TSSK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSSK2_HUMAN
• UniProt AC: Q96PF2
• Protein Name: Testis-specific serine/threonine-protein kinase 2
• Gene Name: TSSK2
• Organism: Homo sapiens (Human).
• Sequence Length: 358
• Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compart
• Protein Description: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body..
• Protein Sequence: MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	TVLRKKGYIVGINLG EEEEECCEEEEEEEC	11.00	29083192
22	Phosphorylation	GINLGKGSYAKVKSA EEEECCCCCHHHHHH	25.96	30622161
23	Phosphorylation	INLGKGSYAKVKSAY EEECCCCCHHHHHHH	21.07	22817900
28	O-linked_Glycosylation	GSYAKVKSAYSERLK CCCHHHHHHHHCHHC	35.11	30379171
31	Phosphorylation	AKVKSAYSERLKFNV HHHHHHHHCHHCCEE	18.89	30622161
35	Acetylation	SAYSERLKFNVAVKI HHHHCHHCCEEEEEE	40.91	7851299
41	Acetylation	LKFNVAVKIIDRKKT HCCEEEEEEECCCCC	24.98	7851309
66	Phosphorylation	REMDILATVNHGSII HHCCEEEEECCCCEE	20.56	30622161
71	Phosphorylation	LATVNHGSIIKTYEI EEEECCCCEEEEEEE	17.37	24719451
87	Phosphorylation	ETSDGRIYIIMELGV ECCCCCEEEEEEECC	5.30	-
153	Phosphorylation	KDFNIKLSDFGFSKR CCCCEEHHHCCCCHH	26.37	30622161
158	Phosphorylation	KLSDFGFSKRCLRDS EHHHCCCCHHHEECC	21.41	30622161
174	Phosphorylation	GRIILSKTFCGSAAY CCEEEEEECCCCHHH	22.30	30622161
178	Phosphorylation	LSKTFCGSAAYAAPE EEEECCCCHHHHCHH	15.77	30622161
181	Phosphorylation	TFCGSAAYAAPEVLQ ECCCCHHHHCHHHHH	11.74	25693802
197	Phosphorylation	IPYQPKVYDIWSLGV CCCCCCCHHHHHHHH	14.08	-
207	Phosphorylation	WSLGVILYIMVCGSM HHHHHHHHHHHHCCC	3.94	-
258	Phosphorylation	RMLQPDVSQRLHIDE HHHCCCHHHHCCHHH	19.57	-
280	Phosphorylation	QPPKPKATSSASFKR CCCCCCCCCCCCCEE	29.37	30622161
281	Phosphorylation	PPKPKATSSASFKRE CCCCCCCCCCCCEEC	28.85	30622161
282	Phosphorylation	PKPKATSSASFKREG CCCCCCCCCCCEECC	24.47	30622161
284	Phosphorylation	PKATSSASFKREGEG CCCCCCCCCEECCCC	32.99	24719451
349	Phosphorylation	RAKDHHISGAEVGKA HHHHCCCCHHHCCCC	27.82	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSSK2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSSK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSSK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSKS_HUMAN	TSKS	physical	15044604
TSSK2_HUMAN	TSSK2	physical	15044604
A4_HUMAN	APP	physical	21832049
ZC3HF_HUMAN	ZC3H15	physical	22939629
HS90A_HUMAN	HSP90AA1	physical	22939624

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.