LMAN1_HUMAN - dbPTM
LMAN1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LMAN1_HUMAN
UniProt AC P49257
Protein Name Protein ERGIC-53
Gene Name LMAN1
Organism Homo sapiens (Human).
Sequence Length 510
Subcellular Localization Endoplasmic reticulum-Golgi intermediate compartment membrane
Single-pass type I membrane protein. Golgi apparatus membrane
Single-pass membrane protein. Endoplasmic reticulum membrane
Single-pass type I membrane protein.
Protein Description Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins..
Protein Sequence MAGSRQRGLRARVRPLFCALLLSLGRFVRGDGVGGDPAVALPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSSDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQGLEGPVFGSADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKITYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTEPGKEPPTPDKEISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPAEEIFESVGDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISKRGAGMPGQHGQITQQELDTVVKTQHEILRQVNEMKNSMSETVRLVSGMQHPGSAGGVYETTQHFIDIKEHLHIVKRDIDNLVQRNMPSNEKPKCPELPPFPSCLSTVHFIIFVVVQTVLFIGYIMYRSQQEAAAKKFF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
49AcetylationPHRRFEYKYSFKGPH
CCCCEEEEEEECCCE		27.5027452117
49UbiquitinationPHRRFEYKYSFKGPH
CCCCEEEEEEECCCE		27.50-
50PhosphorylationHRRFEYKYSFKGPHL
CCCEEEEEEECCCEE		20.5927080861
51PhosphorylationRRFEYKYSFKGPHLV
CCEEEEEEECCCEEE		19.1427080861
87UbiquitinationIRVAPSLKSQRGSVW
EEECCCCCCCCCCCE		49.21-
872-HydroxyisobutyrylationIRVAPSLKSQRGSVW
EEECCCCCCCCCCCE		49.21-
276O-linked_GlycosylationEPGKEPPTPDKEISE
CCCCCCCCCCCCCCH		55.6355829373
302UbiquitinationHFQQELDKKKEEFQK
HHHHHHHHHHHHHHC		77.65-
325PhosphorylationPAEEIFESVGDRELR
CHHHHHHHHCCHHHH		22.20-
346UbiquitinationNRIHLEIKQLNRQLD
CCCHHHHHHHHHHHH		39.0821890473
3462-HydroxyisobutyrylationNRIHLEIKQLNRQLD
CCCHHHHHHHHHHHH		39.08-
346MalonylationNRIHLEIKQLNRQLD
CCCHHHHHHHHHHHH		39.0826320211
346AcetylationNRIHLEIKQLNRQLD
CCCHHHHHHHHHHHH		39.0827452117
3722-HydroxyisobutyrylationSLTEEISKRGAGMPG
HHHHHHHHCCCCCCC		61.59-
372UbiquitinationSLTEEISKRGAGMPG
HHHHHHHHCCCCCCC		61.5921890473
377SulfoxidationISKRGAGMPGQHGQI
HHHCCCCCCCCCCCC		3.1430846556
385O-linked_GlycosylationPGQHGQITQQELDTV
CCCCCCCCHHHHHHH		19.1381023729
3942-HydroxyisobutyrylationQELDTVVKTQHEILR
HHHHHHHHHHHHHHH		37.82-
407AcetylationLRQVNEMKNSMSETV
HHHHHHHHHCHHHHH		39.4327452117
407UbiquitinationLRQVNEMKNSMSETV
HHHHHHHHHCHHHHH		39.43-
418PhosphorylationSETVRLVSGMQHPGS
HHHHHHHHCCCCCCC		32.8927251275
418O-linked_GlycosylationSETVRLVSGMQHPGS
HHHHHHHHCCCCCCC		32.89OGP
425O-linked_GlycosylationSGMQHPGSAGGVYET
HCCCCCCCCCCCCCC		28.3520166139
425PhosphorylationSGMQHPGSAGGVYET
HCCCCCCCCCCCCCC		28.3520166139
430PhosphorylationPGSAGGVYETTQHFI
CCCCCCCCCCCCEEE		15.7226471730
432O-linked_GlycosylationSAGGVYETTQHFIDI
CCCCCCCCCCEEEEH		17.6755830767
432PhosphorylationSAGGVYETTQHFIDI
CCCCCCCCCCEEEEH		17.6727251275
433O-linked_GlycosylationAGGVYETTQHFIDIK
CCCCCCCCCEEEEHH		14.2255830773
433PhosphorylationAGGVYETTQHFIDIK
CCCCCCCCCEEEEHH		14.2227251275
440UbiquitinationTQHFIDIKEHLHIVK
CCEEEEHHHHHHHHH		35.02-
447UbiquitinationKEHLHIVKRDIDNLV
HHHHHHHHHHHHHHH		43.69-
4472-HydroxyisobutyrylationKEHLHIVKRDIDNLV
HHHHHHHHHHHHHHH		43.69-
474PhosphorylationPELPPFPSCLSTVHF
CCCCCCCCHHHHHHH		28.2421601212
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LMAN1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LMAN1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LMAN1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FA8_HUMANF8physical
14629470
BAP31_HUMANBCAP31physical
19342655
BAP29_HUMANBCAP29physical
19342655
CALX_HUMANCANXphysical
19342655
1A02_HUMANHLA-Aphysical
19342655
1A03_HUMANHLA-Aphysical
19342655
1A01_HUMANHLA-Aphysical
19342655
1A26_HUMANHLA-Aphysical
19342655
RBGPR_HUMANRAB3GAP2physical
22337587
RB3GP_HUMANRAB3GAP1physical
22337587
HSP7C_HUMANHSPA8physical
22337587
COPA_HUMANCOPAphysical
22337587
TERA_HUMANVCPphysical
22337587
TBB3_HUMANTUBB3physical
22337587
TBB4B_HUMANTUBB4Bphysical
22337587
COPB2_HUMANCOPB2physical
22337587
COPE_HUMANCOPEphysical
22337587
COPB_HUMANCOPB1physical
22337587
DNJC7_HUMANDNAJC7physical
22337587
PDIA1_HUMANP4HBphysical
22337587
A4_HUMANAPPphysical
21832049
YBOX1_HUMANYBX1physical
22939629
TMED2_HUMANTMED2physical
22939629
PIGS_HUMANPIGSphysical
22939629
ALDOA_HUMANALDOAphysical
26344197
ALDOC_HUMANALDOCphysical
26344197
AT1A1_HUMANATP1A1physical
26344197
AT1B1_HUMANATP1B1physical
26344197
AT2A2_HUMANATP2A2physical
26344197
ATPA_HUMANATP5A1physical
26344197
ATPG_HUMANATP5C1physical
26344197
CALX_HUMANCANXphysical
26344197
CY1_HUMANCYC1physical
26344197
EIF3I_HUMANEIF3Iphysical
26344197
LEG1_HUMANLGALS1physical
26344197
MTCH2_HUMANMTCH2physical
26344197
NDUB8_HUMANNDUFB8physical
26344197
PDIA1_HUMANP4HBphysical
26344197
PDCD6_HUMANPDCD6physical
26344197
PHB_HUMANPHBphysical
26344197
PHB2_HUMANPHB2physical
26344197
SSRA_HUMANSSR1physical
26344197
STML2_HUMANSTOML2physical
26344197
TMEDA_HUMANTMED10physical
26344197
TMED4_HUMANTMED4physical
26344197
TMED9_HUMANTMED9physical
26344197
EFTU_HUMANTUFMphysical
26344197
QCR1_HUMANUQCRC1physical
26344197
QCR2_HUMANUQCRC2physical
26344197
QCR8_HUMANUQCRQphysical
26344197
TECT2_HUMANTCTN2physical
27173435
Drug and Disease Associations
Kegg Disease
H00221 Combined deficiency of factors V and VIII (F5F8D)
OMIM Disease
227300Factor V and factor VIII combined deficiency 1 (F5F8D1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LMAN1_HUMAN

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