TSKS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSKS_HUMAN
• UniProt AC: Q9UJT2
• Protein Name: Testis-specific serine kinase substrate
• Gene Name: TSKS
• Organism: Homo sapiens (Human).
• Sequence Length: 592
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Concentrates in spermatid centrioles during flagellogenesis.
• Protein Description: May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development..
• Protein Sequence: MASVVVKTIWQSKEIHEAGDTPTGVESCSQLVPEAPRRVTSRAKGIPKKKKAVSFHGVEPQMSHQPMHWCLNLKRSSACTNVSLLNLAAMEPTDSTGTDSTVEDLSGQLTLAGPPASPTLPWDPDDADITEILSGVNSGLVRAKDSITSLKEKTNRVNQHVQSLQSECSVLSENLERRRQEAEELEGYCIQLKENCWKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQEAELQEPEEKQEPEEKQEPEEKQKPEAGLSWNSLGPAATSQGCPGPPGSPDKPSRPHGLVPAGWGMGPRAGEGPYVSEQELQKLFTGIEELRREVSSLTARWHQEEGAVQEALRLLGGLGGRVDGFLGQWERAQREQAQTARDLQELRGRADELCTMVERSAVSVASLRSELEGLGPLKPILEEFGRQFQNSRRGPDLSMNLDRSHQGNCARCASQGSQLSTESLQQLLDRALTSLVDEVKQRGLTPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKPEEKMATLDHLHLKMCSLHDHLSNLPLEGSTGTMGGGSSAGTPPKQGGSAPEQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	HEAGDTPTGVESCSQ HHCCCCCCCHHHHHH	56.82	25693802
27	Phosphorylation	DTPTGVESCSQLVPE CCCCCHHHHHHHCCC	19.36	25693802
29	Phosphorylation	PTGVESCSQLVPEAP CCCHHHHHHHCCCCC	35.51	25693802
40	Phosphorylation	PEAPRRVTSRAKGIP CCCCHHHHHCCCCCC	15.64	29083192
41	Phosphorylation	EAPRRVTSRAKGIPK CCCHHHHHCCCCCCC	27.64	29083192
54	Phosphorylation	PKKKKAVSFHGVEPQ CCCCCCEEECCCCCC	19.18	-
163	Phosphorylation	RVNQHVQSLQSECSV HHHHHHHHHHHHHHH	27.56	24719451
202	Phosphorylation	NCWKVTRSVEDAEIK CCEEECCCHHHHHHH	22.09	30622161
217	Phosphorylation	TNVLKQNSALLEEKL HHHHHHCHHHHHHHH	20.14	-
288	Phosphorylation	GCPGPPGSPDKPSRP CCCCCCCCCCCCCCC	35.38	-
316	Phosphorylation	AGEGPYVSEQELQKL CCCCCCCCHHHHHHH	27.93	30622161
335	Phosphorylation	EELRREVSSLTARWH HHHHHHHHHHHHHHH	18.19	30622161
336	Phosphorylation	ELRREVSSLTARWHQ HHHHHHHHHHHHHHH	34.61	30622161
338	Phosphorylation	RREVSSLTARWHQEE HHHHHHHHHHHHHHH	19.00	30622161
535	Phosphorylation	RAKNLLLTDKMKPEE HHHHCHHCCCCCHHH	33.28	29396449
569	Phosphorylation	SNLPLEGSTGTMGGG HCCCCCCCCCCCCCC	17.81	-
570	Phosphorylation	NLPLEGSTGTMGGGS CCCCCCCCCCCCCCC	47.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
288	S	Phosphorylation	Kinase	TSSK1	Q9BXA7	Uniprot
288	S	Phosphorylation	Kinase	TSSK2	Q96PF2	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSKS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSKS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TSSK2_HUMAN	TSSK2	physical	15044604
A4_HUMAN	APP	physical	21832049
UBP10_HUMAN	USP10	physical	22939629
PGTB1_HUMAN	PGGT1B	physical	28514442
CAVN1_HUMAN	PTRF	physical	28514442
TRAF3_HUMAN	TRAF3	physical	28514442
RGPD8_HUMAN	RGPD8	physical	28514442
BL1S2_HUMAN	BLOC1S2	physical	28514442
FP100_HUMAN	C17orf70	physical	28514442
DTBP1_HUMAN	DTNBP1	physical	28514442
RGPD5_HUMAN	RGPD5	physical	28514442
CC85B_HUMAN	CCDC85B	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442
POC1A_HUMAN	POC1A	physical	28514442
EXOC1_HUMAN	EXOC1	physical	28514442
ANM3_HUMAN	PRMT3	physical	28514442
SNAPN_HUMAN	SNAPIN	physical	28514442
FNTA_HUMAN	FNTA	physical	28514442
SPAG5_HUMAN	SPAG5	physical	28514442
UTF1_HUMAN	UTF1	physical	28514442
GSK3B_HUMAN	GSK3B	physical	28514442
RBGP1_HUMAN	RABGAP1	physical	28514442
EXOC7_HUMAN	EXOC7	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.