GGA3_HUMAN - dbPTM
GGA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GGA3_HUMAN
UniProt AC Q9NZ52
Protein Name ADP-ribosylation factor-binding protein GGA3
Gene Name GGA3
Organism Homo sapiens (Human).
Sequence Length 723
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein . Endosome membrane
Peripheral membrane protein .
Protein Description Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif..
Protein Sequence MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAEAEGESLESWLNK
CCCHHHHHHHHHHHH		48.5728348404
15 (in isoform 1)Ubiquitination-55.1821890473
15UbiquitinationSLESWLNKATNPSNR
HHHHHHHHCCCCCCC		55.1821890473
15UbiquitinationSLESWLNKATNPSNR
HHHHHHHHCCCCCCC		55.1821890473
15UbiquitinationSLESWLNKATNPSNR
HHHHHHHHCCCCCCC		55.1821890473
38UbiquitinationGFCDQINKELEGPQI
HHHHHHHHHCCCHHH		66.36-
53UbiquitinationAVRLLAHKIQSPQEW
HHHHHHHHCCCHHHH		36.51-
95AcetylationRFLNELIKVVSPKYL
HHHHHHHHHHCHHHC		49.5625953088
98PhosphorylationNELIKVVSPKYLGDR
HHHHHHHCHHHCCHH		20.75-
100UbiquitinationLIKVVSPKYLGDRVS
HHHHHCHHHCCHHHC		45.6721890473
100 (in isoform 1)Ubiquitination-45.6721890473
100AcetylationLIKVVSPKYLGDRVS
HHHHHCHHHCCHHHC		45.6725953088
100UbiquitinationLIKVVSPKYLGDRVS
HHHHHCHHHCCHHHC		45.6721890473
122PhosphorylationIELLYSWTMALPEEA
HHHHHHHHHCCCHHH		6.1418452278
132 (in isoform 2)Ubiquitination-35.2821890473
132UbiquitinationLPEEAKIKDAYHMLK
CCHHHHHHHHHHHHH		35.2821890473
135PhosphorylationEAKIKDAYHMLKRQG
HHHHHHHHHHHHHCC		9.6327642862
139UbiquitinationKDAYHMLKRQGIVQS
HHHHHHHHHCCCCCC		34.79-
141 (in isoform 2)Ubiquitination-44.3621890473
146PhosphorylationKRQGIVQSDPPIPVD
HHCCCCCCCCCCCCC		40.9928555341
147 (in isoform 2)Ubiquitination-35.5821890473
147UbiquitinationRQGIVQSDPPIPVDR
HCCCCCCCCCCCCCC		35.5821890473
152 (in isoform 2)Ubiquitination-8.8921890473
155PhosphorylationPPIPVDRTLIPSPPP
CCCCCCCCCCCCCCC		25.2828176443
159PhosphorylationVDRTLIPSPPPRPKN
CCCCCCCCCCCCCCC		42.9423401153
162 (in isoform 2)Ubiquitination-69.4621890473
162UbiquitinationTLIPSPPPRPKNPVF
CCCCCCCCCCCCCCC		69.4621890473
165 (in isoform 1)Ubiquitination-75.1421890473
165UbiquitinationPSPPPRPKNPVFDDE
CCCCCCCCCCCCCHH		75.1421890473
165 (in isoform 2)Ubiquitination-75.1421890473
165UbiquitinationPSPPPRPKNPVFDDE
CCCCCCCCCCCCCHH		75.1421890473
165UbiquitinationPSPPPRPKNPVFDDE
CCCCCCCCCCCCCHH		75.1421890473
169 (in isoform 2)Ubiquitination-11.7621890473
174 (in isoform 1)Ubiquitination-51.3321890473
174UbiquitinationPVFDDEEKSKLLAKL
CCCCHHHHHHHHHHH		51.3321906983
176UbiquitinationFDDEEKSKLLAKLLK
CCHHHHHHHHHHHHH		59.60-
180 (in isoform 1)Ubiquitination-55.0821890473
180UbiquitinationEKSKLLAKLLKSKNP
HHHHHHHHHHHCCCH		55.0821890473
180UbiquitinationEKSKLLAKLLKSKNP
HHHHHHHHHHHCCCH		55.0821890473
183UbiquitinationKLLAKLLKSKNPDDL
HHHHHHHHCCCHHHH		70.58-
185 (in isoform 1)Ubiquitination-71.5521890473
185UbiquitinationLAKLLKSKNPDDLQE
HHHHHHCCCHHHHHH		71.5521906983
195UbiquitinationDDLQEANKLIKSMVK
HHHHHHHHHHHHHHH		59.6521890473
195 (in isoform 1)Ubiquitination-59.6521890473
195UbiquitinationDDLQEANKLIKSMVK
HHHHHHHHHHHHHHH		59.6521890473
198UbiquitinationQEANKLIKSMVKEDE
HHHHHHHHHHHHHHH		42.8221890473
198 (in isoform 1)Ubiquitination-42.8221890473
198UbiquitinationQEANKLIKSMVKEDE
HHHHHHHHHHHHHHH		42.8221890473
202 (in isoform 1)Ubiquitination-51.2921890473
202UbiquitinationKLIKSMVKEDEARIQ
HHHHHHHHHHHHHHH		51.2921906983
210UbiquitinationEDEARIQKVTKRLHT
HHHHHHHHHHHHHHC		49.88-
213UbiquitinationARIQKVTKRLHTLEE
HHHHHHHHHHHCHHH		56.82-
217PhosphorylationKVTKRLHTLEEVNNN
HHHHHHHCHHHHHHH		40.22-
231 (in isoform 2)Ubiquitination-4.3021890473
258UbiquitinationLFDQCENKRRTLFKL
HHHHHHHHHHHHHHH		22.44-
261PhosphorylationQCENKRRTLFKLASE
HHHHHHHHHHHHHHC		40.3530624053
264 (in isoform 1)Ubiquitination-46.3821890473
264UbiquitinationNKRRTLFKLASETED
HHHHHHHHHHHCCCC		46.3822053931
267PhosphorylationRTLFKLASETEDNDN
HHHHHHHHCCCCCCC		56.3330624053
269PhosphorylationLFKLASETEDNDNSL
HHHHHHCCCCCCCCH		46.2530624053
275PhosphorylationETEDNDNSLGDILQA
CCCCCCCCHHHHHHH		36.2710749927
339PhosphorylationLDTTNSLSSVLAPAP
CCCCCCCHHHCCCCC		20.4416135791
347O-linked_GlycosylationSVLAPAPTPPSSGIP
HHCCCCCCCCCCCCC		50.35OGP
368PhosphorylationQASGPPRSRSSSQAE
CCCCCCCCCCCCCCC		42.1416135791
370PhosphorylationSGPPRSRSSSQAEAT
CCCCCCCCCCCCCCC		35.2725627689
371PhosphorylationGPPRSRSSSQAEATL
CCCCCCCCCCCCCCC		25.9225627689
372PhosphorylationPPRSRSSSQAEATLG
CCCCCCCCCCCCCCC		34.3625159151
388PhosphorylationSSTSNALSWLDEELL
CCHHHHHHHCCHHHH		24.1528464451
425PhosphorylationHLLQREQSDLDFFSP
HHHHHHHCCCCCCCC		35.0723401153
431PhosphorylationQSDLDFFSPRPGTAA
HCCCCCCCCCCCCCC		21.7230266825
473O-linked_GlycosylationPAPVVPASVPAPSAG
CCCCCCCCCCCCCCC		23.6723301498
478O-linked_GlycosylationPASVPAPSAGSSLFS
CCCCCCCCCCCCHHC		47.5723301498
486O-linked_GlycosylationAGSSLFSTGVAPALA
CCCCHHCCCCCCHHC		28.4823301498
529O-linked_GlycosylationLLEEAKVTSGLVKPT
HHHHHCCCCCCCCCC		19.1723301498
529PhosphorylationLLEEAKVTSGLVKPT
HHHHHCCCCCCCCCC		19.1723312004
530PhosphorylationLEEAKVTSGLVKPTT
HHHHCCCCCCCCCCC		32.8723312004
536PhosphorylationTSGLVKPTTSPLIPT
CCCCCCCCCCCCCCC		33.9029978859
537PhosphorylationSGLVKPTTSPLIPTT
CCCCCCCCCCCCCCC		36.5525850435
538PhosphorylationGLVKPTTSPLIPTTT
CCCCCCCCCCCCCCC		21.8625627689
548MethylationIPTTTPARPLLPFST
CCCCCCCCCCCCCCC		24.49-
548DimethylationIPTTTPARPLLPFST
CCCCCCCCCCCCCCC		24.49-
559PhosphorylationPFSTGPGSPLFQPLS
CCCCCCCCCCCCCCC		22.8926657352
572PhosphorylationLSFQSQGSPPKGPEL
CCCCCCCCCCCCCCC		30.3226074081
592UbiquitinationHVPLESIKPSSALPV
EEEHHHCCCCCCCCE		48.39-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseVPS18Q9P253
PMID:16996030
-KUbiquitinationE3 ubiquitin ligaseNEDD4P46934
PMID:17116753
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GGA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GGA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TS101_HUMANTSG101physical
15039775
ARF1_HUMANARF1physical
11301005
CLH1_HUMANCLTCphysical
11301005
RABE1_HUMANRABEP1physical
12505986
VPS18_HUMANVPS18physical
16996030
UBC_HUMANUBCphysical
14660606
PACS1_HUMANPACS1physical
16977309
ARF6_HUMANARF6physical
20848231
RABE1_HUMANRABEP1physical
12858162
SYNRG_HUMANSYNRGphysical
12858162
EPN4_HUMANCLINT1physical
12858162
UBC_HUMANUBCphysical
15966896
ARF6_HUMANARF6physical
18199687
UBC_HUMANUBCphysical
15701688
RABE1_HUMANRABEP1physical
16473621
GGA1_HUMANGGA1physical
14638859
GGA2_HUMANGGA2physical
14638859
MPRI_HUMANIGF2Rphysical
11859375
MPRD_HUMANM6PRphysical
11859375
MON2_HUMANMON2physical
18418388
UBC_BOVINUBCphysical
20150893
RNF11_HUMANRNF11physical
25195858
ITCH_HUMANITCHphysical
25195858
ARF1_HUMANARF1physical
11950392
TOLIP_HUMANTOLLIPphysical
15047686
ARF6_HUMANARF6physical
19327867
ARF6_HUMANARF6physical
17804820
CYH2_HUMANCYTH2physical
17804820
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GGA3_HUMAN

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Related Literatures of Post-Translational Modification

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