dbPTM

SI1L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SI1L1_HUMAN
UniProt AC	O43166
Protein Name	Signal-induced proliferation-associated 1-like protein 1
Gene Name	SIPA1L1
Organism	Homo sapiens (Human).
Sequence Length	1804
Subcellular Localization	Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse, synaptosome. Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons
Protein Description	Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)..
Protein Sequence	MTSLKRSQTERPLATDRASVVGTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAPVGPPRSEGSHHITSTPGVPKMGVRARIADWPPRKENIKESSRSSQEIETSSCLDSLSSKSSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTRPSENMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKTGPSLHREYGSTSSIDKQGTSGESFFDLLKGYKDDKSDRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSASFSSPMGSTEDLNSKGSLSMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESASFESTLSSHCTNAGVAVLEVPKENLVLHLDRVKRYIVEHVDLGAYYYRKFFYQKEHWNYFGADENLGPVAVSIRREKPDEMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVVPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRVHNPCSDSVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAEDYNKAMELDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSTDTSLKIFYERGECVSVGSFINIEEIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLRQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEFKFPFRNNNKWQRNASKGPHSPQVPSQVQSPMTSRLNAGKGDGKMPPPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSDTGSVGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSIADQMAYSYRGPQDFNSFVLEQHEYTEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESELNSYNYLQGTSADSGIDTTSYGPSHGSTASLGAATSSPRSGPGKEKVAPLWHSSSEVISMADRTLETESHGLDRKTESSLSLDIHSKSQAGSTPLTRENSTFSINDAASHTSTMSSRHSASPVVFTSARSSPKEELHPAAPSQLAPSFSSSSSSSSGPRSFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKSFKFHALSSPQSPFPSTPTSRRALHRTLSDESIYNSQREHFFTSRASLLDQALPNDVLFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFSASDSSLTDIQETRRQPMPDPGLMPLPDTAADLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEDQALAQMKPYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVQHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSLKRSQT ------CCCCCCCCC	54.81	26074081
3	Phosphorylation	-----MTSLKRSQTE -----CCCCCCCCCC	43.69	26074081
5	Methylation	---MTSLKRSQTERP ---CCCCCCCCCCCC	50.17	-
7	Phosphorylation	-MTSLKRSQTERPLA -CCCCCCCCCCCCCC	39.61	26074081
9	Phosphorylation	TSLKRSQTERPLATD CCCCCCCCCCCCCCC	34.90	26074081
15	Phosphorylation	QTERPLATDRASVVG CCCCCCCCCCCEEEC	33.43	26074081
19	Phosphorylation	PLATDRASVVGTDGT CCCCCCCEEECCCCC	20.45	26074081
23	Phosphorylation	DRASVVGTDGTPKVH CCCEEECCCCCCCCC	21.46	26074081
26	Phosphorylation	SVVGTDGTPKVHTDD EEECCCCCCCCCCCH	23.81	21815630
31	Phosphorylation	DGTPKVHTDDFYMRR CCCCCCCCCHHHHHH	40.01	-
35	Phosphorylation	KVHTDDFYMRRFRSQ CCCCCHHHHHHHHHC	9.19	27642862
41	Phosphorylation	FYMRRFRSQNGSLGS HHHHHHHHCCCCCCC	25.86	22210691
45	Phosphorylation	RFRSQNGSLGSSVMA HHHHCCCCCCCCEEE	36.79	25599653
48	Phosphorylation	SQNGSLGSSVMAPVG HCCCCCCCCEEECCC	25.67	25599653
49	Phosphorylation	QNGSLGSSVMAPVGP CCCCCCCCEEECCCC	17.70	27251275
59	Phosphorylation	APVGPPRSEGSHHIT ECCCCCCCCCCCCCC	52.67	21130716
66	Phosphorylation	SEGSHHITSTPGVPK CCCCCCCCCCCCCCC	23.38	23186163
67	Phosphorylation	EGSHHITSTPGVPKM CCCCCCCCCCCCCCC	31.81	23186163
68	Phosphorylation	GSHHITSTPGVPKMG CCCCCCCCCCCCCCC	18.53	29214152
93	Phosphorylation	RKENIKESSRSSQEI CHHHHCCCCCCCHHH	26.50	30266825
94	Phosphorylation	KENIKESSRSSQEIE HHHHCCCCCCCHHHC	36.95	25849741
96	Phosphorylation	NIKESSRSSQEIETS HHCCCCCCCHHHCHH	38.02	25849741
97	Phosphorylation	IKESSRSSQEIETSS HCCCCCCCHHHCHHH	30.62	25849741
102	Phosphorylation	RSSQEIETSSCLDSL CCCHHHCHHHHHHHH	31.44	27251275
104	Phosphorylation	SQEIETSSCLDSLSS CHHHCHHHHHHHHCC	26.56	28985074
113	Phosphorylation	LDSLSSKSSPVSQGS HHHHCCCCCCCCCCC	41.65	25159151
114	Phosphorylation	DSLSSKSSPVSQGSS HHHCCCCCCCCCCCC	32.81	30576142
117	Phosphorylation	SSKSSPVSQGSSVSL CCCCCCCCCCCCEEC	32.01	27251275
120	Phosphorylation	SSPVSQGSSVSLNSN CCCCCCCCCEECCCC	21.67	29888752
121	Phosphorylation	SPVSQGSSVSLNSND CCCCCCCCEECCCCC	23.66	29888752
123	Phosphorylation	VSQGSSVSLNSNDSA CCCCCCEECCCCCHH	24.63	29888752
126	Phosphorylation	GSSVSLNSNDSAMLK CCCEECCCCCHHHHH	47.51	28985074
129	Phosphorylation	VSLNSNDSAMLKSIQ EECCCCCHHHHHHHH	21.59	29888752
134	Phosphorylation	NDSAMLKSIQNTLKN CCHHHHHHHHHHHCC	25.99	29888752
138	Phosphorylation	MLKSIQNTLKNKTRP HHHHHHHHHCCCCCC	23.80	29888752
143	Phosphorylation	QNTLKNKTRPSENMD HHHHCCCCCCCCCCC	58.15	30622161
146	Phosphorylation	LKNKTRPSENMDSRF HCCCCCCCCCCCHHH	38.01	30631047
151	Phosphorylation	RPSENMDSRFLMPEA CCCCCCCHHHCCCCC	17.73	30631047
159	Phosphorylation	RFLMPEAYPSSPRKA HHCCCCCCCCCHHHH	11.28	23927012
161	Phosphorylation	LMPEAYPSSPRKALR CCCCCCCCCHHHHHH	40.05	29255136
162	Phosphorylation	MPEAYPSSPRKALRR CCCCCCCCHHHHHHH	24.99	29255136
174	Phosphorylation	LRRIRQRSNSDITIS HHHHHHHCCCCCEEE	32.14	25884760
176	Phosphorylation	RIRQRSNSDITISEL HHHHHCCCCCEEEEE	31.47	22617229
179	Phosphorylation	QRSNSDITISELDVD HHCCCCCEEEEECCC	24.36	30576142
181	Phosphorylation	SNSDITISELDVDSF CCCCCEEEEECCCCC	24.37	28122231
187	Phosphorylation	ISELDVDSFDECISP EEEECCCCCHHHCCC	34.15	26074081
193	Phosphorylation	DSFDECISPTYKTGP CCCHHHCCCCCCCCC	23.89	25137130
195	Phosphorylation	FDECISPTYKTGPSL CHHHCCCCCCCCCCC	30.75	25137130
196	Phosphorylation	DECISPTYKTGPSLH HHHCCCCCCCCCCCC	15.22	26074081
198	Phosphorylation	CISPTYKTGPSLHRE HCCCCCCCCCCCCHH	43.86	23403867
201	Phosphorylation	PTYKTGPSLHREYGS CCCCCCCCCCHHHCC	37.85	23403867
206	Phosphorylation	GPSLHREYGSTSSID CCCCCHHHCCCCCCC	19.14	30266825
208	Phosphorylation	SLHREYGSTSSIDKQ CCCHHHCCCCCCCCC	24.98	23927012
209	Phosphorylation	LHREYGSTSSIDKQG CCHHHCCCCCCCCCC	23.33	30266825
210	Phosphorylation	HREYGSTSSIDKQGT CHHHCCCCCCCCCCC	27.30	30266825
211	Phosphorylation	REYGSTSSIDKQGTS HHHCCCCCCCCCCCC	34.59	30266825
217	Phosphorylation	SSIDKQGTSGESFFD CCCCCCCCCCCHHHH	30.94	30266825
218	Phosphorylation	SIDKQGTSGESFFDL CCCCCCCCCCHHHHH	47.60	30266825
221	Phosphorylation	KQGTSGESFFDLLKG CCCCCCCHHHHHHHC	34.44	24719451
234	Phosphorylation	KGYKDDKSDRGPTPT HCCCCCCCCCCCCCC	39.26	23312004
239	Phosphorylation	DKSDRGPTPTKLSDF CCCCCCCCCCCHHHE	46.55	18491316
241	Phosphorylation	SDRGPTPTKLSDFLI CCCCCCCCCHHHEEE	47.28	23312004
244	Phosphorylation	GPTPTKLSDFLITGG CCCCCCHHHEEECCC	28.07	22199227
249	Phosphorylation	KLSDFLITGGGKGSG CHHHEEECCCCCCCC	31.74	28450419
255	Phosphorylation	ITGGGKGSGFSLDVI ECCCCCCCCCCEEEC	39.90	30266825
258	Phosphorylation	GGKGSGFSLDVIDGP CCCCCCCCEEECCCC	27.47	30266825
262	Ubiquitination	SGFSLDVIDGPISQR CCCCEEECCCCCCHH	5.17	22817900
267	Phosphorylation	DVIDGPISQRENLRL EECCCCCCHHHHHHH	26.73	23090842
286	Phosphorylation	EKPLKRRSKSETGDS CCCCCCCCCCCCCCH	44.56	30266825
288	Phosphorylation	PLKRRSKSETGDSSI CCCCCCCCCCCCHHH	41.45	29255136
290	Phosphorylation	KRRSKSETGDSSIFR CCCCCCCCCCHHHHH	54.07	30266825
293	Phosphorylation	SKSETGDSSIFRKLR CCCCCCCHHHHHHHH	27.03	24702127
293	Ubiquitination	SKSETGDSSIFRKLR CCCCCCCHHHHHHHH	27.03	22817900
294	Phosphorylation	KSETGDSSIFRKLRN CCCCCCHHHHHHHHC	30.41	24702127
310	Phosphorylation	KGEELGKSSDLEDNR CCHHCCCCCCCCCCC	27.56	30108239
311	Phosphorylation	GEELGKSSDLEDNRS CHHCCCCCCCCCCCC	50.10	28188228
318	Phosphorylation	SDLEDNRSEDSVRPW CCCCCCCCCCCCCCC	52.59	30266825
321	Phosphorylation	EDNRSEDSVRPWTCP CCCCCCCCCCCCCCC	18.90	30266825
326	Phosphorylation	EDSVRPWTCPKCFAH CCCCCCCCCCCHHCC	22.93	30108239
337	Ubiquitination	CFAHYDVQSILFDLN HHCCCCHHHHHHHHH	23.12	30230243
359	Phosphorylation	NVIKRRNTTTGASAA CHHHCCCCCCHHHHH	24.75	30108239
360	Phosphorylation	VIKRRNTTTGASAAA HHHCCCCCCHHHHHH	27.12	30108239
361	Phosphorylation	IKRRNTTTGASAAAV HHCCCCCCHHHHHHH	28.81	27282143
364	Phosphorylation	RNTTTGASAAAVASL CCCCCHHHHHHHHHH	21.56	30108239
370	Phosphorylation	ASAAAVASLVSGPLS HHHHHHHHHHHCCCC	23.78	30108239
373	Phosphorylation	AAVASLVSGPLSHSA HHHHHHHHCCCCCCC	39.73	30108239
377	Phosphorylation	SLVSGPLSHSASFSS HHHHCCCCCCCCCCC	20.66	30108239
379	Phosphorylation	VSGPLSHSASFSSPM HHCCCCCCCCCCCCC	23.41	30108239
381	Phosphorylation	GPLSHSASFSSPMGS CCCCCCCCCCCCCCC	28.77	30108239
383	Phosphorylation	LSHSASFSSPMGSTE CCCCCCCCCCCCCCC	30.91	30108239
384	Phosphorylation	SHSASFSSPMGSTED CCCCCCCCCCCCCCC	19.52	30108239
388	Phosphorylation	SFSSPMGSTEDLNSK CCCCCCCCCCCCCCC	23.52	30108239
389	Phosphorylation	FSSPMGSTEDLNSKG CCCCCCCCCCCCCCC	27.99	30108239
394	Phosphorylation	GSTEDLNSKGSLSMD CCCCCCCCCCCCCCC	45.77	30108239
397	Phosphorylation	EDLNSKGSLSMDQGD CCCCCCCCCCCCCCC	22.47	28674419
399	Phosphorylation	LNSKGSLSMDQGDDK CCCCCCCCCCCCCCC	23.24	-
430	Phosphorylation	GEGERKISLSKSNSG CCCEEEEECCCCCCC	29.62	24719451
534	Ubiquitination	KENGSPYNYRIIFRT HHCCCCCCEEEEEEC	24.00	23000965
550	Phosphorylation	ELMTLRGSVLEDAIP CCHHHCCCHHHHHCC	19.66	28387310
563	Phosphorylation	IPSTAKHSTARGLPL CCCCCCCCCCCCCCH	24.05	28387310
565	Ubiquitination	STAKHSTARGLPLKE CCCCCCCCCCCCHHH	13.42	23000965
663	Phosphorylation	KYRAQLDTKTDSTGT HHHEECCCCCCCCCC	44.42	29083192
664	Ubiquitination	YRAQLDTKTDSTGTH HHEECCCCCCCCCCC	50.42	29967540
665	Phosphorylation	RAQLDTKTDSTGTHS HEECCCCCCCCCCCC	36.96	29083192
667	Phosphorylation	QLDTKTDSTGTHSLY ECCCCCCCCCCCCEE	33.69	29083192
668	Phosphorylation	LDTKTDSTGTHSLYT CCCCCCCCCCCCEEE	49.24	29083192
670	Phosphorylation	TKTDSTGTHSLYTTY CCCCCCCCCCEEEEE	14.37	29083192
672	Phosphorylation	TDSTGTHSLYTTYKD CCCCCCCCEEEEECC	23.94	29083192
674	Phosphorylation	STGTHSLYTTYKDYE CCCCCCEEEEECCCE	10.47	29083192
675	Phosphorylation	TGTHSLYTTYKDYEI CCCCCEEEEECCCEE	29.01	29083192
676	Phosphorylation	GTHSLYTTYKDYEIM CCCCEEEEECCCEEE	18.28	29083192
677	Phosphorylation	THSLYTTYKDYEIMF CCCEEEEECCCEEEE	8.28	29083192
680	Phosphorylation	LYTTYKDYEIMFHVS EEEEECCCEEEEEEE	11.82	29083192
687	Phosphorylation	YEIMFHVSTMLPYTP CEEEEEEEECCCCCC	10.26	29083192
688	Phosphorylation	EIMFHVSTMLPYTPN EEEEEEEECCCCCCC	22.95	29083192
692	Phosphorylation	HVSTMLPYTPNNKQQ EEEECCCCCCCCHHH	30.76	29083192
693	Phosphorylation	VSTMLPYTPNNKQQL EEECCCCCCCCHHHH	20.01	29083192
724	Phosphorylation	EPGAQPFSPKNIRSH CCCCCCCCCCHHHHH	41.47	24719451
763	Phosphorylation	TRSRDVPSFGPPIPK ECCCCCCCCCCCCCC	42.56	28787133
787	Ubiquitination	FRDFLLAKVINAENA HHHHHHHHHHCHHHH	43.55	22817900
787 (in isoform 1)	Ubiquitination	-	43.55	21906983
787 (in isoform 2)	Ubiquitination	-	43.55	21906983
797	Ubiquitination	NAENAAHKSEKFRAM CHHHHHHHHHHHHHH	56.43	29967540
800	Ubiquitination	NAAHKSEKFRAMATR HHHHHHHHHHHHHHH	47.44	-
819	Ubiquitination	YLKDLAEKNVTNTPI HHHHHHHCCCCCCCC	51.62	29967540
831	Ubiquitination	TPIDPSGKFPFISLA CCCCCCCCCCCEEEC	54.95	30230243
845	Phosphorylation	ASKKKEKSKPYPGAE CCCCCCCCCCCCCCC	39.70	22210691
854	Phosphorylation	PYPGAELSSMGAIVW CCCCCCHHHHHHEEE	15.13	22210691
855	Phosphorylation	YPGAELSSMGAIVWA CCCCCHHHHHHEEEE	33.58	22210691
894	Phosphorylation	LIEQETKSVVFNCSC EEEECCCEEEEEEEC	30.82	20068231
900	Phosphorylation	KSVVFNCSCRDVIGW CEEEEEEECCCCCCC	17.19	20068231
908	Phosphorylation	CRDVIGWTSTDTSLK CCCCCCCCCCCCCEE	19.28	20068231
909	Phosphorylation	RDVIGWTSTDTSLKI CCCCCCCCCCCCEEE	20.13	20068231
910	Phosphorylation	DVIGWTSTDTSLKIF CCCCCCCCCCCEEEE	35.60	20068231
912	Phosphorylation	IGWTSTDTSLKIFYE CCCCCCCCCEEEEEE	35.73	20068231
913	Phosphorylation	GWTSTDTSLKIFYER CCCCCCCCEEEEEEC	30.40	20068231
918	Phosphorylation	DTSLKIFYERGECVS CCCEEEEEECCCEEE	14.27	20068231
980	Phosphorylation	IVADVEPYGYAWQAG EEEECCCCCHHHHCC	14.84	-
982	Phosphorylation	ADVEPYGYAWQAGLR EECCCCCHHHHCCCC	9.98	-
1032	Phosphorylation	IPPHDDCTPRRSCSE ECCCCCCCCCCCCCC	27.16	28555341
1034	Phosphorylation	PHDDCTPRRSCSETY CCCCCCCCCCCCCCC	25.62	32142685
1036	Phosphorylation	DDCTPRRSCSETYRM CCCCCCCCCCCCCCE	24.23	27732954
1038	Phosphorylation	CTPRRSCSETYRMPV CCCCCCCCCCCCEEE	33.93	27732954
1040	Phosphorylation	PRRSCSETYRMPVME CCCCCCCCCCEEEEE	10.51	27732954
1041	Phosphorylation	RRSCSETYRMPVMEY CCCCCCCCCEEEEEE	10.81	27732954
1048	Phosphorylation	YRMPVMEYKMNEGVS CCEEEEEEECCCCCC	9.46	-
1055	Phosphorylation	YKMNEGVSYEFKFPF EECCCCCCEEEEECC	29.78	-
1056	Phosphorylation	KMNEGVSYEFKFPFR ECCCCCCEEEEECCC	23.99	25159151
1059	Ubiquitination	EGVSYEFKFPFRNNN CCCCEEEEECCCCCC	39.94	23000965
1073	Phosphorylation	NKWQRNASKGPHSPQ CCCCCCCCCCCCCCC	41.51	29496963
1074	Ubiquitination	KWQRNASKGPHSPQV CCCCCCCCCCCCCCC	74.23	29967540
1078	Phosphorylation	NASKGPHSPQVPSQV CCCCCCCCCCCCHHC	21.84	25159151
1083	Phosphorylation	PHSPQVPSQVQSPMT CCCCCCCHHCCCCCC	44.09	30266825
1087	Phosphorylation	QVPSQVQSPMTSRLN CCCHHCCCCCCCCCC	20.13	30266825
1090	Phosphorylation	SQVQSPMTSRLNAGK HHCCCCCCCCCCCCC	17.68	30266825
1091	Phosphorylation	QVQSPMTSRLNAGKG HCCCCCCCCCCCCCC	28.63	30266825
1114	O-linked_Glycosylation	RAANIPRSISSDGRP HHHCCCCCCCCCCCC	22.82	30379171
1114	Phosphorylation	RAANIPRSISSDGRP HHHCCCCCCCCCCCC	22.82	30108239
1116	Phosphorylation	ANIPRSISSDGRPLE HCCCCCCCCCCCCCC	24.51	23401153
1117	Phosphorylation	NIPRSISSDGRPLER CCCCCCCCCCCCCCC	42.27	23090842
1127	Phosphorylation	RPLERRLSPGSDIYV CCCCCCCCCCCCEEE	25.96	30266825
1130	Phosphorylation	ERRLSPGSDIYVTVS CCCCCCCCCEEEEHH	24.99	30266825
1133	Phosphorylation	LSPGSDIYVTVSSMA CCCCCCEEEEHHHHH	8.61	22617229
1134	Phosphorylation	SPGSDIYVTVSSMAL CCCCCEEEEHHHHHH	4.32	33259812
1135	O-linked_Glycosylation	PGSDIYVTVSSMALA CCCCEEEEHHHHHHH	9.56	30379171
1135	Phosphorylation	PGSDIYVTVSSMALA CCCCEEEEHHHHHHH	9.56	28450419
1137	Phosphorylation	SDIYVTVSSMALARS CCEEEEHHHHHHHHH	12.67	24117733
1138	Phosphorylation	DIYVTVSSMALARSQ CEEEEHHHHHHHHHH	12.07	24117733
1144	Phosphorylation	SSMALARSQCRNSPS HHHHHHHHHHCCCCC	28.20	23927012
1149	Phosphorylation	ARSQCRNSPSNLSSS HHHHHCCCCCCCCCC	15.45	22167270
1151	Phosphorylation	SQCRNSPSNLSSSSD HHHCCCCCCCCCCCC	50.66	28355574
1154	Phosphorylation	RNSPSNLSSSSDTGS CCCCCCCCCCCCCCC	32.21	24732914
1155	Phosphorylation	NSPSNLSSSSDTGSV CCCCCCCCCCCCCCC	36.71	24732914
1156	Phosphorylation	SPSNLSSSSDTGSVG CCCCCCCCCCCCCCC	28.93	24732914
1157	Phosphorylation	PSNLSSSSDTGSVGG CCCCCCCCCCCCCCC	40.93	24732914
1159	Phosphorylation	NLSSSSDTGSVGGTY CCCCCCCCCCCCCCC	33.05	24732914
1161	Phosphorylation	SSSSDTGSVGGTYRQ CCCCCCCCCCCCCCC	21.49	24732914
1165	Phosphorylation	DTGSVGGTYRQKSMP CCCCCCCCCCCCCCC	15.03	24732914
1166	Phosphorylation	TGSVGGTYRQKSMPE CCCCCCCCCCCCCCC	17.83	24732914
1169	Ubiquitination	VGGTYRQKSMPEGFG CCCCCCCCCCCCCCC	39.46	29967540
1170	Phosphorylation	GGTYRQKSMPEGFGV CCCCCCCCCCCCCCC	31.09	28450419
1178	O-linked_Glycosylation	MPEGFGVSRRSPASI CCCCCCCCCCCCHHC	23.50	30379171
1178	Phosphorylation	MPEGFGVSRRSPASI CCCCCCCCCCCCHHC	23.50	30576142
1181	Phosphorylation	GFGVSRRSPASIDRQ CCCCCCCCCHHCCCC	24.57	28355574
1184	Phosphorylation	VSRRSPASIDRQNTQ CCCCCCHHCCCCCCC	28.53	22167270
1190	Phosphorylation	ASIDRQNTQSDIGGS HHCCCCCCCCCCCCC	22.55	21406692
1192	Phosphorylation	IDRQNTQSDIGGSGK CCCCCCCCCCCCCCC	29.20	21406692
1197	Phosphorylation	TQSDIGGSGKSTPSW CCCCCCCCCCCCCCC	37.52	25849741
1199	Ubiquitination	SDIGGSGKSTPSWQR CCCCCCCCCCCCCCC	53.50	29967540
1200	Phosphorylation	DIGGSGKSTPSWQRS CCCCCCCCCCCCCCC	49.42	28985074
1201	Phosphorylation	IGGSGKSTPSWQRSE CCCCCCCCCCCCCCC	25.48	28985074
1207	Phosphorylation	STPSWQRSEDSIADQ CCCCCCCCCCCHHHH	30.56	29083192
1207 (in isoform 2)	Phosphorylation	-	30.56	30108239
1207 (in isoform 3)	Phosphorylation	-	30.56	30108239
1210	Phosphorylation	SWQRSEDSIADQMAY CCCCCCCCHHHHHHH	18.67	28188228
1210 (in isoform 2)	Phosphorylation	-	18.67	30108239
1210 (in isoform 3)	Phosphorylation	-	18.67	30108239
1218	Phosphorylation	IADQMAYSYRGPQDF HHHHHHHHCCCCCCH	9.98	28188228
1219	Phosphorylation	ADQMAYSYRGPQDFN HHHHHHHCCCCCCHH	13.60	-
1255	Phosphorylation	VLPAFRESPSGRLMR HHHHHHHCCCCCCCC	21.80	30266825
1257	Phosphorylation	PAFRESPSGRLMRQD HHHHHCCCCCCCCCC	45.91	25159151
1270	Phosphorylation	QDPVVHLSPNKQGHS CCCEEECCCCCCCCC	16.14	30266825
1277	Phosphorylation	SPNKQGHSDSHYSSH CCCCCCCCCCCCCCC	47.86	30576142
1279	Phosphorylation	NKQGHSDSHYSSHSS CCCCCCCCCCCCCCC	27.60	30576142
1282	Phosphorylation	GHSDSHYSSHSSSNT CCCCCCCCCCCCCCC	19.02	30576142
1283	Phosphorylation	HSDSHYSSHSSSNTL CCCCCCCCCCCCCCC	21.88	-
1285	Phosphorylation	DSHYSSHSSSNTLSS CCCCCCCCCCCCCCC	37.09	-
1286	Phosphorylation	SHYSSHSSSNTLSSN CCCCCCCCCCCCCCC	23.37	-
1289	Phosphorylation	SSHSSSNTLSSNASS CCCCCCCCCCCCCCC	29.93	30576142
1296	Phosphorylation	TLSSNASSAHSDEKW CCCCCCCCCCCCCCC	27.82	30576142
1299	Phosphorylation	SNASSAHSDEKWYDG CCCCCCCCCCCCCCC	47.37	30576142
1326	Phosphorylation	LQGTSADSGIDTTSY HCCCCCCCCCCCCCC	37.05	-
1330	Phosphorylation	SADSGIDTTSYGPSH CCCCCCCCCCCCCCC	18.74	-
1349	Phosphorylation	SLGAATSSPRSGPGK CCCCCCCCCCCCCCC	21.70	20058876
1365	Phosphorylation	KVAPLWHSSSEVISM CCCCCCCCHHHHHHH	24.79	30266825
1366	Phosphorylation	VAPLWHSSSEVISMA CCCCCCCHHHHHHHH	20.03	30266825
1367	Phosphorylation	APLWHSSSEVISMAD CCCCCCHHHHHHHHH	38.61	30266825
1371	Phosphorylation	HSSSEVISMADRTLE CCHHHHHHHHHHHHH	17.06	23403867
1376	Phosphorylation	VISMADRTLETESHG HHHHHHHHHHHHCCC	29.50	28674419
1388	Phosphorylation	SHGLDRKTESSLSLD CCCCCCCCCCCEEEE	41.83	30266825
1390	Phosphorylation	GLDRKTESSLSLDIH CCCCCCCCCEEEEEC	41.64	30266825
1391	Phosphorylation	LDRKTESSLSLDIHS CCCCCCCCEEEEECC	18.75	30266825
1393	Phosphorylation	RKTESSLSLDIHSKS CCCCCCEEEEECCCC	26.41	30266825
1398	Phosphorylation	SLSLDIHSKSQAGST CEEEEECCCCCCCCC	34.04	30266825
1400	Phosphorylation	SLDIHSKSQAGSTPL EEEECCCCCCCCCCC	28.42	24732914
1404	Phosphorylation	HSKSQAGSTPLTREN CCCCCCCCCCCCCCC	29.84	30266825
1405	Phosphorylation	SKSQAGSTPLTRENS CCCCCCCCCCCCCCC	22.77	30266825
1408	O-linked_Glycosylation	QAGSTPLTRENSTFS CCCCCCCCCCCCEEE	36.82	30379171
1408	Phosphorylation	QAGSTPLTRENSTFS CCCCCCCCCCCCEEE	36.82	24702127
1412	Phosphorylation	TPLTRENSTFSINDA CCCCCCCCEEECCCH	26.52	23401153
1413	Phosphorylation	PLTRENSTFSINDAA CCCCCCCEEECCCHH	32.74	28985074
1415	Phosphorylation	TRENSTFSINDAASH CCCCCEEECCCHHHC	22.14	26074081
1421	Phosphorylation	FSINDAASHTSTMSS EECCCHHHCCCCCCC	29.08	26074081
1423	Phosphorylation	INDAASHTSTMSSRH CCCHHHCCCCCCCCC	24.33	26074081
1424	O-linked_Glycosylation	NDAASHTSTMSSRHS CCHHHCCCCCCCCCC	19.38	30379171
1424	Phosphorylation	NDAASHTSTMSSRHS CCHHHCCCCCCCCCC	19.38	26074081
1425	Phosphorylation	DAASHTSTMSSRHSA CHHHCCCCCCCCCCC	23.40	26074081
1427	Phosphorylation	ASHTSTMSSRHSASP HHCCCCCCCCCCCCC	25.06	26074081
1428	Phosphorylation	SHTSTMSSRHSASPV HCCCCCCCCCCCCCE	24.16	30576142
1431	Phosphorylation	STMSSRHSASPVVFT CCCCCCCCCCCEEEE	29.36	23401153
1433	Phosphorylation	MSSRHSASPVVFTSA CCCCCCCCCEEEECC	22.65	29255136
1438	Phosphorylation	SASPVVFTSARSSPK CCCCEEEECCCCCCH	15.18	30266825
1439	Phosphorylation	ASPVVFTSARSSPKE CCCEEEECCCCCCHH	15.38	30266825
1442	Phosphorylation	VVFTSARSSPKEELH EEEECCCCCCHHHCC	51.19	23401153
1443	Phosphorylation	VFTSARSSPKEELHP EEECCCCCCHHHCCC	34.14	30278072
1454	Phosphorylation	ELHPAAPSQLAPSFS HCCCCCHHHCCCCCC	32.85	30278072
1459	Phosphorylation	APSQLAPSFSSSSSS CHHHCCCCCCCCCCC	31.96	25850435
1461	Phosphorylation	SQLAPSFSSSSSSSS HHCCCCCCCCCCCCC	33.38	25850435
1462	Phosphorylation	QLAPSFSSSSSSSSG HCCCCCCCCCCCCCC	32.03	25850435
1463	Phosphorylation	LAPSFSSSSSSSSGP CCCCCCCCCCCCCCC	32.80	25850435
1464	Phosphorylation	APSFSSSSSSSSGPR CCCCCCCCCCCCCCC	35.87	25850435
1465	Phosphorylation	PSFSSSSSSSSGPRS CCCCCCCCCCCCCCC	35.87	25850435
1466	Phosphorylation	SFSSSSSSSSGPRSF CCCCCCCCCCCCCCC	30.39	30576142
1467	Phosphorylation	FSSSSSSSSGPRSFY CCCCCCCCCCCCCCC	41.06	25850435
1468	Phosphorylation	SSSSSSSSGPRSFYP CCCCCCCCCCCCCCC	55.56	25850435
1474	Phosphorylation	SSGPRSFYPRQGATS CCCCCCCCCCCCCCC	9.96	30576142
1482	Acetylation	PRQGATSKYLIGWKK CCCCCCCEEECCCCC	39.46	25953088
1488	Acetylation	SKYLIGWKKPEGTIN CEEECCCCCCCCCCC	53.92	25953088
1496	Phosphorylation	KPEGTINSVGFMDTR CCCCCCCCCCEECCC	21.55	28555341
1508	Phosphorylation	DTRKRHQSDGNEIAH CCCHHCCCCCCHHHH	41.16	29255136
1516	Phosphorylation	DGNEIAHTRLRASTR CCCHHHHHHHHHHHC	23.52	28176443
1521	Phosphorylation	AHTRLRASTRDLRAS HHHHHHHHHCCHHCC	19.96	30576142
1522	Phosphorylation	HTRLRASTRDLRASP HHHHHHHHCCHHCCC	27.50	26074081
1528	Phosphorylation	STRDLRASPKPTSKS HHCCHHCCCCCCCCC	27.33	23401153
1532	Phosphorylation	LRASPKPTSKSTIEE HHCCCCCCCCCHHHH	55.71	30266825
1533	Phosphorylation	RASPKPTSKSTIEED HCCCCCCCCCHHHHH	32.89	23403867
1535	Phosphorylation	SPKPTSKSTIEEDLK CCCCCCCCHHHHHHH	34.09	26074081
1536	Phosphorylation	PKPTSKSTIEEDLKK CCCCCCCHHHHHHHH	35.82	26074081
1549	Phosphorylation	KKLIDLESPTPESQK HHHHCCCCCCCHHHH	41.17	19664994
1551	Phosphorylation	LIDLESPTPESQKSF HHCCCCCCCHHHHCC	49.30	22167270
1554	Phosphorylation	LESPTPESQKSFKFH CCCCCCHHHHCCEEE	44.08	30266825
1557	Phosphorylation	PTPESQKSFKFHALS CCCHHHHCCEEEECC	26.49	26434776
1564	Phosphorylation	SFKFHALSSPQSPFP CCEEEECCCCCCCCC	40.53	23401153
1565	Phosphorylation	FKFHALSSPQSPFPS CEEEECCCCCCCCCC	28.01	22167270
1568	Phosphorylation	HALSSPQSPFPSTPT EECCCCCCCCCCCCH	31.71	30266825
1572	Phosphorylation	SPQSPFPSTPTSRRA CCCCCCCCCCHHHHH	47.61	30266825
1573	Phosphorylation	PQSPFPSTPTSRRAL CCCCCCCCCHHHHHH	30.72	27273156
1575	Phosphorylation	SPFPSTPTSRRALHR CCCCCCCHHHHHHHH	34.65	23927012
1576	Phosphorylation	PFPSTPTSRRALHRT CCCCCCHHHHHHHHH	22.44	23927012
1583	Phosphorylation	SRRALHRTLSDESIY HHHHHHHHCCCHHHH	21.62	29255136
1585	Phosphorylation	RALHRTLSDESIYNS HHHHHHCCCHHHHHH	38.42	19664994
1588	Phosphorylation	HRTLSDESIYNSQRE HHHCCCHHHHHHHHH	35.05	30266825
1590	Phosphorylation	TLSDESIYNSQREHF HCCCHHHHHHHHHHH	20.31	23927012
1592	Phosphorylation	SDESIYNSQREHFFT CCHHHHHHHHHHHCC	17.40	23927012
1599	Phosphorylation	SQREHFFTSRASLLD HHHHHHCCCHHHHHH	19.16	23927012
1600	Phosphorylation	QREHFFTSRASLLDQ HHHHHCCCHHHHHHH	22.23	23927012
1601	Asymmetric dimethylarginine	REHFFTSRASLLDQA HHHHCCCHHHHHHHH	25.74	-
1601	Methylation	REHFFTSRASLLDQA HHHHCCCHHHHHHHH	25.74	-
1603	Phosphorylation	HFFTSRASLLDQALP HHCCCHHHHHHHHCC	28.49	26657352
1611	Phosphorylation	LLDQALPNDVLFSST HHHHHCCCCEEEECC	53.53	32142685
1618	Phosphorylation	NDVLFSSTYPSLPKS CCEEEECCCCCCCCC	37.95	28122231
1619	Phosphorylation	DVLFSSTYPSLPKSL CEEEECCCCCCCCCC	7.86	27251275
1621	Phosphorylation	LFSSTYPSLPKSLPL EEECCCCCCCCCCCC	47.06	30183078
1625	Phosphorylation	TYPSLPKSLPLRRPS CCCCCCCCCCCCCCC	33.02	23403867
1628	Phosphorylation	SLPKSLPLRRPSYTL CCCCCCCCCCCCEEC	9.83	33259812
1632	Phosphorylation	SLPLRRPSYTLGMKS CCCCCCCCEECCCHH	29.01	27273156
1633	Phosphorylation	LPLRRPSYTLGMKSL CCCCCCCEECCCHHH	14.52	27273156
1634	Phosphorylation	PLRRPSYTLGMKSLH CCCCCCEECCCHHHC	22.60	23927012
1639	Phosphorylation	SYTLGMKSLHGEFSA CEECCCHHHCCCCCC	19.39	28176443
1645	Phosphorylation	KSLHGEFSASDSSLT HHHCCCCCCCCCCCC	23.66	30266825
1647	Phosphorylation	LHGEFSASDSSLTDI HCCCCCCCCCCCCHH	36.51	30266825
1649	Phosphorylation	GEFSASDSSLTDIQE CCCCCCCCCCCHHHH	25.42	30266825
1650	Phosphorylation	EFSASDSSLTDIQET CCCCCCCCCCHHHHH	40.03	30266825
1652	Phosphorylation	SASDSSLTDIQETRR CCCCCCCCHHHHHCC	32.76	30266825
1657	Phosphorylation	SLTDIQETRRQPMPD CCCHHHHHCCCCCCC	18.12	30108239
1679 (in isoform 3)	Phosphorylation	-	9.09	22777824
1687 (in isoform 3)	Phosphorylation	-	53.90	22617229
1689	Phosphorylation	LVDAAKAYEVQRASF HHHHHHHHHHHHHHH	18.87	-
1690 (in isoform 3)	Phosphorylation	-	36.71	22617229
1695	Phosphorylation	AYEVQRASFFAASDE HHHHHHHHHEECCCC	24.08	30576142
1700	Phosphorylation	RASFFAASDENHRPL HHHHEECCCCCCCCC	41.87	30576142
1706 (in isoform 3)	Phosphorylation	-	24.10	26471730
1707 (in isoform 3)	Phosphorylation	-	5.69	27732954
1708	Phosphorylation	DENHRPLSAASNSDQ CCCCCCCCCCCCCHH	25.19	25159151
1708 (in isoform 3)	Phosphorylation	-	25.19	27732954
1711	Phosphorylation	HRPLSAASNSDQLED CCCCCCCCCCHHHHH	36.26	28355574
1711 (in isoform 3)	Phosphorylation	-	36.26	27732954
1712 (in isoform 3)	Phosphorylation	-	44.90	27732954
1713	Phosphorylation	PLSAASNSDQLEDQA CCCCCCCCHHHHHHH	25.00	22617229
1714 (in isoform 3)	Phosphorylation	-	62.42	27732954
1727	Phosphorylation	ALAQMKPYSSSKDSS HHHHCCCCCCCCCCC	18.70	26074081
1728	Phosphorylation	LAQMKPYSSSKDSSP HHHCCCCCCCCCCCH	36.34	30576142
1729	Phosphorylation	AQMKPYSSSKDSSPT HHCCCCCCCCCCCHH	35.25	30576142
1730	Phosphorylation	QMKPYSSSKDSSPTL HCCCCCCCCCCCHHH	34.24	30576142
1733	Phosphorylation	PYSSSKDSSPTLASK CCCCCCCCCHHHHHH	41.79	22617229
1734	Phosphorylation	YSSSKDSSPTLASKV CCCCCCCCHHHHHHH	31.85	29255136
1736	Phosphorylation	SSKDSSPTLASKVDQ CCCCCCHHHHHHHHH	36.58	23898821
1739	Phosphorylation	DSSPTLASKVDQLEG CCCHHHHHHHHHHHH	36.00	26074081
1767	Ubiquitination	EDKAHLQAEVQHLRE HHHHHHHHHHHHHHH	25.86	29967540
1768	Ubiquitination	DKAHLQAEVQHLRED HHHHHHHHHHHHHHH	29.74	29967540
1788	Ubiquitination	EESQNASDKLKKFTE HHHHCHHHHHHHHHH	58.87	29967540
1789	Ubiquitination	ESQNASDKLKKFTEW HHHCHHHHHHHHHHH	60.76	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1326	S	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
1330	T	Phosphorylation	Kinase	PLK2	Q9NYY3	Uniprot
1349	S	Phosphorylation	Kinase	CDK5	Q00535	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	UBE3A	Q05086	PMID:12036950
-	K	Ubiquitination	E3 ubiquitin ligase	E6	P03126	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1349	S	Phosphorylation		-
Phosphorylated at Ser-1349 by CDK5, creating a docking site for the POLO box domains of PLK2.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SI1L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSSK2_HUMAN	TSSK2	physical	22939629
KI13B_HUMAN	KIF13B	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
CING_HUMAN	CGN	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435
HDAC7_HUMAN	HDAC7	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SI1L1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-288; SER-1549;THR-1583; SER-1585; SER-1647 AND SER-1650, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1549; THR-1551;SER-1585; TYR-1727 AND SER-1730, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1585, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1255; SER-1270; SER-1549AND SER-1585, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-161 AND SER-1433, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1257; SER-1270;SER-1433; SER-1528 AND SER-1549, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1549 AND SER-1585, ANDMASS SPECTROMETRY.	15302935 [Abstract]

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