dbPTM

DJC13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DJC13_HUMAN
UniProt AC	O75165
Protein Name	DnaJ homolog subfamily C member 13
Gene Name	DNAJC13
Organism	Homo sapiens (Human).
Sequence Length	2243
Subcellular Localization	Early endosome . Early endosome membrane Peripheral membrane protein . Endosome membrane .
Protein Description	Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR. [PubMed: 18256511]
Protein Sequence	MNIIRENKDLACFYTTKHSWRGKYKRVFSVGTHAITTYNPNTLEVTNQWPYGDICSISPVGKGQGTEFNLTFRKGSGKKSETLKFSTEHRTELLTEALRFRTDFSEGKITGRRYNCYKHHWSDSRKPVILEVTPGGFDQINPATNRVLCSYDYRNIEGFVDLSDYQGGFCILYGGFSRLHLFASEQREEIIKSAIDHAGNYIGISLRIRKEPLEFEQYLNLRFGKYSTDESITSLAEFVVQKISPRHSEPVKRVLALTETCLVERDPATYNIATLKPLGEVFALVCDSENPQLFTIEFIKGQVRKYSSTERDSLLASLLDGVRASGNRDVCVKMTPTHKGQRWGLLSMPVDEEVESLHLRFLATPPNGNFADAVFRFNANISYSGVLHAVTQDGLFSENKEKLINNAITALLSQEGDVVASNAELESQFQAVRRLVASKAGFLAFTQLPKFRERLGVKVVKALKRSNNGIIHAAVDMLCALMCPMHDDYDLRQEQLNKASLLSSKKFLENLLEKFNSHVDHGTGALVISSLLDFLTFALCAPYSETTEGQQFDMLLEMVASNGRTLFKLFQHPSMAIIKGAGLVMKAIIEEGDKEIATKMQELALSEGALPRHLHTAMFTISSDQRMLTNRQLSRHLVGLWTADNATATNLLKRILPPGLLAYLESSDLVPEKDADRMHVRDNVKIAMDQYGKFNKVPEWQRLAGKAAKEVEKFAKEKVDLVLMHWRDRMGIAQKENINQKPVVLRKRRQRIKIEANWDLFYYRFGQDHARSNLIWNFKTREELKDTLESEMRAFNIDRELGSANVISWNHHEFEVKYECLAEEIKIGDYYLRLLLEEDENEESGSIKRSYEFFNELYHRFLLTPKVNMKCLCLQALAIVYGRCHEEIGPFTDTRYIIGMLERCTDKLERDRLILFLNKLILNKKNVKDLMDSNGIRILVDLLTLAHLHVSRATVPLQSNVIEAAPDMKRESEKEWYFGNADKERSGPYGFHEMQELWTKGMLNAKTRCWAQGMDGWRPLQSIPQLKWCLLASGQAVLNETDLATLILNMLITMCGYFPSRDQDNAIIRPLPKVKRLLSDSTCLPHIIQLLLTFDPILVEKVAILLYHIMQDNPQLPRLYLSGVFFFIMMYTGSNVLPVARFLKYTHTKQAFKSEETKGQDIFQRSILGHILPEAMVCYLENYEPEKFSEIFLGEFDTPEAIWSSEMRRLMIEKIAAHLADFTPRLQSNTRALYQYCPIPIINYPQLENELFCNIYYLKQLCDTLRFPDWPIKDPVKLLKDTLDAWKKEVEKKPPMMSIDDAYEVLNLPQGQGPHDESKIRKAYFRLAQKYHPDKNPEGRDMFEKVNKAYEFLCTKSAKIVDGPDPENIILILKTQSILFNRHKEDLQPYKYAGYPMLIRTITMETSDDLLFSKESPLLPAATELAFHTVNCSALNAEELRRENGLEVLQEAFSRCVAVLTRASKPSDMSVQVCGYISKCYSVAAQFEECREKITEMPSIIKDLCRVLYFGKSIPRVAALGVECVSSFAVDFWLQTHLFQAGILWYLLGFLFNYDYTLEESGIQKSEETNQQEVANSLAKLSVHALSRLGGYLAEEQATPENPTIRKSLAGMLTPYVARKLAVASVTEILKMLNSNTESPYLIWNNSTRAELLEFLESQQENMIKKGDCDKTYGSEFVYSDHAKELIVGEIFVRVYNEVPTFQLEVPKAFAASLLDYIGSQAQYLHTFMAITHAAKVESEQHGDRLPRVEMALEALRNVIKYNPGSESECIGHFKLIFSLLRVHGAGQVQQLALEVVNIVTSNQDCVNNIAESMVLSSLLALLHSLPSSRQLVLETLYALTSSTKIIKEAMAKGALIYLLDMFCNSTHPQVRAQTAELFAKMTADKLIGPKVRITLMKFLPSVFMDAMRDNPEAAVHIFEGTHENPELIWNDNSRDKVSTTVREMMLEHFKNQQDNPEANWKLPEDFAVVFGEAEGELAVGGVFLRIFIAQPAWVLRKPREFLIALLEKLTELLEKNNPHGETLETLTMATVCLFSAQPQLADQVPPLGHLPKVIQAMNHRNNAIPKSAIRVIHALSENELCVRAMASLETIGPLMNGMKKRADTVGLACEAINRMFQKEQSELVAQALKADLVPYLLKLLEGIGLENLDSPAATKAQIVKALKAMTRSLQYGEQVNEILCRSSVWSAFKDQKHDLFISESQTAGYLTGPGVAGYLTAGTSTSVMSNLPPPVDHEAGDLGYQT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	NKDLACFYTTKHSWR CCCEEEEEECCCCCC	17.24	28851738
15	Phosphorylation	KDLACFYTTKHSWRG CCEEEEEECCCCCCC	14.76	28851738
16	Phosphorylation	DLACFYTTKHSWRGK CEEEEEECCCCCCCC	18.51	28851738
17	Acetylation	LACFYTTKHSWRGKY EEEEEECCCCCCCCC	28.04	25953088
17	Malonylation	LACFYTTKHSWRGKY EEEEEECCCCCCCCC	28.04	26320211
19	Phosphorylation	CFYTTKHSWRGKYKR EEEECCCCCCCCCEE	21.74	28851738
23	Acetylation	TKHSWRGKYKRVFSV CCCCCCCCCEEEEEE	38.74	19824163
25	Acetylation	HSWRGKYKRVFSVGT CCCCCCCEEEEEEEC	45.64	19824169
82	Phosphorylation	GSGKKSETLKFSTEH CCCCCCCEEECCHHH	42.19	19413330
84	Acetylation	GKKSETLKFSTEHRT CCCCCEEECCHHHHH	44.69	19608861
102	Phosphorylation	TEALRFRTDFSEGKI HHHHHCCCCCCCCCC	38.39	19664994
108	Ubiquitination	RTDFSEGKITGRRYN CCCCCCCCCCCCCEE	32.80	-
110	Phosphorylation	DFSEGKITGRRYNCY CCCCCCCCCCCEECC	28.28	-
114	Phosphorylation	GKITGRRYNCYKHHW CCCCCCCEECCCCCC	14.28	-
117	Phosphorylation	TGRRYNCYKHHWSDS CCCCEECCCCCCCCC	15.09	-
201	Phosphorylation	AIDHAGNYIGISLRI HHHHHHCEEEEEEEE	10.29	-
210	Ubiquitination	GISLRIRKEPLEFEQ EEEEEEECCCCCHHH	62.40	-
244	Phosphorylation	EFVVQKISPRHSEPV HHHHHHCCCCCCCCH	23.94	30177828
248	Phosphorylation	QKISPRHSEPVKRVL HHCCCCCCCCHHHHH	44.89	30177828
308	Phosphorylation	GQVRKYSSTERDSLL CCHHHCCCCCCHHHH	31.06	-
313	Phosphorylation	YSSTERDSLLASLLD CCCCCCHHHHHHHHH	31.35	21712546
317	Phosphorylation	ERDSLLASLLDGVRA CCHHHHHHHHHHHHH	29.45	25247763
325	Phosphorylation	LLDGVRASGNRDVCV HHHHHHHCCCCCEEE	26.49	25247763
333	Ubiquitination	GNRDVCVKMTPTHKG CCCCEEEEECCCCCC	31.74	-
364	Phosphorylation	LHLRFLATPPNGNFA CEEEEEECCCCCCHH	41.23	27050516
439	Ubiquitination	VRRLVASKAGFLAFT HHHHHHHHHCHHHHH	42.67	-
450	Ubiquitination	LAFTQLPKFRERLGV HHHHCCHHHHHHHCH	66.69	-
450	Acetylation	LAFTQLPKFRERLGV HHHHCCHHHHHHHCH	66.69	25953088
506	Ubiquitination	ASLLSSKKFLENLLE HHHHCCHHHHHHHHH	58.07	-
574	Phosphorylation	FKLFQHPSMAIIKGA HHHHCCCCHHHHHCH	20.79	25690035
594	Ubiquitination	AIIEEGDKEIATKMQ HHHHHCCHHHHHHHH	62.97	-
606	Phosphorylation	KMQELALSEGALPRH HHHHHHHCCCCCCCH	28.51	-
616	Phosphorylation	ALPRHLHTAMFTISS CCCCHHEEEEEEECH	26.61	29978859
620	Phosphorylation	HLHTAMFTISSDQRM HHEEEEEEECHHHHH	13.58	29978859
622	Phosphorylation	HTAMFTISSDQRMLT EEEEEEECHHHHHHH	25.46	29978859
623	Phosphorylation	TAMFTISSDQRMLTN EEEEEECHHHHHHHH	33.63	29978859
634	Phosphorylation	MLTNRQLSRHLVGLW HHHHHHHHHHHCCHH	14.87	-
642	Phosphorylation	RHLVGLWTADNATAT HHHCCHHHCCCHHHH	29.22	-
673	Ubiquitination	SSDLVPEKDADRMHV CCCCCCCCCCCCCHH	52.74	-
685	Ubiquitination	MHVRDNVKIAMDQYG CHHHHHHEEHHHHCC	30.88	-
691	Phosphorylation	VKIAMDQYGKFNKVP HEEHHHHCCCCCCCH	20.30	-
693	Ubiquitination	IAMDQYGKFNKVPEW EHHHHCCCCCCCHHH	40.61	-
696	Ubiquitination	DQYGKFNKVPEWQRL HHCCCCCCCHHHHHH	63.40	-
735	Ubiquitination	DRMGIAQKENINQKP HHCCCCHHCCCCCCC	43.64	-
741	Ubiquitination	QKENINQKPVVLRKR HHCCCCCCCEECEEH	34.98	-
741	Malonylation	QKENINQKPVVLRKR HHCCCCCCCEECEEH	34.98	26320211
785	Ubiquitination	FKTREELKDTLESEM CCCHHHHHHHHHHHH	52.53	-
830	Phosphorylation	EEIKIGDYYLRLLLE EECCHHHHHHHHHHC	10.13	25884760
848	Ubiquitination	NEESGSIKRSYEFFN CCCCCCCCHHHHHHH	36.67	21906983
851	Phosphorylation	SGSIKRSYEFFNELY CCCCCHHHHHHHHHH	22.31	29759185
858	Phosphorylation	YEFFNELYHRFLLTP HHHHHHHHHHHHCCC	5.69	29759185
864	Phosphorylation	LYHRFLLTPKVNMKC HHHHHHCCCCCCHHH	24.18	-
866	Malonylation	HRFLLTPKVNMKCLC HHHHCCCCCCHHHHH	40.79	26320211
892	Phosphorylation	HEEIGPFTDTRYIIG CCCCCCCCCHHHHHH	39.33	21815630
905	Phosphorylation	IGMLERCTDKLERDR HHHHHHHCHHCHHHH	42.25	23917254
944	Phosphorylation	RILVDLLTLAHLHVS HHHHHHHHHHHHHHC	29.24	-
969	Ubiquitination	IEAAPDMKRESEKEW CHHCCCCCCHHHCCE	61.46	21906983
983	Ubiquitination	WYFGNADKERSGPYG EECCCCCCCCCCCCC	53.25	-
1000	Ubiquitination	EMQELWTKGMLNAKT HHHHHHHHHCCCCCC	30.64	-
1006	Malonylation	TKGMLNAKTRCWAQG HHHCCCCCCHHHHCC	35.11	26320211
1120	Phosphorylation	NPQLPRLYLSGVFFF CCCCCHHHHHHHHHE	10.49	22817900
1122	Phosphorylation	QLPRLYLSGVFFFIM CCCHHHHHHHHHEEE	21.25	-
1131	Phosphorylation	VFFFIMMYTGSNVLP HHHEEECCCCCCHHH	7.20	22817900
1145	Phosphorylation	PVARFLKYTHTKQAF HHHHHHHHHHHHHHH	13.10	-
1149	Ubiquitination	FLKYTHTKQAFKSEE HHHHHHHHHHHCCCC	31.83	-
1158	Ubiquitination	AFKSEETKGQDIFQR HHCCCCCCCCCHHHH	58.83	-
1189	Phosphorylation	NYEPEKFSEIFLGEF CCCHHHHHHHHCCCC	40.63	30576142
1204	Phosphorylation	DTPEAIWSSEMRRLM CCHHHHCCHHHHHHH	15.42	30576142
1223	Phosphorylation	AAHLADFTPRLQSNT HHHHCCCCHHHHCCC	14.19	24719451
1303	Phosphorylation	MMSIDDAYEVLNLPQ CCCCCHHHHHHCCCC	17.36	28796482
1330	Ubiquitination	AYFRLAQKYHPDKNP HHHHHHHHHCCCCCC	39.66	-
1330	Acetylation	AYFRLAQKYHPDKNP HHHHHHHHHCCCCCC	39.66	25953088
1335	Ubiquitination	AQKYHPDKNPEGRDM HHHHCCCCCCCCHHH	78.01	-
1348	Ubiquitination	DMFEKVNKAYEFLCT HHHHHHHHHHHHHHH	56.16	-
1350	Phosphorylation	FEKVNKAYEFLCTKS HHHHHHHHHHHHHCC	14.60	30622161
1355	Phosphorylation	KAYEFLCTKSAKIVD HHHHHHHHCCCEECC	30.13	30622161
1356	Ubiquitination	AYEFLCTKSAKIVDG HHHHHHHCCCEECCC	47.63	-
1359	Ubiquitination	FLCTKSAKIVDGPDP HHHHCCCEECCCCCH	50.80	21906983
1374	Ubiquitination	ENIILILKTQSILFN HHEEEEEECHHHHHC	37.21	21906983
1390	Phosphorylation	HKEDLQPYKYAGYPM CHHHCCCCCCCCCCE	12.04	-
1392	Phosphorylation	EDLQPYKYAGYPMLI HHCCCCCCCCCCEEE	10.22	-
1395	Phosphorylation	QPYKYAGYPMLIRTI CCCCCCCCCEEEEEE	4.18	-
1413	Phosphorylation	TSDDLLFSKESPLLP CCCCCCCCCCCCCCH	35.17	24719451
1461	Phosphorylation	SRCVAVLTRASKPSD HHHHHHHHHCCCCCC	20.00	27251275
1464	Phosphorylation	VAVLTRASKPSDMSV HHHHHHCCCCCCCCC	41.63	27251275
1467	Phosphorylation	LTRASKPSDMSVQVC HHHCCCCCCCCCCHH	50.08	27251275
1478	Phosphorylation	VQVCGYISKCYSVAA CCHHHHHHHHHHHHH	14.27	27251275
1482	Phosphorylation	GYISKCYSVAAQFEE HHHHHHHHHHHHHHH	18.10	27251275
1499	Phosphorylation	EKITEMPSIIKDLCR HHHHCCHHHHHHHHH	35.32	24719451
1580	Ubiquitination	EVANSLAKLSVHALS HHHHHHHHHHHHHHH	46.73	-
1608	Phosphorylation	ENPTIRKSLAGMLTP CCCHHHHHHHHCCHH	17.38	-
1614	Phosphorylation	KSLAGMLTPYVARKL HHHHHCCHHHHHHHH	12.04	29759185
1616	Phosphorylation	LAGMLTPYVARKLAV HHHCCHHHHHHHHHH	11.08	29759185
1625	Phosphorylation	ARKLAVASVTEILKM HHHHHHHHHHHHHHH	23.99	24719451
1627	Phosphorylation	KLAVASVTEILKMLN HHHHHHHHHHHHHHC	18.14	30301811
1641	Phosphorylation	NSNTESPYLIWNNST CCCCCCCEEECCCCH	21.79	25147952
1665	Ubiquitination	SQQENMIKKGDCDKT HHHHHCHHCCCCCCC	39.68	21906983
1666	Ubiquitination	QQENMIKKGDCDKTY HHHHCHHCCCCCCCC	49.40	-
1701	Phosphorylation	RVYNEVPTFQLEVPK ECCCCCCCEEEECCH	29.23	22817900
1751	Sulfoxidation	DRLPRVEMALEALRN CCCHHHHHHHHHHHH	4.76	21406390
1829	Phosphorylation	LLHSLPSSRQLVLET HHHCCCHHHHHHHHH	23.31	-
1836	Phosphorylation	SRQLVLETLYALTSS HHHHHHHHHHHHHCC	22.40	29396449
1838	Phosphorylation	QLVLETLYALTSSTK HHHHHHHHHHHCCCH	13.64	29396449
1841	Phosphorylation	LETLYALTSSTKIIK HHHHHHHHCCCHHHH	16.68	29396449
1842	Phosphorylation	ETLYALTSSTKIIKE HHHHHHHCCCHHHHH	36.54	29396449
1843	Phosphorylation	TLYALTSSTKIIKEA HHHHHHCCCHHHHHH	28.60	29396449
1844	Phosphorylation	LYALTSSTKIIKEAM HHHHHCCCHHHHHHH	26.48	29396449
1848	Malonylation	TSSTKIIKEAMAKGA HCCCHHHHHHHHCCH	42.78	26320211
1883	Phosphorylation	AELFAKMTADKLIGP HHHHHHHHHHHHHCH	30.88	22210691
1886	Ubiquitination	FAKMTADKLIGPKVR HHHHHHHHHHCHHHH	39.27	-
1891	Malonylation	ADKLIGPKVRITLMK HHHHHCHHHHHHHHH	38.64	26320211
1951	Ubiquitination	EMMLEHFKNQQDNPE HHHHHHHHCCCCCCC	56.61	-
2011	Phosphorylation	IALLEKLTELLEKNN HHHHHHHHHHHHHHC	35.34	29396449
2067	Ubiquitination	HRNNAIPKSAIRVIH HCCCCCCHHHHHHHH	46.54	21906983
2077	Phosphorylation	IRVIHALSENELCVR HHHHHHCCCCHHHHH	38.88	28857561
2088	Phosphorylation	LCVRAMASLETIGPL HHHHHHHHHHHHHHH	17.41	20068231
2101	Ubiquitination	PLMNGMKKRADTVGL HHHCCHHHHHHHHHH	43.88	2190698
2119	Ubiquitination	AINRMFQKEQSELVA HHHHHHHHHHHHHHH	46.59	-
2130	Ubiquitination	ELVAQALKADLVPYL HHHHHHHHCCHHHHH	42.76	-
2136	Phosphorylation	LKADLVPYLLKLLEG HHCCHHHHHHHHHHC	19.72	20068231
2151	Phosphorylation	IGLENLDSPAATKAQ CCCCCCCCCHHHHHH	21.43	17192257
2155	Phosphorylation	NLDSPAATKAQIVKA CCCCCHHHHHHHHHH	29.08	29083192
2156	Ubiquitination	LDSPAATKAQIVKAL CCCCHHHHHHHHHHH	33.30	-
2161	Ubiquitination	ATKAQIVKALKAMTR HHHHHHHHHHHHHHH	50.02	-
2161	Malonylation	ATKAQIVKALKAMTR HHHHHHHHHHHHHHH	50.02	26320211
2167	O-linked_Glycosylation	VKALKAMTRSLQYGE HHHHHHHHHHHHHHH	23.20	30379171
2190	Ubiquitination	SSVWSAFKDQKHDLF HHHHHHHCCCCCCEE	59.99	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DJC13_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DJC13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DJC13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP1G1_HUMAN	AP1G1	physical	26344197
VATA_HUMAN	ATP6V1A	physical	26344197
ANM7_HUMAN	PRMT7	physical	26344197
EDRF1_HUMAN	EDRF1	physical	27173435
FYB2_HUMAN	C1orf168	physical	27173435
I2BP1_HUMAN	IRF2BP1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616361	Parkinson disease 21 (PARK21)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DJC13_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-84, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2151, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1843, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1701, AND MASSSPECTROMETRY.	18187866 [Abstract]