CTCFL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTCFL_HUMAN
• UniProt AC: Q8NI51
• Protein Name: Transcriptional repressor CTCFL
• Gene Name: CTCFL
• Organism: Homo sapiens (Human).
• Sequence Length: 663
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters..
• Protein Sequence: MAATEISVLSEQFTKIKELELMPEKGLKEEEKDGVCREKDHRSPSELEAERTSGAFQDSVLEEEVELVLAPSEESEKYILTLQTVHFTSEAVELQDMSLLSIQQQEGVQVVVQQPGPGLLWLEEGPRQSLQQCVAISIQQELYSPQEMEVLQFHALEENVMVASEDSKLAVSLAETTGLIKLEEEQEKNQLLAERTKEQLFFVETMSGDERSDEIVLTVSNSNVEEQEDQPTAGQADAEKAKSTKNQRKTKGAKGTFHCDVCMFTSSRMSSFNRHMKTHTSEKPHLCHLCLKTFRTVTLLRNHVNTHTGTRPYKCNDCNMAFVTSGELVRHRRYKHTHEKPFKCSMCKYASVEASKLKRHVRSHTGERPFQCCQCSYASRDTYKLKRHMRTHSGEKPYECHICHTRFTQSGTMKIHILQKHGENVPKYQCPHCATIIARKSDLRVHMRNLHAYSAAELKCRYCSAVFHERYALIQHQKTHKNEKRFKCKHCSYACKQERHMTAHIRTHTGEKPFTCLSCNKCFRQKQLLNAHFRKYHDANFIPTVYKCSKCGKGFSRWINLHRHSEKCGSGEAKSAASGKGRRTRKRKQTILKEATKGQKEAAKGWKEAANGDEAAAEEASTTKGEQFPGEMFPVACRETTARVKEEVDEGVTCEMLLNTMDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAATEISVLSE ----CCHHHHHHHHH	25.06	24043423
7	Phosphorylation	-MAATEISVLSEQFT -CCHHHHHHHHHHHH	15.69	24043423
10	Phosphorylation	ATEISVLSEQFTKIK HHHHHHHHHHHHHHH	27.48	24043423
14	Phosphorylation	SVLSEQFTKIKELEL HHHHHHHHHHHHHHC	31.39	24043423
43	Phosphorylation	CREKDHRSPSELEAE CCCCCCCCHHHHHHH	29.38	24719451
52	Phosphorylation	SELEAERTSGAFQDS HHHHHHHHCCCCCCC	24.02	-
53	Phosphorylation	ELEAERTSGAFQDSV HHHHHHHCCCCCCCH	34.05	-
129	Phosphorylation	LEEGPRQSLQQCVAI ECCCCCCCHHHHHHH	29.44	24043423
137	Phosphorylation	LQQCVAISIQQELYS HHHHHHHHHHCCCCC	12.47	24043423
143	Phosphorylation	ISIQQELYSPQEMEV HHHHCCCCCHHHHHH	19.97	24043423
144	Phosphorylation	SIQQELYSPQEMEVL HHHCCCCCHHHHHHH	32.50	24043423
164	Phosphorylation	EENVMVASEDSKLAV CCCEEEECCCCHHHH	30.44	24043423
167	Phosphorylation	VMVASEDSKLAVSLA EEEECCCCHHHHHHH	26.05	24043423
256	Phosphorylation	KTKGAKGTFHCDVCM CCCCCCCEEECCEEE	14.97	-
265	Phosphorylation	HCDVCMFTSSRMSSF ECCEEEEECCCHHHH	10.02	29083192
266	Phosphorylation	CDVCMFTSSRMSSFN CCEEEEECCCHHHHH	12.51	29083192
267	Phosphorylation	DVCMFTSSRMSSFNR CEEEEECCCHHHHHH	29.01	29083192
270	Phosphorylation	MFTSSRMSSFNRHMK EEECCCHHHHHHHHC	30.57	29083192
271	Phosphorylation	FTSSRMSSFNRHMKT EECCCHHHHHHHHCC	19.73	29083192
334	Phosphorylation	ELVRHRRYKHTHEKP HHHHCCCCCCCCCCC	13.69	28152594
337	Phosphorylation	RHRRYKHTHEKPFKC HCCCCCCCCCCCCCC	27.81	28152594
345	Phosphorylation	HEKPFKCSMCKYASV CCCCCCCCCCCCEEH	28.01	29083192
349	Phosphorylation	FKCSMCKYASVEASK CCCCCCCCEEHHHHH	10.12	29083192
351	Phosphorylation	CSMCKYASVEASKLK CCCCCCEEHHHHHHH	19.87	29083192
391	Phosphorylation	KLKRHMRTHSGEKPY HHHHHHHCCCCCCCE	16.90	22210691
393	Phosphorylation	KRHMRTHSGEKPYEC HHHHHCCCCCCCEEE	48.29	28985074
410	Phosphorylation	CHTRFTQSGTMKIHI ECCEECCCCCEEEEE	32.92	25627689
411 (in isoform 5)	Phosphorylation	-	21.73	22210691
412	Phosphorylation	TRFTQSGTMKIHILQ CEECCCCCEEEEEEH	22.12	27732954
412 (in isoform 5)	Phosphorylation	-	22.12	22210691
464	Phosphorylation	ELKCRYCSAVFHERY HHHHHHHHHHHHHHH	20.66	24719451
471	Phosphorylation	SAVFHERYALIQHQK HHHHHHHHHHHHCHH	11.63	28152594
472 (in isoform 4)	Phosphorylation	-	12.38	22210691
473 (in isoform 4)	Phosphorylation	-	2.61	22210691
507	Phosphorylation	HMTAHIRTHTGEKPF HEEEEEEECCCCCCE	24.16	-
509	Phosphorylation	TAHIRTHTGEKPFTC EEEEEECCCCCCEEE	46.56	-
575	Phosphorylation	CGSGEAKSAASGKGR CCCCCHHHHHCCCCH	35.79	-
578	Phosphorylation	GEAKSAASGKGRRTR CCHHHHHCCCCHHHH	40.53	24719451
640	Phosphorylation	FPVACRETTARVKEE CCCCCCCCCHHHHHH	13.35	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTCFL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTCFL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTCFL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM7_HUMAN	PRMT7	physical	17048991
BAG6_HUMAN	BAG6	physical	18765639
SP1_HUMAN	SP1	physical	17260018
SP1_HUMAN	SP1	physical	25363021
TBP_HUMAN	TBP	physical	25363021

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.