BI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BI1_HUMAN
• UniProt AC: P55061
• Protein Name: Bax inhibitor 1
• Gene Name: TMBIM6
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Suppressor of apoptosis. [PubMed: 21075086 Modulates unfolded protein response signaling]
• Protein Sequence: MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MNIFDRKINFDALL -CCCHHCCCCHHHHH	43.79	18781797
15	Ubiquitination	INFDALLKFSHITPS CCHHHHHHHCCCCHH	45.75	21906983
28	2-Hydroxyisobutyrylation	PSTQQHLKKVYASFA HHHHHHHHHHHHHHH	37.76	-
28	Ubiquitination	PSTQQHLKKVYASFA HHHHHHHHHHHHHHH	37.76	21906983
65	Ubiquitination	LLSALGSLILMIWLM HHHHHHHHHHHHHHH	3.11	-
73	Ubiquitination	ILMIWLMATPHSHET HHHHHHHHCCCCCHH	18.79	-
86	Ubiquitination	ETEQKRLGLLAGFAF HHHHHHHHHHHHHHH	23.76	-
87	Ubiquitination	TEQKRLGLLAGFAFL HHHHHHHHHHHHHHH	3.33	-
230	Ubiquitination	MILAMNEKDKKKEKK HHHHHCHHHHHHHCC	70.60	21906983
288	Ubiquitination	---------------------------------------------------------- ----------------------------------------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	BFAR	Q9NZS9	PMID:21068390

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCL2_HUMAN	BCL2	physical	9660918
BFAR_HUMAN	BFAR	physical	21068390
VTI1A_HUMAN	VTI1A	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Ubiquitylation

"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry.";
Meierhofer D., Wang X., Huang L., Kaiser P.;
J. Proteome Res. 7:4566-4576(2008).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-7, AND MASS SPECTROMETRY.
PubMed: 18781797