K2013_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2013_HUMAN
• UniProt AC: Q8IYS2
• Protein Name: Uncharacterized protein KIAA2013
• Gene Name: KIAA2013
• Organism: Homo sapiens (Human).
• Sequence Length: 634
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MWLQQRLKGLPGLLSSSWARRLLCLLGLLLLLLWFGGSGARRAAGGLHLLPWSRGEPGAAEPSACLEAATRAWRGLRERGEVVPLGPGVPALVANGFLALDVAANRLWVTPGEREPAVAPDFVPFVQLRPLSALAEAGEAVLLLREGLLRRVRCLQLGSPGPGPVAAGPGPASVSGLAAGSGRDCVLLQEDFLAHRGRPHVYLQRIQLNNPTERVAALQTVGPTAGPAPKAFTSTLEKVGDHQFLLYSGRSPPTPTGLVHLVVVAAKKLVNRLQVAPKTQLDETVLWVVHVSGPINPQVLKSKAAKELKALQDLARKEMLELLDMPAAELLQDHQLLWAQLFSPGVEMKKITDTHTPSGLTVNLTLYYMLSCSPAPLLSPSLSHRERDQMESTLNYEDHCFSGHATMHAENLWPGRLSSVQQILQLSDLWRLTLQKRGCKGLVKVGAPGILQGMVLSFGGLQFTENHLQFQADPDVLHNSYALHGIRYKNDHINLAVLADAEGKPYLHVSVESRGQPVKIYACKAGCLDEPVELTSAPTGHTFSVMVTQPITPLLYISTDLTHLQDLRHTLHLKAILAHDEHMAQQDPGLPFLFWFSVASLITLFHLFLFKLIYNEYCGPGAKPLFRSKEDPSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	O-linked_Glycosylation	GLHLLPWSRGEPGAA CCCCEECCCCCCCCC	28.59	OGP
159	Phosphorylation	VRCLQLGSPGPGPVA HHHHCCCCCCCCCCC	34.96	-
173	O-linked_Glycosylation	AAGPGPASVSGLAAG CCCCCCCCCCHHHCC	21.68	OGP
224	O-linked_Glycosylation	ALQTVGPTAGPAPKA EECCCCCCCCCCCCH	38.01	55827579
230 (in isoform 2)	Ubiquitination	-	59.23	21906983
230 (in isoform 1)	Ubiquitination	-	59.23	21906983
230	Ubiquitination	PTAGPAPKAFTSTLE CCCCCCCCHHHHHHH	59.23	2190698
233	O-linked_Glycosylation	GPAPKAFTSTLEKVG CCCCCHHHHHHHHHC	26.17	OGP
363	N-linked_Glycosylation	TPSGLTVNLTLYYML CCCCCEEEEEEEEHH	23.28	UniProtKB CARBOHYD
373	O-linked_Glycosylation	LYYMLSCSPAPLLSP EEEHHHCCCCCCCCC	22.26	OGP
381	Phosphorylation	PAPLLSPSLSHRERD CCCCCCCCCCHHHHH	38.84	-
519	Ubiquitination	ESRGQPVKIYACKAG ECCCCEEEEEEEECC	36.36	-
519 (in isoform 2)	Ubiquitination	-	36.36	-
548	O-linked_Glycosylation	HTFSVMVTQPITPLL CEEEEEEECCCCCEE	15.55	OGP
629	Ubiquitination	AKPLFRSKEDPSV-- CCCCCCCCCCCCC--	62.98	33845483
646 (in isoform 2)	Phosphorylation	-		30266825
649 (in isoform 2)	Phosphorylation	-		26270265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2013_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2013_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2013_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VMA21_HUMAN	VMA21	physical	28514442
TM199_HUMAN	TMEM199	physical	28514442
CC115_HUMAN	CCDC115	physical	28514442
VPP1_HUMAN	ATP6V0A1	physical	28514442
VATL_HUMAN	ATP6V0C	physical	28514442
VAS1_HUMAN	ATP6AP1	physical	28514442
BI1_HUMAN	TMBIM6	physical	28514442
VATF_HUMAN	ATP6V1F	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
AMGO1_HUMAN	AMIGO1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.