VA0D2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VA0D2_HUMAN
• UniProt AC: Q8N8Y2
• Protein Name: V-type proton ATPase subunit d 2
• Gene Name: ATP6V0D2
• Organism: Homo sapiens (Human).
• Sequence Length: 350
• Protein Description: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity)..
• Protein Sequence: MLEGAELYFNVDHGYLEGLVRGCKASLLTQQDYINLVQCETLEDLKIHLQTTDYGNFLANHTNPLTVSKIDTEMRKRLCGEFEYFRNHSLEPLSTFLTYMTCSYMIDNVILLMNGALQKKSVKEILGKCHPLGRFTEMEAVNIAETPSDLFNAILIETPLAPFFQDCMSENALDELNIELLRNKLYKSYLEAFYKFCKNHGDVTAEVMCPILEFEADRRAFIITLNSFGTELSKEDRETLYPTFGKLYPEGLRLLAQAEDFDQMKNVADHYGVYKPLFEAVGGSGGKTLEDVFYEREVQMNVLAFNRQFHYGVFYAYVKLKEQEIRNIVWIAECISQRHRTKINSYIPIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	LTVSKIDTEMRKRLC CCHHCCCHHHHHHHH	34.84	26270265
189	Phosphorylation	RNKLYKSYLEAFYKF HHHHHHHHHHHHHHH	12.38	-
265	Acetylation	AEDFDQMKNVADHYG CCCHHHHHHHHHHHC	42.51	7668745
341	Phosphorylation	CISQRHRTKINSYIP HHHHHHHHHHHHCCC	30.10	24114839
346	Phosphorylation	HRTKINSYIPIL--- HHHHHHHCCCCC---	13.26	24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VA0D2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VA0D2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VA0D2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADRM1_HUMAN	ADRM1	physical	19818731
AGO3_HUMAN	AGO3	physical	21988832
NDUB8_HUMAN	NDUFB8	physical	21988832
RS3_HUMAN	RPS3	physical	21988832
RB15B_HUMAN	RBM15B	physical	21988832
VMA21_HUMAN	VMA21	physical	28514442
TM199_HUMAN	TMEM199	physical	28514442
VPP3_HUMAN	TCIRG1	physical	28514442
CC115_HUMAN	CCDC115	physical	28514442
VPP1_HUMAN	ATP6V0A1	physical	28514442
VATL_HUMAN	ATP6V0C	physical	28514442
FKB15_HUMAN	FKBP15	physical	28514442
K2013_HUMAN	KIAA2013	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.