BAP31_HUMAN - dbPTM
BAP31_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BAP31_HUMAN
UniProt AC P51572
Protein Name B-cell receptor-associated protein 31
Gene Name BCAP31
Organism Homo sapiens (Human).
Sequence Length 246
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane
Multi-pass membrane protein . May shuttle between the ER and the intermediate compartment/cis-Golgi complex.
Protein Description Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis..
Protein Sequence MSLQWTAVATFLYAEVFVVLLLCIPFISPKRWQKIFKSRLVELLVSYGNTFFVVLIVILVLLVIDAVREIRKYDDVTEKVNLQNNPGAMEHFHMKLFRAQRNLYIAGFSLLLSFLLRRLVTLISQQATLLASNEAFKKQAESASEAAKKYMEENDQLKKGAAVDGGKLDVGNAEVKLEEENRSLKADLQKLKDELASTKQKLEKAENQVLAMRKQSEGLTKEYDRLLEEHAKLQAAVDGPMDKKEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34UbiquitinationISPKRWQKIFKSRLV
CCHHHHHHHHHHHHH		43.0527667366
37UbiquitinationKRWQKIFKSRLVELL
HHHHHHHHHHHHHHH		37.83-
62UbiquitinationLIVILVLLVIDAVRE
HHHHHHHHHHHHHHH		2.1827667366
72AcetylationDAVREIRKYDDVTEK
HHHHHHHCCCCCHHH		59.7127452117
72UbiquitinationDAVREIRKYDDVTEK
HHHHHHHCCCCCHHH		59.7121906983
73PhosphorylationAVREIRKYDDVTEKV
HHHHHHCCCCCHHHC		13.92-
79UbiquitinationKYDDVTEKVNLQNNP
CCCCCHHHCCCCCCC		27.3621906983
95AcetylationAMEHFHMKLFRAQRN
HHHHHHHHHHHHHHC		35.5825825284
95UbiquitinationAMEHFHMKLFRAQRN
HHHHHHHHHHHHHHC		35.5821906983
101UbiquitinationMKLFRAQRNLYIAGF
HHHHHHHHCHHHHHH		33.8527667366
104PhosphorylationFRAQRNLYIAGFSLL
HHHHHCHHHHHHHHH		7.7122210691
109PhosphorylationNLYIAGFSLLLSFLL
CHHHHHHHHHHHHHH		19.7222210691
113PhosphorylationAGFSLLLSFLLRRLV
HHHHHHHHHHHHHHH		17.5122210691
137UbiquitinationLASNEAFKKQAESAS
HHCCHHHHHHHHHHH		51.5321906983
138UbiquitinationASNEAFKKQAESASE
HCCHHHHHHHHHHHH		48.5721906983
139UbiquitinationSNEAFKKQAESASEA
CCHHHHHHHHHHHHH		51.4521963094
146UbiquitinationQAESASEAAKKYMEE
HHHHHHHHHHHHHHH		23.2921963094
146UbiquitinationQAESASEAAKKYMEE
HHHHHHHHHHHHHHH		23.2921890473
146 (in isoform 2)Ubiquitination-23.29-
148UbiquitinationESASEAAKKYMEEND
HHHHHHHHHHHHHCC		52.0321906983
149UbiquitinationSASEAAKKYMEENDQ
HHHHHHHHHHHHCCH		45.1427667366
149AcetylationSASEAAKKYMEENDQ
HHHHHHHHHHHHCCH		45.1427452117
151SulfoxidationSEAAKKYMEENDQLK
HHHHHHHHHHCCHHC		7.7621406390
158AcetylationMEENDQLKKGAAVDG
HHHCCHHCCCCCCCC		43.4527452117
158UbiquitinationMEENDQLKKGAAVDG
HHHCCHHCCCCCCCC		43.4521906983
159UbiquitinationEENDQLKKGAAVDGG
HHCCHHCCCCCCCCC		63.4721906983
162UbiquitinationDQLKKGAAVDGGKLD
CHHCCCCCCCCCCCC		14.4921890473
162UbiquitinationDQLKKGAAVDGGKLD
CHHCCCCCCCCCCCC		14.4921963094
162 (in isoform 2)Ubiquitination-14.49-
167UbiquitinationGAAVDGGKLDVGNAE
CCCCCCCCCCCCCCE		47.2221906983
167AcetylationGAAVDGGKLDVGNAE
CCCCCCCCCCCCCCE		47.2223236377
167NeddylationGAAVDGGKLDVGNAE
CCCCCCCCCCCCCCE		47.2232015554
176UbiquitinationDVGNAEVKLEEENRS
CCCCCEEHHHHHHHH		41.5121906983
176AcetylationDVGNAEVKLEEENRS
CCCCCEEHHHHHHHH		41.5123236377
185UbiquitinationEEENRSLKADLQKLK
HHHHHHHHHHHHHHH		40.8921906983
190AcetylationSLKADLQKLKDELAS
HHHHHHHHHHHHHHH		65.8723749302
190UbiquitinationSLKADLQKLKDELAS
HHHHHHHHHHHHHHH		65.8727667366
192UbiquitinationKADLQKLKDELASTK
HHHHHHHHHHHHHHH		57.0821906983
197PhosphorylationKLKDELASTKQKLEK
HHHHHHHHHHHHHHH		49.0823911959
198PhosphorylationLKDELASTKQKLEKA
HHHHHHHHHHHHHHH		31.7127251275
199UbiquitinationKDELASTKQKLEKAE
HHHHHHHHHHHHHHH		42.8321906983
201UbiquitinationELASTKQKLEKAENQ
HHHHHHHHHHHHHHH		61.2322817900
201AcetylationELASTKQKLEKAENQ
HHHHHHHHHHHHHHH		61.2325953088
204UbiquitinationSTKQKLEKAENQVLA
HHHHHHHHHHHHHHH		72.0127667366
204AcetylationSTKQKLEKAENQVLA
HHHHHHHHHHHHHHH		72.0120167786
205UbiquitinationTKQKLEKAENQVLAM
HHHHHHHHHHHHHHH		16.1727667366
212SulfoxidationAENQVLAMRKQSEGL
HHHHHHHHHHHCCCC		4.8721406390
214UbiquitinationNQVLAMRKQSEGLTK
HHHHHHHHHCCCCHH		45.1233845483
215UbiquitinationQVLAMRKQSEGLTKE
HHHHHHHHCCCCHHH		36.0327667366
216PhosphorylationVLAMRKQSEGLTKEY
HHHHHHHCCCCHHHH		36.3523882029
216 (in isoform 2)Ubiquitination-36.35-
216UbiquitinationVLAMRKQSEGLTKEY
HHHHHHHCCCCHHHH		36.3527667366
220PhosphorylationRKQSEGLTKEYDRLL
HHHCCCCHHHHHHHH		32.4629514088
221UbiquitinationKQSEGLTKEYDRLLE
HHCCCCHHHHHHHHH		60.3621906983
223PhosphorylationSEGLTKEYDRLLEEH
CCCCHHHHHHHHHHH		14.1220068231
225 (in isoform 2)Ubiquitination-40.03-
225UbiquitinationGLTKEYDRLLEEHAK
CCHHHHHHHHHHHHH		40.0327667366
226 (in isoform 2)Ubiquitination-6.88-
226UbiquitinationLTKEYDRLLEEHAKL
CHHHHHHHHHHHHHH		6.8827667366
232UbiquitinationRLLEEHAKLQAAVDG
HHHHHHHHHHHHHCC		42.9332015554
234NeddylationLEEHAKLQAAVDGPM
HHHHHHHHHHHCCCC		26.9432015554
234UbiquitinationLEEHAKLQAAVDGPM
HHHHHHHHHHHCCCC		26.9432142685
234 (in isoform 2)Ubiquitination-26.94-
241SulfoxidationQAAVDGPMDKKEE--
HHHHCCCCCCCCC--		16.8321406390
243AcetylationAVDGPMDKKEE----
HHCCCCCCCCC----		56.6923236377
243UbiquitinationAVDGPMDKKEE----
HHCCCCCCCCC----		56.6932142685
243 (in isoform 2)Ubiquitination-56.69-
244UbiquitinationVDGPMDKKEE-----
HCCCCCCCCC-----		63.9121906983
252 (in isoform 2)Ubiquitination--
252UbiquitinationEE-------------
CC-------------		27667366
257 (in isoform 2)Ubiquitination--
257Ubiquitination------------------
------------------		27667366
259 (in isoform 2)Ubiquitination--
259Ubiquitination--------------------
--------------------		22817900
264Phosphorylation-------------------------
-------------------------		27251275
266Acetylation---------------------------
---------------------------		-
266Ubiquitination---------------------------
---------------------------		22817900
268Ubiquitination-----------------------------
-----------------------------		22817900
271 (in isoform 2)Ubiquitination--
271Ubiquitination--------------------------------
--------------------------------		21890473
271Ubiquitination--------------------------------
--------------------------------		27667366
281Ubiquitination------------------------------------------
------------------------------------------		33845483
283Phosphorylation--------------------------------------------
--------------------------------------------		24719451
288 (in isoform 2)Ubiquitination--
288Ubiquitination-------------------------------------------------
-------------------------------------------------		27667366
290Phosphorylation---------------------------------------------------
---------------------------------------------------		-
299Ubiquitination------------------------------------------------------------
------------------------------------------------------------		32015554
310 (in isoform 2)Ubiquitination--
310Ubiquitination-----------------------------------------------------------------------
-----------------------------------------------------------------------		27667366
311 (in isoform 2)Ubiquitination--
311Ubiquitination------------------------------------------------------------------------
------------------------------------------------------------------------		21963094
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BAP31_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BAP31_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BAP31_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BAP31_HUMANBCAP31physical
12886015
BAP31_HUMANBCAP31physical
10958671
MYH10_HUMANMYH10physical
10958671
ACTG_HUMANACTG1physical
10958671
BCL2_HUMANBCL2physical
9334338
CASP8_HUMANCASP8physical
9334338
B2CL1_HUMANBCL2L1physical
9334338
VAMP3_HUMANVAMP3physical
9396746
A4_HUMANAPPphysical
12529377
BFAR_HUMANBFARphysical
14502241
SC61B_HUMANSEC61Bphysical
18555783
TRAM1_HUMANTRAM1physical
18555783
CFTR_HUMANCFTRphysical
18555783
DERL1_HUMANDERL1physical
18555783
RNF5_HUMANRNF5physical
18555783
1A02_HUMANHLA-Aphysical
19342655
1A03_HUMANHLA-Aphysical
19342655
1A01_HUMANHLA-Aphysical
19342655
1A26_HUMANHLA-Aphysical
19342655
BAP31_HUMANBCAP31physical
19342655
BAP29_HUMANBCAP29physical
19342655
LMAN1_HUMANLMAN1physical
19342655
MYH10_HUMANMYH10physical
12605685
ACTG_HUMANACTG1physical
12605685
ITAM_HUMANITGAMphysical
15294914
B2CL1_HUMANBCL2L1physical
12594175
FIS1_HUMANFIS1physical
21183955
HACD2_HUMANPTPLBphysical
15024066
CALX_HUMANCANXphysical
11851433
CASP8_HUMANCASP8physical
11917123
CALX_HUMANCANXphysical
11917123
A2AP_HUMANSERPINF2physical
21988832
KLK10_HUMANKLK10physical
21988832
RER1_HUMANRER1physical
26344197
TPM2_HUMANTPM2physical
26344197
EPCAM_HUMANEPCAMphysical
24898727
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300475Deafness, dystonia, and cerebral hypomyelination (DDCH)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BAP31_HUMAN

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Related Literatures of Post-Translational Modification

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