dbPTM

DCLK1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCLK1_HUMAN
UniProt AC	O15075
Protein Name	Serine/threonine-protein kinase DCLK1
Gene Name	DCLK1
Organism	Homo sapiens (Human).
Sequence Length	740
Subcellular Localization
Protein Description	Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system..
Protein Sequence	MSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEVRENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQDDFLLDESECRVVKSTSYTKIASSSRRSTTKSPGPSRRSKSPASTSSVNGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDGPGEEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPNSTAAGVSVIATTALDKERQVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSPF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFGRDMEL ------CCCCCCCCC	36.09	25849741
2 (in isoform 2)	Phosphorylation	-	36.09	27251275
32	Phosphorylation	SRVNGLPSPTHSAHC CCCCCCCCCCCCCCC	47.69	22167270
32 (in isoform 2)	Phosphorylation	-	47.69	27251275
34	Phosphorylation	VNGLPSPTHSAHCSF CCCCCCCCCCCCCHH	32.57	22167270
34 (in isoform 2)	Phosphorylation	-	32.57	27251275
36	Phosphorylation	GLPSPTHSAHCSFYR CCCCCCCCCCCHHHH	23.37	22617229
40	Phosphorylation	PTHSAHCSFYRTRTL CCCCCCCHHHHHCCH	18.55	23403867
42	Phosphorylation	HSAHCSFYRTRTLQT CCCCCHHHHHCCHHH	8.52	23403867
44	Phosphorylation	AHCSFYRTRTLQTLS CCCHHHHHCCHHHHC	19.34	28857561
46	Phosphorylation	CSFYRTRTLQTLSSE CHHHHHCCHHHHCCC	23.70	25849741
46 (in isoform 2)	Phosphorylation	-	23.70	27251275
49	Phosphorylation	YRTRTLQTLSSEKKA HHHCCHHHHCCCCCC	31.55	28857561
51	Phosphorylation	TRTLQTLSSEKKAKK HCCHHHHCCCCCCCE	39.58	28857561
52	Phosphorylation	RTLQTLSSEKKAKKV CCHHHHCCCCCCCEE	57.45	28857561
68	Phosphorylation	FYRNGDRYFKGIVYA EEECCCCCCEEEEEE	17.87	-
77	Phosphorylation	KGIVYAISPDRFRSF EEEEEEECHHHHHCH	16.75	22617229
77 (in isoform 2)	Phosphorylation	-	16.75	27251275
118	Phosphorylation	IDGLKKISSLDQLVE ECHHHHHCCHHHHHC	33.46	27251275
119	Phosphorylation	DGLKKISSLDQLVEG CHHHHHCCHHHHHCC	39.16	27251275
119 (in isoform 2)	Phosphorylation	-	39.16	27251275
128	Phosphorylation	DQLVEGESYVCGSIE HHHHCCCCEECCCCC	33.45	23898821
151	Phosphorylation	KNVNPNWSVNVKTTS CCCCCCCEEEEECCC	15.51	28857561
164	Phosphorylation	TSASRAVSSLATAKG CCHHHHHHHHHHCCC	20.74	25849741
164 (in isoform 2)	Phosphorylation	-	20.74	27251275
165	Phosphorylation	SASRAVSSLATAKGS CHHHHHHHHHHCCCC	18.54	26699800
168	Phosphorylation	RAVSSLATAKGSPSE HHHHHHHHCCCCHHH	33.91	26699800
172	Phosphorylation	SLATAKGSPSEVREN HHHHCCCCHHHHHHC	25.25	25849741
172 (in isoform 2)	Phosphorylation	-	25.25	24719451
174	Phosphorylation	ATAKGSPSEVRENKD HHCCCCHHHHHHCCC	50.88	23403867
209	Phosphorylation	RILLNKKTAHSFEQV HHHCCCCCCCCHHHH	31.08	28857561
212	Phosphorylation	LNKKTAHSFEQVLTD CCCCCCCCHHHHHHH	28.19	28857561
265	Phosphorylation	CGPEKFRYQDDFLLD ECHHHHCCCCCCCCC	21.30	-
274	Phosphorylation	DDFLLDESECRVVKS CCCCCCHHHCEEEEC	41.48	28857561
280	Ubiquitination	ESECRVVKSTSYTKI HHHCEEEECCCCEEE	45.20	-
281	Phosphorylation	SECRVVKSTSYTKIA HHCEEEECCCCEEEE	15.81	21130716
282	Phosphorylation	ECRVVKSTSYTKIAS HCEEEECCCCEEEEC	21.75	21130716
283	Phosphorylation	CRVVKSTSYTKIASS CEEEECCCCEEEECC	37.59	21130716
284	Phosphorylation	RVVKSTSYTKIASSS EEEECCCCEEEECCC	16.49	21130716
285	Phosphorylation	VVKSTSYTKIASSSR EEECCCCEEEECCCC	18.75	21130716
286	Ubiquitination	VKSTSYTKIASSSRR EECCCCEEEECCCCC	28.21	-
289	Phosphorylation	TSYTKIASSSRRSTT CCCEEEECCCCCCCC	32.11	21130716
290	Phosphorylation	SYTKIASSSRRSTTK CCEEEECCCCCCCCC	20.88	21130716
291	Phosphorylation	YTKIASSSRRSTTKS CEEEECCCCCCCCCC	29.26	21130716
294	Phosphorylation	IASSSRRSTTKSPGP EECCCCCCCCCCCCC	39.04	25849741
296	Phosphorylation	SSSRRSTTKSPGPSR CCCCCCCCCCCCCCC	30.67	25849741
298	Phosphorylation	SRRSTTKSPGPSRRS CCCCCCCCCCCCCCC	32.75	25849741
298 (in isoform 2)	Phosphorylation	-	32.75	24719451
302	Phosphorylation	TTKSPGPSRRSKSPA CCCCCCCCCCCCCCC	46.36	26699800
305	Phosphorylation	SPGPSRRSKSPASTS CCCCCCCCCCCCCCC	36.05	23927012
305 (in isoform 2)	Phosphorylation	-	36.05	24719451
307	Phosphorylation	GPSRRSKSPASTSSV CCCCCCCCCCCCCCC	27.26	23927012
307 (in isoform 2)	Phosphorylation	-	27.26	24719451
310	Phosphorylation	RRSKSPASTSSVNGT CCCCCCCCCCCCCCC	32.00	23927012
311	Phosphorylation	RSKSPASTSSVNGTP CCCCCCCCCCCCCCC	27.42	23403867
312	Phosphorylation	SKSPASTSSVNGTPG CCCCCCCCCCCCCCC	29.78	23927012
313	Phosphorylation	KSPASTSSVNGTPGS CCCCCCCCCCCCCCC	21.49	23927012
317	Phosphorylation	STSSVNGTPGSQLST CCCCCCCCCCCCCCC	21.19	23403867
320	Phosphorylation	SVNGTPGSQLSTPRS CCCCCCCCCCCCCCC	29.20	23403867
320 (in isoform 2)	Phosphorylation	-	29.20	27251275
323	Phosphorylation	GTPGSQLSTPRSGKS CCCCCCCCCCCCCCC	28.82	23403867
324	Phosphorylation	TPGSQLSTPRSGKSP CCCCCCCCCCCCCCC	31.17	23403867
327	Phosphorylation	SQLSTPRSGKSPSPS CCCCCCCCCCCCCCC	52.34	24670416
327 (in isoform 2)	Phosphorylation	-	52.34	27251275
330	Phosphorylation	STPRSGKSPSPSPTS CCCCCCCCCCCCCCC	33.85	19664994
330 (in isoform 2)	Phosphorylation	-	33.85	24719451
332	Phosphorylation	PRSGKSPSPSPTSPG CCCCCCCCCCCCCCC	45.13	22617229
332 (in isoform 2)	Phosphorylation	-	45.13	24719451
334	Phosphorylation	SGKSPSPSPTSPGSL CCCCCCCCCCCCCCC	45.18	22617229
334 (in isoform 2)	Phosphorylation	-	45.18	24719451
336	Phosphorylation	KSPSPSPTSPGSLRK CCCCCCCCCCCCCCC	52.47	22617229
336 (in isoform 2)	Phosphorylation	-	52.47	27251275
337	Phosphorylation	SPSPSPTSPGSLRKQ CCCCCCCCCCCCCCC	30.55	28355574
337 (in isoform 2)	Phosphorylation	-	30.55	24719451
340	Phosphorylation	PSPTSPGSLRKQRSS CCCCCCCCCCCCCCC	28.52	30631047
346	Phosphorylation	GSLRKQRSSQHGGSS CCCCCCCCCCCCCCC	31.68	20363803
347	Phosphorylation	SLRKQRSSQHGGSST CCCCCCCCCCCCCCH	28.52	25849741
347 (in isoform 2)	Phosphorylation	-	28.52	27251275
352	Phosphorylation	RSSQHGGSSTSLAST CCCCCCCCCHHHHCC	34.73	23911959
352 (in isoform 2)	Phosphorylation	-	34.73	24719451
353	Phosphorylation	SSQHGGSSTSLASTK CCCCCCCCHHHHCCC	25.87	23927012
354	Phosphorylation	SQHGGSSTSLASTKV CCCCCCCHHHHCCCC	29.47	23927012
354 (in isoform 2)	Phosphorylation	-	29.47	27251275
355	Phosphorylation	QHGGSSTSLASTKVC CCCCCCHHHHCCCCC	24.72	23927012
355 (in isoform 2)	Phosphorylation	-	24.72	24719451
358	Phosphorylation	GSSTSLASTKVCSSM CCCHHHHCCCCCCCC	33.77	20363803
358 (in isoform 2)	Phosphorylation	-	33.77	27251275
359	Phosphorylation	SSTSLASTKVCSSMD CCHHHHCCCCCCCCC	23.14	23927012
363	Phosphorylation	LASTKVCSSMDENDG HHCCCCCCCCCCCCC	31.52	26657352
364	Phosphorylation	ASTKVCSSMDENDGP HCCCCCCCCCCCCCC	25.73	26657352
364 (in isoform 2)	Phosphorylation	-	25.73	24719451
376	Phosphorylation	DGPGEEVSEEGFQIP CCCCCCCCCCCCCCC	32.96	30177828
395	Phosphorylation	ERYKVGRTIGDGNFA CEEECCCEECCCCEE	24.31	28857561
413 (in isoform 4)	Phosphorylation	-	11.98	27251275
415 (in isoform 3)	Phosphorylation	-	32.47	22985185
419 (in isoform 4)	Phosphorylation	-	33.92	24719451
428 (in isoform 4)	Phosphorylation	-	49.53	27251275
438	Phosphorylation	HMIQNEVSILRRVKH HHCHHHHHHHHHCCC	15.10	28857561
459	Phosphorylation	IEEMDVPTELYLVME EECCCCCHHHHHHHH	38.17	30387612
462	Phosphorylation	MDVPTELYLVMELVK CCCCHHHHHHHHHHH	7.33	30387612
489	Phosphorylation	KYTERDASGMLYNLA CCCCCCHHHHHHHHH	29.08	28857561
493	Phosphorylation	RDASGMLYNLASAIK CCHHHHHHHHHHHHH	10.15	23090842
497	Phosphorylation	GMLYNLASAIKYLHS HHHHHHHHHHHHHHH	33.42	23090842
520	Phosphorylation	KPENLLVYEHQDGSK CHHHEEEEEECCCCC	13.99	21082442
660	Phosphorylation	PENEHQLSVAGKIKK CCCHHHHHHHHHHHH	11.89	28857561
678	Phosphorylation	TGPKPNSTAAGVSVI CCCCCCCCCCCEEEE	27.45	28857561
683	Phosphorylation	NSTAAGVSVIATTAL CCCCCCEEEEEECCC	13.59	28857561
709	Phosphorylation	NQDVRSRYKAQPAPP CHHHHHHHHCCCCCC	16.36	23312004
720	Phosphorylation	PAPPELNSESEDYSP CCCCCCCCCCCCCCC	55.94	25849741
722	Phosphorylation	PPELNSESEDYSPSS CCCCCCCCCCCCCCC	35.27	28857561
722 (in isoform 2)	Phosphorylation	-	35.27	22985185
725	Phosphorylation	LNSESEDYSPSSSET CCCCCCCCCCCCCCC	20.59	26657352
726	Phosphorylation	NSESEDYSPSSSETV CCCCCCCCCCCCCCC	30.54	25849741
728	Phosphorylation	ESEDYSPSSSETVRS CCCCCCCCCCCCCCC	40.32	27732954
729	Phosphorylation	SEDYSPSSSETVRSP CCCCCCCCCCCCCCC	35.26	27732954
730	Phosphorylation	EDYSPSSSETVRSPN CCCCCCCCCCCCCCC	41.44	27732954
732	Phosphorylation	YSPSSSETVRSPNSP CCCCCCCCCCCCCCC	24.14	27732954
735	Phosphorylation	SSSETVRSPNSPF-- CCCCCCCCCCCCC--	24.89	24076635
738	Phosphorylation	ETVRSPNSPF----- CCCCCCCCCC-----	30.94	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DCLK1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCLK1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCLK1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KI13B_HUMAN	KIF13B	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
CING_HUMAN	CGN	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435
RPTOR_HUMAN	RPTOR	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435
HDAC7_HUMAN	HDAC7	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DCLK1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-330; SER-332; SER-334;THR-336 AND SER-337, AND MASS SPECTROMETRY.	19413330 [Abstract]