| UniProt ID | MED23_HUMAN | |
|---|---|---|
| UniProt AC | Q9ULK4 | |
| Protein Name | Mediator of RNA polymerase II transcription subunit 23 | |
| Gene Name | MED23 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1368 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.. | |
| Protein Sequence | METQLQSIFEEVVKTEVIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWGGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMHLRDRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWVPDDTYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVSGKEVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVISSPSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNSGSPAPQSNQVPVSLPVTQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----METQLQSIFE -----CHHHHHHHHH | 46.57 | 24043423 | |
| 7 | Phosphorylation | -METQLQSIFEEVVK -CHHHHHHHHHHHHH | 37.53 | 24043423 | |
| 242 | Ubiquitination | GAICNSWKLDPATLR CCCCCCCCCCCCCCC | 42.72 | - | |
| 242 | Acetylation | GAICNSWKLDPATLR CCCCCCCCCCCCCCC | 42.72 | 25953088 | |
| 242 | Ubiquitination | GAICNSWKLDPATLR CCCCCCCCCCCCCCC | 42.72 | - | |
| 253 (in isoform 5) | Ubiquitination | - | 47.99 | 21890473 | |
| 253 (in isoform 3) | Ubiquitination | - | 47.99 | 21890473 | |
| 253 | Ubiquitination | ATLRFPLKGLLPYDK CCCCCCCCCCCCCCC | 47.99 | 21890473 | |
| 253 (in isoform 4) | Ubiquitination | - | 47.99 | 21890473 | |
| 253 | Ubiquitination | ATLRFPLKGLLPYDK CCCCCCCCCCCCCCC | 47.99 | 21890473 | |
| 253 (in isoform 2) | Ubiquitination | - | 47.99 | 21890473 | |
| 253 (in isoform 1) | Ubiquitination | - | 47.99 | 21890473 | |
| 260 (in isoform 5) | Ubiquitination | - | 50.95 | 21890473 | |
| 260 | Ubiquitination | KGLLPYDKDLFEPQT CCCCCCCCCCCCHHH | 50.95 | 21890473 | |
| 260 (in isoform 4) | Ubiquitination | - | 50.95 | 21890473 | |
| 260 (in isoform 2) | Ubiquitination | - | 50.95 | 21890473 | |
| 260 (in isoform 3) | Ubiquitination | - | 50.95 | 21890473 | |
| 260 (in isoform 1) | Ubiquitination | - | 50.95 | 21890473 | |
| 260 | Ubiquitination | KGLLPYDKDLFEPQT CCCCCCCCCCCCHHH | 50.95 | 21890473 | |
| 291 | Ubiquitination | CNMLGLNKQHKQRCP HHHHCCCHHHHCCCC | 59.84 | - | |
| 291 | Acetylation | CNMLGLNKQHKQRCP HHHHCCCHHHHCCCC | 59.84 | 25953088 | |
| 291 | Ubiquitination | CNMLGLNKQHKQRCP HHHHCCCHHHHCCCC | 59.84 | - | |
| 294 | Ubiquitination | LGLNKQHKQRCPVLE HCCCHHHHCCCCCHH | 36.62 | - | |
| 294 | Ubiquitination | LGLNKQHKQRCPVLE HCCCHHHHCCCCCHH | 36.62 | - | |
| 450 | Phosphorylation | LQIPIPHSLRLHHEF CCCCCCHHHHHHHHH | 15.16 | 27080861 | |
| 465 (in isoform 5) | Ubiquitination | - | 46.22 | 21890473 | |
| 465 (in isoform 4) | Ubiquitination | - | 46.22 | 21890473 | |
| 465 | Ubiquitination | LQQSLRNKSLQMNDY HHHHHHCCCCCCCHH | 46.22 | 21906983 | |
| 465 (in isoform 1) | Ubiquitination | - | 46.22 | 21890473 | |
| 466 | Phosphorylation | QQSLRNKSLQMNDYK HHHHHCCCCCCCHHH | 27.64 | 24114839 | |
| 471 (in isoform 2) | Ubiquitination | - | 40.54 | 21890473 | |
| 471 (in isoform 3) | Ubiquitination | - | 40.54 | 21890473 | |
| 512 | Phosphorylation | MRIPLPGTNCMASGS EEECCCCCCCCCCCC | 24.25 | - | |
| 530 | Phosphorylation | LPMNLLDSLTVHAKM CCCCHHHHHHHHHHH | 26.38 | 23532336 | |
| 532 | Phosphorylation | MNLLDSLTVHAKMSL CCHHHHHHHHHHHHH | 17.75 | 23532336 | |
| 545 | Phosphorylation | SLIHSIATRVIKLAH HHHHHHHHHHHHHHH | 24.65 | - | |
| 554 | Ubiquitination | VIKLAHAKSSVALAP HHHHHHHHHHHHHHH | 33.14 | - | |
| 555 | Phosphorylation | IKLAHAKSSVALAPA HHHHHHHHHHHHHHH | 30.72 | - | |
| 556 | Phosphorylation | KLAHAKSSVALAPAL HHHHHHHHHHHHHHH | 15.65 | 29759185 | |
| 568 | Phosphorylation | PALVETYSRLLVYME HHHHHHHHHHHHHHH | 24.71 | 29759185 | |
| 654 | Phosphorylation | STALRLITALGSSEV HHHHHHHHHHCCCCC | 22.03 | 20068231 | |
| 658 | Phosphorylation | RLITALGSSEVQPQF HHHHHHCCCCCCCCH | 24.95 | 20068231 | |
| 659 | Phosphorylation | LITALGSSEVQPQFT HHHHHCCCCCCCCHH | 39.73 | 20068231 | |
| 666 | Phosphorylation | SEVQPQFTRFLSDPK CCCCCCHHHHHCCCC | 18.44 | 20068231 | |
| 673 (in isoform 1) | Ubiquitination | - | 57.14 | 21890473 | |
| 673 | Ubiquitination | TRFLSDPKTVLSAES HHHHCCCCCCCCCCC | 57.14 | 21906983 | |
| 673 (in isoform 5) | Ubiquitination | - | 57.14 | 21890473 | |
| 673 (in isoform 4) | Ubiquitination | - | 57.14 | 21890473 | |
| 679 (in isoform 3) | Ubiquitination | - | 56.13 | 21890473 | |
| 679 (in isoform 2) | Ubiquitination | - | 56.13 | 21890473 | |
| 690 | Phosphorylation | LNRALILTLARATHV HHHHHHHHHHHHHCC | 16.04 | 24719451 | |
| 758 | Ubiquitination | ESRFNLKKNVEEEYR HHHCCCCHHHHHHHH | 70.19 | - | |
| 766 | Ubiquitination | NVEEEYRKWKSMSNE HHHHHHHHHHHCCCC | 59.06 | - | |
| 868 | S-palmitoylation | TLDRLILCLAMRSHE HHHHHHHHHHHCCCC | 1.48 | 29575903 | |
| 905 | Ubiquitination | NRVSDFVKENSPEHW HHHHHHHHHCCHHHH | 51.69 | - | |
| 920 | Ubiquitination | LQNDWHTKHMNYHKK HHCCHHHHCCCHHHH | 28.15 | - | |
| 1050 | Ubiquitination | CLSDTYLKCAMNARE CCCHHHHHHHHCCCC | 14.99 | - | |
| 1082 | Ubiquitination | LVDTMAGKSPGPFPN HHHHHCCCCCCCCCC | 43.89 | - | |
| 1132 (in isoform 5) | Ubiquitination | - | 35.12 | 21890473 | |
| 1132 (in isoform 1) | Ubiquitination | - | 35.12 | 21890473 | |
| 1132 | Ubiquitination | ALLNVVLKSQPLVPR HHHHHHHHCCCCCCH | 35.12 | 2190698 | |
| 1132 (in isoform 4) | Ubiquitination | - | 35.12 | 21890473 | |
| 1138 (in isoform 3) | Ubiquitination | - | 45.62 | 21890473 | |
| 1176 | Phosphorylation | VSVISSPSLTSETEW EEECCCCCCCCCCCC | 46.34 | - | |
| 1311 | Acetylation | MFTGDSVKEQVEKII HHCCCCHHHHHHHHH | 46.51 | 26051181 | |
| 1316 | Ubiquitination | SVKEQVEKIICNLKP CHHHHHHHHHHCCHH | 38.22 | - | |
| 1322 | Ubiquitination | EKIICNLKPALKLRL HHHHHCCHHHHHHHH | 17.79 | - | |
| 1326 | Acetylation | CNLKPALKLRLRFIT HCCHHHHHHHHHHHH | 33.40 | 25953088 | |
| 1350 | Phosphorylation | VPPQAMNSGSPAPQS CCCCCCCCCCCCCCC | 27.80 | 18691976 | |
| 1352 | Phosphorylation | PQAMNSGSPAPQSNQ CCCCCCCCCCCCCCC | 20.08 | 20068231 | |
| 1357 | Phosphorylation | SGSPAPQSNQVPVSL CCCCCCCCCCCCCCC | 28.33 | 26074081 | |
| 1363 | Phosphorylation | QSNQVPVSLPVTQ-- CCCCCCCCCCCCC-- | 22.38 | 20068231 | |
| 1367 | Phosphorylation | VPVSLPVTQ------ CCCCCCCCC------ | 26.99 | 20068231 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MED23_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MED23_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MED23_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614249 | Mental retardation, autosomal recessive 18 (MRT18) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1352, AND MASSSPECTROMETRY. | |
