CATG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CATG_HUMAN
• UniProt AC: P08311
• Protein Name: Cathepsin G
• Gene Name: CTSG
• Organism: Homo sapiens (Human).
• Sequence Length: 255
• Subcellular Localization: Cell surface .
• Protein Description: Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride..
• Protein Sequence: MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	N-linked_Glycosylation	HCWGSNINVTLGAHN HHHCCCCEEEECHHH	25.60	UniProtKB CARBOHYD
85	Phosphorylation	NIQRRENTQQHITAR HHCCCCCHHHHHHHH	25.50	23532336
140	Phosphorylation	QEGLRPGTLCTVAGW CCCCCCCCEEEECCC	22.72	22210691
233	Phosphorylation	EVFTRVSSFLPWIRT HHHHHHHHHHHHHHH	28.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CATG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CATG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CATG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PARP1_HUMAN	PARP1	physical	11536009
SPB4_HUMAN	SERPINB4	physical	12949073
ENV_HV1H2	env	physical	8194606
K1H1_HUMAN	KRT31	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
GASP2_HUMAN	GPRASP2	physical	26186194
YTHD1_HUMAN	YTHDF1	physical	26186194
RS27A_HUMAN	RPS27A	physical	26186194
TCF25_HUMAN	TCF25	physical	26186194
FREM2_HUMAN	FREM2	physical	26186194
WIZ_HUMAN	WIZ	physical	26186194
RS27A_HUMAN	RPS27A	physical	28514442
GASP2_HUMAN	GPRASP2	physical	28514442
TCF25_HUMAN	TCF25	physical	28514442
YTHD1_HUMAN	YTHDF1	physical	28514442
PSMG3_HUMAN	PSMG3	physical	28514442
WIZ_HUMAN	WIZ	physical	28514442
FREM2_HUMAN	FREM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.