SYNRG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYNRG_HUMAN
• UniProt AC: Q9UMZ2
• Protein Name: Synergin gamma
• Gene Name: SYNRG
• Organism: Homo sapiens (Human).
• Sequence Length: 1314
• Subcellular Localization: Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Associates with membranes via the adapter protein complex AP-1. Colocalizes with AP1G1 (By similarity)..
• Protein Description: May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins..
• Protein Sequence: MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGESFAEFRSAGTDDGFTDFKTADSVSPLEPPTKDKTFPPSFPSGTIQQKQQTQVKNPLNLADLDMFSSVNCSSEKPLSFSAVFSTSKSVSTPQSTGSAATMTALAATKTSSLADDFGEFSLFGEYSGLAPVGEQDDFADFMAFSNSSISSEQKPDDKYDALKEEASPVPLTSNVGSTVKGGQNSTAASTKYDVFRQLSLEGSGLGVEDLKDNTPSGKSDDDFADFHSSKFSSINSDKSLGEKAVAFRHTKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAADIEDLKYAAFGSYSSNFAVSTLTSYDWSDRDDATQGRKLSPFVLSAGSGSPSATSILQKKETSFGSSENITMTSLSKVTTFVSEDALPETTFPALASFKDTIPQTSEQKEYENRDYKDFTKQDLPTAERSQEATCPSPASSGASQETPNECSDDFGEFQSEKPKISKFDFLVATSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLNEKPALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALNVIKKANDTLNGISSSSVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLATLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEEKPAEEHPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLVLPDLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MALRPGAGSGG ----CCCCCCCCCCC	34.37	115389349
154	Phosphorylation	KQKLRLLSSVKPKTG HHHHHHHHCCCCCCC	37.36	28555341
155	Phosphorylation	QKLRLLSSVKPKTGE HHHHHHHCCCCCCCC	33.84	28555341
172	Ubiquitination	RDDALEAIKGNLDGF HHHHHHHHHCCCCCC	4.24	29967540
173	Ubiquitination	DDALEAIKGNLDGFS HHHHHHHHCCCCCCC	49.12	29967540
188	Phosphorylation	RDAKMHPTPASHPKK CCCCCCCCCCCCCCC	19.46	24719451
194	Acetylation	PTPASHPKKPGPSLE CCCCCCCCCCCCCHH	67.20	7664715
202 (in isoform 8)	Phosphorylation	-	55.17	25999147
203 (in isoform 3)	Phosphorylation	-	34.32	25999147
203 (in isoform 4)	Phosphorylation	-	34.32	25999147
203 (in isoform 6)	Phosphorylation	-	34.32	25999147
203 (in isoform 7)	Phosphorylation	-	34.32	25999147
203 (in isoform 9)	Phosphorylation	-	34.32	25999147
219	Acetylation	TSGQEQIKLNTSEVG CCCCCEEEECHHHCC	35.06	7664725
223	Phosphorylation	EQIKLNTSEVGHKAL CEEEECHHHCCCCCC	29.25	25159151
234	Phosphorylation	HKALGPGSSKKYPSL CCCCCCCCCCCCCHH	41.96	28102081
235	Phosphorylation	KALGPGSSKKYPSLM CCCCCCCCCCCCHHH	38.80	28102081
311	Sulfoxidation	KKILETTMTPTGIDT HHHHHHCCCCCCCCH	5.73	21406390
322	Phosphorylation	GIDTAKLYPILMSSG CCCHHHHHHHHHCCC	6.37	24719451
327	Phosphorylation	KLYPILMSSGLPRET HHHHHHHCCCCCHHH	20.15	24719451
328	Phosphorylation	LYPILMSSGLPRETL HHHHHHCCCCCHHHH	30.31	23312004
352	Acetylation	TTPGKLTKEELYTVL CCCCCCCHHHHHHHH	60.68	19608861
352	Ubiquitination	TTPGKLTKEELYTVL CCCCCCCHHHHHHHH	60.68	29967540
389	Phosphorylation	AAPIPTLSGFSMTLP CCCCCCCCCCEEECC	40.03	19651622
391	Ubiquitination	PIPTLSGFSMTLPTP CCCCCCCCEEECCCC	3.97	29967540
434	Acetylation	VGPVGGAAAQASSGF ECCCCHHHHHHHCCC	11.90	19608861
434	Ubiquitination	VGPVGGAAAQASSGF ECCCCHHHHHHHCCC	11.90	29967540
435	Acetylation	GPVGGAAAQASSGFI CCCCHHHHHHHCCCC	12.63	-
435	Acetylation	GPVGGAAAQASSGFI CCCCHHHHHHHCCCC	12.63	19608861
435	Ubiquitination	GPVGGAAAQASSGFI CCCCHHHHHHHCCCC	12.63	29967540
467	Phosphorylation	DFQDASKSGSLDDSF HHHHHHHCCCCCCCC	30.99	30278072
469	Phosphorylation	QDASKSGSLDDSFSD HHHHHCCCCCCCCHH	35.40	25159151
473	Phosphorylation	KSGSLDDSFSDFQEL HCCCCCCCCHHHHHC	26.73	23927012
473	Ubiquitination	KSGSLDDSFSDFQEL HCCCCCCCCHHHHHC	26.73	29967540
474	Ubiquitination	SGSLDDSFSDFQELP CCCCCCCCHHHHHCC	11.91	29967540
475	Phosphorylation	GSLDDSFSDFQELPA CCCCCCCHHHHHCCC	41.28	30266825
483	Phosphorylation	DFQELPASSKTSNSQ HHHHCCCCCCCCCCC	30.35	23403867
484	Phosphorylation	FQELPASSKTSNSQH HHHCCCCCCCCCCCC	41.90	23403867
486	Phosphorylation	ELPASSKTSNSQHGN HCCCCCCCCCCCCCC	34.78	27080861
487	Phosphorylation	LPASSKTSNSQHGNS CCCCCCCCCCCCCCC	37.92	28857561
489	Phosphorylation	ASSKTSNSQHGNSAP CCCCCCCCCCCCCCC	24.26	27080861
494	Phosphorylation	SNSQHGNSAPSLLMP CCCCCCCCCCCEEEC	46.26	28857561
497	Phosphorylation	QHGNSAPSLLMPLPG CCCCCCCCEEECCCC	33.57	27080861
506	Acetylation	LMPLPGTKALPSMDK EECCCCCCCCCCCCH	54.57	25953088
510	Phosphorylation	PGTKALPSMDKYAVF CCCCCCCCCCHHHHH	40.23	23403867
513	Acetylation	KALPSMDKYAVFKGI CCCCCCCHHHHHEEE	26.85	19608861
513	Ubiquitination	KALPSMDKYAVFKGI CCCCCCCHHHHHEEE	26.85	19608861
514	Phosphorylation	ALPSMDKYAVFKGIA CCCCCCHHHHHEEEC	12.06	28796482
518	Acetylation	MDKYAVFKGIAADKS CCHHHHHEEECCCCC	42.69	25953088
539	Phosphorylation	PGDPGDKYSAFRELE CCCCCCHHHHHHHHH	15.24	28796482
540	Phosphorylation	GDPGDKYSAFRELEQ CCCCCHHHHHHHHHH	27.03	28796482
548	Phosphorylation	AFRELEQTAENKPLG HHHHHHHHHHCCCCC	26.94	23186163
552	Ubiquitination	LEQTAENKPLGESFA HHHHHHCCCCCHHHH	32.88	29967540
557	Phosphorylation	ENKPLGESFAEFRSA HCCCCCHHHHHHHHC	28.14	25159151
559	Phosphorylation	KPLGESFAEFRSAGT CCCCHHHHHHHHCCC	25.05	32142685
563	Phosphorylation	ESFAEFRSAGTDDGF HHHHHHHHCCCCCCC	36.05	23312004
566	Phosphorylation	AEFRSAGTDDGFTDF HHHHHCCCCCCCCCC	30.54	23312004
571	Phosphorylation	AGTDDGFTDFKTADS CCCCCCCCCCCCCCC	46.16	30624053
575	Phosphorylation	DGFTDFKTADSVSPL CCCCCCCCCCCCCCC	35.37	23403867
578	Phosphorylation	TDFKTADSVSPLEPP CCCCCCCCCCCCCCC	23.25	30266825
580	Phosphorylation	FKTADSVSPLEPPTK CCCCCCCCCCCCCCC	27.93	30266825
583	Acetylation	ADSVSPLEPPTKDKT CCCCCCCCCCCCCCC	53.25	19608861
583	Ubiquitination	ADSVSPLEPPTKDKT CCCCCCCCCCCCCCC	53.25	29967540
586	Phosphorylation	VSPLEPPTKDKTFPP CCCCCCCCCCCCCCC	63.69	23403867
590	Phosphorylation	EPPTKDKTFPPSFPS CCCCCCCCCCCCCCC	52.05	20068231
591	Phosphorylation	PPTKDKTFPPSFPSG CCCCCCCCCCCCCCC	11.74	32142685
621	Phosphorylation	LADLDMFSSVNCSSE HHHHHHCCCCCCCCC	27.09	27251275
622	Phosphorylation	ADLDMFSSVNCSSEK HHHHHCCCCCCCCCC	13.19	27251275
622	Ubiquitination	ADLDMFSSVNCSSEK HHHHHCCCCCCCCCC	13.19	29967540
626	Phosphorylation	MFSSVNCSSEKPLSF HCCCCCCCCCCCCCE	36.01	25627689
630	Ubiquitination	VNCSSEKPLSFSAVF CCCCCCCCCCEEEEE	29.23	29967540
634	Phosphorylation	SEKPLSFSAVFSTSK CCCCCCEEEEEECCC	21.83	25159151
635	Ubiquitination	EKPLSFSAVFSTSKS CCCCCEEEEEECCCC	12.36	29967540
638	Phosphorylation	LSFSAVFSTSKSVST CCEEEEEECCCCCCC	25.77	25627689
639	Phosphorylation	SFSAVFSTSKSVSTP CEEEEEECCCCCCCC	28.80	25627689
640	Phosphorylation	FSAVFSTSKSVSTPQ EEEEEECCCCCCCCC	23.02	25627689
641	Phosphorylation	SAVFSTSKSVSTPQS EEEEECCCCCCCCCC	55.77	32142685
642	Phosphorylation	AVFSTSKSVSTPQST EEEECCCCCCCCCCC	22.52	20068231
644	O-linked_Glycosylation	FSTSKSVSTPQSTGS EECCCCCCCCCCCCC	41.27	23301498
644	Phosphorylation	FSTSKSVSTPQSTGS EECCCCCCCCCCCCC	41.27	25159151
645	Phosphorylation	STSKSVSTPQSTGSA ECCCCCCCCCCCCCH	24.16	25159151
648	Phosphorylation	KSVSTPQSTGSAATM CCCCCCCCCCCHHHH	35.62	25159151
649	Phosphorylation	SVSTPQSTGSAATMT CCCCCCCCCCHHHHH	29.88	28270605
651	Phosphorylation	STPQSTGSAATMTAL CCCCCCCCHHHHHHH	18.15	25159151
654	Phosphorylation	QSTGSAATMTALAAT CCCCCHHHHHHHHHH	18.12	28270605
656	Phosphorylation	TGSAATMTALAATKT CCCHHHHHHHHHHCC	17.73	28270605
661	Phosphorylation	TMTALAATKTSSLAD HHHHHHHHCCCHHCC	29.28	28270605
665	Acetylation	LAATKTSSLADDFGE HHHHCCCHHCCCCCC	32.57	19608861
665	Ubiquitination	LAATKTSSLADDFGE HHHHCCCHHCCCCCC	32.57	29967540
666	Acetylation	AATKTSSLADDFGEF HHHCCCHHCCCCCCC	6.41	-
666	Acetylation	AATKTSSLADDFGEF HHHCCCHHCCCCCCC	6.41	19608861
666	Ubiquitination	AATKTSSLADDFGEF HHHCCCHHCCCCCCC	6.41	29967540
673	Phosphorylation	LADDFGEFSLFGEYS HCCCCCCCCCCEEEC	8.66	32142685
674	Phosphorylation	ADDFGEFSLFGEYSG CCCCCCCCCCEEECC	20.63	19664994
691	Phosphorylation	PVGEQDDFADFMAFS CCCCCCCHHHHHHHC	10.65	-
691 (in isoform 6)	Phosphorylation	-	10.65	28634120
693 (in isoform 6)	Phosphorylation	-	33.57	28634120
694 (in isoform 6)	Phosphorylation	-	3.22	28348404
699 (in isoform 6)	Phosphorylation	-	33.07	28348404
701 (in isoform 6)	Phosphorylation	-	30.64	28348404
704	Ubiquitination	FSNSSISSEQKPDDK HCCCCCCCCCCCCCH	42.23	29967540
705	Ubiquitination	SNSSISSEQKPDDKY CCCCCCCCCCCCCHH	56.70	29967540
711 (in isoform 6)	Phosphorylation	-	53.03	29523821
712	Phosphorylation	EQKPDDKYDALKEEA CCCCCCHHHHHHHHC	17.28	23312004
712	Ubiquitination	EQKPDDKYDALKEEA CCCCCCHHHHHHHHC	17.28	29967540
713	Ubiquitination	QKPDDKYDALKEEAS CCCCCHHHHHHHHCC	51.68	29967540
713 (in isoform 6)	Phosphorylation	-	51.68	29523821
715 (in isoform 6)	Phosphorylation	-	7.01	29523821
717	Ubiquitination	DKYDALKEEASPVPL CHHHHHHHHCCCCCC	60.69	29967540
717 (in isoform 6)	Phosphorylation	-	60.69	29523821
718	Ubiquitination	KYDALKEEASPVPLT HHHHHHHHCCCCCCC	53.51	29967540
718 (in isoform 6)	Phosphorylation	-	53.51	29523821
720	Phosphorylation	DALKEEASPVPLTSN HHHHHHCCCCCCCCC	29.70	30266825
725	Phosphorylation	EASPVPLTSNVGSTV HCCCCCCCCCCCCEE	16.52	30266825
726	Phosphorylation	ASPVPLTSNVGSTVK CCCCCCCCCCCCEEC	36.88	30266825
729	Phosphorylation	VPLTSNVGSTVKGGQ CCCCCCCCCEECCCC	23.11	32645325
730	Phosphorylation	PLTSNVGSTVKGGQN CCCCCCCCEECCCCC	26.24	20068231
731	Phosphorylation	LTSNVGSTVKGGQNS CCCCCCCEECCCCCC	21.95	20068231
733	Phosphorylation	SNVGSTVKGGQNSTA CCCCCEECCCCCCCC	58.37	32142685
734	Phosphorylation	NVGSTVKGGQNSTAA CCCCEECCCCCCCCH	38.29	32142685
738	Phosphorylation	TVKGGQNSTAASTKY EECCCCCCCCHHHHH	16.13	28555341
742	Phosphorylation	GQNSTAASTKYDVFR CCCCCCHHHHHHHHH	23.98	28555341
743	Phosphorylation	QNSTAASTKYDVFRQ CCCCCHHHHHHHHHH	28.97	-
744	Acetylation	NSTAASTKYDVFRQL CCCCHHHHHHHHHHH	36.64	19608861
744	Ubiquitination	NSTAASTKYDVFRQL CCCCHHHHHHHHHHH	36.64	19608861
745	Phosphorylation	STAASTKYDVFRQLS CCCHHHHHHHHHHHC	19.89	-
752	Phosphorylation	YDVFRQLSLEGSGLG HHHHHHHCCCCCCCC	18.94	19664994
756	Phosphorylation	RQLSLEGSGLGVEDL HHHCCCCCCCCHHHC	22.82	30266825
762	Ubiquitination	GSGLGVEDLKDNTPS CCCCCHHHCCCCCCC	57.52	29967540
767	Phosphorylation	VEDLKDNTPSGKSDD HHHCCCCCCCCCCCC	29.03	23927012
769	Phosphorylation	DLKDNTPSGKSDDDF HCCCCCCCCCCCCCH	57.74	23927012
772	Phosphorylation	DNTPSGKSDDDFADF CCCCCCCCCCCHHHH	50.20	25159151
774	Phosphorylation	TPSGKSDDDFADFHS CCCCCCCCCHHHHHH	61.08	27251275
774 (in isoform 9)	Phosphorylation	-	61.08	28634120
776	Phosphorylation	SGKSDDDFADFHSSK CCCCCCCHHHHHHHH	10.13	33259812
776 (in isoform 9)	Phosphorylation	-	10.13	28634120
777	Phosphorylation	GKSDDDFADFHSSKF CCCCCCHHHHHHHHH	26.08	33259812
777 (in isoform 9)	Phosphorylation	-	26.08	28348404
781	Phosphorylation	DDFADFHSSKFSSIN CCHHHHHHHHHHCCC	34.91	26434776
782	Phosphorylation	DFADFHSSKFSSINS CHHHHHHHHHHCCCC	29.20	26434776
782 (in isoform 9)	Phosphorylation	-	29.20	28348404
783	Acetylation	FADFHSSKFSSINSD HHHHHHHHHHCCCCC	52.89	25953088
783	Ubiquitination	FADFHSSKFSSINSD HHHHHHHHHHCCCCC	52.89	29967540
784	Ubiquitination	ADFHSSKFSSINSDK HHHHHHHHHCCCCCC	8.17	29967540
784 (in isoform 9)	Phosphorylation	-	8.17	28348404
785	Phosphorylation	DFHSSKFSSINSDKS HHHHHHHHCCCCCCC	33.76	26657352
786	Phosphorylation	FHSSKFSSINSDKSL HHHHHHHCCCCCCCH	28.99	23401153
789	Phosphorylation	SKFSSINSDKSLGEK HHHHCCCCCCCHHHH	44.75	26055452
791	Acetylation	FSSINSDKSLGEKAV HHCCCCCCCHHHHEE	47.61	25953088
791	Ubiquitination	FSSINSDKSLGEKAV HHCCCCCCCHHHHEE	47.61	29967540
792	Phosphorylation	SSINSDKSLGEKAVA HCCCCCCCHHHHEEE	46.74	30108239
794 (in isoform 9)	Phosphorylation	-	41.26	29523821
796	Acetylation	SDKSLGEKAVAFRHT CCCCHHHHEEEEECC	46.49	25953088
796	Phosphorylation	SDKSLGEKAVAFRHT CCCCHHHHEEEEECC	46.49	27251275
796	Ubiquitination	SDKSLGEKAVAFRHT CCCCHHHHEEEEECC	46.49	29967540
796 (in isoform 9)	Phosphorylation	-	46.49	29523821
798 (in isoform 9)	Phosphorylation	-	8.40	29523821
800 (in isoform 9)	Phosphorylation	-	4.77	29523821
801 (in isoform 9)	Phosphorylation	-	27.16	29523821
803	Phosphorylation	KAVAFRHTKEDSASV HEEEEECCCCCCCCC	31.69	20873877
807	Phosphorylation	FRHTKEDSASVKSLD EECCCCCCCCCEECC	24.43	23663014
809	Phosphorylation	HTKEDSASVKSLDLP CCCCCCCCCEECCCC	33.75	27362937
812	Phosphorylation	EDSASVKSLDLPSIG CCCCCCEECCCCCCC	25.59	19664994
813	Phosphorylation	DSASVKSLDLPSIGG CCCCCEECCCCCCCC	6.94	32142685
817	Phosphorylation	VKSLDLPSIGGSSVG CEECCCCCCCCCCCC	40.96	30266825
821	Phosphorylation	DLPSIGGSSVGKEDS CCCCCCCCCCCCCCC	19.35	25159151
822	Phosphorylation	LPSIGGSSVGKEDSE CCCCCCCCCCCCCCC	37.86	21815630
828	Ubiquitination	SSVGKEDSEDALSVQ CCCCCCCCCCCHHHE	38.17	20972266
829	Ubiquitination	SVGKEDSEDALSVQF CCCCCCCCCCHHHEE	60.67	-
829	Ubiquitination	SVGKEDSEDALSVQF CCCCCCCCCCHHHEE	60.67	20972266
833	Phosphorylation	EDSEDALSVQFDMKL CCCCCCHHHEEEEEH	18.65	27499020
840	Phosphorylation	SVQFDMKLADVGGDL HHEEEEEHHHCCCCC	3.85	32142685
841	Phosphorylation	VQFDMKLADVGGDLK HEEEEEHHHCCCCCH	12.15	32142685
845	Ubiquitination	MKLADVGGDLKHVMS EEHHHCCCCCHHHCC	36.61	29967540
849	Ubiquitination	DVGGDLKHVMSDSSL HCCCCCHHHCCCCCC	28.01	20972266
850	Ubiquitination	VGGDLKHVMSDSSLD CCCCCHHHCCCCCCC	3.62	-
850	Ubiquitination	VGGDLKHVMSDSSLD CCCCCHHHCCCCCCC	3.62	20972266
852	Phosphorylation	GDLKHVMSDSSLDLP CCCHHHCCCCCCCCC	33.00	25159151
854	Phosphorylation	LKHVMSDSSLDLPTV CHHHCCCCCCCCCCC	26.03	25159151
855	Phosphorylation	KHVMSDSSLDLPTVS HHHCCCCCCCCCCCC	30.78	25159151
856	Phosphorylation	HVMSDSSLDLPTVSG HHCCCCCCCCCCCCC	10.18	32645325
857	Phosphorylation	VMSDSSLDLPTVSGQ HCCCCCCCCCCCCCC	53.18	32645325
858	Phosphorylation	MSDSSLDLPTVSGQH CCCCCCCCCCCCCCC	4.67	32142685
860	Phosphorylation	DSSLDLPTVSGQHPP CCCCCCCCCCCCCCC	34.30	28122231
862	Phosphorylation	SLDLPTVSGQHPPAA CCCCCCCCCCCCCCC	34.90	30108239
867	Ubiquitination	TVSGQHPPAADIEDL CCCCCCCCCCCHHHH	37.65	29967540
873	Ubiquitination	PPAADIEDLKYAAFG CCCCCHHHHCHHHHC	49.12	24816145
889	Ubiquitination	YSSNFAVSTLTSYDW CCCCEEEEECCCCCC	17.80	29967540
890	Ubiquitination	SSNFAVSTLTSYDWS CCCEEEEECCCCCCC	27.70	29967540
894	Phosphorylation	AVSTLTSYDWSDRDD EEEECCCCCCCCCCC	19.05	-
898	Ubiquitination	LTSYDWSDRDDATQG CCCCCCCCCCCCCCC	54.49	24816145
906	Ubiquitination	RDDATQGRKLSPFVL CCCCCCCCCCCCEEE	27.24	20972266
907	Ubiquitination	DDATQGRKLSPFVLS CCCCCCCCCCCEEEE	61.21	20972266
909	Phosphorylation	ATQGRKLSPFVLSAG CCCCCCCCCEEEECC	21.23	25159151
909	Ubiquitination	ATQGRKLSPFVLSAG CCCCCCCCCEEEECC	21.23	29967540
911	Ubiquitination	QGRKLSPFVLSAGSG CCCCCCCEEEECCCC	8.52	29967540
912	Ubiquitination	GRKLSPFVLSAGSGS CCCCCCEEEECCCCC	4.72	29967540
914	Phosphorylation	KLSPFVLSAGSGSPS CCCCEEEECCCCCCC	25.86	23403867
917	Phosphorylation	PFVLSAGSGSPSATS CEEEECCCCCCCHHH	35.50	28102081
919	Phosphorylation	VLSAGSGSPSATSIL EEECCCCCCCHHHHH	19.85	25159151
921	Phosphorylation	SAGSGSPSATSILQK ECCCCCCCHHHHHHH	45.97	28102081
923	Phosphorylation	GSGSPSATSILQKKE CCCCCCHHHHHHHCC	22.19	23403867
924	Phosphorylation	SGSPSATSILQKKET CCCCCHHHHHHHCCC	22.48	23403867
927	Ubiquitination	PSATSILQKKETSFG CCHHHHHHHCCCCCC	53.78	20972266
928	Ubiquitination	SATSILQKKETSFGS CHHHHHHHCCCCCCC	49.48	20972266
930	Ubiquitination	TSILQKKETSFGSSE HHHHHHCCCCCCCCC	57.64	20972266
931	Phosphorylation	SILQKKETSFGSSEN HHHHHCCCCCCCCCC	37.93	23401153
932	Phosphorylation	ILQKKETSFGSSENI HHHHCCCCCCCCCCE	28.80	29255136
935	Phosphorylation	KKETSFGSSENITMT HCCCCCCCCCCEEEE	32.25	19664994
936	Phosphorylation	KETSFGSSENITMTS CCCCCCCCCCEEEEE	34.73	29255136
937	Ubiquitination	ETSFGSSENITMTSL CCCCCCCCCEEEEEH	55.11	29967540
940	Phosphorylation	FGSSENITMTSLSKV CCCCCCEEEEEHHHE	26.44	23927012
942	Phosphorylation	SSENITMTSLSKVTT CCCCEEEEEHHHEEE	20.19	23927012
943	Phosphorylation	SENITMTSLSKVTTF CCCEEEEEHHHEEEE	21.59	23927012
945	Phosphorylation	NITMTSLSKVTTFVS CEEEEEHHHEEEEEC	25.50	23927012
951	Ubiquitination	LSKVTTFVSEDALPE HHHEEEEECCCCCCC	6.02	20972266
952	Phosphorylation	SKVTTFVSEDALPET HHEEEEECCCCCCCC	26.10	28348404
955	Ubiquitination	TTFVSEDALPETTFP EEEECCCCCCCCCCH	22.44	24816145
956	Ubiquitination	TFVSEDALPETTFPA EEECCCCCCCCCCHH	6.44	24816145
966	Phosphorylation	TTFPALASFKDTIPQ CCCHHHHHCCCCCCC	33.41	24719451
968	Ubiquitination	FPALASFKDTIPQTS CHHHHHCCCCCCCCH	52.01	29967540
970	Phosphorylation	ALASFKDTIPQTSEQ HHHHCCCCCCCCHHH	34.84	30177828
974	Phosphorylation	FKDTIPQTSEQKEYE CCCCCCCCHHHHHHH	28.95	30177828
975	Phosphorylation	KDTIPQTSEQKEYEN CCCCCCCHHHHHHHC	32.55	30177828
980	Phosphorylation	QTSEQKEYENRDYKD CCHHHHHHHCCCHHH	26.07	28796482
980	Ubiquitination	QTSEQKEYENRDYKD CCHHHHHHHCCCHHH	26.07	24816145
981	Ubiquitination	TSEQKEYENRDYKDF CHHHHHHHCCCHHHH	47.05	24816145
983	Ubiquitination	EQKEYENRDYKDFTK HHHHHHCCCHHHHCC	36.37	29967540
985	Phosphorylation	KEYENRDYKDFTKQD HHHHCCCHHHHCCCC	14.82	29083192
989	Phosphorylation	NRDYKDFTKQDLPTA CCCHHHHCCCCCCCC	37.62	29083192
990	Ubiquitination	RDYKDFTKQDLPTAE CCHHHHCCCCCCCCH	41.63	29967540
991	Ubiquitination	DYKDFTKQDLPTAER CHHHHCCCCCCCCHH	55.18	23000965
992	Ubiquitination	YKDFTKQDLPTAERS HHHHCCCCCCCCHHH	57.05	29967540
995	Phosphorylation	FTKQDLPTAERSQEA HCCCCCCCCHHHHHC	48.74	30576142
997	Ubiquitination	KQDLPTAERSQEATC CCCCCCCHHHHHCCC	56.17	23000965
999	Phosphorylation	DLPTAERSQEATCPS CCCCCHHHHHCCCCC	24.71	28450419
1000	Ubiquitination	LPTAERSQEATCPSP CCCCHHHHHCCCCCC	51.03	24816145
1001	Ubiquitination	PTAERSQEATCPSPA CCCHHHHHCCCCCCC	47.39	24816145
1002	Ubiquitination	TAERSQEATCPSPAS CCHHHHHCCCCCCCC	13.58	20972266
1003	Phosphorylation	AERSQEATCPSPASS CHHHHHCCCCCCCCC	24.97	28450419
1006	Phosphorylation	SQEATCPSPASSGAS HHHCCCCCCCCCCCC	34.93	21712546
1007	Ubiquitination	QEATCPSPASSGASQ HHCCCCCCCCCCCCC	22.70	20972266
1008	Ubiquitination	EATCPSPASSGASQE HCCCCCCCCCCCCCC	22.21	20972266
1009	Phosphorylation	ATCPSPASSGASQET CCCCCCCCCCCCCCC	32.46	25849741
1010	Phosphorylation	TCPSPASSGASQETP CCCCCCCCCCCCCCC	40.25	23663014
1013	Phosphorylation	SPASSGASQETPNEC CCCCCCCCCCCCCCC	31.88	23663014
1016	Phosphorylation	SSGASQETPNECSDD CCCCCCCCCCCCCCC	24.63	25394399
1020	Ubiquitination	SQETPNECSDDFGEF CCCCCCCCCCCHHHC	7.40	29967540
1021	Phosphorylation	QETPNECSDDFGEFQ CCCCCCCCCCHHHCC	33.75	30576142
1025	Ubiquitination	NECSDDFGEFQSEKP CCCCCCHHHCCCCCC	41.63	24816145
1026	Ubiquitination	ECSDDFGEFQSEKPK CCCCCHHHCCCCCCC	40.27	-
1026	Ubiquitination	ECSDDFGEFQSEKPK CCCCCHHHCCCCCCC	40.27	24816145
1028	Ubiquitination	SDDFGEFQSEKPKIS CCCHHHCCCCCCCCC	46.51	20972266
1029	Phosphorylation	DDFGEFQSEKPKISK CCHHHCCCCCCCCCH	53.56	26552605
1029	Ubiquitination	DDFGEFQSEKPKISK CCHHHCCCCCCCCCH	53.56	20972266
1032	Ubiquitination	GEFQSEKPKISKFDF HHCCCCCCCCCHHCE	34.85	24816145
1033	Ubiquitination	EFQSEKPKISKFDFL HCCCCCCCCCHHCEE	71.35	24816145
1034	Ubiquitination	FQSEKPKISKFDFLV CCCCCCCCCHHCEEE	8.00	24816145
1035	Ubiquitination	QSEKPKISKFDFLVA CCCCCCCCHHCEEEE	33.14	-
1036	Ubiquitination	SEKPKISKFDFLVAT CCCCCCCHHCEEEEC	53.04	29967540
1037	Ubiquitination	EKPKISKFDFLVATS CCCCCCHHCEEEECC	6.83	-
1037	Ubiquitination	EKPKISKFDFLVATS CCCCCCHHCEEEECC	6.83	29967540
1043	Phosphorylation	KFDFLVATSQSKMKS HHCEEEECCHHHCCC	21.59	27251275
1044	Phosphorylation	FDFLVATSQSKMKSS HCEEEECCHHHCCCC	23.79	21815630
1046	Phosphorylation	FLVATSQSKMKSSEE EEEECCHHHCCCCHH	34.19	27251275
1050	Phosphorylation	TSQSKMKSSEEMIKS CCHHHCCCCHHHHHH	39.21	20068231
1051	Phosphorylation	SQSKMKSSEEMIKSE CHHHCCCCHHHHHHH	31.87	23403867
1057	Phosphorylation	SSEEMIKSELATFDL CCHHHHHHHHHHCCC	27.24	20068231
1057	Ubiquitination	SSEEMIKSELATFDL CCHHHHHHHHHHCCC	27.24	24816145
1058	Ubiquitination	SEEMIKSELATFDLS CHHHHHHHHHHCCCC	37.10	24816145
1059	Ubiquitination	EEMIKSELATFDLSV HHHHHHHHHHCCCCC	7.60	24816145
1061	Phosphorylation	MIKSELATFDLSVQG HHHHHHHHCCCCCCC	30.24	20068231
1064	Ubiquitination	SELATFDLSVQGSHK HHHHHCCCCCCCCCC	4.76	29967540
1065	Phosphorylation	ELATFDLSVQGSHKR HHHHCCCCCCCCCCC	17.78	20068231
1065	Ubiquitination	ELATFDLSVQGSHKR HHHHCCCCCCCCCCC	17.78	29967540
1066	Ubiquitination	LATFDLSVQGSHKRS HHHCCCCCCCCCCCC	10.98	-
1066	Ubiquitination	LATFDLSVQGSHKRS HHHCCCCCCCCCCCC	10.98	29967540
1069	Phosphorylation	FDLSVQGSHKRSLSL CCCCCCCCCCCCCCC	14.56	20068231
1071	Acetylation	LSVQGSHKRSLSLGD CCCCCCCCCCCCCCC	45.43	12437011
1073	Phosphorylation	VQGSHKRSLSLGDKE CCCCCCCCCCCCCCC	27.41	30266825
1073	Ubiquitination	VQGSHKRSLSLGDKE CCCCCCCCCCCCCCC	27.41	23000965
1074	Ubiquitination	QGSHKRSLSLGDKEI CCCCCCCCCCCCCCC	5.94	23000965
1075	Phosphorylation	GSHKRSLSLGDKEIS CCCCCCCCCCCCCCC	31.39	29255136
1078	Ubiquitination	KRSLSLGDKEISRSS CCCCCCCCCCCCCCC	51.19	24816145
1079	Acetylation	RSLSLGDKEISRSSP CCCCCCCCCCCCCCC	55.97	25953088
1079	Ubiquitination	RSLSLGDKEISRSSP CCCCCCCCCCCCCCC	55.97	23000965
1080	Ubiquitination	SLSLGDKEISRSSPS CCCCCCCCCCCCCCC	51.44	23000965
1082	Phosphorylation	SLGDKEISRSSPSPA CCCCCCCCCCCCCHH	27.48	23927012
1083	Ubiquitination	LGDKEISRSSPSPAL CCCCCCCCCCCCHHH	46.98	24816145
1084	Phosphorylation	GDKEISRSSPSPALE CCCCCCCCCCCHHHC	39.55	23401153
1085	Phosphorylation	DKEISRSSPSPALEQ CCCCCCCCCCHHHCC	28.43	25159151
1087	Phosphorylation	EISRSSPSPALEQPF CCCCCCCCHHHCCCC	25.42	23401153
1098	Phosphorylation	EQPFRDRSNTLNEKP CCCCCCCCCCCCCCC	38.16	25159151
1100	Phosphorylation	PFRDRSNTLNEKPAL CCCCCCCCCCCCCCC	32.01	25159151
1102	Ubiquitination	RDRSNTLNEKPALPV CCCCCCCCCCCCCHH	53.89	24816145
1103	Ubiquitination	DRSNTLNEKPALPVI CCCCCCCCCCCCHHH	64.63	24816145
1104	Ubiquitination	RSNTLNEKPALPVIR CCCCCCCCCCCHHHH	34.22	24816145
1110	Ubiquitination	EKPALPVIRDKYKDL CCCCCHHHHHHHHHC	4.44	29967540
1111	Ubiquitination	KPALPVIRDKYKDLT CCCCHHHHHHHHHCC	34.30	29967540
1113	Ubiquitination	ALPVIRDKYKDLTGE CCHHHHHHHHHCCCC	44.33	-
1115	Ubiquitination	PVIRDKYKDLTGEVE HHHHHHHHHCCCCCC	52.59	29967540
1118	Ubiquitination	RDKYKDLTGEVEENE HHHHHHCCCCCCCHH	41.24	23000965
1119	Ubiquitination	DKYKDLTGEVEENER HHHHHCCCCCCCHHH	44.22	23000965
1124	Ubiquitination	LTGEVEENERYAYEW CCCCCCCHHHHHHHH	26.07	23000965
1125	Ubiquitination	TGEVEENERYAYEWQ CCCCCCHHHHHHHHH	50.80	23000965
1127	Phosphorylation	EVEENERYAYEWQRC CCCCHHHHHHHHHHH	13.83	28796482
1127	Ubiquitination	EVEENERYAYEWQRC CCCCHHHHHHHHHHH	13.83	24816145
1129	Phosphorylation	EENERYAYEWQRCLG CCHHHHHHHHHHHHH	14.57	28796482
1134	Ubiquitination	YAYEWQRCLGSALNV HHHHHHHHHHHHHHH	2.78	24816145
1135	Ubiquitination	AYEWQRCLGSALNVI HHHHHHHHHHHHHHH	7.09	24816145
1138	Ubiquitination	WQRCLGSALNVIKKA HHHHHHHHHHHHHHH	11.02	24816145
1143	Ubiquitination	GSALNVIKKANDTLN HHHHHHHHHHHHCCC	41.36	29967540
1144	Ubiquitination	SALNVIKKANDTLNG HHHHHHHHHHHCCCC	41.10	-
1150	Ubiquitination	KKANDTLNGISSSSV HHHHHCCCCCCCHHH	48.09	23000965
1151	Ubiquitination	KANDTLNGISSSSVC HHHHCCCCCCCHHHH	25.03	23000965
1152	Ubiquitination	ANDTLNGISSSSVCT HHHCCCCCCCHHHHH	3.34	23000965
1153	Ubiquitination	NDTLNGISSSSVCTE HHCCCCCCCHHHHHH	26.09	24816145
1156	Ubiquitination	LNGISSSSVCTEVIQ CCCCCCHHHHHHHHH	24.14	23000965
1157	Ubiquitination	NGISSSSVCTEVIQS CCCCCHHHHHHHHHH	5.17	23000965
1158	Ubiquitination	GISSSSVCTEVIQSA CCCCHHHHHHHHHHH	2.65	23000965
1159	Ubiquitination	ISSSSVCTEVIQSAQ CCCHHHHHHHHHHHC	31.00	24816145
1160	Ubiquitination	SSSSVCTEVIQSAQG CCHHHHHHHHHHHCH	32.28	24816145
1176	Ubiquitination	EYLLGVVEVYRVTKR HHHHHHEEEEECCCC	31.27	23000965
1177	Ubiquitination	YLLGVVEVYRVTKRV HHHHHEEEEECCCCC	2.21	24816145
1178	Ubiquitination	LLGVVEVYRVTKRVE HHHHEEEEECCCCCH	5.95	24816145
1179	Ubiquitination	LGVVEVYRVTKRVEL HHHEEEEECCCCCHH	34.50	24816145
1180	Ubiquitination	GVVEVYRVTKRVELG HHEEEEECCCCCHHC	3.97	24816145
1182	Ubiquitination	VEVYRVTKRVELGIK EEEEECCCCCHHCCH	52.14	23000965
1184	Ubiquitination	VYRVTKRVELGIKAT EEECCCCCHHCCHHH	8.31	24816145
1189	Ubiquitination	KRVELGIKATAVCSE CCCHHCCHHHHHCHH	37.58	29967540
1192	Ubiquitination	ELGIKATAVCSEKLQ HHCCHHHHHCHHHHH	12.74	29967540
1193	Ubiquitination	LGIKATAVCSEKLQQ HCCHHHHHCHHHHHH	2.99	29967540
1196	Ubiquitination	KATAVCSEKLQQLLK HHHHHCHHHHHHHHH	53.29	23000965
1197	Ubiquitination	ATAVCSEKLQQLLKD HHHHCHHHHHHHHHH	34.99	23000965
1202	Ubiquitination	SEKLQQLLKDIDKVW HHHHHHHHHHHHHHH	3.99	23000965
1203	Ubiquitination	EKLQQLLKDIDKVWN HHHHHHHHHHHHHHH	62.32	23000965
1204	Ubiquitination	KLQQLLKDIDKVWNN HHHHHHHHHHHHHHH	55.05	24816145
1205	Ubiquitination	LQQLLKDIDKVWNNL HHHHHHHHHHHHHHH	5.44	24816145
1216	Ubiquitination	WNNLIGFMSLATLTP HHHHHHHHHHCCCCC	2.43	-
1216	Ubiquitination	WNNLIGFMSLATLTP HHHHHHHHHHCCCCC	2.43	29967540
1220	Ubiquitination	IGFMSLATLTPDENS HHHHHHCCCCCCCCC	36.14	23000965
1226	Ubiquitination	ATLTPDENSLDFSSC CCCCCCCCCCCHHHH	56.08	23000965
1231	Ubiquitination	DENSLDFSSCMLRPG CCCCCCHHHHCCCCC	23.46	23000965
1237	Ubiquitination	FSSCMLRPGIKNAQE HHHHCCCCCCCCHHH	44.92	23000965
1252	Ubiquitination	LACGVCLLNVDSRSR HHHEEEEEECCCCCC	5.06	23000965
1253	Ubiquitination	ACGVCLLNVDSRSRK HHEEEEEECCCCCCC	23.70	23000965
1258	Ubiquitination	LLNVDSRSRKEEKPA EEECCCCCCCCCCCH	52.21	23000965
1259	Ubiquitination	LNVDSRSRKEEKPAE EECCCCCCCCCCCHH	49.66	23000965
1270	Ubiquitination	KPAEEHPKKAFNSET CCHHHCCCHHHCCCC	59.65	23000965
1271	Ubiquitination	PAEEHPKKAFNSETD CHHHCCCHHHCCCCC	63.76	23000965
1276	Ubiquitination	PKKAFNSETDSFKLA CCHHHCCCCCCEEEC	58.71	23000965
1277	Ubiquitination	KKAFNSETDSFKLAY CHHHCCCCCCEEECC	36.44	23000965
1283	Ubiquitination	ETDSFKLAYGGHQYH CCCCEEECCCCCEEE	11.08	23000965
1297	Ubiquitination	HASCANFWINCVEPK EEEEEEEEEEECCCC	4.82	23000965
1298	Ubiquitination	ASCANFWINCVEPKP EEEEEEEEEECCCCC	2.21	23000965
1303	Ubiquitination	FWINCVEPKPPGLVL EEEEECCCCCCCCCC	33.77	23000965
1304	Ubiquitination	WINCVEPKPPGLVLP EEEECCCCCCCCCCC	50.79	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYNRG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYNRG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYNRG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SCAM1_HUMAN	SCAMP1	physical	10777571

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-513 AND LYS-744, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-752; SER-852AND SER-855, AND MASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752; SER-935 ANDSER-1073, AND MASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-919; SER-935AND SER-936, AND MASS SPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473; SER-752; SER-909;SER-919; SER-935 AND SER-1075, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752, AND MASSSPECTROMETRY.
PubMed: 18691976

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1075, AND MASSSPECTROMETRY.
PubMed: 18088087

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-752 AND SER-756, ANDMASS SPECTROMETRY.
PubMed: 15302935