dbPTM

NADAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NADAP_HUMAN
UniProt AC	Q9BWU0
Protein Name	Kanadaptin
Gene Name	SLC4A1AP
Organism	Homo sapiens (Human).
Sequence Length	796
Subcellular Localization	Nucleus . Cytoplasm . Mainly nuclear. Small amounts are found in the cytoplasm.
Protein Description
Protein Sequence	MLAPLRNAPGREGATSPSPPTDATGSLGEWDVDRNVKTEGWVSKERISKLHRLRMADILSQSETLASQDLSGDFKKPALPVSPAARSKAPASSSSNPEEVQKEGPTALQDSNSGEPDIPPPQPDCGDFRSLQEEQSRPPTAVSSPGGPARAPPYQEPPWGGPATAPYSLETLKGGTILGTRSLKGTSYCLFGRLSGCDVCLEHPSVSRYHAVLQHRASGPDGECDSNGPGFYLYDLGSTHGTFLNKTRIPPRTYCRVHVGHVVRFGGSTRLFILQGPEEDREAESELTVTQLKELRKQQQILLEKKMLGEDSDEEEEMDTSERKINAGSQDDEMGCTWGMGEDAVEDDAEENPIVLEFQQEREAFYIKDPKKALQGFFDREGEELEYEFDEQGHSTWLCRVRLPVDDSTGKQLVAEAIHSGKKKEAMIQCSLEACRILDTLGLLRQEAVSRKRKAKNWEDEDFYDSDDDTFLDRTGLIEKKRLNRMKKAGKIDEKPETFESLVAKLNDAERELSEISERLKASSQVLSESPSQDSLDAFMSEMKSGSTLDGVSRKKLHLRTFELRKEQQRLKGLIKIVKPAEIPELKKTETQTTGAENKAKKLTLPLFGAMKGGSKFKLKTGTVGKLPPKRPELPPTLMRMKDEPEVEEEEEEEEEEEKEKEEHEKKKLEDGSLSRPQPEIEPEAAVQEMRPPTDLTHFKETQTHENMSQLSEEEQNKDYQDCSKTTSLCAGPSASKNEYEKSRGELKKKKTPGPGKLPPTLSSKYPEDDPDYCVWVPPEGQSGDGRTHLNDKYGY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	APGREGATSPSPPTD CCCCCCCCCCCCCCC	52.61	27732954
16	Phosphorylation	PGREGATSPSPPTDA CCCCCCCCCCCCCCC	23.89	27732954
18	Phosphorylation	REGATSPSPPTDATG CCCCCCCCCCCCCCC	43.19	22210691
21	Phosphorylation	ATSPSPPTDATGSLG CCCCCCCCCCCCCCC	41.47	27732954
24	Phosphorylation	PSPPTDATGSLGEWD CCCCCCCCCCCCCCC	30.07	27732954
26	Phosphorylation	PPTDATGSLGEWDVD CCCCCCCCCCCCCCC	28.93	27732954
60	Phosphorylation	LRMADILSQSETLAS HHHHHHHHCHHHHHH	31.81	29083192
62	Phosphorylation	MADILSQSETLASQD HHHHHHCHHHHHHCC	29.22	29083192
64	Phosphorylation	DILSQSETLASQDLS HHHHCHHHHHHCCCC	32.63	26074081
67	Phosphorylation	SQSETLASQDLSGDF HCHHHHHHCCCCCCC	27.60	26074081
71	Phosphorylation	TLASQDLSGDFKKPA HHHHCCCCCCCCCCC	44.60	26074081
82	Phosphorylation	KKPALPVSPAARSKA CCCCCCCCHHHHCCC	13.59	29255136
87	Phosphorylation	PVSPAARSKAPASSS CCCHHHHCCCCCCCC	28.57	26074081
92	Phosphorylation	ARSKAPASSSSNPEE HHCCCCCCCCCCHHH	29.69	26074081
93	Phosphorylation	RSKAPASSSSNPEEV HCCCCCCCCCCHHHH	39.63	26074081
94	Phosphorylation	SKAPASSSSNPEEVQ CCCCCCCCCCHHHHH	31.47	26074081
95	Phosphorylation	KAPASSSSNPEEVQK CCCCCCCCCHHHHHH	59.35	26074081
106	Phosphorylation	EVQKEGPTALQDSNS HHHHHCCCCCCCCCC	51.35	26074081
130	Phosphorylation	PDCGDFRSLQEEQSR CCCCCCHHHHHHHHC	34.10	26552605
136	Phosphorylation	RSLQEEQSRPPTAVS HHHHHHHHCCCCCCC	50.46	29978859
140	Phosphorylation	EEQSRPPTAVSSPGG HHHHCCCCCCCCCCC	42.23	30266825
143	Phosphorylation	SRPPTAVSSPGGPAR HCCCCCCCCCCCCCC	28.49	30266825
144	Phosphorylation	RPPTAVSSPGGPARA CCCCCCCCCCCCCCC	22.44	30266825
173	Acetylation	PYSLETLKGGTILGT CCEEEECCCCEEEEC	63.82	26051181
176	Phosphorylation	LETLKGGTILGTRSL EEECCCCEEEECCCC	23.00	21406692
180	Phosphorylation	KGGTILGTRSLKGTS CCCEEEECCCCCCCC	17.40	21406692
182	Phosphorylation	GTILGTRSLKGTSYC CEEEECCCCCCCCEE	33.98	21406692
195	Phosphorylation	YCLFGRLSGCDVCLE EEEEEECCCCCEECC	35.69	-
238	Phosphorylation	FYLYDLGSTHGTFLN EEEEECCCCCCCCCC	25.24	26074081
239	Phosphorylation	YLYDLGSTHGTFLNK EEEECCCCCCCCCCC	23.64	26074081
246	Acetylation	THGTFLNKTRIPPRT CCCCCCCCCCCCCCC	41.13	26051181
281	Methylation	LQGPEEDREAESELT EECCHHHHHHHHCCC	48.59	115480795
297	Ubiquitination	TQLKELRKQQQILLE HHHHHHHHHHHHHHH	66.15	29967540
312	O-linked_Glycosylation	KKMLGEDSDEEEEMD HHHHCCCCCHHHHCC	42.49	30379171
312	Phosphorylation	KKMLGEDSDEEEEMD HHHHCCCCCHHHHCC	42.49	22167270
320	Phosphorylation	DEEEEMDTSERKINA CHHHHCCHHHCHHCC	31.04	23927012
321	Phosphorylation	EEEEMDTSERKINAG HHHHCCHHHCHHCCC	31.01	23927012
329	Phosphorylation	ERKINAGSQDDEMGC HCHHCCCCCCCCCCC	28.20	28348404
337	Phosphorylation	QDDEMGCTWGMGEDA CCCCCCCCCCCCCCC	21.23	26714015
368	Ubiquitination	EREAFYIKDPKKALQ HHHEEECCCHHHHHC	57.51	29967540
408	Phosphorylation	VRLPVDDSTGKQLVA EEEECCCCCCHHHHH	34.30	21815630
409	Phosphorylation	RLPVDDSTGKQLVAE EEECCCCCCHHHHHH	56.23	20068231
420	Phosphorylation	LVAEAIHSGKKKEAM HHHHHHHCCCCHHHH	46.31	20068231
422	Ubiquitination	AEAIHSGKKKEAMIQ HHHHHCCCCHHHHHH	64.78	33845483
427	Sulfoxidation	SGKKKEAMIQCSLEA CCCCHHHHHHHHHHH	1.97	21406390
440	Phosphorylation	EACRILDTLGLLRQE HHHHHHHHHHHHHHH	21.20	-
450	Phosphorylation	LLRQEAVSRKRKAKN HHHHHHHHHHHHCCC	38.85	29116813
464	Phosphorylation	NWEDEDFYDSDDDTF CCCCCCCCCCCCCCC	27.19	30266825
466	Phosphorylation	EDEDFYDSDDDTFLD CCCCCCCCCCCCCCC	31.40	22167270
470	Phosphorylation	FYDSDDDTFLDRTGL CCCCCCCCCCCCCCH	32.85	22167270
475	Phosphorylation	DDTFLDRTGLIEKKR CCCCCCCCCHHHHHH	35.69	26434776
480	Ubiquitination	DRTGLIEKKRLNRMK CCCCHHHHHHHHHHH	35.88	29967540
491	Ubiquitination	NRMKKAGKIDEKPET HHHHHCCCCCCCCHH	52.42	24816145
495	Acetylation	KAGKIDEKPETFESL HCCCCCCCCHHHHHH	44.39	26051181
495	Sumoylation	KAGKIDEKPETFESL HCCCCCCCCHHHHHH	44.39	28112733
495	Ubiquitination	KAGKIDEKPETFESL HCCCCCCCCHHHHHH	44.39	29967540
505	Ubiquitination	TFESLVAKLNDAERE HHHHHHHHHHHHHHH	40.10	29967540
521	Ubiquitination	SEISERLKASSQVLS HHHHHHHHHHHHHHH	53.06	29967540
523	Phosphorylation	ISERLKASSQVLSES HHHHHHHHHHHHHCC	21.51	27732954
524	Phosphorylation	SERLKASSQVLSESP HHHHHHHHHHHHCCC	29.21	17525332
528	Phosphorylation	KASSQVLSESPSQDS HHHHHHHHCCCCHHH	36.85	25159151
530	Phosphorylation	SSQVLSESPSQDSLD HHHHHHCCCCHHHHH	26.86	25159151
532	Phosphorylation	QVLSESPSQDSLDAF HHHHCCCCHHHHHHH	56.76	17525332
535	Phosphorylation	SESPSQDSLDAFMSE HCCCCHHHHHHHHHH	22.10	25159151
541	Phosphorylation	DSLDAFMSEMKSGST HHHHHHHHHCCCCCC	28.25	20068231
544	Ubiquitination	DAFMSEMKSGSTLDG HHHHHHCCCCCCCCC	47.84	22817900
545	Phosphorylation	AFMSEMKSGSTLDGV HHHHHCCCCCCCCCC	36.34	20068231
547	Phosphorylation	MSEMKSGSTLDGVSR HHHCCCCCCCCCCCH	32.65	20068231
548	Phosphorylation	SEMKSGSTLDGVSRK HHCCCCCCCCCCCHH	32.18	20068231
553	Phosphorylation	GSTLDGVSRKKLHLR CCCCCCCCHHHHHHH	43.86	20068231
587	Acetylation	PAEIPELKKTETQTT HHHCCCCCCCCCCCC	56.86	20167786
588	Acetylation	AEIPELKKTETQTTG HHCCCCCCCCCCCCC	65.30	20167786
604	Phosphorylation	ENKAKKLTLPLFGAM HHHHHHHCHHCCCCC	34.90	28555341
612	Acetylation	LPLFGAMKGGSKFKL HHCCCCCCCCCCEEE	60.63	25953088
642	Acetylation	PPTLMRMKDEPEVEE CCCCCCCCCCCCCCH	48.88	26051181
702	Phosphorylation	DLTHFKETQTHENMS CCCCHHHHHCCHHHH	39.08	28287266
704	Phosphorylation	THFKETQTHENMSQL CCHHHHHCCHHHHHC	38.28	28122231
709	Phosphorylation	TQTHENMSQLSEEEQ HHCCHHHHHCCHHHH	39.28	17525332
712	Phosphorylation	HENMSQLSEEEQNKD CHHHHHCCHHHHCCC	35.01	29255136
718	Acetylation	LSEEEQNKDYQDCSK CCHHHHCCCHHHHHH	58.46	26051181
720	Phosphorylation	EEEQNKDYQDCSKTT HHHHCCCHHHHHHHH	14.09	28796482
724	Phosphorylation	NKDYQDCSKTTSLCA CCCHHHHHHHHHCCC	41.13	20873877
725	Ubiquitination	KDYQDCSKTTSLCAG CCHHHHHHHHHCCCC	63.25	33845483
734	Phosphorylation	TSLCAGPSASKNEYE HHCCCCCCCCCCHHH	44.23	25159151
736	Phosphorylation	LCAGPSASKNEYEKS CCCCCCCCCCHHHHC	40.11	25627689
737	Acetylation	CAGPSASKNEYEKSR CCCCCCCCCHHHHCH	54.22	26051181
740	Phosphorylation	PSASKNEYEKSRGEL CCCCCCHHHHCHHHH	37.74	-
766	Phosphorylation	PPTLSSKYPEDDPDY CCCHHCCCCCCCCCC	17.50	27642862
773	Phosphorylation	YPEDDPDYCVWVPPE CCCCCCCCEEECCCC	8.35	28796482
793	Ubiquitination	GRTHLNDKYGY---- CCCCCCCCCCC----	39.23	19608861
793	Acetylation	GRTHLNDKYGY---- CCCCCCCCCCC----	39.23	19608861
794	Phosphorylation	RTHLNDKYGY----- CCCCCCCCCC-----	25.23	27642862
796	Phosphorylation	HLNDKYGY------- CCCCCCCC-------	16.58	25839225

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NADAP_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NADAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NADAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B3AT_HUMAN	SLC4A1	physical	9422766
A4_HUMAN	APP	physical	21832049
WIPF2_HUMAN	WIPF2	physical	22939629
DCLK1_HUMAN	DCLK1	physical	26344197
TPM2_HUMAN	TPM2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NADAP_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-793, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312 AND SER-466, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312; SER-466 ANDSER-535, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312; SER-466 ANDSER-530, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-524; SER-532; SER-709AND SER-712, AND MASS SPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-312 AND SER-466, ANDMASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-466 AND SER-530, ANDMASS SPECTROMETRY.	15302935 [Abstract]