TNR16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR16_HUMAN
• UniProt AC: P08138
• Protein Name: Tumor necrosis factor receptor superfamily member 16
• Gene Name: NGFR
• Organism: Homo sapiens (Human).
• Sequence Length: 427
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver..
• Protein Sequence: MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSESTATSPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	N-linked_Glycosylation	VAQPCGANQTVCEPC CCCCCCCCCCCCCCC	24.28	UniProtKB CARBOHYD
238	O-linked_Glycosylation	VVTTVMGSSQPVVTR HHHHCCCCCCCEEEC	14.01	OGP
277	Phosphorylation	IAFKRWNSCKQNKQG HHHHHHHHHHCCCCC	18.74	19710323
287	Phosphorylation	QNKQGANSRPVNQTP CCCCCCCCCCCCCCC	37.11	23312004
293	Phosphorylation	NSRPVNQTPPPEGEK CCCCCCCCCCCCCCC	32.34	26657352
303	Phosphorylation	PEGEKLHSDSGISVD CCCCCCCCCCCCCCC	43.86	22817900
305	Phosphorylation	GEKLHSDSGISVDSQ CCCCCCCCCCCCCCC	40.83	25850435
308	Phosphorylation	LHSDSGISVDSQSLH CCCCCCCCCCCCCCC	24.32	25850435
311	Phosphorylation	DSGISVDSQSLHDQQ CCCCCCCCCCCCCCC	21.36	29255136
313	Phosphorylation	GISVDSQSLHDQQPH CCCCCCCCCCCCCCC	31.46	29255136
321	Phosphorylation	LHDQQPHTQTASGQA CCCCCCCCCCCCCCC	34.01	25850435
323	Phosphorylation	DQQPHTQTASGQALK CCCCCCCCCCCCCCC	24.77	25850435
325	Phosphorylation	QPHTQTASGQALKGD CCCCCCCCCCCCCCC	34.52	30242111
336	Phosphorylation	LKGDGGLYSSLPPAK CCCCCCCCCCCCHHH	10.25	22817900
343	Ubiquitination	YSSLPPAKREEVEKL CCCCCHHHHHHHHHH	67.14	32142685
354	Phosphorylation	VEKLLNGSAGDTWRH HHHHHCCCCHHHHHH	28.18	25850435
358	Phosphorylation	LNGSAGDTWRHLAGE HCCCCHHHHHHHHHH	24.39	25850435
421	Phosphorylation	VESLCSESTATSPV- HHHHHCCCCCCCCC-	13.67	27251275
422	Phosphorylation	ESLCSESTATSPV-- HHHHCCCCCCCCC--	29.87	27251275
424	Phosphorylation	LCSESTATSPV---- HHCCCCCCCCC----	33.38	27251275
425	Phosphorylation	CSESTATSPV----- HCCCCCCCCC-----	22.62	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
277	S	Phosphorylation	Kinase	PRKCG	P05129	GPS
303	S	Phosphorylation	Kinase	PRKACB	P22694	GPS
303	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
303	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
-	K	Ubiquitination	E3 ubiquitin ligase	CBL	P22681	PMID:15337528
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF6	Q9Y4K3	PMID:16252010

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAPCB_HUMAN	PRKACB	physical	12682012
NSE3_HUMAN	NDNL2	physical	14593116
NECD_HUMAN	NDN	physical	14593116
FSCN1_HUMAN	FSCN1	physical	12789270
MAGD1_HUMAN	MAGED1	physical	12716928
NECD_HUMAN	NDN	physical	12716928
TRADD_HUMAN	TRADD	physical	12604596
NECD_HUMAN	NDN	physical	12414813
MAGH1_HUMAN	MAGEH1	physical	12414813
CAV1_HUMAN	CAV1	physical	9867838
BEX3_HUMAN	NGFRAP1	physical	10764727
TRAF1_HUMAN	TRAF1	physical	10514511
TRAF3_HUMAN	TRAF3	physical	10514511
TRAF4_HUMAN	TRAF4	physical	10514511
TRAF5_HUMAN	TRAF5	physical	10514511
TRAF6_HUMAN	TRAF6	physical	10514511
TRAF2_HUMAN	TRAF2	physical	10514511
TRAF4_HUMAN	TRAF4	physical	9626059
TRI37_HUMAN	TRIM37	physical	11279055
TRAF6_HUMAN	TRAF6	physical	14960584
TNR16_HUMAN	NGFR	physical	14960584
BEX3_HUMAN	NGFRAP1	physical	17355907
BFAR_HUMAN	BFAR	physical	22566094
TRAF6_HUMAN	TRAF6	physical	23017601
SQSTM_HUMAN	SQSTM1	physical	23017601
IKKB_HUMAN	IKBKB	physical	23017601
MDM2_HUMAN	MDM2	physical	27282385
P53_HUMAN	TP53	physical	27282385

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.