dbPTM

HAUS6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HAUS6_HUMAN
UniProt AC	Q7Z4H7
Protein Name	HAUS augmin-like complex subunit 6
Gene Name	HAUS6
Organism	Homo sapiens (Human).
Sequence Length	955
Subcellular Localization	Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to interphase centrosomes and to mitotic spindle microtubules.
Protein Description	Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin..
Protein Sequence	MSSASVTAFEKEHLWMYLQALGFEPGPATIACGKIVSHTHLGVNMFDKLNRDAFHIISYFLFQVLDQSLTKEVFKFCWPPFDQKSDTEFRKHCCEWIKRISGECGSSFPQVVGSLFLSPGGPKFIHLMYHFARFVAMKYIKSNSKNSSHHFVETFNIKPQDLHKCIARCHFARSRFLQILQRQDCVTQKYQENAQLSVKQVRNLRSECIGLENQIKKMEPYDDHSNMEEKIQKVRSLWASVNETLMFLEKEREVVSSVLSLVNQYALDGTNVAINIPRLLLDKIEKQMFQLHIGNVYEAGKLNLLTVIQLLNEVLKVMKYERCQADQARLTVDLHYLEKETKFQKERLSDLKHMRYRIKDDLTTIRHSVVEKQGEWHKKWKEFLGLSPFSLIKGWTPSVDLLPPMSPLSFDPASEEVYAKSILCQYPASLPDAHKQHNQENGCRGDSDTLGALHDLANSPASFLSQSVSSSDRNSVTVLEKDTKMGTPKEKNEAISKKIPEFEVENSPLSDVAKNTESSAFGGSLPAKKSDPFQKEQDHLVEEVARAVLSDSPQLSEGKEIKLEELIDSLGSNPFLTRNQIPRTPENLITEIRSSWRKAIEMEENRTKEPIQMDAEHREVLPESLPVLHNQREFSMADFLLETTVSDFGQSHLTEEKVISDCECVPQKHVLTSHIDEPPTQNQSDLLNKKVICKQDLECLAFTKLSETSRMETFSPAVGNRIDVMGGSEEEFMKILDHLEVSCNKPSTNKTMLWNSFQISSGISSKSFKDNDFGILHETLPEEVGHLSFNSSSSSEANFKLEPNSPMHGGTLLEDVVGGRQTTPESDFNLQALRSRYEALKKSLSKKREESYLSNSQTPERHKPELSPTPQNVQTDDTLNFLDTCDLHTEHIKPSLRTSIGERKRSLSPLIKFSPVEQRLRTTIACSLGELPNLKEEDILNKSLDAKEPPSDLTR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Ubiquitination	YFLFQVLDQSLTKEV HHHHHHHCHHHCHHH	36.85	22817900
67	Ubiquitination	FLFQVLDQSLTKEVF HHHHHHCHHHCHHHH	35.86	22817900
68	Phosphorylation	LFQVLDQSLTKEVFK HHHHHCHHHCHHHHH	37.36	-
69	Ubiquitination	FQVLDQSLTKEVFKF HHHHCHHHCHHHHHH	7.06	22817900
70	Phosphorylation	QVLDQSLTKEVFKFC HHHCHHHCHHHHHHH	30.33	-
91	Ubiquitination	KSDTEFRKHCCEWIK CCCHHHHHHHHHHHH	46.44	29967540
97	Ubiquitination	RKHCCEWIKRISGEC HHHHHHHHHHHHCCC	0.72	21963094
98	Ubiquitination	KHCCEWIKRISGECG HHHHHHHHHHHCCCC	44.76	22817900
128	Ubiquitination	GPKFIHLMYHFARFV CHHHHHHHHHHHHHH	1.19	22817900
131	Ubiquitination	FIHLMYHFARFVAMK HHHHHHHHHHHHHHH	2.62	22817900
135	Ubiquitination	MYHFARFVAMKYIKS HHHHHHHHHHHHHHC	4.19	22817900
139	Phosphorylation	ARFVAMKYIKSNSKN HHHHHHHHHHCCCCC	10.66	21406692
142	Phosphorylation	VAMKYIKSNSKNSSH HHHHHHHCCCCCCCC	36.46	21406692
144	Phosphorylation	MKYIKSNSKNSSHHF HHHHHCCCCCCCCCE	40.06	21406692
158	Ubiquitination	FVETFNIKPQDLHKC EEEECCCCHHHHHHH	37.42	29967540
177	Ubiquitination	HFARSRFLQILQRQD HHHHHHHHHHHHHHH	2.77	22817900
189	Ubiquitination	RQDCVTQKYQENAQL HHHCHHHHHHHHHCC	39.26	-
197	Phosphorylation	YQENAQLSVKQVRNL HHHHHCCCHHHHHHH	18.39	24719451
199	Ubiquitination	ENAQLSVKQVRNLRS HHHCCCHHHHHHHHH	39.43	21906983
199 (in isoform 1)	Ubiquitination	-	39.43	21906983
199 (in isoform 2)	Ubiquitination	-	39.43	21906983
216	Ubiquitination	IGLENQIKKMEPYDD HCCHHHHHHCCCCCC	35.98	29967540
217	Ubiquitination	GLENQIKKMEPYDDH CCHHHHHHCCCCCCC	50.56	-
221	Phosphorylation	QIKKMEPYDDHSNME HHHHCCCCCCCCCHH	22.24	-
258	Ubiquitination	EREVVSSVLSLVNQY HHHHHHHHHHHHHHH	3.07	22817900
259	Ubiquitination	REVVSSVLSLVNQYA HHHHHHHHHHHHHHH	3.37	22817900
263	Ubiquitination	SSVLSLVNQYALDGT HHHHHHHHHHHCCCC	34.14	22817900
280	Ubiquitination	AINIPRLLLDKIEKQ EECHHHHHHHHHHHH	6.49	22817900
281	Ubiquitination	INIPRLLLDKIEKQM ECHHHHHHHHHHHHH	8.14	22817900
283	Ubiquitination	IPRLLLDKIEKQMFQ HHHHHHHHHHHHHHC	53.38	21906983
283 (in isoform 1)	Ubiquitination	-	53.38	21906983
283 (in isoform 2)	Ubiquitination	-	53.38	21906983
286	Ubiquitination	LLLDKIEKQMFQLHI HHHHHHHHHHHCCCC	51.00	22817900
311	Ubiquitination	LLTVIQLLNEVLKVM HHHHHHHHHHHHHHH	2.69	21963094
312	Ubiquitination	LTVIQLLNEVLKVMK HHHHHHHHHHHHHHH	46.02	22817900
339	Acetylation	VDLHYLEKETKFQKE EEHHHHHHHCHHCHH	69.00	25953088
339	Ubiquitination	VDLHYLEKETKFQKE EEHHHHHHHCHHCHH	69.00	29967540
342	Ubiquitination	HYLEKETKFQKERLS HHHHHHCHHCHHHHH	47.06	22817900
345	Ubiquitination	EKETKFQKERLSDLK HHHCHHCHHHHHHHC	48.19	22817900
349	Phosphorylation	KFQKERLSDLKHMRY HHCHHHHHHHCHHHH	47.30	23312004
352	Acetylation	KERLSDLKHMRYRIK HHHHHHHCHHHHHHH	40.10	25953088
352	Ubiquitination	KERLSDLKHMRYRIK HHHHHHHCHHHHHHH	40.10	21906983
352 (in isoform 1)	Ubiquitination	-	40.10	21906983
352 (in isoform 2)	Ubiquitination	-	40.10	21906983
356	Phosphorylation	SDLKHMRYRIKDDLT HHHCHHHHHHHCCHH	14.76	26074081
359	Ubiquitination	KHMRYRIKDDLTTIR CHHHHHHHCCHHHHC	35.87	29967540
363	Phosphorylation	YRIKDDLTTIRHSVV HHHHCCHHHHCHHHH	27.46	26074081
364	Phosphorylation	RIKDDLTTIRHSVVE HHHCCHHHHCHHHHH	24.26	28555341
368	Phosphorylation	DLTTIRHSVVEKQGE CHHHHCHHHHHHCCH	20.29	26074081
372	Ubiquitination	IRHSVVEKQGEWHKK HCHHHHHHCCHHHHH	52.58	29967540
381	Ubiquitination	GEWHKKWKEFLGLSP CHHHHHHHHHHCCCH	47.68	-
385	Ubiquitination	KKWKEFLGLSPFSLI HHHHHHHCCCHHHHC	29.45	29967540
387	Phosphorylation	WKEFLGLSPFSLIKG HHHHHCCCHHHHCCC	23.31	22617229
390	Phosphorylation	FLGLSPFSLIKGWTP HHCCCHHHHCCCCCC	32.35	23403867
391	Ubiquitination	LGLSPFSLIKGWTPS HCCCHHHHCCCCCCC	4.86	22817900
396	Phosphorylation	FSLIKGWTPSVDLLP HHHCCCCCCCCCCCC	17.85	28176443
398	Phosphorylation	LIKGWTPSVDLLPPM HCCCCCCCCCCCCCC	22.38	20873877
406	Phosphorylation	VDLLPPMSPLSFDPA CCCCCCCCCCCCCCC	28.59	28176443
409	Phosphorylation	LPPMSPLSFDPASEE CCCCCCCCCCCCCCH	30.87	22199227
411	Ubiquitination	PMSPLSFDPASEEVY CCCCCCCCCCCCHHH	34.18	22817900
414	Phosphorylation	PLSFDPASEEVYAKS CCCCCCCCCHHHHHH	39.41	22199227
415	Ubiquitination	LSFDPASEEVYAKSI CCCCCCCCHHHHHHH	54.30	22817900
416	Ubiquitination	SFDPASEEVYAKSIL CCCCCCCHHHHHHHH	38.03	22817900
418	Phosphorylation	DPASEEVYAKSILCQ CCCCCHHHHHHHHHH	16.16	22199227
420	Ubiquitination	ASEEVYAKSILCQYP CCCHHHHHHHHHHCC	21.97	29967540
421	Phosphorylation	SEEVYAKSILCQYPA CCHHHHHHHHHHCCC	16.78	28555341
426	Phosphorylation	AKSILCQYPASLPDA HHHHHHHCCCCCCHH	10.36	28450419
429	Phosphorylation	ILCQYPASLPDAHKQ HHHHCCCCCCHHHHH	35.61	30576142
446	Ubiquitination	QENGCRGDSDTLGAL CCCCCCCCHHHHHHH	24.80	29967540
447	Phosphorylation	ENGCRGDSDTLGALH CCCCCCCHHHHHHHH	35.01	27080861
449	Phosphorylation	GCRGDSDTLGALHDL CCCCCHHHHHHHHHH	30.92	27080861
459	Phosphorylation	ALHDLANSPASFLSQ HHHHHHCCCHHHHHH	19.08	25159151
462	Phosphorylation	DLANSPASFLSQSVS HHHCCCHHHHHHHCC	30.06	18669648
462	Ubiquitination	DLANSPASFLSQSVS HHHCCCHHHHHHHCC	30.06	22817900
463	Ubiquitination	LANSPASFLSQSVSS HHCCCHHHHHHHCCC	9.16	22817900
465	Phosphorylation	NSPASFLSQSVSSSD CCCHHHHHHHCCCCC	20.56	27080861
467	Phosphorylation	PASFLSQSVSSSDRN CHHHHHHHCCCCCCC	22.16	21712546
472	Ubiquitination	SQSVSSSDRNSVTVL HHHCCCCCCCCEEEE	56.58	22817900
473	Ubiquitination	QSVSSSDRNSVTVLE HHCCCCCCCCEEEEE	38.99	22817900
475	Phosphorylation	VSSSDRNSVTVLEKD CCCCCCCCEEEEECC	21.76	-
477	Ubiquitination	SSDRNSVTVLEKDTK CCCCCCEEEEECCCC	21.13	22817900
479	Ubiquitination	DRNSVTVLEKDTKMG CCCCEEEEECCCCCC	5.03	29967540
481	Ubiquitination	NSVTVLEKDTKMGTP CCEEEEECCCCCCCC	67.54	29967540
483	Phosphorylation	VTVLEKDTKMGTPKE EEEEECCCCCCCCHH	33.72	-
487	Phosphorylation	EKDTKMGTPKEKNEA ECCCCCCCCHHHHHH	27.91	27174698
493	Ubiquitination	GTPKEKNEAISKKIP CCCHHHHHHHHHHCC	59.45	27667366
494	Ubiquitination	TPKEKNEAISKKIPE CCHHHHHHHHHHCCC	22.28	22817900
497	Ubiquitination	EKNEAISKKIPEFEV HHHHHHHHHCCCCEE	48.92	22817900
498	Ubiquitination	KNEAISKKIPEFEVE HHHHHHHHCCCCEEE	57.62	21906983
498 (in isoform 1)	Ubiquitination	-	57.62	21906983
498 (in isoform 2)	Ubiquitination	-	57.62	21906983
500	Ubiquitination	EAISKKIPEFEVENS HHHHHHCCCCEEECC	49.45	29967540
507	Phosphorylation	PEFEVENSPLSDVAK CCCEEECCCHHHHHH	17.45	19664994
510	Phosphorylation	EVENSPLSDVAKNTE EEECCCHHHHHHCCC	33.16	25159151
511	Ubiquitination	VENSPLSDVAKNTES EECCCHHHHHHCCCC	52.67	22817900
514	Ubiquitination	SPLSDVAKNTESSAF CCHHHHHHCCCCCCC	65.34	29967540
516	Phosphorylation	LSDVAKNTESSAFGG HHHHHHCCCCCCCCC	36.22	26074081
516	Ubiquitination	LSDVAKNTESSAFGG HHHHHHCCCCCCCCC	36.22	22817900
518	Phosphorylation	DVAKNTESSAFGGSL HHHHCCCCCCCCCCC	25.57	26074081
519	Phosphorylation	VAKNTESSAFGGSLP HHHCCCCCCCCCCCC	22.76	25159151
524	Phosphorylation	ESSAFGGSLPAKKSD CCCCCCCCCCCCCCC	31.40	25159151
524	Ubiquitination	ESSAFGGSLPAKKSD CCCCCCCCCCCCCCC	31.40	22817900
527	Ubiquitination	AFGGSLPAKKSDPFQ CCCCCCCCCCCCCCH	36.88	22817900
528	Ubiquitination	FGGSLPAKKSDPFQK CCCCCCCCCCCCCHH	51.36	21906983
528 (in isoform 1)	Ubiquitination	-	51.36	21906983
528 (in isoform 2)	Ubiquitination	-	51.36	21906983
529	Ubiquitination	GGSLPAKKSDPFQKE CCCCCCCCCCCCHHH	63.30	22817900
530	Phosphorylation	GSLPAKKSDPFQKEQ CCCCCCCCCCCHHHH	50.22	23401153
535	Ubiquitination	KKSDPFQKEQDHLVE CCCCCCHHHHHHHHH	58.69	29967540
549	Phosphorylation	EEVARAVLSDSPQLS HHHHHHHHCCCCCCC	4.61	32645325
550	Phosphorylation	EVARAVLSDSPQLSE HHHHHHHCCCCCCCC	29.46	30266825
552	Phosphorylation	ARAVLSDSPQLSEGK HHHHHCCCCCCCCCC	15.92	29255136
556	Phosphorylation	LSDSPQLSEGKEIKL HCCCCCCCCCCEEEH	38.77	30266825
559	Ubiquitination	SPQLSEGKEIKLEEL CCCCCCCCEEEHHHH	52.82	21906983
559 (in isoform 1)	Ubiquitination	-	52.82	21906983
559 (in isoform 2)	Ubiquitination	-	52.82	21906983
562	Ubiquitination	LSEGKEIKLEELIDS CCCCCEEEHHHHHHH	51.44	22817900
563	Ubiquitination	SEGKEIKLEELIDSL CCCCEEEHHHHHHHH	8.31	29967540
569	Phosphorylation	KLEELIDSLGSNPFL EHHHHHHHHCCCCCC	27.86	28450419
572	Phosphorylation	ELIDSLGSNPFLTRN HHHHHHCCCCCCCCC	46.77	28450419
573	Ubiquitination	LIDSLGSNPFLTRNQ HHHHHCCCCCCCCCC	29.55	22817900
577	Phosphorylation	LGSNPFLTRNQIPRT HCCCCCCCCCCCCCC	28.14	28450419
584	Phosphorylation	TRNQIPRTPENLITE CCCCCCCCHHHHHHH	29.60	19664994
590	Phosphorylation	RTPENLITEIRSSWR CCHHHHHHHHHHHHH	28.64	23927012
598	Ubiquitination	EIRSSWRKAIEMEEN HHHHHHHHHHHCHHC	47.67	29967540
607	Phosphorylation	IEMEENRTKEPIQMD HHCHHCCCCCCCCCC	51.87	28555341
608	Ubiquitination	EMEENRTKEPIQMDA HCHHCCCCCCCCCCH	59.25	21906983
608 (in isoform 1)	Ubiquitination	-	59.25	21906983
622	Ubiquitination	AEHREVLPESLPVLH HHHHHHCCCCCCCCC	34.01	29967540
624	Phosphorylation	HREVLPESLPVLHNQ HHHHCCCCCCCCCCC	35.71	28555341
625	Ubiquitination	REVLPESLPVLHNQR HHHCCCCCCCCCCCC	3.03	22817900
629	Ubiquitination	PESLPVLHNQREFSM CCCCCCCCCCCCCCH	28.72	22817900
630	Ubiquitination	ESLPVLHNQREFSMA CCCCCCCCCCCCCHH	38.14	22817900
633	Ubiquitination	PVLHNQREFSMADFL CCCCCCCCCCHHHHH	32.10	29967540
644	Phosphorylation	ADFLLETTVSDFGQS HHHHHHCCHHHHCCC	14.50	22067460
646	Phosphorylation	FLLETTVSDFGQSHL HHHHCCHHHHCCCCC	25.73	22067460
654	Ubiquitination	DFGQSHLTEEKVISD HHCCCCCCCCEEECC	36.35	22817900
655	Ubiquitination	FGQSHLTEEKVISDC HCCCCCCCCEEECCC	63.28	22817900
657	Ubiquitination	QSHLTEEKVISDCEC CCCCCCCEEECCCEE	38.34	29967540
659	Ubiquitination	HLTEEKVISDCECVP CCCCCEEECCCEEEC	4.21	22817900
660	Phosphorylation	LTEEKVISDCECVPQ CCCCEEECCCEEECC	38.91	25159151
668	Ubiquitination	DCECVPQKHVLTSHI CCEEECCCCEECCCC	29.61	29967540
669	Ubiquitination	CECVPQKHVLTSHID CEEECCCCEECCCCC	17.99	32015554
673	Phosphorylation	PQKHVLTSHIDEPPT CCCCEECCCCCCCCC	17.81	29214152
680	Phosphorylation	SHIDEPPTQNQSDLL CCCCCCCCCCHHHHH	51.36	28555341
684	Phosphorylation	EPPTQNQSDLLNKKV CCCCCCHHHHHCCCE	37.46	28555341
689	Ubiquitination	NQSDLLNKKVICKQD CHHHHHCCCEEEHHH	48.68	21906983
689 (in isoform 1)	Ubiquitination	-	48.68	21906983
690	Ubiquitination	QSDLLNKKVICKQDL HHHHHCCCEEEHHHH	35.44	22817900
694	Ubiquitination	LNKKVICKQDLECLA HCCCEEEHHHHHHHH	35.40	22817900
699	Ubiquitination	ICKQDLECLAFTKLS EEHHHHHHHHEECCC	4.28	29967540
704	Ubiquitination	LECLAFTKLSETSRM HHHHHEECCCCCCCC	43.49	32015554
706	Phosphorylation	CLAFTKLSETSRMET HHHEECCCCCCCCCC	40.14	21712546
708	Phosphorylation	AFTKLSETSRMETFS HEECCCCCCCCCCCC	20.46	27134283
709	Phosphorylation	FTKLSETSRMETFSP EECCCCCCCCCCCCC	26.11	27134283
710	Ubiquitination	TKLSETSRMETFSPA ECCCCCCCCCCCCCC	34.08	29967540
713	Phosphorylation	SETSRMETFSPAVGN CCCCCCCCCCCCCCC	21.77	29255136
715	Phosphorylation	TSRMETFSPAVGNRI CCCCCCCCCCCCCCE	21.26	29255136
725	Sulfoxidation	VGNRIDVMGGSEEEF CCCCEECCCCCHHHH	4.45	21406390
725	Ubiquitination	VGNRIDVMGGSEEEF CCCCEECCCCCHHHH	4.45	22817900
728	Phosphorylation	RIDVMGGSEEEFMKI CEECCCCCHHHHHHH	35.78	25159151
730	Ubiquitination	DVMGGSEEEFMKILD ECCCCCHHHHHHHHH	59.23	22817900
734	Ubiquitination	GSEEEFMKILDHLEV CCHHHHHHHHHHHHH	45.50	29967540
742	Phosphorylation	ILDHLEVSCNKPSTN HHHHHHHHCCCCCCC	11.55	25159151
745	Ubiquitination	HLEVSCNKPSTNKTM HHHHHCCCCCCCCCE	44.68	29967540
747	Phosphorylation	EVSCNKPSTNKTMLW HHHCCCCCCCCCEEE	46.34	23186163
748	Phosphorylation	VSCNKPSTNKTMLWN HHCCCCCCCCCEEEE	49.62	23186163
788	Phosphorylation	PEEVGHLSFNSSSSS CHHHCCCEECCCCCC	19.39	20873877
791	Phosphorylation	VGHLSFNSSSSSEAN HCCCEECCCCCCCCC	29.59	20873877
792	Phosphorylation	GHLSFNSSSSSEANF CCCEECCCCCCCCCE	35.03	20873877
793	Phosphorylation	HLSFNSSSSSEANFK CCEECCCCCCCCCEE	37.39	20873877
794	Phosphorylation	LSFNSSSSSEANFKL CEECCCCCCCCCEEE	33.86	20873877
795	Phosphorylation	SFNSSSSSEANFKLE EECCCCCCCCCEEEC	42.55	20873877
805	Phosphorylation	NFKLEPNSPMHGGTL CEEECCCCCCCCCCE	34.02	30266825
807	Ubiquitination	KLEPNSPMHGGTLLE EECCCCCCCCCCEEE	4.62	22817900
811	Phosphorylation	NSPMHGGTLLEDVVG CCCCCCCCEEECCCC	32.53	29255136
811	Ubiquitination	NSPMHGGTLLEDVVG CCCCCCCCEEECCCC	32.53	22817900
812	Ubiquitination	SPMHGGTLLEDVVGG CCCCCCCEEECCCCC	5.80	29967540
822	Phosphorylation	DVVGGRQTTPESDFN CCCCCCCCCCCCHHH	42.85	25159151
823	Phosphorylation	VVGGRQTTPESDFNL CCCCCCCCCCCHHHH	19.40	25159151
826	Phosphorylation	GRQTTPESDFNLQAL CCCCCCCCHHHHHHH	49.02	19691289
837	Phosphorylation	LQALRSRYEALKKSL HHHHHHHHHHHHHHH	13.55	-
842	Ubiquitination	SRYEALKKSLSKKRE HHHHHHHHHHHHHHH	58.44	22817900
843	Phosphorylation	RYEALKKSLSKKREE HHHHHHHHHHHHHHH	35.97	-
846	Ubiquitination	ALKKSLSKKREESYL HHHHHHHHHHHHHHH	62.23	22817900
847	Ubiquitination	LKKSLSKKREESYLS HHHHHHHHHHHHHHC	62.76	21906983
847 (in isoform 1)	Ubiquitination	-	62.76	21906983
851	Phosphorylation	LSKKREESYLSNSQT HHHHHHHHHHCCCCC	26.99	21712546
852	Phosphorylation	SKKREESYLSNSQTP HHHHHHHHHCCCCCC	19.89	21712546
854	Phosphorylation	KREESYLSNSQTPER HHHHHHHCCCCCCCC	26.63	29496963
856	Phosphorylation	EESYLSNSQTPERHK HHHHHCCCCCCCCCC	31.86	28985074
858	Phosphorylation	SYLSNSQTPERHKPE HHHCCCCCCCCCCCC	27.26	25159151
858	Ubiquitination	SYLSNSQTPERHKPE HHHCCCCCCCCCCCC	27.26	29967540
863	Ubiquitination	SQTPERHKPELSPTP CCCCCCCCCCCCCCC	46.54	-
867	Phosphorylation	ERHKPELSPTPQNVQ CCCCCCCCCCCCCCC	25.68	29255136
869	Phosphorylation	HKPELSPTPQNVQTD CCCCCCCCCCCCCCC	33.84	29255136
873	Phosphorylation	LSPTPQNVQTDDTLN CCCCCCCCCCCCCCC	5.66	32142685
875	Phosphorylation	PTPQNVQTDDTLNFL CCCCCCCCCCCCCHH	31.40	30108239
877	Ubiquitination	PQNVQTDDTLNFLDT CCCCCCCCCCCHHHH	57.38	29967540
878	Phosphorylation	QNVQTDDTLNFLDTC CCCCCCCCCCHHHHC	26.81	30108239
884	Phosphorylation	DTLNFLDTCDLHTEH CCCCHHHHCCCCCCC	15.29	24144214
889	Phosphorylation	LDTCDLHTEHIKPSL HHHCCCCCCCCCHHH	36.23	24144214
893	Ubiquitination	DLHTEHIKPSLRTSI CCCCCCCCHHHHCCC	30.38	29967540
895	Phosphorylation	HTEHIKPSLRTSIGE CCCCCCHHHHCCCCC	26.02	24144214
898	Phosphorylation	HIKPSLRTSIGERKR CCCHHHHCCCCCCCC	29.95	25627689
899	Phosphorylation	IKPSLRTSIGERKRS CCHHHHCCCCCCCCC	23.35	25627689
900	Ubiquitination	KPSLRTSIGERKRSL CHHHHCCCCCCCCCC	7.03	29967540
906	Phosphorylation	SIGERKRSLSPLIKF CCCCCCCCCCCCCCC	35.91	23927012
907	Ubiquitination	IGERKRSLSPLIKFS CCCCCCCCCCCCCCC	7.69	22817900
908	Phosphorylation	GERKRSLSPLIKFSP CCCCCCCCCCCCCCC	20.93	23927012
912	Ubiquitination	RSLSPLIKFSPVEQR CCCCCCCCCCCHHHH	47.69	32015554
914	Phosphorylation	LSPLIKFSPVEQRLR CCCCCCCCCHHHHHH	24.04	25159151
923	Phosphorylation	VEQRLRTTIACSLGE HHHHHHHHHHCHHCC	10.51	28555341
927	Phosphorylation	LRTTIACSLGELPNL HHHHHHCHHCCCCCC	30.32	21712546
935	Ubiquitination	LGELPNLKEEDILNK HCCCCCCCHHHHHCC	66.74	29967540
942	Ubiquitination	KEEDILNKSLDAKEP CHHHHHCCCCCCCCC	49.29	22817900
943	Phosphorylation	EEDILNKSLDAKEPP HHHHHCCCCCCCCCC	30.34	23401153
947	Ubiquitination	LNKSLDAKEPPSDLT HCCCCCCCCCCCCCC	71.12	22817900
947 (in isoform 1)	Ubiquitination	-	71.12	21906983
951	Phosphorylation	LDAKEPPSDLTR--- CCCCCCCCCCCC---	56.84	26074081
954	Phosphorylation	KEPPSDLTR------ CCCCCCCCC------	39.05	21815630

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HAUS6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HAUS6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HAUS6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAUS5_HUMAN	HAUS5	physical	19369198
HAUS8_HUMAN	HAUS8	physical	19369198
NEDD1_HUMAN	NEDD1	physical	19369198
HAUS7_HUMAN	HAUS7	physical	19369198
HAUS3_HUMAN	HAUS3	physical	19369198
RBM7_HUMAN	RBM7	physical	19369198
HAUS1_HUMAN	HAUS1	physical	19369198
HAUS2_HUMAN	HAUS2	physical	19369198
HAUS4_HUMAN	HAUS4	physical	19369198
YBOX3_HUMAN	YBX3	physical	19369198
A4_HUMAN	APP	physical	21832049
KDM1A_HUMAN	KDM1A	physical	23455924
BMAL1_HUMAN	ARNTL	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
PSMD9_HUMAN	PSMD9	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
YETS4_HUMAN	YEATS4	physical	27173435
TFPT_HUMAN	TFPT	physical	27173435
PKN3_HUMAN	PKN3	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HAUS6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-406 AND SER-552, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507; SER-552; THR-584;SER-715; SER-728; SER-906; SER-908 AND SER-914, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507; SER-552; THR-584;SER-715 AND THR-858, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-584 AND SER-805, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-459; SER-552; THR-584AND SER-715, AND MASS SPECTROMETRY.	19007248 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-552; SER-908 ANDSER-914, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-584, AND MASSSPECTROMETRY.	16565220 [Abstract]