HAUS4_HUMAN - dbPTM
HAUS4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HAUS4_HUMAN
UniProt AC Q9H6D7
Protein Name HAUS augmin-like complex subunit 4
Gene Name HAUS4
Organism Homo sapiens (Human).
Sequence Length 363
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Localizes to interphase centrosomes and to mitotic spindle microtubules.
Protein Description Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex..
Protein Sequence MASGDFCSPGEGMEILQQVCSKQLPPCNLSKEDLLQNPYFSKLLLNLSQHVDESGLSLTLAKEQAQAWKEVRLHKTTWLRSEILHRVIQELLVDYYVKIQDTNVTSEDKKFHETLEQRLLVTELMRLLGPSQEREIPPLLGLEKADLLELMPLSEDFVWMRARLQQEVEEQLKKKCFTLLCYYDPNSDADSETVKAAKVWKLAEVLVGEQQQCQDAKSQQKEQMLLLEKKSAAYSQVLLRCLTLLQRLLQEHRLKTQSELDRINAQYLEVKCGAMILKLRMEELKILSDTYTVEKVEVHRLIRDRLEGAIHLQEQDMENSRQVLNSYEVLGEEFDRLVKEYTVLKQATENKRWALQEFSKVYR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MASGDFCSPG
-----CCCCCCCCCC		37.2828348404
8PhosphorylationMASGDFCSPGEGMEI
CCCCCCCCCCCHHHH		35.6125159151
22UbiquitinationILQQVCSKQLPPCNL
HHHHHHHCCCCCCCC		51.2129967540
31UbiquitinationLPPCNLSKEDLLQNP
CCCCCCCHHHHHCCH		59.4229967540
42UbiquitinationLQNPYFSKLLLNLSQ
HCCHHHHHHHHHHHH		33.0032015554
62UbiquitinationGLSLTLAKEQAQAWK
CCCHHHHHHHHHHHH		54.1729967540
69UbiquitinationKEQAQAWKEVRLHKT
HHHHHHHHHHHCCCC		49.7232015554
75UbiquitinationWKEVRLHKTTWLRSE
HHHHHCCCCHHHHHH		52.85-
109UbiquitinationTNVTSEDKKFHETLE
CCCCCCCHHHHHHHH		53.9733845483
110 (in isoform 4)Ubiquitination-65.36-
110UbiquitinationNVTSEDKKFHETLEQ
CCCCCCHHHHHHHHH		65.3629967540
128UbiquitinationVTELMRLLGPSQERE
HHHHHHHHCCCCCCC		7.1829967540
156UbiquitinationELMPLSEDFVWMRAR
HHCCCCCCHHHHHHH		39.7729967540
172UbiquitinationQQEVEEQLKKKCFTL
HHHHHHHHHHHCEEE		11.2621963094
173UbiquitinationQEVEEQLKKKCFTLL
HHHHHHHHHHCEEEE		50.2929967540
175UbiquitinationVEEQLKKKCFTLLCY
HHHHHHHHCEEEEEE		32.75-
176UbiquitinationEEQLKKKCFTLLCYY
HHHHHHHCEEEEEEC		4.2922817900
182PhosphorylationKCFTLLCYYDPNSDA
HCEEEEEECCCCCCC		15.75-
183PhosphorylationCFTLLCYYDPNSDAD
CEEEEEECCCCCCCC		24.75-
184UbiquitinationFTLLCYYDPNSDADS
EEEEEECCCCCCCCC		14.9429967540
201UbiquitinationVKAAKVWKLAEVLVG
HHHHHHHHHHHHHHC		40.5829967540
217UbiquitinationQQQCQDAKSQQKEQM
HHHHHHHHHHHHHHH		58.0221963094
221UbiquitinationQDAKSQQKEQMLLLE
HHHHHHHHHHHHHHH		42.1322817900
229UbiquitinationEQMLLLEKKSAAYSQ
HHHHHHHHHHHHHHH		52.5829967540
230UbiquitinationQMLLLEKKSAAYSQV
HHHHHHHHHHHHHHH		35.63-
234 (in isoform 2)Ubiquitination-10.1921890473
236 (in isoform 3)Ubiquitination-19.7321890473
240UbiquitinationAYSQVLLRCLTLLQR
HHHHHHHHHHHHHHH		14.8329967540
243PhosphorylationQVLLRCLTLLQRLLQ
HHHHHHHHHHHHHHH		29.1123612710
250UbiquitinationTLLQRLLQEHRLKTQ
HHHHHHHHHCCCCCH		49.3829967540
255UbiquitinationLLQEHRLKTQSELDR
HHHHCCCCCHHHHHH		44.46-
267PhosphorylationLDRINAQYLEVKCGA
HHHHHHHHHHHHHHH		11.4725839225
271AcetylationNAQYLEVKCGAMILK
HHHHHHHHHHHHHHH		19.9925953088
271MalonylationNAQYLEVKCGAMILK
HHHHHHHHHHHHHHH		19.9926320211
285UbiquitinationKLRMEELKILSDTYT
HHHHHHHCHHHCCEE		44.9029967540
291PhosphorylationLKILSDTYTVEKVEV
HCHHHCCEEEEEHHH		17.4925627689
294UbiquitinationLSDTYTVEKVEVHRL
HHCCEEEEEHHHHHH		43.5129967540
295UbiquitinationSDTYTVEKVEVHRLI
HCCEEEEEHHHHHHH		39.0829967540
300UbiquitinationVEKVEVHRLIRDRLE
EEEHHHHHHHHHHHC		36.6729967540
306UbiquitinationHRLIRDRLEGAIHLQ
HHHHHHHHCCCCCCC		9.2529967540
315 (in isoform 4)Ubiquitination-42.2521890473
315UbiquitinationGAIHLQEQDMENSRQ
CCCCCCHHHHHHHHH		42.2521890473
339UbiquitinationEEFDRLVKEYTVLKQ
HHHHHHHHHHHHHHH		49.9829967540
341PhosphorylationFDRLVKEYTVLKQAT
HHHHHHHHHHHHHHH		9.0929083192
342PhosphorylationDRLVKEYTVLKQATE
HHHHHHHHHHHHHHH		22.0629083192
345UbiquitinationVKEYTVLKQATENKR
HHHHHHHHHHHHCHH		33.2829967540
345AcetylationVKEYTVLKQATENKR
HHHHHHHHHHHHCHH		33.2821339330
348PhosphorylationYTVLKQATENKRWAL
HHHHHHHHHCHHHHH		37.2822461510
351UbiquitinationLKQATENKRWALQEF
HHHHHHCHHHHHHHH		42.9829967540
351AcetylationLKQATENKRWALQEF
HHHHHHCHHHHHHHH		42.9821339330
359PhosphorylationRWALQEFSKVYR---
HHHHHHHHHHCC---		22.0628555341
360UbiquitinationWALQEFSKVYR----
HHHHHHHHHCC----		48.9129967540
360 (in isoform 1)Ubiquitination-48.9121890473
362PhosphorylationLQEFSKVYR------
HHHHHHHCC------		17.84-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HAUS4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HAUS4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HAUS4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HAUS6_HUMANHAUS6physical
19369198
GGA3_HUMANGGA3physical
26344197
HAUS1_HUMANHAUS1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HAUS4_HUMAN

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Related Literatures of Post-Translational Modification

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