REPS2_HUMAN - dbPTM
REPS2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID REPS2_HUMAN
UniProt AC Q8NFH8
Protein Name RalBP1-associated Eps domain-containing protein 2
Gene Name REPS2
Organism Homo sapiens (Human).
Sequence Length 660
Subcellular Localization Cytoplasm.
Protein Description Involved in growth factor signaling through its influence on the Ral signaling pathway..
Protein Sequence MEAAAAAAAAAAAAAAAGGGCGSGPPPLLLSEGEQQCYSELFARCAGAAGGGPGSGPPEAARVAPGTATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVRIESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQQETQSPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRSFSVERELQDNSSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEALPKDVSEDPATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLNKVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKDVLYSQPPSKPIRRKFRPENQATENQEPSTAASGPASAATMKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
45 (in isoform 3)Phosphorylation-3.5321955146
47 (in isoform 3)Phosphorylation-21.4221955146
49 (in isoform 3)Phosphorylation-19.0821955146
51 (in isoform 3)Phosphorylation-34.1021955146
55 (in isoform 3)Phosphorylation-51.7826657352
58 (in isoform 3)Phosphorylation-47.5926657352
59 (in isoform 3)Phosphorylation-59.0821955146
63 (in isoform 3)Phosphorylation-6.9021955146
103PhosphorylationCGAKRVGYFGPTQFY
HCCCCCCCCCHHHHH		11.51-
107PhosphorylationRVGYFGPTQFYIALK
CCCCCCHHHHHHHHH		31.52-
110PhosphorylationYFGPTQFYIALKLIA
CCCHHHHHHHHHHHH		3.88-
121PhosphorylationKLIAAAQSGLPVRIE
HHHHHHHHCCCEEEE		37.2619413330
165PhosphorylationGTKVQIPYLTTEKNS
CCEEECCEEECCCCC		20.5027067055
167PhosphorylationKVQIPYLTTEKNSFK
EEECCEEECCCCCCC		27.3728348404
168PhosphorylationVQIPYLTTEKNSFKR
EECCEEECCCCCCCC		42.2224719451
172PhosphorylationYLTTEKNSFKRMDDE
EEECCCCCCCCCCHH		43.1228348404
184 (in isoform 4)Phosphorylation-46.4521955146
185PhosphorylationDEDKQQETQSPTMSP
HHHHHHHCCCCCCCC		29.9723312004
186 (in isoform 4)Phosphorylation-46.8121955146
186PhosphorylationEDKQQETQSPTMSPL
HHHHHHCCCCCCCCC		46.8124719451
187PhosphorylationDKQQETQSPTMSPLA
HHHHHCCCCCCCCCC		29.7422777824
188 (in isoform 4)Phosphorylation-23.4621955146
189PhosphorylationQQETQSPTMSPLASP
HHHCCCCCCCCCCCC		35.2128348404
190 (in isoform 4)Phosphorylation-4.3921955146
191PhosphorylationETQSPTMSPLASPPS
HCCCCCCCCCCCCCC		21.1722777824
194PhosphorylationSPTMSPLASPPSSPP
CCCCCCCCCCCCCCC		24.3124719451
194 (in isoform 4)Phosphorylation-24.3126657352
195PhosphorylationPTMSPLASPPSSPPH
CCCCCCCCCCCCCCC		45.0522777824
197PhosphorylationMSPLASPPSSPPHYQ
CCCCCCCCCCCCCCC		44.9724719451
197 (in isoform 4)Phosphorylation-44.9726657352
198PhosphorylationSPLASPPSSPPHYQR
CCCCCCCCCCCCCCC		59.8823312004
198 (in isoform 4)Phosphorylation-59.8821955146
199PhosphorylationPLASPPSSPPHYQRV
CCCCCCCCCCCCCCC		48.5022777824
202 (in isoform 4)Phosphorylation-34.4421955146
203PhosphorylationPPSSPPHYQRVPLSH
CCCCCCCCCCCCCCC		12.0923312004
212PhosphorylationRVPLSHGYSKLRSSA
CCCCCCCHHHHHHCH		9.3721722762
213PhosphorylationVPLSHGYSKLRSSAE
CCCCCCHHHHHHCHH		29.7921722762
217PhosphorylationHGYSKLRSSAEQMHP
CCHHHHHHCHHHHCC		44.3225849741
218PhosphorylationGYSKLRSSAEQMHPA
CHHHHHHCHHHHCCC		29.4125849741
226PhosphorylationAEQMHPAPYEARQPL
HHHHCCCCCCCCCCC		31.7627642862
227PhosphorylationEQMHPAPYEARQPLV
HHHCCCCCCCCCCCC		25.0722210691
239PhosphorylationPLVQPEGSSSGGPGT
CCCCCCCCCCCCCCC		21.4825627689
240PhosphorylationLVQPEGSSSGGPGTK
CCCCCCCCCCCCCCC		43.8128555341
241PhosphorylationVQPEGSSSGGPGTKP
CCCCCCCCCCCCCCC		49.8425627689
253PhosphorylationTKPLRHQASLIRSFS
CCCCHHHHHHHHHHC		10.5324719451
254PhosphorylationKPLRHQASLIRSFSV
CCCHHHHHHHHHHCE		20.1222617229
258PhosphorylationHQASLIRSFSVEREL
HHHHHHHHHCEEHHH		18.1923927012
259PhosphorylationQASLIRSFSVERELQ
HHHHHHHHCEEHHHC		7.3324719451
260PhosphorylationASLIRSFSVERELQD
HHHHHHHCEEHHHCC		25.0628355574
269PhosphorylationERELQDNSSYPDEPW
EHHHCCCCCCCCCCC		39.2728450419
270PhosphorylationRELQDNSSYPDEPWR
HHHCCCCCCCCCCCC		47.1128450419
271PhosphorylationELQDNSSYPDEPWRI
HHCCCCCCCCCCCCC		17.9630576142
303PhosphorylationDPSSFISGSVAKNFF
CHHHHCCHHHHHHCC		22.7124719451
304PhosphorylationPSSFISGSVAKNFFT
HHHHCCHHHHHHCCC		16.4724275569
385PhosphorylationWDCQLFDSYSESLPA
CCCCCHHHCCCCCCC		24.1927642862
387PhosphorylationCQLFDSYSESLPANQ
CCCHHHCCCCCCCCC		25.3527251275
404PhosphorylationRDLNRMEKTSVKDMA
CCHHHHCCCCHHHHH		36.4424719451
405PhosphorylationDLNRMEKTSVKDMAD
CHHHHCCCCHHHHHC		25.9924719451
406PhosphorylationLNRMEKTSVKDMADL
HHHHCCCCHHHHHCC		37.9328857561
421PhosphorylationPVPNQDVTSDDKQAL
CCCCCCCCCCHHHHH		34.4323312004
422PhosphorylationVPNQDVTSDDKQALK
CCCCCCCCCHHHHHH		43.5923312004
441PhosphorylationEALPKDVSEDPATPK
HHCCCCCCCCCCCCC		46.5528102081
445PhosphorylationKDVSEDPATPKDSNS
CCCCCCCCCCCCCCC		49.1824719451
446PhosphorylationDVSEDPATPKDSNSL
CCCCCCCCCCCCCCC		35.9421815630
449PhosphorylationEDPATPKDSNSLKAR
CCCCCCCCCCCCCCC		55.0124719451
450PhosphorylationDPATPKDSNSLKARP
CCCCCCCCCCCCCCC		34.1524719451
459PhosphorylationSLKARPRSRSYSSTS
CCCCCCCCCCCCCCC		28.4125849741
460PhosphorylationLKARPRSRSYSSTSI
CCCCCCCCCCCCCCH		40.6724719451
461PhosphorylationKARPRSRSYSSTSIE
CCCCCCCCCCCCCHH		30.5221712546
462PhosphorylationARPRSRSYSSTSIEE
CCCCCCCCCCCCHHH		12.9122199227
463PhosphorylationRPRSRSYSSTSIEEA
CCCCCCCCCCCHHHH		28.5228355574
464PhosphorylationPRSRSYSSTSIEEAM
CCCCCCCCCCHHHHH		20.2422199227
465PhosphorylationRSRSYSSTSIEEAMK
CCCCCCCCCHHHHHH		27.9926657352
466PhosphorylationSRSYSSTSIEEAMKR
CCCCCCCCHHHHHHC		29.9222617229
478PhosphorylationMKRGEDPPTPPPRPQ
HHCCCCCCCCCCCCC		70.6124719451
479PhosphorylationKRGEDPPTPPPRPQK
HCCCCCCCCCCCCCC		54.5430266825
487PhosphorylationPPPRPQKTHSRASSL
CCCCCCCCCCCCCCC		21.6028450419
489PhosphorylationPRPQKTHSRASSLDL
CCCCCCCCCCCCCCH		34.4725849741
491PhosphorylationPQKTHSRASSLDLNK
CCCCCCCCCCCCHHH		13.3924719451
492PhosphorylationQKTHSRASSLDLNKV
CCCCCCCCCCCHHHH		30.2622167270
493PhosphorylationKTHSRASSLDLNKVF
CCCCCCCCCCHHHHC		25.5625159151
502PhosphorylationDLNKVFQPSVPATKS
CHHHHCCCCCCCCCC		26.3224719451
503PhosphorylationLNKVFQPSVPATKSG
HHHHCCCCCCCCCCC		29.9227080861
507O-linked_GlycosylationFQPSVPATKSGLLPP
CCCCCCCCCCCCCCC		21.4828657654
508PhosphorylationQPSVPATKSGLLPPP
CCCCCCCCCCCCCCC		44.6324719451
509PhosphorylationPSVPATKSGLLPPPP
CCCCCCCCCCCCCCC		30.2524719451
543PhosphorylationLPQLSRAPSQAAESS
HHHHCCCHHHHHHCC		26.3424719451
544PhosphorylationPQLSRAPSQAAESSP
HHHCCCHHHHHHCCC		31.3126055452
548PhosphorylationRAPSQAAESSPAKKD
CCHHHHHHCCCCCCC		55.5624719451
549PhosphorylationAPSQAAESSPAKKDV
CHHHHHHCCCCCCCC		36.5730278072
550PhosphorylationPSQAAESSPAKKDVL
HHHHHHCCCCCCCCC		22.0030278072
557PhosphorylationSPAKKDVLYSQPPSK
CCCCCCCCCCCCCCC		4.9627642862
558PhosphorylationPAKKDVLYSQPPSKP
CCCCCCCCCCCCCCC		12.7121945579
559PhosphorylationAKKDVLYSQPPSKPI
CCCCCCCCCCCCCCH		31.8621945579
562PhosphorylationDVLYSQPPSKPIRRK
CCCCCCCCCCCHHHH		47.5524719451
563PhosphorylationVLYSQPPSKPIRRKF
CCCCCCCCCCHHHHC		58.7221945579
610AcetylationKQSSKQKKAIQTAIR
CCCHHHHHHHHHHHH		48.5030591861
631PhosphorylationAVLARLNSELQQQLK
HHHHHHHHHHHHHHH		44.2530266825
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
463SPhosphorylationKinaseCDK1P06493
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of REPS2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of REPS2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RBP1_HUMANRALBP1physical
9422736
EPN1_HUMANEPN1physical
10557078
AP2A1_HUMANAP2A1physical
10764745
EPN1_HUMANEPN1physical
10764745
NOG2_HUMANGNL2physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of REPS2_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493 AND SER-549, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory