| UniProt ID | TRAF3_HUMAN | |
|---|---|---|
| UniProt AC | Q13114 | |
| Protein Name | TNF receptor-associated factor 3 | |
| Gene Name | TRAF3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 568 | |
| Subcellular Localization | Cytoplasm . Endosome . Mitochondrion. Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. | |
| Protein Description | Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.. | |
| Protein Sequence | MESSKKMDSPGALQTNPPLKLHTDRSAGTPVFVPEQGGYKEKFVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKCTACQESIVKDKVFKDNCCKREILALQIYCRNESRGCAEQLMLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFKKPTGEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVDTSDLPDP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | ESSKKMDSPGALQTN CCCCCCCCCCCCCCC | 23.02 | 29255136 | |
| 15 | Phosphorylation | DSPGALQTNPPLKLH CCCCCCCCCCCCEEC | 51.01 | 23312004 | |
| 26 | Phosphorylation | LKLHTDRSAGTPVFV CEECCCCCCCCCEEC | 33.58 | 27080861 | |
| 29 | Phosphorylation | HTDRSAGTPVFVPEQ CCCCCCCCCEECCCC | 18.92 | 28450419 | |
| 39 | Phosphorylation | FVPEQGGYKEKFVKT ECCCCCCCCHHHCCC | 23.85 | 23186163 | |
| 99 | Ubiquitination | QESIVKDKVFKDNCC CHHHHCCCCCCCCCC | 43.80 | - | |
| 138 | Methylation | GHLLVHLKNDCHFEE HHHHHHCCCCCCCCC | 35.54 | - | |
| 168 | Ubiquitination | DLRDHVEKACKYREA HHHHHHHHHHHHHHH | 58.98 | - | |
| 268 (in isoform 2) | Ubiquitination | - | 52.25 | - | |
| 275 | Phosphorylation | NSLEKKVSLLQNESV HHHHHHHHHHHCHHH | 32.04 | 22617229 | |
| 281 | Phosphorylation | VSLLQNESVEKNKSI HHHHHCHHHHHHHHH | 43.03 | 22617229 | |
| 286 | Ubiquitination | NESVEKNKSIQSLHN CHHHHHHHHHHHHHH | 61.06 | 21890473 | |
| 286 (in isoform 2) | Ubiquitination | - | 61.06 | - | |
| 329 | Ubiquitination | VIDSQAEKLKELDKE HHHHHHHHHHHHHHH | 68.80 | - | |
| 335 | Ubiquitination | EKLKELDKEIRPFRQ HHHHHHHHHHHHHHH | 68.61 | - | |
| 349 | Phosphorylation | QNWEEADSMKSSVES HCHHHHHHHHHHHHH | 34.85 | 27251275 | |
| 351 | Ubiquitination | WEEADSMKSSVESLQ HHHHHHHHHHHHHHH | 43.46 | 21906983 | |
| 356 | Phosphorylation | SMKSSVESLQNRVTE HHHHHHHHHHHHHHH | 32.85 | 30108239 | |
| 366 | Phosphorylation | NRVTELESVDKSAGQ HHHHHHHHHHHHHHH | 48.52 | 30108239 | |
| 369 | Ubiquitination | TELESVDKSAGQVAR HHHHHHHHHHHHHHH | 39.80 | 21890473 | |
| 370 | Phosphorylation | ELESVDKSAGQVARN HHHHHHHHHHHHHHH | 32.92 | 30108239 | |
| 430 (in isoform 2) | Ubiquitination | - | 41.91 | - | |
| 455 | Glutathionylation | GYFGYKMCARVYLNG CCCCCEEEEEEEECC | 1.59 | 22833525 | |
| 459 | Phosphorylation | YKMCARVYLNGDGMG CEEEEEEEECCCCCC | 6.73 | 26074081 | |
| 469 | Phosphorylation | GDGMGKGTHLSLFFV CCCCCCCCCEEEEEE | 24.11 | 26074081 | |
| 472 | Phosphorylation | MGKGTHLSLFFVIMR CCCCCCEEEEEEECC | 18.61 | 26074081 | |
| 513 | Ubiquitination | RHLGDAFKPDPNSSS CCCCCCCCCCCCCCC | 50.67 | 21890473 | |
| 557 | Ubiquitination | KDDTIFIKVIVDTSD CCCEEEEEEEEECCC | 18.37 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 349 | S | Phosphorylation | Kinase | CSNK1E | P49674 | GPS |
| - | K | Ubiquitination | E3 ubiquitin ligase | BIRC3 | Q13489 | PMID:20097753 |
| - | K | Ubiquitination | E3 ubiquitin ligase | TANK | Q92844 | PMID:22199232 |
| - | K | Ubiquitination | E3 ubiquitin ligase | BIRC2 | Q13490 | PMID:20097753 |
| - | K | Ubiquitination | E3 ubiquitin ligase | RNF216 | Q9NWF9 | PMID:15107846 |
| - | K | Ubiquitination | E3 ubiquitin ligase | STUB1 | Q9UNE7 | PMID:18922468 |
| - | K | Ubiquitination | E3 ubiquitin ligase | PELI1 | Q96FA3 | PMID:23603814 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRAF3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRAF3_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614849 | Herpes simplex encephalitis 3 (HSE3) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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