| UniProt ID | VATB1_HUMAN | |
|---|---|---|
| UniProt AC | P15313 | |
| Protein Name | V-type proton ATPase subunit B, kidney isoform | |
| Gene Name | ATP6V1B1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 513 | |
| Subcellular Localization |
Endomembrane system Peripheral membrane protein. Endomembrane. |
|
| Protein Description | Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.. | |
| Protein Sequence | MAMEIDSRPGGLPGSSCNLGAAREHMQAVTRNYITHPRVTYRTVCSVNGPLVVLDRVKFAQYAEIVHFTLPDGTQRSGQVLEVAGTKAIVQVFEGTSGIDARKTTCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPVVMAEDFLDINGQPINPHSRIYPEEMIQTGISPIDVMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKAVLDYHDDNFAIVFAAMGVNMETARFFKSDFEQNGTMGNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRGGSITQIPILTMPNDDITHPIPDLTGFITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHGDVSNQLYACYAIGKDVQAMKAVVGEEALTSEDLLYLEFLQKFEKNFINQGPYENRSVFESLDLGWKLLRIFPKEMLKRIPQAVIDEFYSREGALQDLAPDTAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | RPGGLPGSSCNLGAA CCCCCCCCCCHHHHH | 29.76 | 28857561 | |
| 16 | Phosphorylation | PGGLPGSSCNLGAAR CCCCCCCCCHHHHHH | 16.97 | 28857561 | |
| 33 | Phosphorylation | MQAVTRNYITHPRVT HHHHHHHHCCCCCEE | 12.14 | 22210691 | |
| 35 | Phosphorylation | AVTRNYITHPRVTYR HHHHHHCCCCCEEEE | 18.57 | 22210691 | |
| 118 | Phosphorylation | DILRTPVSEDMLGRV CCCCCCCCHHHCCHH | 29.14 | - | |
| 121 | Sulfoxidation | RTPVSEDMLGRVFNG CCCCCHHHCCHHCCC | 3.62 | 21406390 | |
| 166 | Phosphorylation | YPEEMIQTGISPIDV CHHHHHHCCCCHHHH | 26.09 | 22210691 | |
| 169 | Phosphorylation | EMIQTGISPIDVMNS HHHHCCCCHHHHHHH | 19.69 | 22210691 | |
| 176 | Phosphorylation | SPIDVMNSIARGQKI CHHHHHHHHHCCCCC | 10.26 | 22210691 | |
| 182 | Ubiquitination | NSIARGQKIPIFSAA HHHHCCCCCCEEECC | 53.96 | - | |
| 262 | Phosphorylation | LNLANDPTIERIITP EECCCCCCHHHHCCH | 38.03 | 22210691 | |
| 268 | Phosphorylation | PTIERIITPRLALTT CCHHHHCCHHHHHHH | 10.45 | 22210691 | |
| 285 | Acetylation | FLAYQCEKHVLVILT HHHHHHHCCEEEEEE | 46.79 | 21466224 | |
| 320 | Phosphorylation | GRRGFPGYMYTDLAT CCCCCCCCHHCHHHH | 6.28 | 21406692 | |
| 322 | Phosphorylation | RGFPGYMYTDLATIY CCCCCCHHCHHHHHH | 6.66 | 21406692 | |
| 323 | Phosphorylation | GFPGYMYTDLATIYE CCCCCHHCHHHHHHH | 14.17 | 21406692 | |
| 327 | Phosphorylation | YMYTDLATIYERAGR CHHCHHHHHHHHCCC | 31.24 | 21406692 | |
| 329 | Phosphorylation | YTDLATIYERAGRVE HCHHHHHHHHCCCCC | 8.60 | 21406692 | |
| 383 | Phosphorylation | QLHNRQIYPPINVLP CCCCCCCCCCHHHHH | 8.46 | 20068231 | |
| 391 | Phosphorylation | PPINVLPSLSRLMKS CCHHHHHHHHHHHHH | 34.51 | 20068231 | |
| 393 | Phosphorylation | INVLPSLSRLMKSAI HHHHHHHHHHHHHHH | 27.92 | 20068231 | |
| 397 | Ubiquitination | PSLSRLMKSAIGEGM HHHHHHHHHHHCCCC | 41.13 | 27667366 | |
| 398 | Phosphorylation | SLSRLMKSAIGEGMT HHHHHHHHHHCCCCC | 15.91 | 21082442 | |
| 437 | Ubiquitination | KAVVGEEALTSEDLL HHHHCCCCCCHHHHH | 16.31 | 27667366 | |
| 466 | Phosphorylation | QGPYENRSVFESLDL CCCCCCCHHHHHCCH | 42.62 | 20071362 | |
| 487 | Ubiquitination | IFPKEMLKRIPQAVI HCCHHHHHHCCHHHH | 47.15 | 24816145 | |
| 498 | Phosphorylation | QAVIDEFYSREGALQ HHHHHHHHCCCCHHH | 12.55 | - | |
| 527 | Ubiquitination | --------------------- --------------------- | 24816145 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VATB1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VATB1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VATB1_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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