCCCCCCCCEEEEC	37.01	25627689
73	Phosphorylation	PGSTPPMTVFKGNKR CCCCCCEEEECCCCC	28.67	28122231
105	Phosphorylation	VLEKLSSSIQVKKTR HHHHHHCCCEEEECC	17.42	28555341
118	Acetylation	TRAEGSSKIQARMEQ CCCCCCHHHHHHHHC	40.30	25953088
149	Phosphorylation	PMPFRAPTKPPVGPK CCCCCCCCCCCCCCC	56.02	23186163
150	Acetylation	MPFRAPTKPPVGPKT CCCCCCCCCCCCCCC	46.39	23749302
157	Phosphorylation	KPPVGPKTSPLKDNP CCCCCCCCCCCCCCC	38.42	23927012
158	Phosphorylation	PPVGPKTSPLKDNPS CCCCCCCCCCCCCCC	34.07	23927012
165	Phosphorylation	SPLKDNPSPEPQLDD CCCCCCCCCCCCHHH	48.42	19664994
260	Phosphorylation	LRNDLQLSESGSDSD HHHHHHHHHCCCCCC	19.43	23663014
262	Phosphorylation	NDLQLSESGSDSDD- HHHHHHHCCCCCCC-	39.97	23911959
264	Phosphorylation	LQLSESGSDSDD--- HHHHHCCCCCCC---	43.13	23911959
266	Phosphorylation	LSESGSDSDD----- HHHCCCCCCC-----	45.43	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of EAF1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of EAF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of EAF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELL_HUMAN	ELL	physical	11418481
ELL2_HUMAN	ELL2	physical	11418481
A4_HUMAN	APP	physical	21832049
ELL_HUMAN	ELL	physical	21729782
ELL2_HUMAN	ELL2	physical	21729782
ELL3_HUMAN	ELL3	physical	21729782
AFF4_HUMAN	AFF4	physical	21729782
AFF1_HUMAN	AFF1	physical	21729782
ICE2_HUMAN	ICE2	physical	21729782
ICE1_HUMAN	ICE1	physical	21729782
MIPO1_HUMAN	MIPOL1	physical	25416956
BEND7_HUMAN	BEND7	physical	25416956
EAF2_HUMAN	EAF2	physical	26186194
ASPM_HUMAN	ASPM	physical	26186194
TOP1_HUMAN	TOP1	physical	26186194
FIP1_HUMAN	FIP1L1	physical	26186194
LC7L2_HUMAN	LUC7L2	physical	26186194
LUC7L_HUMAN	LUC7L	physical	26186194
TAF1A_HUMAN	TAF1A	physical	26186194
ICE2_HUMAN	ICE2	physical	26186194
RSBNL_HUMAN	RSBN1L	physical	26186194
RSBN1_HUMAN	RSBN1	physical	26186194
ICE1_HUMAN	ICE1	physical	26186194
RL26L_HUMAN	RPL26L1	physical	26186194
ELL2_HUMAN	ELL2	physical	26186194
CABIN_HUMAN	CABIN1	physical	26186194
PINX1_HUMAN	PINX1	physical	26186194
LC7L3_HUMAN	LUC7L3	physical	26186194
AF9_HUMAN	MLLT3	physical	26186194
ENL_HUMAN	MLLT1	physical	26186194
ELL_HUMAN	ELL	physical	26186194
TAF1B_HUMAN	TAF1B	physical	26186194
PI42C_HUMAN	PIP4K2C	physical	26186194
PI42B_HUMAN	PIP4K2B	physical	26186194
PI42A_HUMAN	PIP4K2A	physical	26186194
SNUT1_HUMAN	SART1	physical	26186194
AFF4_HUMAN	AFF4	physical	26186194
T2FA_HUMAN	GTF2F1	physical	26186194
E41L5_HUMAN	EPB41L5	physical	26186194
E41LB_HUMAN	EPB41L4B	physical	26186194
CAPON_HUMAN	NOS1AP	physical	26186194
KLDC3_HUMAN	KLHDC3	physical	26186194
CPSF4_HUMAN	CPSF4	physical	26186194
ELL3_HUMAN	ELL3	physical	26186194
TAF1D_HUMAN	TAF1D	physical	26186194
AFF1_HUMAN	AFF1	physical	26186194
MMTA2_HUMAN	C1orf35	physical	26186194
RBMX2_HUMAN	RBMX2	physical	26186194
TAF1C_HUMAN	TAF1C	physical	26186194
PLCD3_HUMAN	PLCD3	physical	26186194
CI114_HUMAN	C9orf114	physical	26186194
SP17_HUMAN	SPA17	physical	26186194
SFSWA_HUMAN	SFSWAP	physical	26186194
IKBL1_HUMAN	NFKBIL1	physical	26186194
HOME3_HUMAN	HOMER3	physical	21516116
ELL3_HUMAN	ELL3	physical	28514442
ELL_HUMAN	ELL	physical	28514442
ELL2_HUMAN	ELL2	physical	28514442
ICE1_HUMAN	ICE1	physical	28514442
ICE2_HUMAN	ICE2	physical	28514442
EAF2_HUMAN	EAF2	physical	28514442
AFF4_HUMAN	AFF4	physical	28514442
AFF1_HUMAN	AFF1	physical	28514442
ENL_HUMAN	MLLT1	physical	28514442
CABIN_HUMAN	CABIN1	physical	28514442
IKBL1_HUMAN	NFKBIL1	physical	28514442
E41L5_HUMAN	EPB41L5	physical	28514442
PI42C_HUMAN	PIP4K2C	physical	28514442
PI42A_HUMAN	PIP4K2A	physical	28514442
TAC2N_HUMAN	TC2N	physical	28514442
PI42B_HUMAN	PIP4K2B	physical	28514442
PLCD3_HUMAN	PLCD3	physical	28514442
RSBNL_HUMAN	RSBN1L	physical	28514442
CPSF4_HUMAN	CPSF4	physical	28514442
RSBN1_HUMAN	RSBN1	physical	28514442
TOP1_HUMAN	TOP1	physical	28514442
TAF1A_HUMAN	TAF1A	physical	28514442
CAPON_HUMAN	NOS1AP	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
TAF1C_HUMAN	TAF1C	physical	28514442
TAF1B_HUMAN	TAF1B	physical	28514442
SFSWA_HUMAN	SFSWAP	physical	28514442
TAF1D_HUMAN	TAF1D	physical	28514442
USPL1_HUMAN	USPL1	physical	28514442
FGRL1_HUMAN	FGFRL1	physical	28514442
T2FA_HUMAN	GTF2F1	physical	28514442
E41LB_HUMAN	EPB41L4B	physical	28514442
PINX1_HUMAN	PINX1	physical	28514442
CI114_HUMAN	C9orf114	physical	28514442
LUC7L_HUMAN	LUC7L	physical	28514442
LC7L2_HUMAN	LUC7L2	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
KLDC3_HUMAN	KLHDC3	physical	28514442
RBMX2_HUMAN	RBMX2	physical	28514442
NAF1_HUMAN	NAF1	physical	27173435
DPOD1_HUMAN	POLD1	physical	27173435
CC154_HUMAN	CCDC154	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of EAF1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-150, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-157 AND SER-165, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158 AND SER-165, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, AND MASSSPECTROMETRY.	17081983 [Abstract]