| UniProt ID | ICE2_HUMAN | |
|---|---|---|
| UniProt AC | Q659A1 | |
| Protein Name | Little elongation complex subunit 2 | |
| Gene Name | ICE2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 982 | |
| Subcellular Localization | Nucleus . Colocalizes with COIL in subnuclear Cajal and histone locus bodies. Translocates in the LEC complex to Cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes | |
| Protein Description | Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III.. | |
| Protein Sequence | MSSKMVISEPGLNWDISPKNGLKTFFSRENYKDHSMAPSLKELRVLSNRRIGENLNASASSVENEPAVSSATQAKEKVKTTIGMVLLPKPRVPYPRFSRFSQREQRSYVDLLVKYAKIPANSKAVGINKNDYLQYLDMKKHVNEEVTEFLKFLQNSAKKCAQDYNMLSDDARLFTEKILRACIEQVKKYSEFYTLHEVTSLMGFFPFRVEMGLKLEKTLLALGSVKYVKTVFPSMPIKLQLSKDDIATIETSEQTAEAMHYDISKDPNAEKLVSRYHPQIALTSQSLFTLLNNHGPTYKEQWEIPVCIQVIPVAGSKPVKVIYINSPLPQKKMTMRERNQIFHEVPLKFMMSKNTSVPVSAVFMDKPEEFISEMDMSCEVNECRKIESLENLYLDFDDDVTELETFGVTTTKVSKSPSPASTSTVPNMTDAPTAPKAGTTTVAPSAPDISANSRSLSQILMEQLQKEKQLVTGMDGGPEECKNKDDQGFESCEKVSNSDKPLIQDSDLKTSDALQLENSQEIETSNKNDMTIDILHADGERPNVLENLDNSKEKTVGSEAAKTEDTVLCSSDTDEECLIIDTECKNNSDGKTAVVGSNLSSRPASPNSSSGQASVGNQTNTACSPEESCVLKKPIKRVYKKFDPVGEILKMQDELLKPISRKVPELPLMNLENSKQPSVSEQLSGPSDSSSWPKSGWPSAFQKPKGRLPYELQDYVEDTSEYLAPQEGNFVYKLFSLQDLLLLVRCSVQRIETRPRSKKRKKIRRQFPVYVLPKVEYQACYGVEALTESELCRLWTESLLHSNSSFYVGHIDAFTSKLFLLEEITSEELKEKLSALKISNLFNILQHILKKLSSLQEGSYLLSHAAEDSSLLIYKASDGKVTRTAYNLYKTHCGLPGVPSSLSVPWVPLDPSLLLPYHIHHGRIPCTFPPKSLDTTTQQKIGGTRMPTRSHRNPVSMETKSSCLPAQQVETEGVAPHKRKIT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSSKMVISE ------CCCCEEECC | 24719451 | ||
| 3 | Phosphorylation | -----MSSKMVISEP -----CCCCEEECCC | 23401153 | ||
| 8 | Phosphorylation | MSSKMVISEPGLNWD CCCCEEECCCCCCCC | 29978859 | ||
| 17 | Phosphorylation | PGLNWDISPKNGLKT CCCCCCCCCCCCCHH | 23401153 | ||
| 24 | Phosphorylation | SPKNGLKTFFSRENY CCCCCCHHHHCCCCC | 24719451 | ||
| 60 | Phosphorylation | ENLNASASSVENEPA CCCCCCCCHHCCCCC | 28555341 | ||
| 61 | Phosphorylation | NLNASASSVENEPAV CCCCCCCHHCCCCCC | 28555341 | ||
| 75 | Acetylation | VSSATQAKEKVKTTI CCCHHHHHHHHCCEE | 20167786 | ||
| 89 (in isoform 2) | Ubiquitination | - | 21890473 | ||
| 101 | Phosphorylation | YPRFSRFSQREQRSY CCCCCCCCHHHHHHH | 24719451 | ||
| 108 | Phosphorylation | SQREQRSYVDLLVKY CHHHHHHHHHHHHHH | - | ||
| 115 | Phosphorylation | YVDLLVKYAKIPANS HHHHHHHHCCCCCCC | 24719451 | ||
| 117 | Ubiquitination | DLLVKYAKIPANSKA HHHHHHCCCCCCCCC | - | ||
| 123 | Ubiquitination | AKIPANSKAVGINKN CCCCCCCCCCCCCHH | - | ||
| 129 | Ubiquitination | SKAVGINKNDYLQYL CCCCCCCHHHHHHHH | - | ||
| 132 | Phosphorylation | VGINKNDYLQYLDMK CCCCHHHHHHHHHHH | - | ||
| 135 | Phosphorylation | NKNDYLQYLDMKKHV CHHHHHHHHHHHHHC | - | ||
| 139 | Acetylation | YLQYLDMKKHVNEEV HHHHHHHHHHCCHHH | 7696619 | ||
| 140 | Ubiquitination | LQYLDMKKHVNEEVT HHHHHHHHHCCHHHH | - | ||
| 140 | Acetylation | LQYLDMKKHVNEEVT HHHHHHHHHCCHHHH | 7696629 | ||
| 151 | Acetylation | EEVTEFLKFLQNSAK HHHHHHHHHHHHHHH | 7696639 | ||
| 159 | Ubiquitination | FLQNSAKKCAQDYNM HHHHHHHHHHHHHCC | - | ||
| 177 | Ubiquitination | DARLFTEKILRACIE HHHHHHHHHHHHHHH | - | ||
| 226 | Ubiquitination | LLALGSVKYVKTVFP HHHHCCCEEEEECCC | 21890473 | ||
| 226 (in isoform 1) | Ubiquitination | - | 21890473 | ||
| 226 | Ubiquitination | LLALGSVKYVKTVFP HHHHCCCEEEEECCC | 21890473 | ||
| 248 | Phosphorylation | LSKDDIATIETSEQT ECHHCCEEEECHHHH | - | ||
| 271 | Ubiquitination | SKDPNAEKLVSRYHP CCCCCHHHHHHHHCH | - | ||
| 274 | Phosphorylation | PNAEKLVSRYHPQIA CCHHHHHHHHCHHHE | - | ||
| 284 | Phosphorylation | HPQIALTSQSLFTLL CHHHEEEHHHHHHHH | 20068231 | ||
| 323 | Phosphorylation | SKPVKVIYINSPLPQ CCCEEEEEECCCCCC | 29396449 | ||
| 326 | Phosphorylation | VKVIYINSPLPQKKM EEEEEECCCCCCCCC | 25159151 | ||
| 348 | Ubiquitination | IFHEVPLKFMMSKNT HHHHHCHHHHCCCCC | - | ||
| 388 | Phosphorylation | NECRKIESLENLYLD HHCCCCHHHCCEEEC | 27732954 | ||
| 393 | Phosphorylation | IESLENLYLDFDDDV CHHHCCEEECCCCCC | 27732954 | ||
| 414 | Phosphorylation | GVTTTKVSKSPSPAS CEEEEECCCCCCCCC | 23401153 | ||
| 416 | Phosphorylation | TTTKVSKSPSPASTS EEEECCCCCCCCCCC | 30266825 | ||
| 418 | Phosphorylation | TKVSKSPSPASTSTV EECCCCCCCCCCCCC | 23401153 | ||
| 421 | Phosphorylation | SKSPSPASTSTVPNM CCCCCCCCCCCCCCC | 23401153 | ||
| 422 | Phosphorylation | KSPSPASTSTVPNMT CCCCCCCCCCCCCCC | 30266825 | ||
| 423 | Phosphorylation | SPSPASTSTVPNMTD CCCCCCCCCCCCCCC | 30266825 | ||
| 424 | Phosphorylation | PSPASTSTVPNMTDA CCCCCCCCCCCCCCC | 30266825 | ||
| 429 | Phosphorylation | TSTVPNMTDAPTAPK CCCCCCCCCCCCCCC | 20068231 | ||
| 433 | Phosphorylation | PNMTDAPTAPKAGTT CCCCCCCCCCCCCCC | 20068231 | ||
| 455 | Phosphorylation | DISANSRSLSQILME CCCCCCCCHHHHHHH | 22617229 | ||
| 457 | Phosphorylation | SANSRSLSQILMEQL CCCCCCHHHHHHHHH | 22617229 | ||
| 468 | Ubiquitination | MEQLQKEKQLVTGMD HHHHHHHHCHHHCCC | - | ||
| 472 | Phosphorylation | QKEKQLVTGMDGGPE HHHHCHHHCCCCCHH | - | ||
| 496 | Phosphorylation | FESCEKVSNSDKPLI CHHHHHCCCCCCCCC | 25627689 | ||
| 519 | Phosphorylation | DALQLENSQEIETSN CHHHHCCCCCCCCCC | 25159151 | ||
| 551 | Phosphorylation | VLENLDNSKEKTVGS HHHCCCCCCCCCCCC | 25159151 | ||
| 570 | Phosphorylation | TEDTVLCSSDTDEEC CCCEEEECCCCCCCE | 25137130 | ||
| 571 | Phosphorylation | EDTVLCSSDTDEECL CCEEEECCCCCCCEE | 25137130 | ||
| 573 | Phosphorylation | TVLCSSDTDEECLII EEEECCCCCCCEEEE | 25137130 | ||
| 592 | Phosphorylation | KNNSDGKTAVVGSNL ECCCCCCEEEECCCC | 28450419 | ||
| 597 | Phosphorylation | GKTAVVGSNLSSRPA CCEEEECCCCCCCCC | 28450419 | ||
| 600 | Phosphorylation | AVVGSNLSSRPASPN EEECCCCCCCCCCCC | 23927012 | ||
| 601 | Phosphorylation | VVGSNLSSRPASPNS EECCCCCCCCCCCCC | 23927012 | ||
| 605 | Phosphorylation | NLSSRPASPNSSSGQ CCCCCCCCCCCCCCC | 23401153 | ||
| 608 | Phosphorylation | SRPASPNSSSGQASV CCCCCCCCCCCCCCC | 29255136 | ||
| 609 | Phosphorylation | RPASPNSSSGQASVG CCCCCCCCCCCCCCC | 29255136 | ||
| 610 | Phosphorylation | PASPNSSSGQASVGN CCCCCCCCCCCCCCC | 29255136 | ||
| 614 | Phosphorylation | NSSSGQASVGNQTNT CCCCCCCCCCCCCCC | 29255136 | ||
| 619 | Phosphorylation | QASVGNQTNTACSPE CCCCCCCCCCCCCHH | 30576142 | ||
| 621 | Phosphorylation | SVGNQTNTACSPEES CCCCCCCCCCCHHHH | 25850435 | ||
| 624 | Phosphorylation | NQTNTACSPEESCVL CCCCCCCCHHHHHCC | 25159151 | ||
| 628 | Phosphorylation | TACSPEESCVLKKPI CCCCHHHHHCCCCCH | 20873877 | ||
| 678 | Phosphorylation | LENSKQPSVSEQLSG CCCCCCCCHHHHHCC | 27251275 | ||
| 680 | Phosphorylation | NSKQPSVSEQLSGPS CCCCCCHHHHHCCCC | 27251275 | ||
| 684 | Phosphorylation | PSVSEQLSGPSDSSS CCHHHHHCCCCCCCC | 27251275 | ||
| 687 | Phosphorylation | SEQLSGPSDSSSWPK HHHHCCCCCCCCCCC | 27251275 | ||
| 689 | Phosphorylation | QLSGPSDSSSWPKSG HHCCCCCCCCCCCCC | 27251275 | ||
| 690 | Phosphorylation | LSGPSDSSSWPKSGW HCCCCCCCCCCCCCC | 25627689 | ||
| 691 | Phosphorylation | SGPSDSSSWPKSGWP CCCCCCCCCCCCCCC | 27251275 | ||
| 695 | Phosphorylation | DSSSWPKSGWPSAFQ CCCCCCCCCCCCHHC | 27251275 | ||
| 699 | Phosphorylation | WPKSGWPSAFQKPKG CCCCCCCCHHCCCCC | 27251275 | ||
| 853 | Phosphorylation | QHILKKLSSLQEGSY HHHHHHHHHCCCCCH | 19690332 | ||
| 860 | Phosphorylation | SSLQEGSYLLSHAAE HHCCCCCHHHHHCCC | 19690332 | ||
| 932 | Phosphorylation | PCTFPPKSLDTTTQQ CCCCCCCCCCCCCCH | - | ||
| 935 | Phosphorylation | FPPKSLDTTTQQKIG CCCCCCCCCCCHHCC | - | ||
| 940 | Ubiquitination | LDTTTQQKIGGTRMP CCCCCCHHCCCCCCC | - | ||
| 944 | Phosphorylation | TQQKIGGTRMPTRSH CCHHCCCCCCCCCCC | - | ||
| 948 | Phosphorylation | IGGTRMPTRSHRNPV CCCCCCCCCCCCCCC | - | ||
| 978 | Acetylation | TEGVAPHKRKIT--- CCCCCCCCCCCC--- | 25953088 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ICE2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ICE2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ICE2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ELL_HUMAN | ELL | physical | 21729782 | |
| EAF1_HUMAN | EAF1 | physical | 21729782 | |
| ICE1_HUMAN | ICE1 | physical | 21729782 | |
| TBP_HUMAN | TBP | physical | 21729782 | |
| ACTA_HUMAN | ACTA2 | physical | 26186194 | |
| TCPW_HUMAN | CCT6B | physical | 26186194 | |
| PIGR_HUMAN | PIGR | physical | 26186194 | |
| HPT_HUMAN | HP | physical | 26186194 | |
| TRFL_HUMAN | LTF | physical | 26186194 | |
| MUC5B_HUMAN | MUC5B | physical | 26186194 | |
| A1AT_HUMAN | SERPINA1 | physical | 26186194 | |
| BPIA1_HUMAN | BPIFA1 | physical | 26186194 | |
| ZG16B_HUMAN | ZG16B | physical | 26186194 | |
| PERM_HUMAN | MPO | physical | 26186194 | |
| DMBT1_HUMAN | DMBT1 | physical | 26186194 | |
| CATG_HUMAN | CTSG | physical | 26186194 | |
| MUC5B_HUMAN | MUC5B | physical | 28514442 | |
| PERM_HUMAN | MPO | physical | 28514442 | |
| BPIA1_HUMAN | BPIFA1 | physical | 28514442 | |
| TRFL_HUMAN | LTF | physical | 28514442 | |
| PIGR_HUMAN | PIGR | physical | 28514442 | |
| A1AT_HUMAN | SERPINA1 | physical | 28514442 | |
| HPT_HUMAN | HP | physical | 28514442 | |
| CATG_HUMAN | CTSG | physical | 28514442 | |
| DMBT1_HUMAN | DMBT1 | physical | 28514442 | |
| IGJ_HUMAN | IGJ | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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