RUXG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUXG_HUMAN
• UniProt AC: P62308
• Protein Name: Small nuclear ribonucleoprotein G
• Gene Name: SNRPG
• Organism: Homo sapiens (Human).
• Sequence Length: 76
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
• Protein Description: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing..
• Protein Sequence: MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMVVIRGNSIIMLEALERV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MSKAHPPELK -----CCCCCCHHHH	49.79	23749302
3	Ubiquitination	-----MSKAHPPELK -----CCCCCCHHHH	49.79	-
3	2-Hydroxyisobutyrylation	-----MSKAHPPELK -----CCCCCCHHHH	49.79	-
10	Acetylation	KAHPPELKKFMDKKL CCCCHHHHHHHCCCC	42.16	25953088
10	Ubiquitination	KAHPPELKKFMDKKL CCCCHHHHHHHCCCC	42.16	21890473
10	2-Hydroxyisobutyrylation	KAHPPELKKFMDKKL CCCCHHHHHHHCCCC	42.16	-
11	Acetylation	AHPPELKKFMDKKLS CCCHHHHHHHCCCCE	59.55	11791301
11	Ubiquitination	AHPPELKKFMDKKLS CCCHHHHHHHCCCCE	59.55	21890473
15	Acetylation	ELKKFMDKKLSLKLN HHHHHHCCCCEEEEC	43.77	11791309
16	Acetylation	LKKFMDKKLSLKLNG HHHHHCCCCEEEECC	38.76	69747
20	Ubiquitination	MDKKLSLKLNGGRHV HCCCCEEEECCCCHH	36.21	21890473
20	Acetylation	MDKKLSLKLNGGRHV HCCCCEEEECCCCHH	36.21	25953088
50	Phosphorylation	DECVEMATSGQQNNI HHHHHHHCCCCCCCE	31.89	26126808
51	Phosphorylation	ECVEMATSGQQNNIG HHHHHHCCCCCCCEE	25.68	26126808
66	Phosphorylation	MVVIRGNSIIMLEAL EEEEECCEEEEEEHH	19.13	29523821
75	Methylation	IMLEALERV------ EEEEHHHCC------	40.05	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUXG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUXG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUXG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDT4L_HUMAN	DDIT4L	physical	16189514
GDF9_HUMAN	GDF9	physical	16169070
ERG28_HUMAN	C14orf1	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
CE126_HUMAN	KIAA1377	physical	16169070
TLE1_HUMAN	TLE1	physical	16169070
RUXE_HUMAN	SNRPE	physical	9417867
TACC1_HUMAN	TACC1	physical	12165861
RUXF_HUMAN	SNRPF	physical	22365833
LSM3_HUMAN	LSM3	physical	22365833
IL7RA_HUMAN	IL7R	physical	23151878
DDT4L_HUMAN	DDIT4L	physical	25416956
RSMN_HUMAN	SNRPN	physical	28514442
SNR48_HUMAN	SNRNP48	physical	28514442
RBM40_HUMAN	RNPC3	physical	28514442
U2AFM_HUMAN	ZRSR2	physical	28514442
LSM11_HUMAN	LSM11	physical	28514442
CMTR2_HUMAN	CMTR2	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
NADAP_HUMAN	SLC4A1AP	physical	28514442
RUXE_HUMAN	SNRPE	physical	28514442
PDCD7_HUMAN	PDCD7	physical	28514442
PKRI1_HUMAN	PRKRIP1	physical	28514442
CCD84_HUMAN	CCDC84	physical	28514442
U1SBP_HUMAN	SNRNP35	physical	28514442
ZMAT5_HUMAN	ZMAT5	physical	28514442
STPAP_HUMAN	TUT1	physical	28514442
RU2A_HUMAN	SNRPA1	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
SNR27_HUMAN	SNRNP27	physical	28514442
TOE1_HUMAN	TOE1	physical	28514442
PRPF3_HUMAN	PRPF3	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
MEPCE_HUMAN	MEPCE	physical	28514442
RU2B_HUMAN	SNRPB2	physical	28514442
SMD1_HUMAN	SNRPD1	physical	28514442
SNRPA_HUMAN	SNRPA	physical	28514442
ICLN_HUMAN	CLNS1A	physical	28514442
PAXB1_HUMAN	PAXBP1	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
GEMI2_HUMAN	GEMIN2	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
GEMI5_HUMAN	GEMIN5	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442
RSMB_HUMAN	SNRPB	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
RUXF_HUMAN	SNRPF	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
DDX23_HUMAN	DDX23	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
AKA7A_HUMAN	AKAP7	physical	28514442
AKA7G_HUMAN	AKAP7	physical	28514442
TGS1_HUMAN	TGS1	physical	28514442
SART3_HUMAN	SART3	physical	28514442
HTSF1_HUMAN	HTATSF1	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
PRP6_HUMAN	PRPF6	physical	28514442
TSSC4_HUMAN	TSSC4	physical	28514442
SYF2_HUMAN	SYF2	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
SNUT1_HUMAN	SART1	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
AQR_HUMAN	AQR	physical	28514442
LSM10_HUMAN	LSM10	physical	28514442
CCD12_HUMAN	CCDC12	physical	28514442
SF3B4_HUMAN	SF3B4	physical	28514442
GEMI8_HUMAN	GEMIN8	physical	28514442
SF3B2_HUMAN	SF3B2	physical	28514442
RSRC1_HUMAN	RSRC1	physical	28514442
PRP8_HUMAN	PRPF8	physical	28514442
GPT11_HUMAN	GPATCH11	physical	28514442
CD2B2_HUMAN	CD2BP2	physical	28514442
TXN4A_HUMAN	TXNL4A	physical	28514442
GEMI6_HUMAN	GEMIN6	physical	28514442
PRP31_HUMAN	PRPF31	physical	28514442
SF3B6_HUMAN	SF3B6	physical	28514442
RBM42_HUMAN	RBM42	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
SMD3_HUMAN	SNRPD3	physical	28514442
U5S1_HUMAN	EFTUD2	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
DGC14_HUMAN	DGCR14	physical	28514442
TOP1_HUMAN	TOP1	physical	28514442
RU1C_HUMAN	SNRPC	physical	28514442
PRP4_HUMAN	PRPF4	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
GEMI4_HUMAN	GEMIN4	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
ZGPAT_HUMAN	ZGPAT	physical	28514442
DDX20_HUMAN	DDX20	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.