SCAM2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCAM2_HUMAN
• UniProt AC: O15127
• Protein Name: Secretory carrier-associated membrane protein 2
• Gene Name: SCAMP2
• Organism: Homo sapiens (Human).
• Sequence Length: 329
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein .
• Protein Description: Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface..
• Protein Sequence: MSAFDTNPFADPVDVNPFQDPSVTQLTNAPQGGLAEFNPFSETNAATTVPVTQLPGSSQPAVLQPSVEPTQPTPQAVVSAAQAGLLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWCPVKPCFYQDFSTEIPADYQRICKMLYYLWMLHSVTLFLNLLACLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRSDNSFSFFVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHSLAISVIMMVVAGFFTLCAVLSVFLLQRVHSLYRRTGASFQQAQEEFSQGIFSSRTFHRAASSAAQGAFQGN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	PTPQAVVSAAQAGLL CCHHHHHHHHHHHHH	15.99	30622161
95	Ubiquitination	QQEELDRKAAELERK HHHHHHHHHHHHHHH	52.17	22053931
109	Phosphorylation	KERELQNTVANLHVR HHHHHHHHHHHHHHH	14.18	23401153
197	S-palmitoylation	WFLIFTPCAFLCWYR HHHHHHHHHHHHHHH	3.67	29575903
305	Phosphorylation	QQAQEEFSQGIFSSR HHHHHHHHCCCCCHH	30.67	26074081
310	Phosphorylation	EFSQGIFSSRTFHRA HHHCCCCCHHHHHHH	19.59	28450419
311	Phosphorylation	FSQGIFSSRTFHRAA HHCCCCCHHHHHHHH	25.29	28450419
313	Phosphorylation	QGIFSSRTFHRAASS CCCCCHHHHHHHHHH	26.24	26074081
319	Phosphorylation	RTFHRAASSAAQGAF HHHHHHHHHHHCCHH	21.37	25159151
320	Phosphorylation	TFHRAASSAAQGAFQ HHHHHHHHHHCCHHC	23.93	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCAM2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCAM2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCAM2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAP31_HUMAN	BCAP31	physical	26344197
JAGN1_HUMAN	JAGN1	physical	26344197
PHB_HUMAN	PHB	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319 AND SER-320, ANDMASS SPECTROMETRY.
PubMed: 19413330

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, AND MASSSPECTROMETRY.
PubMed: 18088087