FYB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FYB2_HUMAN
• UniProt AC: Q5VWT5
• Protein Name: FYN-binding protein 2 {ECO:0000244|HGNC:HGNC:27295}
• Gene Name: FYB2 {ECO:0000244|HGNC:HGNC:27295}
• Organism: Homo sapiens (Human).
• Sequence Length: 728
• Subcellular Localization: Membrane raft . Recruited to membrane rafts and immunological synapse after TCR stimulation.
• Protein Description: Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation. [PubMed: 27335501]
• Protein Sequence: MEGEGVRNFKELRAKFQNLDAPPLPGPIKFPAGVSPKGDIGGTQSTQILANGKPLSSNHKQRTPYCSSSESQPLQPQKIKLAQKSEIPKCSNSPGPLGKSTVCSATSSQKASLLLEVTQSNVEIITKEKVMVANSFRNKLWNWEKVSSQKSEMSSALLLANYGSKAIHLEGQKGMGLTPEEPRKKLETKGAQTLPSQKHVVAPKILHNVSEDPSFVISQHIRKSWENPPPERSPASSPCQPIYECELASQAPEKQPDVRHHHLPKTKPLPSIDSLGPPPPKPSRPPIVNLQAFQRQPAAVPKTQGEVTVEEGSLSPERLFNAEFEEPHNYEATISYLRHSGNSINLCTAKEIADPTYEVGIEELQKPGKNFPYPEPSAKHEDKKMKEKQPCELKPKNTEKEPYSNHVFKVDACEGTPEKIQMTNVHTGRRNMLAGKQEAMIDIIQTNPCPEGPKLARHSQGHCGHLEVLESTKETPDLGVSKTSSISEEIYDDVEYSRKEVPKLNYSSSLASSSEENRELYEDVYKTKNNYPKIDLDGKEALKRLQQFFKKEKDRFKIKKTKSKENLSAFSILLPDLELKSQEVIIYDDVDLSEKESKDEDKLKMWKPKFLTPKEKKEKNGAEESESFSPRNFFKTKKQNLEKNRMKREEKLFRERFKYDKEIIVINTAVACSNNSRNGIFDLPISPGEELEVIDTTEQNLVICRNSKGKYGYVLIEHLDFKHQSWSP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Acetylation	TQILANGKPLSSNHK HEEEECCCCCCCCCC		7495621
91	Phosphorylation	KSEIPKCSNSPGPLG CCCCCCCCCCCCCCC		26657352
93	Phosphorylation	EIPKCSNSPGPLGKS CCCCCCCCCCCCCCC		28348404
135	Phosphorylation	EKVMVANSFRNKLWN CCEEEEHHHHHHHCC		27251275
196	Phosphorylation	KGAQTLPSQKHVVAP CCCCCCCCCCCCCCC		23186163
210	Phosphorylation	PKILHNVSEDPSFVI CHHHCCCCCCCCHHH		-
224	Phosphorylation	ISQHIRKSWENPPPE HHHHHHHHCCCCCCC		29457462
243	Phosphorylation	SSPCQPIYECELASQ CCCCCCEEEEECHHC		27642862
303	Phosphorylation	QPAAVPKTQGEVTVE CCCCCCCCCCCEEEE		-
308	Phosphorylation	PKTQGEVTVEEGSLS CCCCCCEEEECCCCC		-
315	Phosphorylation	TVEEGSLSPERLFNA EEECCCCCHHHHHCC		24719451
340	Phosphorylation	TISYLRHSGNSINLC HHEEEHHCCCEEEEE		24275569
357	Phosphorylation	KEIADPTYEVGIEEL HHHCCCCEECCHHHH		27642862
483	Phosphorylation	PDLGVSKTSSISEEI CCCCCCCCCCCCHHH		22798277
484	Phosphorylation	DLGVSKTSSISEEIY CCCCCCCCCCCHHHH		27251275
485	Phosphorylation	LGVSKTSSISEEIYD CCCCCCCCCCHHHHC		22798277
487	Phosphorylation	VSKTSSISEEIYDDV CCCCCCCCHHHHCCC		27251275
491	Phosphorylation	SSISEEIYDDVEYSR CCCCHHHHCCCCHHH		27335501
497	Phosphorylation	IYDDVEYSRKEVPKL HHCCCCHHHCCCCCC		27135362
513	Phosphorylation	YSSSLASSSEENREL CCCCCCCCCHHHHHH		-
514	Phosphorylation	SSSLASSSEENRELY CCCCCCCCHHHHHHH		-
521	Phosphorylation	SEENRELYEDVYKTK CHHHHHHHHHHHHHC		-
525	Phosphorylation	RELYEDVYKTKNNYP HHHHHHHHHHCCCCC		-
587	Phosphorylation	KSQEVIIYDDVDLSE CCCEEEEEECCCCCH		27335501
593	Phosphorylation	IYDDVDLSEKESKDE EEECCCCCHHCCCCH		24275569
643	Acetylation	TKKQNLEKNRMKREE HHHHHHHHHHHHHHH		7672363
647	Acetylation	NLEKNRMKREEKLFR HHHHHHHHHHHHHHH		7672373

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FYB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FYB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FYB2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FYB2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.