SCAM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCAM1_HUMAN
• UniProt AC: O15126
• Protein Name: Secretory carrier-associated membrane protein 1
• Gene Name: SCAMP1
• Organism: Homo sapiens (Human).
• Sequence Length: 338
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein .
• Protein Description: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface..
• Protein Sequence: MSDFDSNPFADPDLNNPFKDPSVTQVTRNVPPGLDEYNPFSDSRTPPPGGVKMPNVPNTQPAIMKPTEEHPAYTQIAKEHALAQAELLKRQEELERKAAELDRREREMQNLSQHGRKNNWPPLPSNFPVGPCFYQDFSVDIPVEFQKTVKLMYYLWMFHAVTLFLNIFGCLAWFCVDSARAVDFGLSILWFLLFTPCSFVCWYRPLYGAFRSDSSFRFFVFFFVYICQFAVHVLQAAGFHNWGNCGWISSLTGLNQNIPVGIMMIIIAALFTASAVISLVMFKKVHGLYRTTGASFEKAQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFKGNQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDFDSNPF ------CCCCCCCCC	47.16	19413330
2	Phosphorylation	------MSDFDSNPF ------CCCCCCCCC	47.16	22617229
6	Phosphorylation	--MSDFDSNPFADPD --CCCCCCCCCCCCC	46.53	28450419
22	Phosphorylation	NNPFKDPSVTQVTRN CCCCCCCCHHEECCC	48.18	24719451
24	Phosphorylation	PFKDPSVTQVTRNVP CCCCCCHHEECCCCC	22.97	26074081
27	Phosphorylation	DPSVTQVTRNVPPGL CCCHHEECCCCCCCC	13.50	26074081
36	Phosphorylation	NVPPGLDEYNPFSDS CCCCCCCCCCCCCCC	52.86	17016520
37	Phosphorylation	VPPGLDEYNPFSDSR CCCCCCCCCCCCCCC	28.00	21945579
41	Phosphorylation	LDEYNPFSDSRTPPP CCCCCCCCCCCCCCC	35.61	21945579
43	Phosphorylation	EYNPFSDSRTPPPGG CCCCCCCCCCCCCCC	36.53	21945579
45	Phosphorylation	NPFSDSRTPPPGGVK CCCCCCCCCCCCCCC	44.06	30266825
52	Ubiquitination	TPPPGGVKMPNVPNT CCCCCCCCCCCCCCC	52.49	21906983
52 (in isoform 1)	Ubiquitination	-	52.49	21890473
52 (in isoform 2)	Ubiquitination	-	52.49	21890473
59	Phosphorylation	KMPNVPNTQPAIMKP CCCCCCCCCCCCCCC	29.84	21945579
65 (in isoform 1)	Ubiquitination	-	42.55	21890473
65 (in isoform 2)	Ubiquitination	-	42.55	21890473
65	Ubiquitination	NTQPAIMKPTEEHPA CCCCCCCCCCCCCHH	42.55	21906983
67	Phosphorylation	QPAIMKPTEEHPAYT CCCCCCCCCCCHHHH	48.78	21945579
73	Phosphorylation	PTEEHPAYTQIAKEH CCCCCHHHHHHHHHH	12.02	21945579
74	Phosphorylation	TEEHPAYTQIAKEHA CCCCHHHHHHHHHHH	18.66	21945579
78 (in isoform 1)	Ubiquitination	-	52.22	21890473
78 (in isoform 2)	Ubiquitination	-	52.22	21890473
78	Ubiquitination	PAYTQIAKEHALAQA HHHHHHHHHHHHHHH	52.22	21906983
89 (in isoform 1)	Ubiquitination	-	65.74	21890473
89	Ubiquitination	LAQAELLKRQEELER HHHHHHHHHHHHHHH	65.74	21890473
89 (in isoform 2)	Ubiquitination	-	65.74	21890473
97	Ubiquitination	RQEELERKAAELDRR HHHHHHHHHHHHHHH	42.44	-
112	Phosphorylation	EREMQNLSQHGRKNN HHHHHHHHHHCHHCC	27.90	25159151
132	S-palmitoylation	SNFPVGPCFYQDFSV CCCCCCCCEECCCCC	4.00	29575903
289	Phosphorylation	FKKVHGLYRTTGASF HHHHHCHHHCCCCCH	15.54	20068231
298	Ubiquitination	TTGASFEKAQQEFAT CCCCCHHHHHHHHHH	49.86	21890473
298 (in isoform 1)	Ubiquitination	-	49.86	21890473
308	Sulfoxidation	QEFATGVMSNKTVQT HHHHHCCCCCHHHHH	3.75	21406390
311	Ubiquitination	ATGVMSNKTVQTAAA HHCCCCCHHHHHHHH	42.65	21906983
311 (in isoform 1)	Ubiquitination	-	42.65	21890473
312	Phosphorylation	TGVMSNKTVQTAAAN HCCCCCHHHHHHHHH	23.30	28387310
315	Phosphorylation	MSNKTVQTAAANAAS CCCHHHHHHHHHHHH	17.58	25002506
322	Phosphorylation	TAAANAASTAASSAA HHHHHHHHHHHHHHH	19.03	25002506
323	Phosphorylation	AAANAASTAASSAAQ HHHHHHHHHHHHHHH	22.86	25002506
327	Phosphorylation	AASTAASSAAQNAFK HHHHHHHHHHHHHHC	23.93	28555341
334 (in isoform 1)	Ubiquitination	-	55.32	21890473
334	Ubiquitination	SAAQNAFKGNQI--- HHHHHHHCCCCC---	55.32	21890473
334	Methylation	SAAQNAFKGNQI--- HHHHHHHCCCCC---	55.32	14507265
334	Acetylation	SAAQNAFKGNQI--- HHHHHHHCCCCC---	55.32	14507265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCAM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCAM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCAM1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITSN1_HUMAN	ITSN1	physical	10777571
SCAM2_HUMAN	SCAMP2	physical	9224770
SCAM1_HUMAN	SCAMP1	physical	9224770
EPS15_HUMAN	EPS15	physical	10777571
SYNRG_HUMAN	SYNRG	physical	10777571
SNP25_HUMAN	SNAP25	physical	10777571
F208B_HUMAN	FAM208B	physical	25416956
ZMIZ2_HUMAN	ZMIZ2	physical	25416956
KR131_HUMAN	KRTAP13-1	physical	25416956
DJC13_HUMAN	DNAJC13	physical	28514442
HAX1_HUMAN	HAX1	physical	28514442
TTC19_HUMAN	TTC19	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.