ANM7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANM7_HUMAN
• UniProt AC: Q9NVM4
• Protein Name: Protein arginine N-methyltransferase 7
• Gene Name: PRMT7
• Organism: Homo sapiens (Human).
• Sequence Length: 692
• Subcellular Localization: Cytoplasm, cytosol . Nucleus .
• Protein Description: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo..
• Protein Sequence: MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKIFCSRAN ------CCEECCCCC	44.48	-
7	Methylation	-MKIFCSRANPTTGS -CCEECCCCCCCCCC	39.29	115488887
11	Phosphorylation	FCSRANPTTGSVEWL ECCCCCCCCCCEEEC	43.53	28348404
12	Phosphorylation	CSRANPTTGSVEWLE CCCCCCCCCCEEECC	28.81	28348404
14	Phosphorylation	RANPTTGSVEWLEED CCCCCCCCEEECCCC	18.12	28348404
24	Phosphorylation	WLEEDEHYDYHQEIA ECCCCCCCCHHHHHH	19.02	28796482
26	Phosphorylation	EEDEHYDYHQEIARS CCCCCCCHHHHHHHH	9.76	28796482
32	Methylation	DYHQEIARSSYADML CHHHHHHHHHHHHHH	31.62	58859143
42	Ubiquitination	YADMLHDKDRNVKYY HHHHHCCCCCCCHHH	48.08	-
47	Ubiquitination	HDKDRNVKYYQGIRA CCCCCCCHHHHHHHH	41.61	-
73	Phosphorylation	ALVLDIGTGTGLLSM EEEEEECCCCCHHHH	31.72	-
109	Acetylation	AAVKIVEKNGFSDKI HHHHHHHHCCCCCCE	52.02	25953088
109	Ubiquitination	AAVKIVEKNGFSDKI HHHHHHHHCCCCCCE	52.02	-
115	Ubiquitination	EKNGFSDKIKVINKH HHCCCCCCEEEEECC	43.14	-
121	Ubiquitination	DKIKVINKHSTEVTV CCEEEEECCCCEEEE	28.01	-
179	Phosphorylation	EAVPHRATVYAQLVE CCCCCCHHHHHHHHH	17.63	21406692
181	Phosphorylation	VPHRATVYAQLVESG CCCCHHHHHHHHHCC	5.58	21406692
187	Phosphorylation	VYAQLVESGRMWSWN HHHHHHHCCCCCCCC	24.99	21406692
262	S-nitrosylation	QVSSSAACHSRRFEP HCCCCHHHCCCCCCC	2.75	19483679
262	S-nitrosocysteine	QVSSSAACHSRRFEP HCCCCHHHCCCCCCC	2.75	-
397	Phosphorylation	RYVQALRTVLKPDSV HHHHHHHHHHCCCCE	30.92	20068231
444	Ubiquitination	KLLRKIFKANHLEDK HHHHHHHHHCCHHHH	52.32	-
444	Methylation	KLLRKIFKANHLEDK HHHHHHHHHCCHHHH	52.32	115975693
451	Ubiquitination	KANHLEDKINIIEKR HHCCHHHHHCHHHHC	28.42	-
457	Ubiquitination	DKINIIEKRPELLTN HHHCHHHHCHHHCCC	63.95	-
531	Methylation	FRDLWRIRSPCGDCE EHHHEEECCCCCCCC	26.44	126257599
550	Ubiquitination	HIMDDMIKRALDFRE EEHHHHHHHHHHHHH	25.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANM7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANM7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANM7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDM1_HUMAN	PRDM1	physical	18992153
CTCFL_HUMAN	CTCFL	physical	17048991
H2A2C_HUMAN	HIST2H2AC	physical	17048991
RSMB_HUMAN	SNRPB	physical	17709427
H31_HUMAN	HIST1H3A	physical	22231400
ORF73_HHV8P	HHV8GK18_gp81	physical	22179613
SSRG_HUMAN	SSR3	physical	26496610
REPS2_HUMAN	REPS2	physical	26496610
GANAB_HUMAN	GANAB	physical	26496610
ICE1_HUMAN	ICE1	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.