PIGS_HUMAN - dbPTM
PIGS_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PIGS_HUMAN
UniProt AC Q96S52
Protein Name GPI transamidase component PIG-S
Gene Name PIGS
Organism Homo sapiens (Human).
Sequence Length 555
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates..
Protein Sequence MAAAGAAATHLEVARGKRAALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLRLMVPVTVVFTRESVPLDDQEKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALDHEEEALSSGSVQEAEAMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGIMHREAFNIIGRRIVQVAQAMSLTEDVLAAALADHLPEDKWSAEKRRPLKSSLGYEITFSLLNPDPKSHDVYWDIEGAVRRYVQPFLNALGAAGNFSVDSQILYYAMLGVNPRFDSASSSYYLDMHSLPHVINPVESRLGSSAASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATNAFHSPRWGGIMVYNVDSKTYNASVLPVRVEVDMVRVMEVFLAQLRLLFGIAQPQLPPKCLLSGPTSEGLMTWELDRLLWARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELASGHLASAFVASQEAVTSSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLSLVKIFLETRKSWRKPEKTD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81UbiquitinationVPLDDQEKLPFTVVH
CCCCCCCCCCCEEEE		56.69-
87 (in isoform 2)Ubiquitination-3.3521890473
95 (in isoform 1)Ubiquitination-37.1521890473
95UbiquitinationHEREIPLKYKMKIKC
ECCCCCCCEEEEEEH		37.1521890473
106UbiquitinationKIKCRFQKAYRRALD
EEEHHHHHHHHHHCC		44.68-
194PhosphorylationVQVAQAMSLTEDVLA
HHHHHHHCCCHHHHH		34.8420071362
214PhosphorylationHLPEDKWSAEKRRPL
CCCCCCCCHHHCCCC		32.0824719451
217AcetylationEDKWSAEKRRPLKSS
CCCCCHHHCCCCCCC		54.1230591319
240PhosphorylationLLNPDPKSHDVYWDI
CCCCCCCCCCEEECH		30.2422210691
244PhosphorylationDPKSHDVYWDIEGAV
CCCCCCEEECHHHHH		11.92-
254PhosphorylationIEGAVRRYVQPFLNA
HHHHHHHHHHHHHHH		7.9024043423
267N-linked_GlycosylationNALGAAGNFSVDSQI
HHHCCCCCCCHHHHH		22.69UniProtKB CARBOHYD
269PhosphorylationLGAAGNFSVDSQILY
HCCCCCCCHHHHHHH		29.0824043423
272PhosphorylationAGNFSVDSQILYYAM
CCCCCHHHHHHHHHH		19.5724043423
276PhosphorylationSVDSQILYYAMLGVN
CHHHHHHHHHHHCCC		7.2722210691
277PhosphorylationVDSQILYYAMLGVNP
HHHHHHHHHHHCCCC		5.1024043423
348PhosphorylationKDGAPVATNAFHSPR
CCCCCCCCCCCCCCC		27.5820068231
353PhosphorylationVATNAFHSPRWGGIM
CCCCCCCCCCCCCEE		15.0930243723
370N-linked_GlycosylationNVDSKTYNASVLPVR
ECCCCEEEEEEEEEE		30.85UniProtKB CARBOHYD
372O-linked_GlycosylationDSKTYNASVLPVRVE
CCCEEEEEEEEEEEE		22.1330059200
437PhosphorylationRSVENLATATTTLTS
HCHHHHHHHHHHHHH		27.9226074081
439PhosphorylationVENLATATTTLTSLA
HHHHHHHHHHHHHHH		18.8926074081
440PhosphorylationENLATATTTLTSLAQ
HHHHHHHHHHHHHHH		19.8326074081
441PhosphorylationNLATATTTLTSLAQL
HHHHHHHHHHHHHHH		24.5526074081
443PhosphorylationATATTTLTSLAQLLG
HHHHHHHHHHHHHHH		21.4326074081
444PhosphorylationTATTTLTSLAQLLGK
HHHHHHHHHHHHHHH		25.4826074081
450 (in isoform 2)Ubiquitination-33.5721890473
453PhosphorylationAQLLGKISNIVIKDD
HHHHHHHHCCEECCH		24.8026074081
458UbiquitinationKISNIVIKDDVASEV
HHHCCEECCHHHHHH		36.662190698
458 (in isoform 1)Ubiquitination-36.6621890473
467UbiquitinationDVASEVYKAVAAVQK
HHHHHHHHHHHHHHH		41.37-
536PhosphorylationMAVPILLSLVKIFLE
HHHHHHHHHHHHHHH		27.8924719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PIGS_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PIGS_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PIGS_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PIGU_HUMANPIGUphysical
22939629
PIGT_HUMANPIGTphysical
22939629
VATB1_HUMANATP6V1B1physical
22939629
K1C40_HUMANKRT40physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
FACD2_HUMANFANCD2physical
26496610
PPM1A_HUMANPPM1Aphysical
26496610
SF3A2_HUMANSF3A2physical
26496610
GPAA1_HUMANGPAA1physical
26496610
GPI8_HUMANPIGKphysical
26496610
DNJA2_HUMANDNAJA2physical
26496610
DNJC8_HUMANDNAJC8physical
26496610
SF3B1_HUMANSF3B1physical
26496610
TM131_HUMANTMEM131physical
26496610
PIGT_HUMANPIGTphysical
26496610
MILK2_HUMANMICALL2physical
26496610
YIPF5_HUMANYIPF5physical
26496610
USMG5_HUMANUSMG5physical
26496610
PIGU_HUMANPIGUphysical
26496610
GPHRA_HUMANGPR89Bphysical
27173435
GPHRB_HUMANGPR89Bphysical
27173435
SOAT1_HUMANSOAT1physical
27173435
NDUS1_HUMANNDUFS1physical
27173435
ACAP2_HUMANACAP2physical
27173435
NDUA9_HUMANNDUFA9physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PIGS_HUMAN

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Related Literatures of Post-Translational Modification

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