| UniProt ID | CFAD_HUMAN | |
|---|---|---|
| UniProt AC | P00746 | |
| Protein Name | Complement factor D | |
| Gene Name | CFD | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 253 | |
| Subcellular Localization | Secreted. | |
| Protein Description | Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.. | |
| Protein Sequence | MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 92 | Ubiquitination | LSQPEPSKRLYDVLR CCCCCCCHHHHHHHH | 58.08 | 21890473 | |
| 99 | Ubiquitination | KRLYDVLRAVPHPDS HHHHHHHHHCCCCCC | 33.13 | 21890473 | |
| 123 | Ubiquitination | LLLQLSEKATLGPAV HHHHHHHCCCCCCCC | 43.21 | 2190698 | |
| 130 | Ubiquitination | KATLGPAVRPLPWQR CCCCCCCCCCCCCCC | 7.93 | 21890473 | |
| 192 | Methylation | HDGAITERLMCAESN CCCHHHHHHEEHHHC | 21.04 | - | |
| 199 | Methylation | RLMCAESNRRDSCKG HHEEHHHCCCCCCCC | 34.21 | - | |
| 205 | Ubiquitination | SNRRDSCKGDSGGPL HCCCCCCCCCCCCCE | 70.47 | - | |
| 212 | Ubiquitination | KGDSGGPLVCGGVLE CCCCCCCEECCCEEE | 5.87 | - | |
| 238 | Phosphorylation | NRKKPGIYTRVASYA CCCCCCCHHHHHHHH | 8.39 | 29496907 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CFAD_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CFAD_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CFAD_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CFAD_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 613912 | Complement factor D deficiency (CFDD) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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