NLRX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NLRX1_HUMAN
• UniProt AC: Q86UT6
• Protein Name: NLR family member X1
• Gene Name: NLRX1
• Organism: Homo sapiens (Human).
• Sequence Length: 975
• Subcellular Localization: Mitochondrion outer membrane .
• Protein Description: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction. [PubMed: 18200010 Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12]
• Protein Sequence: MRWGHHLPRASWGSGFRRALQRPDDRIPFLIHWSWPLQGERPFGPPRAFIRHHGSSVDSAPPPGRHGRLFPSASATEAIQRHRRNLAEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPPAELALEHQPPQAGLPPLALSQLFNPDACGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGPAPASLCQLVAQRYTPLKEVLPLMAAAGSHLLFVLHGLEHLNLDFRLAGTGLCSDPEEPQEPAAIIVNLLRKYMLPQASILVTTRPSAIGRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPYCGYAVGGSGVSATPAQRDHLVQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTDPSNLSLMAYAARTMGKLAYEGVSSRKTYFSEEDVCGCLEAGIRTEEEFQLLHIFRRDALRFFLAPCVEPGRAGTFVFTVPAMQEYLAALYIVLGLRKTTLQKVGKEVAELVGRVGEDVSLVLGIMAKLLPLRALPLLFNLIKVVPRVFGRMVGKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPPEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLSSLRQLNLAGVRMTPVKCTVVAAVLGSGRHALDEVNLASCQLDPAGLRTLLPVFLRARKLGLQLNSLGPEACKDLRDLLLHDQCQITTLRLSNNPLTAAGVAVLMEGLAGNTSVTHLSLLHTGLGDEGLELLAAQLDRNRQLQELNVAYNGAGDTAALALARAAREHPSLELLHLYFNELSSEGRQVLRDLGGAAEGGARVVVSLTEGTAVSEYWSVILSEVQRNLNSWDRARVQRHLELLLRDLEDSRGATLNPWRKAQLLRVEGEVRALLEQLGSSGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	IPFLIHWSWPLQGER CCEEEEECCCCCCCC	12.49	-
161	Phosphorylation	ACGRRVQTVVLYGTV CCCCEEEEEEEEEEC	15.10	29083192
165	Phosphorylation	RVQTVVLYGTVGTGK EEEEEEEEEECCCCH	10.11	29083192
167	Phosphorylation	QTVVLYGTVGTGKST EEEEEEEECCCCHHH	11.38	29083192
170	Phosphorylation	VLYGTVGTGKSTLVR EEEEECCCCHHHHHH	36.78	29083192
173	Phosphorylation	GTVGTGKSTLVRKMV EECCCCHHHHHHHHH	28.46	29083192
174	Phosphorylation	TVGTGKSTLVRKMVL ECCCCHHHHHHHHHH	32.53	29083192
285	Phosphorylation	KYMLPQASILVTTRP HHCCCCCCEEEECCC	15.94	-
293	Phosphorylation	ILVTTRPSAIGRIPS EEEECCCHHHCCCCH	29.27	-
300	Phosphorylation	SAIGRIPSKYVGRYG HHHCCCCHHHCCCCC	33.96	24719451
420	Phosphorylation	STDPSNLSLMAYAAR CCCHHHHHHHHHHHH	21.98	25954137
424	Phosphorylation	SNLSLMAYAARTMGK HHHHHHHHHHHHHHH	6.19	25954137
428	Phosphorylation	LMAYAARTMGKLAYE HHHHHHHHHHHHHHC	26.08	25954137
442	Phosphorylation	EGVSSRKTYFSEEDV CCCCCCCCCCCHHHH	28.79	23090842
445	Phosphorylation	SSRKTYFSEEDVCGC CCCCCCCCHHHHHHH	29.66	23090842
514	Phosphorylation	VLGLRKTTLQKVGKE HHHCCHHHHHHHHHH	30.17	-
600	Phosphorylation	VLDQMGASILGVEGP HHHHHCCHHCCCCCC	16.77	-
696	Phosphorylation	RFSAEVLSSLRQLNL CCCHHHHHHHHHCCC	32.28	30301811
697	Phosphorylation	FSAEVLSSLRQLNLA CCHHHHHHHHHCCCC	24.34	25954137
768	Acetylation	SLGPEACKDLRDLLL HCCHHHHHHHHHHHH	67.84	18586729
850	Phosphorylation	AYNGAGDTAALALAR HCCCHHHHHHHHHHH	16.95	26074081
943	Phosphorylation	LLRDLEDSRGATLNP HHHHHHHCCCCCCCH	24.20	-
947	Phosphorylation	LEDSRGATLNPWRKA HHHCCCCCCCHHHHH	29.86	-
973	Phosphorylation	LLEQLGSSGS----- HHHHHCCCCC-----	41.06	28060719
975	Phosphorylation	EQLGSSGS------- HHHCCCCC-------	38.71	28060719

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NLRX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NLRX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NLRX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDIPT_HUMAN	CDIPT	physical	21903422
FAKD5_HUMAN	FASTKD5	physical	21903422
HAUS6_HUMAN	HAUS6	physical	21903422
PRDX3_HUMAN	PRDX3	physical	21903422
SPNS1_HUMAN	SPNS1	physical	21903422
BASI_HUMAN	BSG	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
HERC4_HUMAN	HERC4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.