SPNS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPNS1_HUMAN
• UniProt AC: Q9H2V7
• Protein Name: Protein spinster homolog 1
• Gene Name: SPNS1
• Organism: Homo sapiens (Human).
• Sequence Length: 528
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein . Colocalizes with SDHB.
• Protein Description: Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death..
• Protein Sequence: MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSALIVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVREPPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCATGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGSDTAPF ------CCCCCCCCC	26.63	19413330
11	Phosphorylation	SDTAPFLSQADDPDD CCCCCCCCCCCCCCC	24.57	28122231
24	Phosphorylation	DDGPVPGTPGLPGST CCCCCCCCCCCCCCC	14.23	25850435
30	Phosphorylation	GTPGLPGSTGNPKSE CCCCCCCCCCCCCCC	31.07	21955146
31	Phosphorylation	TPGLPGSTGNPKSEE CCCCCCCCCCCCCCC	47.06	21955146
54	Phosphorylation	LQRITGLSPGRSALI HHHHHCCCCCHHHHH	27.01	24719451
78 (in isoform 3)	Phosphorylation	-	15.44	-
167	Phosphorylation	VGVGEASYSTIAPTL CCCCCCCHHCCHHHH	19.51	22817900
192	Phosphorylation	SRMLSIFYFAIPVGS HHHHHHEEEEEECCC	7.16	22817900
203	Phosphorylation	PVGSGLGYIAGSKVK ECCCCCHHHCCCCHH	7.82	22817900
223	Phosphorylation	WHWALRVTPGLGVVA CHHHHHCCCCHHHHH	12.76	-
287	Phosphorylation	FTAVAFVTGSLALWA CCHHHHHHHHHHHHH	18.01	-
301	Phosphorylation	APAFLLRSRVVLGET HHHHHHHCCEECCCC	29.42	-
505	Phosphorylation	GLLHEAGSTDDRIVV HHHHHCCCCCCEEEE	35.39	25849741
506	Phosphorylation	LLHEAGSTDDRIVVP HHHHCCCCCCEEEEC	40.79	30266825
518	Phosphorylation	VVPQRGRSTRVPVAS EECCCCCCCCCCEEE	24.32	21712546
519	Phosphorylation	VPQRGRSTRVPVASV ECCCCCCCCCCEEEE	34.03	21712546
525	Phosphorylation	STRVPVASVLI---- CCCCCEEEECC----	20.07	24117733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPNS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPNS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPNS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_HUMAN	BCL2	physical	12815463
B2CL1_HUMAN	BCL2L1	physical	12815463

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-518, AND MASSSPECTROMETRY.
PubMed: 18669648