PARP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PARP1_HUMAN
• UniProt AC: P09874
• Protein Name: Poly [ADP-ribose] polymerase 1
• Gene Name: PARP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1014
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Localizes at sites of DNA damage.
• Protein Description: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. [PubMed: 17177976]
• Protein Sequence: MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAESSDKLY ------CCCCCCCEE	36.36	22814378
4	Phosphorylation	----MAESSDKLYRV ----CCCCCCCEEEH	51.39	30108239
5	Phosphorylation	---MAESSDKLYRVE ---CCCCCCCEEEHH	30.21	30108239
7	2-Hydroxyisobutyrylation	-MAESSDKLYRVEYA -CCCCCCCEEEHHHH	49.74	-
7	Acetylation	-MAESSDKLYRVEYA -CCCCCCCEEEHHHH	49.74	25953088
7	Ubiquitination	-MAESSDKLYRVEYA -CCCCCCCEEEHHHH	49.74	-
9	Phosphorylation	AESSDKLYRVEYAKS CCCCCCEEEHHHHHC	20.53	21406692
15	Acetylation	LYRVEYAKSGRASCK EEEHHHHHCCCCCHH	53.17	25953088
15	Ubiquitination	LYRVEYAKSGRASCK EEEHHHHHCCCCCHH	53.17	-
16	Phosphorylation	YRVEYAKSGRASCKK EEHHHHHCCCCCHHH	25.91	24719451
25	Phosphorylation	RASCKKCSESIPKDS CCCHHHCCCCCCHHH	43.17	-
27	Phosphorylation	SCKKCSESIPKDSLR CHHHCCCCCCHHHHE	28.09	-
30	Acetylation	KCSESIPKDSLRMAI HCCCCCCHHHHEEEE	59.27	26051181
32	Phosphorylation	SESIPKDSLRMAIMV CCCCCHHHHEEEEEE	24.81	-
35	Sulfoxidation	IPKDSLRMAIMVQSP CCHHHHEEEEEECCC	3.43	21406390
41	Phosphorylation	RMAIMVQSPMFDGKV EEEEEECCCCCCCCC	13.61	25159151
63	Phosphorylation	CFWKVGHSIRHPDVE EEEECCCCCCCCCCE	18.52	27080861
65	Methylation	WKVGHSIRHPDVEVD EECCCCCCCCCCEEC	38.00	115486469
75	Phosphorylation	DVEVDGFSELRWDDQ CCEECCCCCCCCCCH	41.05	30108239
78	Methylation	VDGFSELRWDDQQKV ECCCCCCCCCCHHHH	30.63	115486477
84	Acetylation	LRWDDQQKVKKTAEA CCCCCHHHHHHHHHH	50.84	23749302
84	Ubiquitination	LRWDDQQKVKKTAEA CCCCCHHHHHHHHHH	50.84	-
87	Ubiquitination	DDQQKVKKTAEAGGV CCHHHHHHHHHHCCC	56.82	-
88	Phosphorylation	DQQKVKKTAEAGGVT CHHHHHHHHHHCCCC	24.82	23663014
95	Phosphorylation	TAEAGGVTGKGQDGI HHHHCCCCCCCCCCC	36.13	23663014
97	Sumoylation	EAGGVTGKGQDGIGS HHCCCCCCCCCCCCC	43.99	-
97	Acetylation	EAGGVTGKGQDGIGS HHCCCCCCCCCCCCC	43.99	19608861
97	Sumoylation	EAGGVTGKGQDGIGS HHCCCCCCCCCCCCC	43.99	19608861
97	Ubiquitination	EAGGVTGKGQDGIGS HHCCCCCCCCCCCCC	43.99	19608861
104	Phosphorylation	KGQDGIGSKAEKTLG CCCCCCCCHHHHHHH	27.11	23663014
105	Sumoylation	GQDGIGSKAEKTLGD CCCCCCCHHHHHHHH	56.18	-
105	Acetylation	GQDGIGSKAEKTLGD CCCCCCCHHHHHHHH	56.18	19608861
105	Sumoylation	GQDGIGSKAEKTLGD CCCCCCCHHHHHHHH	56.18	19608861
108	Acetylation	GIGSKAEKTLGDFAA CCCCHHHHHHHHHHH	54.64	23954790
108	Ubiquitination	GIGSKAEKTLGDFAA CCCCHHHHHHHHHHH	54.64	21890473
109	Phosphorylation	IGSKAEKTLGDFAAE CCCHHHHHHHHHHHH	27.72	28555341
117	Phosphorylation	LGDFAAEYAKSNRST HHHHHHHHHHHCCCC	18.01	28152594
119	Acetylation	DFAAEYAKSNRSTCK HHHHHHHHHCCCCCH	47.57	25953088
119	Ubiquitination	DFAAEYAKSNRSTCK HHHHHHHHHCCCCCH	47.57	21906983
120	Phosphorylation	FAAEYAKSNRSTCKG HHHHHHHHCCCCCHH	29.33	27080861
131	Acetylation	TCKGCMEKIEKGQVR CCHHHHHHHHHCCCE	29.31	19608861
131	Ubiquitination	TCKGCMEKIEKGQVR CCHHHHHHHHHCCCE	29.31	19608861
134	Acetylation	GCMEKIEKGQVRLSK HHHHHHHHCCCEEEC	59.10	25953088
142	Acetylation	GQVRLSKKMVDPEKP CCCEEECCCCCCCCC	40.56	26051181
148	Sumoylation	KKMVDPEKPQLGMID CCCCCCCCCCCCCCC	43.37	-
148	Acetylation	KKMVDPEKPQLGMID CCCCCCCCCCCCCCC	43.37	23954790
148	Sumoylation	KKMVDPEKPQLGMID CCCCCCCCCCCCCCC	43.37	-
148	Ubiquitination	KKMVDPEKPQLGMID CCCCCCCCCCCCCCC	43.37	-
156	Methylation	PQLGMIDRWYHPGCF CCCCCCCCCCCCCCC	25.57	115486437
158	Phosphorylation	LGMIDRWYHPGCFVK CCCCCCCCCCCCCCC	10.07	28152594
165	Acetylation	YHPGCFVKNREELGF CCCCCCCCCHHHHCC	29.99	25953088
165	Ubiquitination	YHPGCFVKNREELGF CCCCCCCCCHHHHCC	29.99	21890473
176	Phosphorylation	ELGFRPEYSASQLKG HHCCCCCCCHHHHCC	16.54	23403867
177	Phosphorylation	LGFRPEYSASQLKGF HCCCCCCCHHHHCCC	21.56	25159151
179	Phosphorylation	FRPEYSASQLKGFSL CCCCCCHHHHCCCEE	30.06	17525332
182	Ubiquitination	EYSASQLKGFSLLAT CCCHHHHCCCEEEEC	50.72	-
185	Phosphorylation	ASQLKGFSLLATEDK HHHHCCCEEEECCCH	31.01	25159151
189	Phosphorylation	KGFSLLATEDKEALK CCCEEEECCCHHHHH	44.69	21815630
192	Sumoylation	SLLATEDKEALKKQL EEEECCCHHHHHHHC	38.36	-
192	2-Hydroxyisobutyrylation	SLLATEDKEALKKQL EEEECCCHHHHHHHC	38.36	-
192	Acetylation	SLLATEDKEALKKQL EEEECCCHHHHHHHC	38.36	25953088
192	Sumoylation	SLLATEDKEALKKQL EEEECCCHHHHHHHC	38.36	28112733
192	Ubiquitination	SLLATEDKEALKKQL EEEECCCHHHHHHHC	38.36	-
196	Acetylation	TEDKEALKKQLPGVK CCCHHHHHHHCCCCC	45.59	23749302
196	Malonylation	TEDKEALKKQLPGVK CCCHHHHHHHCCCCC	45.59	26320211
197	Ubiquitination	EDKEALKKQLPGVKS CCHHHHHHHCCCCCC	58.90	-
203	Sumoylation	KKQLPGVKSEGKRKG HHHCCCCCCCCCCCC	49.02	-
203	Sumoylation	KKQLPGVKSEGKRKG HHHCCCCCCCCCCCC	49.02	25114211
204	Phosphorylation	KQLPGVKSEGKRKGD HHCCCCCCCCCCCCC	49.53	25159151
209	Acetylation	VKSEGKRKGDEVDGV CCCCCCCCCCCCCCH	74.36	26051181
209	Ubiquitination	VKSEGKRKGDEVDGV CCCCCCCCCCCCCCH	74.36	21906983
221	Ubiquitination	DGVDEVAKKKSKKEK CCHHHHHHHHCHHHH	66.95	21906983
224	Phosphorylation	DEVAKKKSKKEKDKD HHHHHHHCHHHHCCC	58.81	-
239	Ubiquitination	SKLEKALKAQNDLIW HHHHHHHHHHHHHHH	53.43	21890473
239	Ubiquitination	SKLEKALKAQNDLIW HHHHHHHHHHHHHHH	53.43	21906983
249	Sumoylation	NDLIWNIKDELKKVC HHHHHHHHHHHHHHC	41.77	-
249	Acetylation	NDLIWNIKDELKKVC HHHHHHHHHHHHHHC	41.77	26822725
249	Sumoylation	NDLIWNIKDELKKVC HHHHHHHHHHHHHHC	41.77	28112733
249	Ubiquitination	NDLIWNIKDELKKVC HHHHHHHHHHHHHHC	41.77	-
253	Acetylation	WNIKDELKKVCSTND HHHHHHHHHHCCCCC	40.90	26051181
254	Acetylation	NIKDELKKVCSTNDL HHHHHHHHHCCCCCH	62.18	30582485
254	Ubiquitination	NIKDELKKVCSTNDL HHHHHHHHHCCCCCH	62.18	-
256	Glutathionylation	KDELKKVCSTNDLKE HHHHHHHCCCCCHHH	5.96	22555962
257	Phosphorylation	DELKKVCSTNDLKEL HHHHHHCCCCCHHHH	32.98	25159151
258	Phosphorylation	ELKKVCSTNDLKELL HHHHHCCCCCHHHHH	27.85	28464451
262	Sumoylation	VCSTNDLKELLIFNK HCCCCCHHHHHEEEC	49.53	-
262	Acetylation	VCSTNDLKELLIFNK HCCCCCHHHHHEEEC	49.53	25825284
262	Sumoylation	VCSTNDLKELLIFNK HCCCCCHHHHHEEEC	49.53	-
262	Ubiquitination	VCSTNDLKELLIFNK HCCCCCHHHHHEEEC	49.53	-
269	Ubiquitination	KELLIFNKQQVPSGE HHHHEEECCCCCCCC	31.21	21890473
269	2-Hydroxyisobutyrylation	KELLIFNKQQVPSGE HHHHEEECCCCCCCC	31.21	-
269	Acetylation	KELLIFNKQQVPSGE HHHHEEECCCCCCCC	31.21	26051181
269	Ubiquitination	KELLIFNKQQVPSGE HHHHEEECCCCCCCC	31.21	21906983
274	Phosphorylation	FNKQQVPSGESAILD EECCCCCCCCCHHHH	57.23	30266825
277	Phosphorylation	QQVPSGESAILDRVA CCCCCCCCHHHHHHC	24.92	30266825
282	Methylation	GESAILDRVADGMVF CCCHHHHHHCCCCEE	23.29	115486445
298	Glutathionylation	ALLPCEECSGQLVFK EEEECHHHCCEEEEE	2.30	22555962
299	Phosphorylation	LLPCEECSGQLVFKS EEECHHHCCEEEEEC	32.62	26714015
306	Phosphorylation	SGQLVFKSDAYYCTG CCEEEEECCCEEECC	18.93	28152594
309	Phosphorylation	LVFKSDAYYCTGDVT EEEECCCEEECCCHH	12.22	28152594
310	Phosphorylation	VFKSDAYYCTGDVTA EEECCCEEECCCHHH	5.81	28152594
311	Glutathionylation	FKSDAYYCTGDVTAW EECCCEEECCCHHHE	1.92	22555962
316	Phosphorylation	YYCTGDVTAWTKCMV EEECCCHHHEEEEEE	22.63	30576142
320	Ubiquitination	GDVTAWTKCMVKTQT CCHHHEEEEEEECCC	15.05	21890473
320	Acetylation	GDVTAWTKCMVKTQT CCHHHEEEEEEECCC	15.05	26051181
320	Ubiquitination	GDVTAWTKCMVKTQT CCHHHEEEEEEECCC	15.05	21906983
324	Acetylation	AWTKCMVKTQTPNRK HEEEEEEECCCCCCC	14.18	26051181
325	Phosphorylation	WTKCMVKTQTPNRKE EEEEEEECCCCCCCC	26.68	23403867
327	Phosphorylation	KCMVKTQTPNRKEWV EEEEECCCCCCCCCC	27.97	27174698
331	Acetylation	KTQTPNRKEWVTPKE ECCCCCCCCCCCHHH	63.67	26051181
331	Sumoylation	KTQTPNRKEWVTPKE ECCCCCCCCCCCHHH	63.67	-
331	Ubiquitination	KTQTPNRKEWVTPKE ECCCCCCCCCCCHHH	63.67	-
335	Phosphorylation	PNRKEWVTPKEFREI CCCCCCCCHHHHHHH	29.71	23403867
337	Ubiquitination	RKEWVTPKEFREISY CCCCCCHHHHHHHHH	61.18	21890473
337	Sumoylation	RKEWVTPKEFREISY CCCCCCHHHHHHHHH	61.18	-
337	Acetylation	RKEWVTPKEFREISY CCCCCCHHHHHHHHH	61.18	26822725
337	Sumoylation	RKEWVTPKEFREISY CCCCCCHHHHHHHHH	61.18	-
337	Ubiquitination	RKEWVTPKEFREISY CCCCCCHHHHHHHHH	61.18	21906983
343	Phosphorylation	PKEFREISYLKKLKV HHHHHHHHHHHHCCC	21.47	28152594
344	Phosphorylation	KEFREISYLKKLKVK HHHHHHHHHHHCCCC	28.36	25367160
346	Acetylation	FREISYLKKLKVKKQ HHHHHHHHHCCCCCC	48.07	25953088
361	Phosphorylation	DRIFPPETSASVAAT CCCCCCCCCCCCCCC	35.05	30266825
362	Phosphorylation	RIFPPETSASVAATP CCCCCCCCCCCCCCC	19.51	30266825
364	Phosphorylation	FPPETSASVAATPPP CCCCCCCCCCCCCCC	16.44	30266825
368	Phosphorylation	TSASVAATPPPSTAS CCCCCCCCCCCCCCC	26.96	23401153
372	Phosphorylation	VAATPPPSTASAPAA CCCCCCCCCCCCCCC	42.24	30266825
373	Phosphorylation	AATPPPSTASAPAAV CCCCCCCCCCCCCCC	30.33	30266825
375	Phosphorylation	TPPPSTASAPAAVNS CCCCCCCCCCCCCCC	34.57	30266825
382	Phosphorylation	SAPAAVNSSASADKP CCCCCCCCCCCCCCC	22.23	23403867
383	Phosphorylation	APAAVNSSASADKPL CCCCCCCCCCCCCCC	22.50	23403867
385	Phosphorylation	AAVNSSASADKPLSN CCCCCCCCCCCCCCC	38.66	23403867
387	ADP-ribosylation	VNSSASADKPLSNMK CCCCCCCCCCCCCCE	51.08	19764761
391	Phosphorylation	ASADKPLSNMKILTL CCCCCCCCCCEEEHH	43.32	24732914
394	Ubiquitination	DKPLSNMKILTLGKL CCCCCCCEEEHHHHH	38.52	21890473
394	Ubiquitination	DKPLSNMKILTLGKL CCCCCCCEEEHHHHH	38.52	21906983
400	Ubiquitination	MKILTLGKLSRNKDE CEEEHHHHHCCCHHH	46.53	21890473
400	Acetylation	MKILTLGKLSRNKDE CEEEHHHHHCCCHHH	46.53	25953088
400	Ubiquitination	MKILTLGKLSRNKDE CEEEHHHHHCCCHHH	46.53	21906983
407	PolyADP-ribosyl glutamic acid	KLSRNKDEVKAMIEK HHCCCHHHHHHHHHH	47.75	-
407	ADP-ribosylation	KLSRNKDEVKAMIEK HHCCCHHHHHHHHHH	47.75	-
409	Sumoylation	SRNKDEVKAMIEKLG CCCHHHHHHHHHHHC	30.14	-
409	Acetylation	SRNKDEVKAMIEKLG CCCHHHHHHHHHHHC	30.14	26822725
409	Sumoylation	SRNKDEVKAMIEKLG CCCHHHHHHHHHHHC	30.14	-
413	PolyADP-ribosyl glutamic acid	DEVKAMIEKLGGKLT HHHHHHHHHHCCCCC	29.19	-
413	ADP-ribosylation	DEVKAMIEKLGGKLT HHHHHHHHHHCCCCC	29.19	-
414	2-Hydroxyisobutyrylation	EVKAMIEKLGGKLTG HHHHHHHHHCCCCCC	41.32	-
414	Acetylation	EVKAMIEKLGGKLTG HHHHHHHHHCCCCCC	41.32	25953088
414	Ubiquitination	EVKAMIEKLGGKLTG HHHHHHHHHCCCCCC	41.32	-
418	Acetylation	MIEKLGGKLTGTANK HHHHHCCCCCCCCCH	40.87	23749302
418	Ubiquitination	MIEKLGGKLTGTANK HHHHHCCCCCCCCCH	40.87	-
420	Phosphorylation	EKLGGKLTGTANKAS HHHCCCCCCCCCHHH	35.65	24732914
422	Phosphorylation	LGGKLTGTANKASLC HCCCCCCCCCHHHHH	23.09	24732914
425	Ubiquitination	KLTGTANKASLCIST CCCCCCCHHHHHHHC	36.57	-
427	Phosphorylation	TGTANKASLCISTKK CCCCCHHHHHHHCHH	25.94	30576142
431	Phosphorylation	NKASLCISTKKEVEK CHHHHHHHCHHHHHH	32.93	30576142
432	Phosphorylation	KASLCISTKKEVEKM HHHHHHHCHHHHHHH	26.65	29083192
433	Sumoylation	ASLCISTKKEVEKMN HHHHHHCHHHHHHHH	39.90	-
433	Acetylation	ASLCISTKKEVEKMN HHHHHHCHHHHHHHH	39.90	25953088
433	Sumoylation	ASLCISTKKEVEKMN HHHHHHCHHHHHHHH	39.90	-
434	Ubiquitination	SLCISTKKEVEKMNK HHHHHCHHHHHHHHH	68.06	-
435	PolyADP-ribosyl glutamic acid	LCISTKKEVEKMNKK HHHHCHHHHHHHHHH	58.42	-
435	ADP-ribosylation	LCISTKKEVEKMNKK HHHHCHHHHHHHHHH	58.42	-
437	PolyADP-ribosyl glutamic acid	ISTKKEVEKMNKKME HHCHHHHHHHHHHHH	47.91	-
437	ADP-ribosylation	ISTKKEVEKMNKKME HHCHHHHHHHHHHHH	47.91	-
438	2-Hydroxyisobutyrylation	STKKEVEKMNKKMEE HCHHHHHHHHHHHHH	53.61	-
444	PolyADP-ribosyl glutamic acid	EKMNKKMEEVKEANI HHHHHHHHHHHHCCE	69.39	-
444	ADP-ribosylation	EKMNKKMEEVKEANI HHHHHHHHHHHHCCE	69.39	-
445	PolyADP-ribosyl glutamic acid	KMNKKMEEVKEANIR HHHHHHHHHHHCCEE	56.22	-
445	ADP-ribosylation	KMNKKMEEVKEANIR HHHHHHHHHHHCCEE	56.22	-
447	2-Hydroxyisobutyrylation	NKKMEEVKEANIRVV HHHHHHHHHCCEEEE	55.15	-
447	Ubiquitination	NKKMEEVKEANIRVV HHHHHHHHHCCEEEE	55.15	-
448	PolyADP-ribosyl glutamic acid	KKMEEVKEANIRVVS HHHHHHHHCCEEEEC	52.72	-
448	ADP-ribosylation	KKMEEVKEANIRVVS HHHHHHHHCCEEEEC	52.72	-
455	Phosphorylation	EANIRVVSEDFLQDV HCCEEEECHHHHHHH	28.70	20068231
456	PolyADP-ribosyl glutamic acid	ANIRVVSEDFLQDVS CCEEEECHHHHHHHC	40.97	-
456	ADP-ribosylation	ANIRVVSEDFLQDVS CCEEEECHHHHHHHC	40.97	-
463	Phosphorylation	EDFLQDVSASTKSLQ HHHHHHHCCCCHHHH	25.45	20068231
465	Phosphorylation	FLQDVSASTKSLQEL HHHHHCCCCHHHHHH	28.94	20068231
466	Phosphorylation	LQDVSASTKSLQELF HHHHCCCCHHHHHHH	25.11	20068231
467	Sumoylation	QDVSASTKSLQELFL HHHCCCCHHHHHHHH	46.83	-
467	Sumoylation	QDVSASTKSLQELFL HHHCCCCHHHHHHHH	46.83	28112733
471	PolyADP-ribosyl glutamic acid	ASTKSLQELFLAHIL CCCHHHHHHHHHHHH	46.94	-
471	ADP-ribosylation	ASTKSLQELFLAHIL CCCHHHHHHHHHHHH	46.94	-
479	Phosphorylation	LFLAHILSPWGAEVK HHHHHHHCCCCCCCE	20.29	28450419
484	PolyADP-ribosyl glutamic acid	ILSPWGAEVKAEPVE HHCCCCCCCEEECEE	40.38	-
484	ADP-ribosylation	ILSPWGAEVKAEPVE HHCCCCCCCEEECEE	40.38	-
486	Sumoylation	SPWGAEVKAEPVEVV CCCCCCCEEECEEEE	38.24	-
486	Sumoylation	SPWGAEVKAEPVEVV CCCCCCCEEECEEEE	38.24	25114211
486	Ubiquitination	SPWGAEVKAEPVEVV CCCCCCCEEECEEEE	38.24	-
488	PolyADP-ribosyl glutamic acid	WGAEVKAEPVEVVAP CCCCCEEECEEEEEC	44.13	-
488	ADP-ribosylation	WGAEVKAEPVEVVAP CCCCCEEECEEEEEC	44.13	19764761
491	PolyADP-ribosyl glutamic acid	EVKAEPVEVVAPRGK CCEEECEEEEECCCC	41.83	-
491	ADP-ribosylation	EVKAEPVEVVAPRGK CCEEECEEEEECCCC	41.83	19764761
498	Acetylation	EVVAPRGKSGAALSK EEEECCCCCCCCCCC	47.17	16204234
499	ADP-ribosylation	VVAPRGKSGAALSKK EEECCCCCCCCCCCC	36.17	28190768
499	Phosphorylation	VVAPRGKSGAALSKK EEECCCCCCCCCCCC	36.17	24719451
504	ADP-ribosylation	GKSGAALSKKSKGQV CCCCCCCCCCCCCCC	33.05	29954836
504	Phosphorylation	GKSGAALSKKSKGQV CCCCCCCCCCCCCCC	33.05	24719451
505	Acetylation	KSGAALSKKSKGQVK CCCCCCCCCCCCCCC	63.01	16204234
507	ADP-ribosylation	GAALSKKSKGQVKEE CCCCCCCCCCCCCCC	45.84	28190768
507	Phosphorylation	GAALSKKSKGQVKEE CCCCCCCCCCCCCCC	45.84	29496963
508	Acetylation	AALSKKSKGQVKEEG CCCCCCCCCCCCCCC	63.34	16204234
508	Methylation	AALSKKSKGQVKEEG CCCCCCCCCCCCCCC	63.34	-
512	Sumoylation	KKSKGQVKEEGINKS CCCCCCCCCCCCCHH	42.01	-
512	2-Hydroxyisobutyrylation	KKSKGQVKEEGINKS CCCCCCCCCCCCCHH	42.01	-
512	Acetylation	KKSKGQVKEEGINKS CCCCCCCCCCCCCHH	42.01	26051181
512	Sumoylation	KKSKGQVKEEGINKS CCCCCCCCCCCCCHH	42.01	28112733
513	PolyADP-ribosyl glutamic acid	KSKGQVKEEGINKSE CCCCCCCCCCCCHHH	63.70	-
513	ADP-ribosylation	KSKGQVKEEGINKSE CCCCCCCCCCCCHHH	63.70	-
514	PolyADP-ribosyl glutamic acid	SKGQVKEEGINKSEK CCCCCCCCCCCHHHH	60.71	-
514	ADP-ribosylation	SKGQVKEEGINKSEK CCCCCCCCCCCHHHH	60.71	-
518	Sumoylation	VKEEGINKSEKRMKL CCCCCCCHHHHHEEE	59.06	-
518	Acetylation	VKEEGINKSEKRMKL CCCCCCCHHHHHEEE	59.06	25953088
518	Sumoylation	VKEEGINKSEKRMKL CCCCCCCHHHHHEEE	59.06	-
519	ADP-ribosylation	KEEGINKSEKRMKLT CCCCCCHHHHHEEEE	43.81	28190768
519	Phosphorylation	KEEGINKSEKRMKLT CCCCCCHHHHHEEEE	43.81	29496963
520	PolyADP-ribosyl glutamic acid	EEGINKSEKRMKLTL CCCCCHHHHHEEEEE	46.41	-
520	ADP-ribosylation	EEGINKSEKRMKLTL CCCCCHHHHHEEEEE	46.41	-
521	Acetylation	EGINKSEKRMKLTLK CCCCHHHHHEEEEEE	65.95	16204234
524	Acetylation	NKSEKRMKLTLKGGA CHHHHHEEEEEECCC	42.21	16204234
526	Phosphorylation	SEKRMKLTLKGGAAV HHHHEEEEEECCCCC	22.39	24719451
528	Ubiquitination	KRMKLTLKGGAAVDP HHEEEEEECCCCCCC	50.49	21890473
528	Sumoylation	KRMKLTLKGGAAVDP HHEEEEEECCCCCCC	50.49	-
528	Acetylation	KRMKLTLKGGAAVDP HHEEEEEECCCCCCC	50.49	25953088
528	Sumoylation	KRMKLTLKGGAAVDP HHEEEEEECCCCCCC	50.49	28112733
528	Ubiquitination	KRMKLTLKGGAAVDP HHEEEEEECCCCCCC	50.49	21906983
537	Phosphorylation	GAAVDPDSGLEHSAH CCCCCCCCCCCCHHH	51.14	29214152
542	Phosphorylation	PDSGLEHSAHVLEKG CCCCCCCHHHHHHHC	15.64	25159151
548	Ubiquitination	HSAHVLEKGGKVFSA CHHHHHHHCCEEEEE	69.66	21890473
548	2-Hydroxyisobutyrylation	HSAHVLEKGGKVFSA CHHHHHHHCCEEEEE	69.66	-
548	Acetylation	HSAHVLEKGGKVFSA CHHHHHHHCCEEEEE	69.66	23749302
548	Malonylation	HSAHVLEKGGKVFSA CHHHHHHHCCEEEEE	69.66	26320211
548	Ubiquitination	HSAHVLEKGGKVFSA CHHHHHHHCCEEEEE	69.66	21890473
551	Ubiquitination	HVLEKGGKVFSATLG HHHHHCCEEEEEEEE	49.10	21890473
551	Acetylation	HVLEKGGKVFSATLG HHHHHCCEEEEEEEE	49.10	26051181
551	Ubiquitination	HVLEKGGKVFSATLG HHHHHCCEEEEEEEE	49.10	21906983
554	Phosphorylation	EKGGKVFSATLGLVD HHCCEEEEEEEECEE	24.27	29396449
556	Phosphorylation	GGKVFSATLGLVDIV CCEEEEEEEECEEEC	21.84	29396449
564	Ubiquitination	LGLVDIVKGTNSYYK EECEEECCCCCCEEE	61.42	21890473
564	Ubiquitination	LGLVDIVKGTNSYYK EECEEECCCCCCEEE	61.42	21906983
571	Acetylation	KGTNSYYKLQLLEDD CCCCCEEEEEEEECC	22.86	26051181
571	Ubiquitination	KGTNSYYKLQLLEDD CCCCCEEEEEEEECC	22.86	-
579	Ubiquitination	LQLLEDDKENRYWIF EEEEECCHHCCEEEE	70.03	21890473
579	Acetylation	LQLLEDDKENRYWIF EEEEECCHHCCEEEE	70.03	23749302
579	Ubiquitination	LQLLEDDKENRYWIF EEEEECCHHCCEEEE	70.03	21906983
582	Methylation	LEDDKENRYWIFRSW EECCHHCCEEEEECC	29.29	115486429
598	Phosphorylation	RVGTVIGSNKLEQMP CCEEEECCCCHHCCC	21.48	26714015
600	Ubiquitination	GTVIGSNKLEQMPSK EEEECCCCHHCCCCH	55.91	21890473
600	Sumoylation	GTVIGSNKLEQMPSK EEEECCCCHHCCCCH	55.91	-
600	Acetylation	GTVIGSNKLEQMPSK EEEECCCCHHCCCCH	55.91	19608861
600	Sumoylation	GTVIGSNKLEQMPSK EEEECCCCHHCCCCH	55.91	19608861
600	Ubiquitination	GTVIGSNKLEQMPSK EEEECCCCHHCCCCH	55.91	21906983
606	Phosphorylation	NKLEQMPSKEDAIEH CCHHCCCCHHHHHHH	43.25	21406692
607	2-Hydroxyisobutyrylation	KLEQMPSKEDAIEHF CHHCCCCHHHHHHHH	54.46	-
607	Acetylation	KLEQMPSKEDAIEHF CHHCCCCHHHHHHHH	54.46	26051181
607	Ubiquitination	KLEQMPSKEDAIEHF CHHCCCCHHHHHHHH	54.46	-
616	Acetylation	DAIEHFMKLYEEKTG HHHHHHHHHHHHHHC	47.15	26822725
621	Acetylation	FMKLYEEKTGNAWHS HHHHHHHHHCCCCCC	50.20	19608861
621	Ubiquitination	FMKLYEEKTGNAWHS HHHHHHHHHCCCCCC	50.20	19608861
629	Acetylation	TGNAWHSKNFTKYPK HCCCCCCCCCCCCCC	43.10	23749302
629	Ubiquitination	TGNAWHSKNFTKYPK HCCCCCCCCCCCCCC	43.10	-
632	Phosphorylation	AWHSKNFTKYPKKFY CCCCCCCCCCCCCCC	38.78	28152594
633	Acetylation	WHSKNFTKYPKKFYP CCCCCCCCCCCCCCC	56.25	25953088
633	Ubiquitination	WHSKNFTKYPKKFYP CCCCCCCCCCCCCCC	56.25	-
634	Phosphorylation	HSKNFTKYPKKFYPL CCCCCCCCCCCCCCE	19.75	28152594
637	Ubiquitination	NFTKYPKKFYPLEID CCCCCCCCCCCEEEC	45.70	21890473
637	Sumoylation	NFTKYPKKFYPLEID CCCCCCCCCCCEEEC	45.70	-
637	Acetylation	NFTKYPKKFYPLEID CCCCCCCCCCCEEEC	45.70	25953088
637	Sumoylation	NFTKYPKKFYPLEID CCCCCCCCCCCEEEC	45.70	-
637	Ubiquitination	NFTKYPKKFYPLEID CCCCCCCCCCCEEEC	45.70	21906983
639	Phosphorylation	TKYPKKFYPLEIDYG CCCCCCCCCEEECCC	18.78	28152594
645	Phosphorylation	FYPLEIDYGQDEEAV CCCEEECCCCCHHHH	23.50	28152594
653	Acetylation	GQDEEAVKKLTVNPG CCCHHHHHHHEECCC	49.46	25953088
653	Sumoylation	GQDEEAVKKLTVNPG CCCHHHHHHHEECCC	49.46	-
653	Ubiquitination	GQDEEAVKKLTVNPG CCCHHHHHHHEECCC	49.46	-
654	Sumoylation	QDEEAVKKLTVNPGT CCHHHHHHHEECCCC	42.67	-
654	Sumoylation	QDEEAVKKLTVNPGT CCHHHHHHHEECCCC	42.67	-
654	Ubiquitination	QDEEAVKKLTVNPGT CCHHHHHHHEECCCC	42.67	-
661	Phosphorylation	KLTVNPGTKSKLPKP HHEECCCCHHCCCHH	33.14	-
662	Acetylation	LTVNPGTKSKLPKPV HEECCCCHHCCCHHH	52.05	25953088
662	Ubiquitination	LTVNPGTKSKLPKPV HEECCCCHHCCCHHH	52.05	-
664	Acetylation	VNPGTKSKLPKPVQD ECCCCHHCCCHHHHH	71.07	26051181
664	Ubiquitination	VNPGTKSKLPKPVQD ECCCCHHCCCHHHHH	71.07	-
667	Acetylation	GTKSKLPKPVQDLIK CCHHCCCHHHHHHHH	69.15	26051181
667	Ubiquitination	GTKSKLPKPVQDLIK CCHHCCCHHHHHHHH	69.15	21890473
674	"N6,N6-dimethyllysine"	KPVQDLIKMIFDVES HHHHHHHHHHHCHHH	32.99	-
674	Acetylation	KPVQDLIKMIFDVES HHHHHHHHHHHCHHH	32.99	27452117
674	Methylation	KPVQDLIKMIFDVES HHHHHHHHHHHCHHH	32.99	-
681	Phosphorylation	KMIFDVESMKKAMVE HHHHCHHHHHHHHHE	35.43	-
683	Acetylation	IFDVESMKKAMVEYE HHCHHHHHHHHHEEE	46.81	23749302
683	Malonylation	IFDVESMKKAMVEYE HHCHHHHHHHHHEEE	46.81	26320211
683	Ubiquitination	IFDVESMKKAMVEYE HHCHHHHHHHHHEEE	46.81	21890473
689	Phosphorylation	MKKAMVEYEIDLQKM HHHHHHEEECCHHCC	13.53	-
695	Ubiquitination	EYEIDLQKMPLGKLS EEECCHHCCCCCCCC	50.19	-
700	Acetylation	LQKMPLGKLSKRQIQ HHCCCCCCCCHHHHH	58.22	25953088
700	Ubiquitination	LQKMPLGKLSKRQIQ HHCCCCCCCCHHHHH	58.22	-
702	Phosphorylation	KMPLGKLSKRQIQAA CCCCCCCCHHHHHHH	29.31	25159151
714	Phosphorylation	QAAYSILSEVQQAVS HHHHHHHHHHHHHHH	33.77	28348404
721	Phosphorylation	SEVQQAVSQGSSDSQ HHHHHHHHCCCCHHH	31.66	28348404
724	Phosphorylation	QQAVSQGSSDSQILD HHHHHCCCCHHHHHH	24.28	28348404
725	Phosphorylation	QAVSQGSSDSQILDL HHHHCCCCHHHHHHH	48.37	28348404
727	Phosphorylation	VSQGSSDSQILDLSN HHCCCCHHHHHHHHH	22.52	28348404
733	Phosphorylation	DSQILDLSNRFYTLI HHHHHHHHHCCEEEC	26.14	24275569
737	Phosphorylation	LDLSNRFYTLIPHDF HHHHHCCEEECCCCC	9.44	-
738	Phosphorylation	DLSNRFYTLIPHDFG HHHHCCEEECCCCCC	18.59	-
748	Sumoylation	PHDFGMKKPPLLNNA CCCCCCCCCCCCCCC	42.87	-
748	Acetylation	PHDFGMKKPPLLNNA CCCCCCCCCCCCCCC	42.87	26051181
748	Sumoylation	PHDFGMKKPPLLNNA CCCCCCCCCCCCCCC	42.87	25114211
748	Ubiquitination	PHDFGMKKPPLLNNA CCCCCCCCCCCCCCC	42.87	-
757	Phosphorylation	PLLNNADSVQAKVEM CCCCCCHHHHHHHHH	17.45	20873877
761	Sumoylation	NADSVQAKVEMLDNL CCHHHHHHHHHHHHH	22.95	-
775	Phosphorylation	LLDIEVAYSLLRGGS HHHHHHHHHHHHCCC	12.67	22817900
776	Phosphorylation	LDIEVAYSLLRGGSD HHHHHHHHHHHCCCC	15.93	28355574
779	Methylation	EVAYSLLRGGSDDSS HHHHHHHHCCCCCCC	53.36	115486461
782	Phosphorylation	YSLLRGGSDDSSKDP HHHHHCCCCCCCCCC	40.86	22167270
785	Phosphorylation	LRGGSDDSSKDPIDV HHCCCCCCCCCCCCC	44.25	30266825
786	Phosphorylation	RGGSDDSSKDPIDVN HCCCCCCCCCCCCCC	48.34	30266825
787	Acetylation	GGSDDSSKDPIDVNY CCCCCCCCCCCCCCH	72.04	23236377
787	Ubiquitination	GGSDDSSKDPIDVNY CCCCCCCCCCCCCCH	72.04	-
794	Phosphorylation	KDPIDVNYEKLKTDI CCCCCCCHHHHCCCE	17.81	23403867
796	Sumoylation	PIDVNYEKLKTDIKV CCCCCHHHHCCCEEE	44.94	-
796	2-Hydroxyisobutyrylation	PIDVNYEKLKTDIKV CCCCCHHHHCCCEEE	44.94	-
796	Acetylation	PIDVNYEKLKTDIKV CCCCCHHHHCCCEEE	44.94	26051181
796	Sumoylation	PIDVNYEKLKTDIKV CCCCCHHHHCCCEEE	44.94	-
796	Ubiquitination	PIDVNYEKLKTDIKV CCCCCHHHHCCCEEE	44.94	-
798	Ubiquitination	DVNYEKLKTDIKVVD CCCHHHHCCCEEEEC	56.04	-
802	Acetylation	EKLKTDIKVVDRDSE HHHCCCEEEECCCCH	38.73	27452117
802	Sumoylation	EKLKTDIKVVDRDSE HHHCCCEEEECCCCH	38.73	-
806	Methylation	TDIKVVDRDSEEAEI CCEEEECCCCHHHHH	37.43	115486485
808	Phosphorylation	IKVVDRDSEEAEIIR EEEECCCCHHHHHHH	37.93	-
815	Methylation	SEEAEIIRKYVKNTH CHHHHHHHHHHHCCC	29.88	115486493
819	Ubiquitination	EIIRKYVKNTHATTH HHHHHHHHCCCCCCC	53.70	-
824	O-linked_Glycosylation	YVKNTHATTHNAYDL HHHCCCCCCCCCCCE	22.45	OGP
824	Phosphorylation	YVKNTHATTHNAYDL HHHCCCCCCCCCCCE	22.45	-
838	Ubiquitination	LEVIDIFKIEREGEC EEEEEEEEEEECCCC	43.95	-
852	Acetylation	CQRYKPFKQLHNRRL CCCCCCHHHHCCCCE	61.55	23749302
852	Ubiquitination	CQRYKPFKQLHNRRL CCCCCCHHHHCCCCE	61.55	-
864	Phosphorylation	RRLLWHGSRTTNFAG CCEEEECCCCCCHHH	17.36	20068231
866	Phosphorylation	LLWHGSRTTNFAGIL EEEECCCCCCHHHHH	27.99	21712546
867	Phosphorylation	LWHGSRTTNFAGILS EEECCCCCCHHHHHH	27.51	21712546
874	Phosphorylation	TNFAGILSQGLRIAP CCHHHHHHCCCEECC	21.93	21712546
878	Methylation	GILSQGLRIAPPEAP HHHHCCCEECCCCCC	29.82	115486453
896	Phosphorylation	YMFGKGIYFADMVSK EECCCCEEHHHHHHC	11.03	-
900	Sulfoxidation	KGIYFADMVSKSANY CCEEHHHHHHCCCCC	3.08	30846556
907	Phosphorylation	MVSKSANYCHTSQGD HHHCCCCCCCCCCCC	5.82	-
940	Acetylation	KHASHISKLPKGKHS HCHHHHHCCCCCCCC	69.11	25953088
940	Ubiquitination	KHASHISKLPKGKHS HCHHHHHCCCCCCCC	69.11	-
949	Ubiquitination	PKGKHSVKGLGKTTP CCCCCCCCCCCCCCC	51.97	-
1006	Acetylation	LKYLLKLKFNFKTSL HHHHHHHEECCCCCC	36.35	26051181
1006	Ubiquitination	LKYLLKLKFNFKTSL HHHHHHHEECCCCCC	36.35	-
1010	Methylation	LKLKFNFKTSLW--- HHHEECCCCCCC---	38.00	24772241
1010	Ubiquitination	LKLKFNFKTSLW--- HHHEECCCCCCC---	38.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
177	S	Phosphorylation	Kinase	AMPKA1	Q13131	PSP
177	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
372	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
373	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
465	S	Phosphorylation	Kinase	PKACA	P17612	PSP
782	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
782	S	Phosphorylation	Kinase	PKACA	P17612	PSP
785	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
785	S	Phosphorylation	Kinase	PKACA	P17612	PSP
786	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
907	Y	Phosphorylation	Kinase	MET	P08581	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	CHFR	Q96EP1	PMID:23268447
-	K	Ubiquitination	E3 ubiquitin ligase	RNF4	P78317	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	RNF146	Q9NTX7	PMID:21825151

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PARP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PARP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	15044383
APTX_HUMAN	APTX	physical	15044383
XRCC1_HUMAN	XRCC1	physical	15044383
PCNA_HUMAN	PCNA	physical	12930846
CENPA_HUMAN	CENPA	physical	12011073
CENPB_HUMAN	CENPB	physical	12011073
BUB3_HUMAN	BUB3	physical	12011073
TF65_HUMAN	RELA	physical	11590148
PARP2_HUMAN	PARP2	physical	11948190
PARP2_MOUSE	Parp2	physical	11948190
BCL2_HUMAN	BCL2	physical	11790116
FOXO1_HUMAN	FOXO1	physical	19281796
H11_HUMAN	HIST1H1A	physical	17214964
PIAS4_HUMAN	PIAS4	physical	19779455
MIC60_HUMAN	IMMT	physical	19762472
BAF_HUMAN	BANF1	physical	19759913
HSP72_HUMAN	HSPA2	physical	19607827
LZTR1_HUMAN	LZTR1	physical	20211142
TRI29_HUMAN	TRIM29	physical	20211142
ZBTB9_HUMAN	ZBTB9	physical	20211142
TOP2B_HUMAN	TOP2B	physical	16794079
PRKDC_HUMAN	PRKDC	physical	16794079
XRCC5_HUMAN	XRCC5	physical	16794079
XRCC6_HUMAN	XRCC6	physical	16794079
SP16H_HUMAN	SUPT16H	physical	16682447
CND1_HUMAN	NCAPD2	physical	16543152
BUB1B_HUMAN	BUB1B	physical	16449973
EP300_HUMAN	EP300	physical	16204234
T2FA_HUMAN	GTF2F1	physical	16204234
MED1_HUMAN	MED1	physical	16204234
MED14_HUMAN	MED14	physical	16204234
MED23_HUMAN	MED23	physical	16204234
MED24_HUMAN	MED24	physical	16204234
MED17_HUMAN	MED17	physical	16204234
MED7_HUMAN	MED7	physical	16204234
CDK8_HUMAN	CDK8	physical	16204234
TR150_HUMAN	THRAP3	physical	16204234
MED6_HUMAN	MED6	physical	16204234
TF65_HUMAN	RELA	physical	16204234
NFKB1_HUMAN	NFKB1	physical	16204234
PARP1_HUMAN	PARP1	physical	16204234
HDAC1_HUMAN	HDAC1	physical	16204234
HDAC2_HUMAN	HDAC2	physical	16204234
HDAC3_HUMAN	HDAC3	physical	16204234
RARA_HUMAN	RARA	physical	15808511
THA_HUMAN	THRA	physical	15808511
MED6_HUMAN	MED6	physical	15808511
PARP1_HUMAN	PARP1	physical	15737996
HIF1A_HUMAN	HIF1A	physical	18314489
CARM1_HUMAN	CARM1	physical	18280497
TF65_HUMAN	RELA	physical	18280497
EP300_HUMAN	EP300	physical	18280497
ANM1_HUMAN	PRMT1	physical	18280497
XRCC5_HUMAN	XRCC5	physical	10400681
XRCC6_HUMAN	XRCC6	physical	10400681
NFAC1_HUMAN	NFATC1	physical	18078995
SP1_HUMAN	SP1	physical	17961220
PARP1_HUMAN	PARP1	physical	20388712
CDN1A_HUMAN	CDKN1A	physical	20303835
PCNA_HUMAN	PCNA	physical	20303835
DPOLB_HUMAN	POLB	physical	20303835
XRCC1_HUMAN	XRCC1	physical	20303835
CDN1A_HUMAN	CDKN1A	physical	20302655
PCNA_HUMAN	PCNA	physical	20302655
DPOLB_HUMAN	POLB	physical	20302655
XRCC1_HUMAN	XRCC1	physical	20302655
PARP3_HUMAN	PARP3	physical	20064938
CTCF_HUMAN	CTCF	physical	20038529
KLF8_HUMAN	KLF8	physical	21518760
APLF_HUMAN	APLF	physical	17396150
XRCC1_HUMAN	XRCC1	physical	12897160
XRCC6_HUMAN	XRCC6	physical	17283121
XRCC5_HUMAN	XRCC5	physical	17283121
TF7L2_HUMAN	TCF7L2	physical	17283121
PARP1_HUMAN	PARP1	physical	17283121
HES1_HUMAN	HES1	physical	21224467
XRCC5_HUMAN	XRCC5	physical	14734561
XRCC6_HUMAN	XRCC6	physical	14734561
WRN_HUMAN	WRN	physical	14734561
PARP1_HUMAN	PARP1	physical	14734561
XRCC6_HUMAN	XRCC6	physical	16490787
XRCC5_HUMAN	XRCC5	physical	16490787
PARP1_HUMAN	PARP1	physical	22683995
CHFR_HUMAN	CHFR	physical	22337872
UBC9_HUMAN	UBE2I	physical	9197546
NPM_MOUSE	Npm1	physical	15615785
NFKB1_HUMAN	NFKB1	physical	16799643
P53_HUMAN	TP53	physical	12898523
ZN423_HUMAN	ZNF423	physical	22863007
E2F1_HUMAN	E2F1	physical	14627987
P53_HUMAN	TP53	physical	14627987
ERCC6_HUMAN	ERCC6	physical	16107709
RL19_HUMAN	RPL19	physical	24140708
OSTP_HUMAN	SPP1	physical	24140708
MAFG_HUMAN	MAFG	physical	24140708
MAFK_HUMAN	MAFK	physical	24140708
MAFF_HUMAN	MAFF	physical	24140708
ABL1_HUMAN	ABL1	physical	24140708
CETN2_HUMAN	CETN2	physical	24140708
RL35_HUMAN	RPL35	physical	24140708
CETN1_HUMAN	CETN1	physical	24140708
RL27A_HUMAN	RPL27A	physical	24140708
PHB_HUMAN	PHB	physical	24140708
RL14_HUMAN	RPL14	physical	24140708
RS8_HUMAN	RPS8	physical	24140708
XRCC5_HUMAN	XRCC5	physical	24140708
TBB5_HUMAN	TUBB	physical	24140708
ATPA_HUMAN	ATP5A1	physical	24140708
DX39A_HUMAN	DDX39A	physical	24140708
TBB1_HUMAN	TUBB1	physical	24140708
DPOG2_HUMAN	POLG2	physical	24140708
XRCC6_HUMAN	XRCC6	physical	24140708
PDLI7_HUMAN	PDLIM7	physical	24140708
RD23A_HUMAN	RAD23A	physical	24140708
HNRH1_HUMAN	HNRNPH1	physical	24140708
UHRF1_HUMAN	UHRF1	physical	24782312
RN146_RAT	Rnf146	physical	24842055
APLF_HUMAN	APLF	physical	18172500
CHFR_HUMAN	CHFR	physical	18172500
DDB2_HUMAN	DDB2	physical	23319653
PARP1_HUMAN	PARP1	physical	22362888
SIR1_HUMAN	SIRT1	physical	19470756
EP300_HUMAN	EP300	physical	12960163
PARP1_HUMAN	PARP1	physical	24636898
JUN_HUMAN	JUN	physical	24636898
EP300_HUMAN	EP300	physical	24636898
CBP_HUMAN	CREBBP	physical	25306110
H1_YEAST	HHO1	genetic	25779917
HUL4_YEAST	HUL4	genetic	25779917
PO152_YEAST	POM152	genetic	25779917
OTU1_YEAST	OTU1	genetic	25779917
SNT1_YEAST	SNT1	genetic	25779917
GAL3_YEAST	GAL3	genetic	25779917
KLF5_HUMAN	KLF5	physical	17283079
PO2F1_HUMAN	POU2F1	physical	9537509
BLID_HUMAN	BLID	physical	25640309
IL24_HUMAN	IL24	physical	25640309
MTA3_HUMAN	MTA3	physical	25640309
RSLAB_HUMAN	RASL10B	physical	25640309
THRSP_HUMAN	THRSP	physical	25640309
BRCA1_HUMAN	BRCA1	physical	25252691
UIMC1_HUMAN	UIMC1	physical	25252691
ABRX1_HUMAN	FAM175A	physical	25252691
PARP1_HUMAN	PARP1	physical	25673562
MACD1_HUMAN	MACROD1	physical	25735744
NEMO_HUMAN	IKBKG	physical	25735744
DTX3L_HUMAN	DTX3L	physical	23230272
PARP9_HUMAN	PARP9	physical	23230272
HPF1_HUMAN	C4orf27	physical	27067600
PARP1_HUMAN	PARP1	physical	27067600
H15_HUMAN	HIST1H1B	physical	27067600
H31T_HUMAN	HIST3H3	physical	28190768
H15_HUMAN	HIST1H1B	physical	28190768
PARP1_HUMAN	PARP1	physical	28190768
HMGA1_HUMAN	HMGA1	physical	28190768
HMGB1_HUMAN	HMGB1	physical	28190768
HMGN1_HUMAN	HMGN1	physical	28190768
HMGN2_HUMAN	HMGN2	physical	28190768
HMGN4_HUMAN	HMGN4	physical	28190768
H31_HUMAN	HIST1H3A	physical	28190768
H33_HUMAN	H3F3A	physical	28190768
H12_HUMAN	HIST1H1C	physical	28190768
H10_HUMAN	H1F0	physical	28190768
HIPK2_HUMAN	HIPK2	physical	27787517
CHIP_HUMAN	STUB1	physical	27787517
RIR2_HUMAN	RRM2	genetic	28319113
BRCA2_HUMAN	BRCA2	genetic	27453043
BRCA1_HUMAN	BRCA1	genetic	27453043

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-97; LYS-105; LYS-131;LYS-600 AND LYS-621, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-782, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41; THR-368 AND SER-782,AND MASS SPECTROMETRY.
PubMed: 18669648

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND MASSSPECTROMETRY.
PubMed: 17525332