BFAR_HUMAN - dbPTM
BFAR_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BFAR_HUMAN
UniProt AC Q9NZS9
Protein Name Bifunctional apoptosis regulator
Gene Name BFAR
Organism Homo sapiens (Human).
Sequence Length 450
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein .
Protein Description Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors..
Protein Sequence MEEPQKSYVNTMDLERDEPLKSTGPQISVSEFSCHCCYDILVNPTTLNCGHSFCRHCLALWWASSKKTECPECREKWEGFPKVSILLRDAIEKLFPDAIRLRFEDIQQNNDIVQSLAAFQKYGNDQIPLAPNTGRANQQMGGGFFSGVLTALTGVAVVLLVYHWSSRESEHDLLVHKAVAKWTAEEVVLWLEQLGPWASLYRERFLSERVNGRLLLTLTEEEFSKTPYTIENSSHRRAILMELERVKALGVKPPQNLWEYKAVNPGRSLFLLYALKSSPRLSLLYLYLFDYTDTFLPFIHTICPLQEDSSGEDIVTKLLDLKEPTWKQWREFLVKYSFLPYQLIAEFAWDWLEVHYWTSRFLIINAMLLSVLELFSFWRIWSRSELKTVPQRMWSHFWKVSTQGLFVAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKELRRLETQVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMEEPQKSYVNTMDLE
CCCCCCHHCCCCCCC		12.5422817900
68PhosphorylationWWASSKKTECPECRE
HHHHCCCCCCHHHHH		46.7028509920
76UbiquitinationECPECREKWEGFPKV
CCHHHHHHCCCCCHH		31.06-
82UbiquitinationEKWEGFPKVSILLRD
HHCCCCCHHHHHHHH		46.4821890473
84PhosphorylationWEGFPKVSILLRDAI
CCCCCHHHHHHHHHH		17.4122210691
93UbiquitinationLLRDAIEKLFPDAIR
HHHHHHHHHCCHHHH		49.68-
97UbiquitinationAIEKLFPDAIRLRFE
HHHHHCCHHHHHHHH		47.4921890473
119UbiquitinationIVQSLAAFQKYGNDQ
HHHHHHHHHHHCCCC		5.5321890473
121UbiquitinationQSLAAFQKYGNDQIP
HHHHHHHHHCCCCCC		48.9821906983
124UbiquitinationAAFQKYGNDQIPLAP
HHHHHHCCCCCCCCC		34.6221890473
133UbiquitinationQIPLAPNTGRANQQM
CCCCCCCCCCCCCCC		27.3021890473
177UbiquitinationEHDLLVHKAVAKWTA
HHHHHHHHHHHHCCH		36.76-
194UbiquitinationVVLWLEQLGPWASLY
HHHHHHHHHHHHHHH		6.9421890473
199UbiquitinationEQLGPWASLYRERFL
HHHHHHHHHHHHHHH		23.2821890473
225UbiquitinationLTEEEFSKTPYTIEN
EEHHHHCCCCCCCCC		59.8621890473
232N-linked_GlycosylationKTPYTIENSSHRRAI
CCCCCCCCCHHHHHH		44.99UniProtKB CARBOHYD
247UbiquitinationLMELERVKALGVKPP
HHHHHHHHHCCCCCC		44.0821890473
252UbiquitinationRVKALGVKPPQNLWE
HHHHCCCCCCCCHHE		49.5421890473
259UbiquitinationKPPQNLWEYKAVNPG
CCCCCHHEEEECCCC		40.08-
261UbiquitinationPQNLWEYKAVNPGRS
CCCHHEEEECCCCCH		34.0521890473
322UbiquitinationVTKLLDLKEPTWKQW
HHHHHCCCCCCHHHH		62.4021890473
327UbiquitinationDLKEPTWKQWREFLV
CCCCCCHHHHHHHHH		42.3221890473
376PhosphorylationLSVLELFSFWRIWSR
HHHHHHHHHHHHHCH		36.2022817900
387UbiquitinationIWSRSELKTVPQRMW
HHCHHHHCCCCHHHH		43.342190698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BFAR_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BFAR_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BFAR_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBC_HUMANUBCphysical
21068390
BI1_HUMANTMBIM6physical
21068390
UB2G2_MOUSEUbe2g2physical
21068390
BCL2_HUMANBCL2physical
10716992
B2CL1_HUMANBCL2L1physical
10716992
CASP8_HUMANCASP8physical
10716992
CASPA_HUMANCASP10physical
10716992
UB2D2_HUMANUBE2D2physical
21068390
TNR16_HUMANNGFRphysical
22566094
UB2D3_HUMANUBE2D3physical
21068390
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BFAR_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-376, AND MASSSPECTROMETRY.

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