A2AP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: A2AP_HUMAN
• UniProt AC: P08697
• Protein Name: Alpha-2-antiplasmin
• Gene Name: SERPINF2
• Organism: Homo sapiens (Human).
• Sequence Length: 491
• Subcellular Localization: Secreted.
• Protein Description: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin..
• Protein Sequence: MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	O-linked_Glycosylation	EPLGRQLTSGPNQEQ CCCCCCCCCCCCHHH	24.25	OGP
36	Phosphorylation	EPLGRQLTSGPNQEQ CCCCCCCCCCCCHHH	24.25	28509920
37	Phosphorylation	PLGRQLTSGPNQEQV CCCCCCCCCCCHHHC	61.93	28509920
37	O-linked_Glycosylation	PLGRQLTSGPNQEQV CCCCCCCCCCCHHHC	61.93	OGP
45	O-linked_Glycosylation	GPNQEQVSPLTLLKL CCCHHHCCCEEEEEC	17.56	OGP
48	Phosphorylation	QEQVSPLTLLKLGNQ HHHCCCEEEEECCCC	33.17	28509920
48	O-linked_Glycosylation	QEQVSPLTLLKLGNQ HHHCCCEEEEECCCC	33.17	OGP
126	N-linked_Glycosylation	HLALGAQNHTLQRLQ HHHHHCCCHHHHHHH	29.58	UniProtKB CARBOHYD
126	N-linked_Glycosylation	HLALGAQNHTLQRLQ HHHHHCCCHHHHHHH	29.58	16335952
250	Phosphorylation	NKFDPSLTQRDSFHL CCCCCCCCCCCCCCC	26.37	20068231
295	N-linked_Glycosylation	AHFPFKNNMSFVVLV EECCCCCCEEEEEEE	28.24	UniProtKB CARBOHYD
295	N-linked_Glycosylation	AHFPFKNNMSFVVLV EECCCCCCEEEEEEE	28.24	16335952
309	N-linked_Glycosylation	VPTHFEWNVSQVLAN EECCCCCCHHHHHHH	19.16	UniProtKB CARBOHYD
309	N-linked_Glycosylation	VPTHFEWNVSQVLAN EECCCCCCHHHHHHH	19.16	16335952
316	N-linked_Glycosylation	NVSQVLANLSWDTLH CHHHHHHHCCCCCCC	30.37	UniProtKB CARBOHYD
316	N-linked_Glycosylation	NVSQVLANLSWDTLH CHHHHHHHCCCCCCC	30.37	2440681
390	Ubiquitination	TLELSEVGVEAAAAT EEEHHHHHHHHHHHH	13.90	29967540
397	O-linked_Glycosylation	GVEAAAATSIAMSRM HHHHHHHHHHHHHHC	18.88	OGP
397	Phosphorylation	GVEAAAATSIAMSRM HHHHHHHHHHHHHHC	18.88	-
398	Phosphorylation	VEAAAATSIAMSRMS HHHHHHHHHHHHHCC	12.01	-
405	Phosphorylation	SIAMSRMSLSSFSVN HHHHHHCCHHHCCCC	24.80	-
407	Phosphorylation	AMSRMSLSSFSVNRP HHHHCCHHHCCCCCC	23.25	-
410	Phosphorylation	RMSLSSFSVNRPFLF HCCHHHCCCCCCEEE	22.04	-
450	Phosphorylation	ELKEQQDSPGNKDFL HHHHCCCCCCCHHHH	30.30	24505115
454	Ubiquitination	QQDSPGNKDFLQSLK CCCCCCCHHHHHHHC	56.63	29967540
459	Phosphorylation	GNKDFLQSLKGFPRG CCHHHHHHHCCCCCC	33.91	24972180
459	O-linked_Glycosylation	GNKDFLQSLKGFPRG CCHHHHHHHCCCCCC	33.91	OGP
484	Phosphorylation	VPPMEEDYPQFGSPK CCCCCCCCCCCCCCC	11.38	2434496
484	Sulfation	VPPMEEDYPQFGSPK CCCCCCCCCCCCCCC	11.38	-
484	Sulfation	VPPMEEDYPQFGSPK CCCCCCCCCCCCCCC	11.38	2434496
489	Phosphorylation	EDYPQFGSPK----- CCCCCCCCCC-----	30.70	24719451
489	O-linked_Glycosylation	EDYPQFGSPK----- CCCCCCCCCC-----	30.70	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of A2AP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of A2AP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of A2AP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CFAD_HUMAN	CFD	physical	12080056
SSRA_HUMAN	SSR1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 262850: Alpha-2-plasmin inhibitor deficiency (APLID)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-126; ASN-295 AND ASN-309,AND MASS SPECTROMETRY.
PubMed: 16335952