CC115_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CC115_HUMAN
• UniProt AC: Q96NT0
• Protein Name: Coiled-coil domain-containing protein 115 {ECO:0000303|PubMed:26833332}
• Gene Name: CCDC115 {ECO:0000303|PubMed:26833332, ECO:0000312|HGNC:HGNC:28178}
• Organism: Homo sapiens (Human).
• Sequence Length: 180
• Subcellular Localization: Endosome . Lysosome . Endoplasmic reticulum-Golgi intermediate compartment . Cytoplasmic vesicle, COPI-coated vesicle . Endoplasmic reticulum .
• Protein Description: Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. [PubMed: 28296633 May be involved in Golgi homeostasis]
• Protein Sequence: MAALDLRAELDSLVLQLLGDLEELEGKRTVLNARVEEGWLSLAKARYAMGAKSVGPLQYASHMEPQVCLHASEAQEGLQKFKVVRAGVHAPEEVGPREAGLRRRKGPTKTPEPESSEAPQDPLNWFGILVPHSLRQAQASFRDGLQLAADIASLQNRIDWGRSQLRGLQEKLKQLEPGAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36 (in isoform 2)	Phosphorylation	-	45.28	29083192
44	Ubiquitination	EGWLSLAKARYAMGA HHHHHHHHHHHHCCC	38.39	21890473
44	Ubiquitination	EGWLSLAKARYAMGA HHHHHHHHHHHHCCC	38.39	21890473
47	Phosphorylation	LSLAKARYAMGAKSV HHHHHHHHHCCCCCC	13.05	28102081
108	Phosphorylation	LRRRKGPTKTPEPES CCCCCCCCCCCCCCC	57.10	28450419
110	Phosphorylation	RRKGPTKTPEPESSE CCCCCCCCCCCCCCC	35.05	28450419
115	Phosphorylation	TKTPEPESSEAPQDP CCCCCCCCCCCCCCC	44.16	24173317
116	Phosphorylation	KTPEPESSEAPQDPL CCCCCCCCCCCCCCC	35.79	28450419
140	Phosphorylation	SLRQAQASFRDGLQL HHHHHHHHHHHHHHH	14.56	27251275
173	Ubiquitination	RGLQEKLKQLEPGAA HHHHHHHHHHCCCCC	65.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CC115_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CC115_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CC115_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.