MYT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYT1_HUMAN
• UniProt AC: Q01538
• Protein Name: Myelin transcription factor 1
• Gene Name: MYT1
• Organism: Homo sapiens (Human).
• Sequence Length: 1121
• Subcellular Localization: Nucleus.
• Protein Description: Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription..
• Protein Sequence: MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKRKLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETSGQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLVEEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRKSTVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPLDTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMHENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSDRILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRMLAPKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVDIEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVTLTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSADLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVGLGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGSFLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSEMEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHMEPICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	SCPTPGCTGSGHVRG CCCCCCCCCCCCCCC	40.05	-
38	Phosphorylation	PTPGCTGSGHVRGKY CCCCCCCCCCCCCCC	13.94	-
45	Phosphorylation	SGHVRGKYSRHRSLQ CCCCCCCCCCCCCCC	17.48	30301811
46	Phosphorylation	GHVRGKYSRHRSLQS CCCCCCCCCCCCCCC	25.70	30301811
50	Phosphorylation	GKYSRHRSLQSCPLA CCCCCCCCCCCCCCH	25.33	30301811
53	Phosphorylation	SRHRSLQSCPLAKKR CCCCCCCCCCCHHHH	24.01	30301811
91	Phosphorylation	DEGYGVDSDGSEDTE ECCCCCCCCCCCCCC	41.27	28188228
94	Phosphorylation	YGVDSDGSEDTEVKD CCCCCCCCCCCCCCC	36.97	28188228
97	Phosphorylation	DSDGSEDTEVKDASV CCCCCCCCCCCCCCC	38.33	27732954
103	Phosphorylation	DTEVKDASVSDESEG CCCCCCCCCCCCCCC	32.08	27732954
105	Phosphorylation	EVKDASVSDESEGTL CCCCCCCCCCCCCEE	32.92	27732954
108	Phosphorylation	DASVSDESEGTLEGA CCCCCCCCCCEECCC	46.44	27732954
111	Phosphorylation	VSDESEGTLEGAEAE CCCCCCCEECCCHHC	19.99	27732954
119	Phosphorylation	LEGAEAETSGQDEIH ECCCHHCCCCCCCCC	45.25	27732954
130	Phosphorylation	DEIHRPETAEGRSPV CCCCCCCCCCCCCCC	32.46	23898821
135	Phosphorylation	PETAEGRSPVKSHFG CCCCCCCCCCHHHCC	44.92	23312004
139	Phosphorylation	EGRSPVKSHFGSNPI CCCCCCHHHCCCCCC	25.04	23312004
143	Phosphorylation	PVKSHFGSNPIGSAT CCHHHCCCCCCCCCC	38.19	23312004
207	Phosphorylation	EAAEGAASEEGEKGL HHHHCCCCCCCCCCC	35.33	27732954
232	Phosphorylation	VEVTTERSQDLCPQS HHHHCCCCCCCCCCC	23.09	27732954
239	Phosphorylation	SQDLCPQSLEDAASE CCCCCCCCHHHHHHH	20.90	27732954
245	Phosphorylation	QSLEDAASEESSKQK CCHHHHHHHHHHHHH	43.55	27732954
248	Phosphorylation	EDAASEESSKQKGIL HHHHHHHHHHHHCCC	38.49	27732954
249	Phosphorylation	DAASEESSKQKGILS HHHHHHHHHHHCCCC	42.24	27732954
333	Phosphorylation	PELRGPESPSPKPEY HHHCCCCCCCCCCCC	33.54	28985074
335	Phosphorylation	LRGPESPSPKPEYSV HCCCCCCCCCCCCEE	55.63	24117733
340	Phosphorylation	SPSPKPEYSVIVEVR CCCCCCCCEEEEEEC	19.43	23312004
341	Phosphorylation	PSPKPEYSVIVEVRS CCCCCCCEEEEEECC	12.05	23312004
348	Phosphorylation	SVIVEVRSDDDKDED EEEEEECCCCCCCCC	51.04	23312004
356	Phosphorylation	DDDKDEDTHSRKSTV CCCCCCCCCCCCCCC	21.50	23312004
358	Phosphorylation	DKDEDTHSRKSTVTD CCCCCCCCCCCCCCC	43.42	23312004
361	Phosphorylation	EDTHSRKSTVTDESE CCCCCCCCCCCCHHH	27.31	27732954
362	Phosphorylation	DTHSRKSTVTDESEM CCCCCCCCCCCHHHH	30.38	27732954
364	Phosphorylation	HSRKSTVTDESEMQD CCCCCCCCCHHHHHH	33.85	27732954
367	Phosphorylation	KSTVTDESEMQDMMT CCCCCCHHHHHHHHH	40.97	27732954
418	Ubiquitination	GEPGKAAKPLDTVRK CCCCCCCCCCHHHHH	51.47	-
427	Phosphorylation	LDTVRKSYYSKDPSR CHHHHHHHHCCCHHH	18.13	22817900
428	Phosphorylation	DTVRKSYYSKDPSRA HHHHHHHHCCCHHHH	19.14	22817900
429	Phosphorylation	TVRKSYYSKDPSRAE HHHHHHHCCCHHHHH	23.50	12738781
462	Phosphorylation	GLYPHHRSLSGCPHK CCCCCCCCCCCCCCC	23.64	-
464	Phosphorylation	YPHHRSLSGCPHKDR CCCCCCCCCCCCCCC	39.33	27251275
506	Phosphorylation	SNRNTHRSLSGCPIA CCCCCCCCCCCCHHH	21.20	27732954
508	Phosphorylation	RNTHRSLSGCPIAAA CCCCCCCCCCHHHHH	39.33	27732954
557	Phosphorylation	KQLEVPPYGSYRPNV EEECCCCCCCCCCCC	16.78	30622161
559	Phosphorylation	LEVPPYGSYRPNVAP ECCCCCCCCCCCCCC	16.48	30622161
560	Phosphorylation	EVPPYGSYRPNVAPA CCCCCCCCCCCCCCC	26.23	30622161
568	Phosphorylation	RPNVAPATPRANLAK CCCCCCCCCCCCHHH	16.55	30622161
606	Phosphorylation	MLAPKIQTSETSPKA CCCCCCCCCCCCCCC	31.81	-
607	Phosphorylation	LAPKIQTSETSPKAF CCCCCCCCCCCCCCH	23.62	-
609	Phosphorylation	PKIQTSETSPKAFQC CCCCCCCCCCCCHHH	50.53	23312004
610	Phosphorylation	KIQTSETSPKAFQCF CCCCCCCCCCCHHHC	21.98	28985074
619	Phosphorylation	KAFQCFDYSQDAEAA CCHHHCCCCHHHHHH	6.49	-
623 (in isoform 2)	Phosphorylation	-	10.74	30177828
624 (in isoform 2)	Phosphorylation	-	55.46	30177828
628 (in isoform 2)	Phosphorylation	-	2.02	27732954
630 (in isoform 2)	Phosphorylation	-	7.03	27732954
631 (in isoform 2)	Phosphorylation	-	12.51	27732954
631	Phosphorylation	EAAHMAATAILNLST HHHHHHHHHHHHHCH	12.51	-
632 (in isoform 2)	Phosphorylation	-	10.27	27732954
633 (in isoform 2)	Phosphorylation	-	1.97	30177828
656	Phosphorylation	TKPQDLPSKSVDIEV CCCCCCCCCCEEEEE	44.88	24719451
685	Phosphorylation	KRENAFPSSSSCSSS CCCCCCCCCCCCCCC	36.08	27732954
686	Phosphorylation	RENAFPSSSSCSSSP CCCCCCCCCCCCCCC	26.89	27732954
687	Phosphorylation	ENAFPSSSSCSSSPG CCCCCCCCCCCCCCC	39.44	27732954
688	Phosphorylation	NAFPSSSSCSSSPGV CCCCCCCCCCCCCCC	21.70	27732954
690	Phosphorylation	FPSSSSCSSSPGVKS CCCCCCCCCCCCCCC	35.48	27732954
691	Phosphorylation	PSSSSCSSSPGVKSP CCCCCCCCCCCCCCC	44.90	27732954
692	Phosphorylation	SSSSCSSSPGVKSPD CCCCCCCCCCCCCCC	14.91	28985074
697	Phosphorylation	SSSPGVKSPDASQRH CCCCCCCCCCHHHHC	26.13	27732954
701	Phosphorylation	GVKSPDASQRHSSTS CCCCCCHHHHCCCCC	34.82	27732954
705	Phosphorylation	PDASQRHSSTSAPSS CCHHHHCCCCCCCCC	37.18	27732954
706	Phosphorylation	DASQRHSSTSAPSSS CHHHHCCCCCCCCCC	21.91	27732954
707	Phosphorylation	ASQRHSSTSAPSSSM HHHHCCCCCCCCCCC	31.74	27732954
708	Phosphorylation	SQRHSSTSAPSSSMT HHHCCCCCCCCCCCC	39.88	27732954
711	Phosphorylation	HSSTSAPSSSMTSPQ CCCCCCCCCCCCCCC	34.46	27732954
712	Phosphorylation	SSTSAPSSSMTSPQS CCCCCCCCCCCCCCC	24.06	27732954
713	Phosphorylation	STSAPSSSMTSPQSS CCCCCCCCCCCCCCC	30.34	27732954
715	Phosphorylation	SAPSSSMTSPQSSQA CCCCCCCCCCCCCCC	38.92	27732954
716	Phosphorylation	APSSSMTSPQSSQAS CCCCCCCCCCCCCCC	16.58	27732954
719	Phosphorylation	SSMTSPQSSQASRQD CCCCCCCCCCCCCCC	28.00	27732954
720	Phosphorylation	SMTSPQSSQASRQDE CCCCCCCCCCCCCCC	25.23	27732954
723	Phosphorylation	SPQSSQASRQDEWDR CCCCCCCCCCCCCCC	23.88	27732954
754	Phosphorylation	ESEPAAHSFASSEAD CCCCCHHHHHCCCCC	20.13	25921289
757	Phosphorylation	PAAHSFASSEADDQE CCHHHHHCCCCCCHH	27.05	25921289
758	Phosphorylation	AAHSFASSEADDQEV CHHHHHCCCCCCHHH	33.12	28985074
864	Phosphorylation	GNYASHRSLSGCPRA CCCCCCCCCCCCCCC	22.82	-
989	Phosphorylation	LSGDEVLSPKFKTSD CCCCCCCCCCCCHHH	31.08	24719451
1034	Phosphorylation	QLQSQISSMEKNLKN HHHHHHHHHHHHHCC	32.37	23879269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PIN1_HUMAN	PIN1	physical	10504341

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.