| UniProt ID | NECD_HUMAN | |
|---|---|---|
| UniProt AC | Q99608 | |
| Protein Name | Necdin | |
| Gene Name | NDN | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 321 | |
| Subcellular Localization | Perikaryon. Nucleus. Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix. | |
| Protein Description | Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).. | |
| Protein Sequence | MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSPPLGPTAAPQAAPPPQAPNDEGDPKALQQAAEEGRAHQAPSAAQPGPAPPAPAQLVQKAHELMWYVLVKDQKKMIIWFPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSLHTMEFALVKALEPEELDRVALSNRMPMTGLLLMILSLIYVKGRGARESAVWNVLRILGLRPWKKHSTFGDVRKLITEEFVQMNYLKYQRVPYVEPPEYEFFWGSRASREITKMQIMEFLARVFKKDPQAWPSRYREALEEARALREANPTAHYPRSSVSED | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 116 | Acetylation | VLVKDQKKMIIWFPD EEECCCCEEEEECHH | 29.69 | 12436801 | |
| 126 | Acetylation | IWFPDMVKDVIGSYK EECHHHHHHHHHHHH | 39.37 | 12436811 | |
| 132 | Phosphorylation | VKDVIGSYKKWCRSI HHHHHHHHHHHHHHH | 16.04 | 25884760 | |
| 159 | Phosphorylation | GLHLRLTSLHTMEFA CHHHHHHHHCHHHHH | 23.81 | 26852163 | |
| 162 | Phosphorylation | LRLTSLHTMEFALVK HHHHHHCHHHHHHHH | 24.56 | 26852163 | |
| 188 | Phosphorylation | LSNRMPMTGLLLMIL HHCCCCHHHHHHHHH | 20.86 | - | |
| 196 | Phosphorylation | GLLLMILSLIYVKGR HHHHHHHHHHHHCCC | 11.20 | 22210691 | |
| 199 | Phosphorylation | LMILSLIYVKGRGAR HHHHHHHHHCCCCHH | 11.03 | 22210691 | |
| 223 | Ubiquitination | ILGLRPWKKHSTFGD HHCCCCCCCCCCHHH | 43.20 | 21890473 | |
| 252 | Phosphorylation | LKYQRVPYVEPPEYE CCCCCCCCCCCCCCC | 18.00 | 29759185 | |
| 272 | Ubiquitination | RASREITKMQIMEFL CCCHHHHHHHHHHHH | 34.17 | - | |
| 285 | Ubiquitination | FLARVFKKDPQAWPS HHHHHHHHCCCCCHH | 64.28 | - | |
| 313 | Phosphorylation | EANPTAHYPRSSVSE HHCCCCCCCCCCCCC | 9.62 | 28111955 | |
| 316 | Phosphorylation | PTAHYPRSSVSED-- CCCCCCCCCCCCC-- | 30.50 | 26699800 | |
| 317 | Phosphorylation | TAHYPRSSVSED--- CCCCCCCCCCCC--- | 30.83 | 26699800 | |
| 319 | Phosphorylation | HYPRSSVSED----- CCCCCCCCCC----- | 37.69 | 26699800 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NECD_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NECD_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NECD_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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