LAX1_HUMAN - dbPTM
LAX1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAX1_HUMAN
UniProt AC Q8IWV1
Protein Name Lymphocyte transmembrane adapter 1
Gene Name LAX1
Organism Homo sapiens (Human).
Sequence Length 398
Subcellular Localization Cell membrane
Single-pass type III membrane protein .
Protein Description Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells..
Protein Sequence MDGVTPTLSTIRGRTLESSTLHVTPRSLDRNKDQITNIFSGFAGLLAILLVVAVFCILWNWNKRKKRQVPYLRVTVMPLLTLPQTRQRAKNIYDILPWRQEDLGRHESRSMRIFSTESLLSRNSESPEHVPSQAGNAFQEHTAHIHATEYAVGIYDNAMVPQMCGNLTPSAHCINVRASRDCASISSEDSHDYVNVPTAEEIAETLASTKSPSRNLFVLPSTQKLEFTEERDEGCGDAGDCTSLYSPGAEDSDSLSNGEGSSQISNDYVNMTGLDLSAIQERQLWVAFQCCRDYENVPAADPSGSQQQAEKDVPSSNIGHVEDKTDDPGTHVQCVKRTFLASGDYADFQPFTQSEDSQMKHREEMSNEDSSDYENVLTAKLGGRDSEQGPGTQLLPDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MDGVTPTLSTIR
---CCCCCCCHHHHC		18.9826503514
7Phosphorylation-MDGVTPTLSTIRGR
-CCCCCCCHHHHCCE		24.7923909892
10PhosphorylationGVTPTLSTIRGRTLE
CCCCCHHHHCCEECC		20.1526503514
14UbiquitinationTLSTIRGRTLESSTL
CHHHHCCEECCCCEE		26.7022505724
15PhosphorylationLSTIRGRTLESSTLH
HHHHCCEECCCCEEE		37.39-
15O-linked_GlycosylationLSTIRGRTLESSTLH
HHHHCCEECCCCEEE		37.39OGP
18O-linked_GlycosylationIRGRTLESSTLHVTP
HCCEECCCCEEECCC		31.56OGP
19O-linked_GlycosylationRGRTLESSTLHVTPR
CCEECCCCEEECCCH		26.13OGP
20O-linked_GlycosylationGRTLESSTLHVTPRS
CEECCCCEEECCCHH		30.11OGP
24O-linked_GlycosylationESSTLHVTPRSLDRN
CCCEEECCCHHHCCC		11.39OGP
71PhosphorylationRKKRQVPYLRVTVMP
HCCCCCCCEEEEEEH		14.3229083192
74UbiquitinationRQVPYLRVTVMPLLT
CCCCCEEEEEEHHHC		4.3422505724
75PhosphorylationQVPYLRVTVMPLLTL
CCCCEEEEEEHHHCC		12.4929083192
90UbiquitinationPQTRQRAKNIYDILP
HHHHHHHHHHHHHCC		46.1722505724
93PhosphorylationRQRAKNIYDILPWRQ
HHHHHHHHHHCCCHH		13.3128796482
108PhosphorylationEDLGRHESRSMRIFS
HHCCCCCCCHHHEEC		24.4327251275
112MethylationRHESRSMRIFSTESL
CCCCCHHHEECHHHH		28.2224395737
115PhosphorylationSRSMRIFSTESLLSR
CCHHHEECHHHHHHC		28.9726657352
116PhosphorylationRSMRIFSTESLLSRN
CHHHEECHHHHHHCC		20.8830108239
118PhosphorylationMRIFSTESLLSRNSE
HHEECHHHHHHCCCC		34.4030108239
121PhosphorylationFSTESLLSRNSESPE
ECHHHHHHCCCCCCC		34.4130108239
184PhosphorylationRASRDCASISSEDSH
EECCCCCCCCCCCCC		29.3626657352
186PhosphorylationSRDCASISSEDSHDY
CCCCCCCCCCCCCCC		25.7727251275
187PhosphorylationRDCASISSEDSHDYV
CCCCCCCCCCCCCCC		43.6927251275
190PhosphorylationASISSEDSHDYVNVP
CCCCCCCCCCCCCCC		17.7626657352
193PhosphorylationSSEDSHDYVNVPTAE
CCCCCCCCCCCCCHH		6.6212359715
205PhosphorylationTAEEIAETLASTKSP
CHHHHHHHHHCCCCC		20.7126074081
208PhosphorylationEIAETLASTKSPSRN
HHHHHHHCCCCCCCC		39.2126074081
209PhosphorylationIAETLASTKSPSRNL
HHHHHHCCCCCCCCE		29.9026074081
211PhosphorylationETLASTKSPSRNLFV
HHHHCCCCCCCCEEE		28.3526074081
213PhosphorylationLASTKSPSRNLFVLP
HHCCCCCCCCEEEEC		40.6726074081
221PhosphorylationRNLFVLPSTQKLEFT
CCEEEECCCCEEEEE		39.0327251275
222PhosphorylationNLFVLPSTQKLEFTE
CEEEECCCCEEEEEC		27.9927251275
260UbiquitinationDSLSNGEGSSQISND
CCCCCCCCCCCCCCC		33.7129967540
268PhosphorylationSSQISNDYVNMTGLD
CCCCCCCCCCCCCCC		9.6612359715
294PhosphorylationAFQCCRDYENVPAAD
HHHHHCCCCCCCCCC		7.0528796482
320UbiquitinationVPSSNIGHVEDKTDD
CCCCCCCCCEECCCC		18.9229967540
336UbiquitinationGTHVQCVKRTFLASG
CCEEEEEEEEEECCC		54.0429967540
338PhosphorylationHVQCVKRTFLASGDY
EEEEEEEEEECCCCC		19.7928348404
342PhosphorylationVKRTFLASGDYADFQ
EEEEEECCCCCCCCC		34.0528348404
345PhosphorylationTFLASGDYADFQPFT
EEECCCCCCCCCCCC		16.1729978859
352PhosphorylationYADFQPFTQSEDSQM
CCCCCCCCCCHHHHH		37.5629978859
370PhosphorylationEEMSNEDSSDYENVL
HHHCCCCCCHHHHHH		20.9430108239
371PhosphorylationEMSNEDSSDYENVLT
HHCCCCCCHHHHHHH		57.4430108239
373PhosphorylationSNEDSSDYENVLTAK
CCCCCCHHHHHHHHC		16.0219605366
378PhosphorylationSDYENVLTAKLGGRD
CHHHHHHHHCCCCCC		19.9130108239
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
193YPhosphorylationKinaseSYKP43405
PSP
193YPhosphorylationKinaseLCKP06239
PSP
268YPhosphorylationKinaseSYKP43405
PSP
268YPhosphorylationKinaseLCKP06239
PSP
294YPhosphorylationKinaseSYKP43405
PSP
294YPhosphorylationKinaseLCKP06239
PSP
373YPhosphorylationKinaseSYKP43405
PSP
373YPhosphorylationKinaseLCKP06239
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAX1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAX1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
STALP_HUMANSTAMBPL1physical
25416956
CREB1_HUMANCREB1physical
26186194
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAX1_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-345 AND TYR-373, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory