dbPTM

CREB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CREB1_HUMAN
UniProt AC	P16220
Protein Name	Cyclic AMP-responsive element-binding protein 1
Gene Name	CREB1
Organism	Homo sapiens (Human).
Sequence Length	341
Subcellular Localization	Nucleus .
Protein Description	Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells..
Protein Sequence	MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	O-linked_Glycosylation	IATLAQVSMPAAHAT HEHHEEECCCCCCCC	13.63	30169966
47	O-linked_Glycosylation	SMPAAHATSSAPTVT CCCCCCCCCCCCEEE	17.22	30169966
48	O-linked_Glycosylation	MPAAHATSSAPTVTL CCCCCCCCCCCEEEE	25.86	30169966
49	O-linked_Glycosylation	PAAHATSSAPTVTLV CCCCCCCCCCEEEEE	33.63	30169966
52	O-linked_Glycosylation	HATSSAPTVTLVQLP CCCCCCCEEEEEECC	26.32	30169966
54	O-linked_Glycosylation	TSSAPTVTLVQLPNG CCCCCEEEEEECCCC	24.56	30169966
91	Acetylation	QTVQSSCKDLKRLFS HHHHHHHHHHHHHHC	68.96	12595525
94	Acetylation	QSSCKDLKRLFSGTQ HHHHHHHHHHHCCCE	58.13	12595525
97 (in isoform 2)	Phosphorylation	-	8.01	-
98	Phosphorylation	KDLKRLFSGTQISTI HHHHHHHCCCEEEEE	45.59	30108239
100	Phosphorylation	LKRLFSGTQISTIAE HHHHHCCCEEEEEEC	22.87	15073328
103	Phosphorylation	LFSGTQISTIAESED HHCCCEEEEEECCCC	12.16	30576142
104	Phosphorylation	FSGTQISTIAESEDS HCCCEEEEEECCCCC	26.32	28450419
107 (in isoform 2)	Phosphorylation	-	51.30	-
108	Phosphorylation	QISTIAESEDSQESV EEEEEECCCCCHHHH	37.37	22617229
111	Phosphorylation	TIAESEDSQESVDSV EEECCCCCHHHHHCC	31.62	17525332
114	Phosphorylation	ESEDSQESVDSVTDS CCCCCHHHHHCCCHH	24.48	22617229
115 (in isoform 2)	Phosphorylation	-	6.64	-
117	Phosphorylation	DSQESVDSVTDSQKR CCHHHHHCCCHHHHH	25.43	28450419
119 (in isoform 2)	Phosphorylation	-	33.61	-
119	Phosphorylation	QESVDSVTDSQKRRE HHHHHCCCHHHHHHH	33.61	17525332
121	Phosphorylation	SVDSVTDSQKRREIL HHHCCCHHHHHHHHH	28.38	17426037
122 (in isoform 2)	Ubiquitination	-	46.19	21890473
128 (in isoform 2)	Phosphorylation	-	2.53	-
128	Phosphorylation	SQKRREILSRRPSYR HHHHHHHHHCCHHHH	2.53	23186163
129	Phosphorylation	QKRREILSRRPSYRK HHHHHHHHCCHHHHH	31.72	7798217
133	Phosphorylation	EILSRRPSYRKILND HHHHCCHHHHHHHHH	35.44	22322096
134	Phosphorylation	ILSRRPSYRKILNDL HHHCCHHHHHHHHHH	20.71	26074081
136	Ubiquitination	SRRPSYRKILNDLSS HCCHHHHHHHHHHCC	43.22	21890473
136	Sumoylation	SRRPSYRKILNDLSS HCCHHHHHHHHHHCC	43.22	28112733
136 (in isoform 1)	Ubiquitination	-	43.22	21890473
136	Ubiquitination	SRRPSYRKILNDLSS HCCHHHHHHHHHHCC	43.22	21890473
136	Acetylation	SRRPSYRKILNDLSS HCCHHHHHHHHHHCC	43.22	12595525
142	Phosphorylation	RKILNDLSSDAPGVP HHHHHHHCCCCCCCC	29.09	29255136
143	Phosphorylation	KILNDLSSDAPGVPR HHHHHHCCCCCCCCC	45.12	30266825
156	Phosphorylation	PRIEEEKSEEETSAP CCCCHHCCCCCCCCC	54.22	8552098
186 (in isoform 1)	O-linked_Glycosylation	-	16.49	30169966
219	Ubiquitination	AAATQPGTTILQYAQ CCCCCCCCEEEEEEE	19.83	21890473
227 (in isoform 1)	O-linked_Glycosylation	-	20.77	30169966
228 (in isoform 1)	O-linked_Glycosylation	-	26.50	30169966
237 (in isoform 1)	O-linked_Glycosylation	-	32.20	30169966
251 (in isoform 1)	O-linked_Glycosylation	-	19.76	30169966
251	Phosphorylation	AASGDVQTYQIRTAP ECCCCCEEEEEEECC	19.76	26074081
252	Phosphorylation	ASGDVQTYQIRTAPT CCCCCEEEEEEECCC	5.71	26074081
256	Phosphorylation	VQTYQIRTAPTSTIA CEEEEEEECCCCCCC	38.32	23403867
256 (in isoform 2)	Phosphorylation	-	38.32	-
257	Phosphorylation	QTYQIRTAPTSTIAP EEEEEEECCCCCCCC	8.77	20573984
259	Phosphorylation	YQIRTAPTSTIAPGV EEEEECCCCCCCCCE	35.72	30243723
260	Phosphorylation	QIRTAPTSTIAPGVV EEEECCCCCCCCCEE	19.43	30243723
261	Phosphorylation	IRTAPTSTIAPGVVM EEECCCCCCCCCEEE	24.52	25072903
268	Sulfoxidation	TIAPGVVMASSPALP CCCCCEEEECCCCCC	2.52	21406390
270	Phosphorylation	APGVVMASSPALPTQ CCCEEEECCCCCCCC	20.82	23401153
271	Phosphorylation	PGVVMASSPALPTQP CCEEEECCCCCCCCC	12.49	30278072
276	Phosphorylation	ASSPALPTQPAEEAA ECCCCCCCCCHHHHH	48.30	28102081
285	Sumoylation	PAEEAARKREVRLMK CHHHHHHHHHHHHHH	48.46	12552083
285	Sumoylation	PAEEAARKREVRLMK CHHHHHHHHHHHHHH	48.46	-
304	Sumoylation	ARECRRKKKEYVKCL HHHHHHHHHHHHHHH	49.37	-
304	Sumoylation	ARECRRKKKEYVKCL HHHHHHHHHHHHHHH	49.37	12552083
309	Ubiquitination	RKKKEYVKCLENRVA HHHHHHHHHHHHHHH	32.00	-
314	Methylation	YVKCLENRVAVLENQ HHHHHHHHHHHHHHC	14.38	-
316 (in isoform 2)	Ubiquitination	-	9.28	21890473
323	Ubiquitination	AVLENQNKTLIEELK HHHHHCCHHHHHHHH	34.64	-
330	Ubiquitination	KTLIEELKALKDLYC HHHHHHHHHHHHHHC	55.76	21890473
330 (in isoform 1)	Ubiquitination	-	55.76	21890473
333	Ubiquitination	IEELKALKDLYCHKS HHHHHHHHHHHCCCC	51.01	-
336	Phosphorylation	LKALKDLYCHKSD-- HHHHHHHHCCCCC--	11.57	28102081
339	Ubiquitination	LKDLYCHKSD----- HHHHHCCCCC-----	53.40	-
340	Phosphorylation	KDLYCHKSD------ HHHHCCCCC------	25.53	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
94	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
94	S	Phosphorylation	Kinase	CK1A	P48729	PSP
97	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
97	S	Phosphorylation	Kinase	ATM	Q13315	PSP
97	S	Phosphorylation	Kinase	CK1A	P48729	PSP
98	S	Phosphorylation	Kinase	PRKD1	Q15139	GPS
98	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
100	T	Phosphorylation	Kinase	ATM	Q13315	GPS
100	S	Phosphorylation	Kinase	CK1A	P48729	PSP
100	T	Phosphorylation	Kinase	ATM	Q13315	PSP
107	S	Phosphorylation	Kinase	ATR	Q13535	PSP
107	S	Phosphorylation	Kinase	ATM	Q13315	PSP
108	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
108	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
111	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
111	S	Phosphorylation	Kinase	ATM	Q13315	PhosphoELM
111	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
114	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
115	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
115	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
119	S	Phosphorylation	Kinase	AKT2	P31751	Uniprot
119	S	Phosphorylation	Kinase	ATM	Q13315	PSP
119	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
119	S	Phosphorylation	Kinase	PKCE	Q02156	PSP
119	S	Phosphorylation	Kinase	P90RSK	Q15418	PSP
119	S	Phosphorylation	Kinase	CAMK4	Q16566	Uniprot
119	S	Phosphorylation	Kinase	RSK3	Q15349	PSP
119	S	Phosphorylation	Kinase	CAMK1	Q14012	Uniprot
119	S	Phosphorylation	Kinase	RSK2	P51812	PSP
119	S	Phosphorylation	Kinase	AKT1	P31749	Uniprot
119	S	Phosphorylation	Kinase	CAMK2	-	Uniprot
119	S	Phosphorylation	Kinase	MSK2	O75676	PSP
119	S	Phosphorylation	Kinase	MSK1	O75582	PSP
119	S	Phosphorylation	Kinase	PKACA	P05132	PSP
119	S	Phosphorylation	Kinase	PKACA	P17612	PSP
119	S	Phosphorylation	Kinase	COT	P41279	PSP
119	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
119	S	Phosphorylation	Kinase	SGK1	O00141	Uniprot
119	S	Phosphorylation	Kinase	SGK1	Q9WVC6	PSP
119	S	Phosphorylation	Kinase	DYRK3	Q922Y0	PSP
119	S	Phosphorylation	Kinase	TSSK4	Q6SA08	Uniprot
121	S	Phosphorylation	Kinase	ATR	Q13535	PhosphoELM
121	S	Phosphorylation	Kinase	ATM	Q13315	PhosphoELM
129	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
129	S	Phosphorylation	Kinase	GSK-3_GROUP	-	PhosphoELM
129	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
129	S	Phosphorylation	Kinase	GSK3B	P49841	GPS
133	S	Phosphorylation	Kinase	DYRK3	Q922Y0	GPS
133	S	Phosphorylation	Kinase	ATM	Q13315	GPS
133	S	Phosphorylation	Kinase	SGK_GROUP	-	PhosphoELM
133	S	Phosphorylation	Kinase	RSK_GROUP	-	PhosphoELM
133	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
133	S	Phosphorylation	Kinase	SGK-FAMILY	-	GPS
133	S	Phosphorylation	Kinase	RSK-SUBFAMILY	-	GPS
133	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
133	S	Phosphorylation	Kinase	CAMK1-FAMILY	-	GPS
133	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
133	S	Phosphorylation	Kinase	TSSK4	Q6SA08	GPS
133	S	Phosphorylation	Kinase	DYRK3	O43781	PhosphoELM
133	S	Phosphorylation	Kinase	SGK1	Q9WVC6	GPS
133	S	Phosphorylation	Kinase	PRKD1	Q15139	GPS
133	S	Phosphorylation	Kinase	MAPKAPK2	P49137	GPS
133	S	Phosphorylation	Kinase	MAP3K8	P41279	GPS
133	S	Phosphorylation	Kinase	KKCC1	Q8N5S9	PhosphoELM
133	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS
133	S	Phosphorylation	Kinase	CAMK4	Q16566	GPS
133	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
133	S	Phosphorylation	Kinase	CAMK2B	Q13554	GPS
133	S	Phosphorylation	Kinase	RPS6KA2	Q15349	GPS
133	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
133	S	Phosphorylation	Kinase	RPS6KA4	O75676	GPS
133	S	Phosphorylation	Kinase	PRKACA	P05132	GPS
133	S	Phosphorylation	Kinase	RPS6KA5	O75582	GPS
142	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
142	S	Phosphorylation	Kinase	CK1A	P48729	PSP
142	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
156	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
256	S	Phosphorylation	Kinase	CDK1	P06493	PSP
257	S	Phosphorylation	Kinase	CDK1	P06493	PSP
257	S	Phosphorylation	Kinase	HIPK2	Q9H2X6	Uniprot
270	S	Phosphorylation	Kinase	CDK1	P06493	GPS
271	S	Phosphorylation	Kinase	CDK1	P06493	GPS
271	S	Phosphorylation	Kinase	HIPK2	Q9H2X6	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
119	S	Phosphorylation	8065343
CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity (By similarity).
119	S	Phosphorylation	8065343
Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
119	S	Phosphorylation	8065343
Phosphorylated by TSSK4 on Ser-119.
119	S	Phosphorylation	8065343
Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119.
119	S	Phosphorylation	8065343
Phosphorylation of Ser-119 allows CREBBP binding.
119	S	Phosphorylation	8065343
Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated.
119	S	Phosphorylation	8065343
Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation.
128	S	Phosphorylation	23186163
Phosphorylated by CaMK2 on Ser-128.
128	S	Phosphorylation	23186163
Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated.
128	S	Phosphorylation	23186163
Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation.
257	S	Phosphorylation	20573984
Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP.
271	K	Sumoylation	12552083
Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein.
290	K	Sumoylation	12552083
Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CREB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEBPB_HUMAN	CEBPB	physical	12773552
EP300_HUMAN	EP300	physical	10506141
CBP_HUMAN	CREBBP	physical	9786917
CBP_HUMAN	CREBBP	physical	12196545
P53_HUMAN	TP53	physical	10848610
RBBP4_HUMAN	RBBP4	physical	10866654
ERG28_HUMAN	C14orf1	physical	16169070
VIME_HUMAN	VIM	physical	16169070
CHD3_HUMAN	CHD3	physical	16169070
FHL5_HUMAN	FHL5	physical	11046156
FHL2_HUMAN	FHL2	physical	11046156
FHL3_HUMAN	FHL3	physical	11046156
HDAC8_HUMAN	HDAC8	physical	19070599
TF2AA_HUMAN	GTF2A1	physical	20936779
SRBP2_HUMAN	SREBF2	physical	20936779
UBC9_HUMAN	UBE2I	physical	20936779
ZMYM2_HUMAN	ZMYM2	physical	20936779
PIAS1_HUMAN	PIAS1	physical	20936779
TOX4_HUMAN	TOX4	physical	20936779
HIPK3_HUMAN	HIPK3	physical	20936779
ZHX1_HUMAN	ZHX1	physical	20936779
ATF6A_HUMAN	ATF6	physical	20936779
POGZ_HUMAN	POGZ	physical	20936779
CRTC1_HUMAN	CRTC1	physical	20936779
ZN451_HUMAN	ZNF451	physical	20936779
RN111_HUMAN	RNF111	physical	20936779
MCAF1_HUMAN	ATF7IP	physical	20936779
CHD8_HUMAN	CHD8	physical	20936779
K2026_HUMAN	KIAA2026	physical	20936779
RFX3_HUMAN	RFX3	physical	20211142
ZNF35_HUMAN	ZNF35	physical	20211142
TRI22_HUMAN	TRIM22	physical	20211142
MTF2_HUMAN	MTF2	physical	20211142
SUZ12_HUMAN	SUZ12	physical	20211142
ZN436_HUMAN	ZNF436	physical	20211142
ZNF92_HUMAN	ZNF92	physical	20211142
SMCA4_HUMAN	SMARCA4	physical	16675956
CARM1_HUMAN	CARM1	physical	16330542
HDAC1_HUMAN	HDAC1	physical	12567184
HDAC2_HUMAN	HDAC2	physical	12567184
PO2F1_HUMAN	POU2F1	physical	12391146
CCDC6_HUMAN	CCDC6	physical	20498639
HDAC1_HUMAN	HDAC1	physical	20473547
HDAC2_HUMAN	HDAC2	physical	20473547
JUN_HUMAN	JUN	physical	2138276
RGS13_HUMAN	RGS13	physical	20974683
ATX3_HUMAN	ATXN3	physical	11572863
NC2B_HUMAN	DR1	physical	22939629
SRA1_HUMAN	SRA1	physical	20398657
DAXX_HUMAN	DAXX	physical	22185778
CREB1_HUMAN	CREB1	physical	23661758
P53_HUMAN	TP53	physical	16611888
DEAF1_HUMAN	DEAF1	physical	23846693
TSSK4_HUMAN	TSSK4	physical	21988832
NR5A2_HUMAN	NR5A2	physical	18191017
CREM_HUMAN	CREM	physical	22531917
HD_HUMAN	HTT	physical	16207717
CBP_HUMAN	CREBBP	physical	8413673
CTNB1_HUMAN	CTNNB1	physical	17962194
ATF1_HUMAN	ATF1	physical	25609649
ZBT21_HUMAN	ZBTB21	physical	25609649
H2B1A_HUMAN	HIST1H2BA	physical	25609649
JUN_HUMAN	JUN	physical	25609649
H31T_HUMAN	HIST3H3	physical	25609649
HMGA1_HUMAN	HMGA1	physical	25609649
ZN131_HUMAN	ZNF131	physical	25609649
MECP2_HUMAN	MECP2	physical	25609649
NFIX_HUMAN	NFIX	physical	25609649
RECQ1_HUMAN	RECQL	physical	25609649
HMGA2_HUMAN	HMGA2	physical	25609649
TTF2_HUMAN	TTF2	physical	25609649
CE024_HUMAN	C5orf24	physical	25609649
CREM_HUMAN	CREM	physical	25609649
ARNT_HUMAN	ARNT	physical	25609649
H2B1J_HUMAN	HIST1H2BJ	physical	25609649
NFAC2_HUMAN	NFATC2	physical	25609649
NFIA_HUMAN	NFIA	physical	25609649
HXD13_HUMAN	HOXD13	physical	25609649
JUND_HUMAN	JUND	physical	25609649
NFIC_HUMAN	NFIC	physical	25609649
NFIL3_HUMAN	NFIL3	physical	25609649
NFYA_HUMAN	NFYA	physical	25609649
NIT2_HUMAN	NIT2	physical	25609649
PBX2_HUMAN	PBX2	physical	25609649
RPB1_HUMAN	POLR2A	physical	25609649
XRCC1_HUMAN	XRCC1	physical	25609649
ANR17_HUMAN	ANKRD17	physical	25609649
F192A_HUMAN	FAM192A	physical	25609649
TRAF3_HUMAN	TRAF3	physical	26755589
CBP_HUMAN	CREBBP	physical	12933667
GCR_HUMAN	NR3C1	physical	20203101
STAT3_HUMAN	STAT3	physical	26508788

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
612160	Angiomatoid fibrous histiocytoma (AFH)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00131	Adenosine monophosphate
DB01183	Naloxone

Regulatory Network of CREB1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Regulation of genotoxic stress response by homeodomain-interactingprotein kinase 2 through phosphorylation of cyclic AMP responseelement-binding protein at serine 271."; Sakamoto K., Huang B.-W., Iwasaki K., Hailemariam K.,Ninomiya-Tsuji J., Tsuji Y.; Mol. Biol. Cell 21:2966-2974(2010). Cited for: PHOSPHORYLATION AT SER-271 BY HIPK2, MUTAGENESIS OF SER-271, ANDINTERACTION WITH HIPK2.	20573984 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111 AND THR-119, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Serum/glucocorticoid-inducible kinase can phosphorylate the cyclicAMP response element binding protein, CREB."; David S., Kalb R.G.; FEBS Lett. 579:1534-1538(2005). Cited for: PHOSPHORYLATION AT SER-133 BY SGK1, AND INTERACTION WITH SGK1.	15733869 [Abstract]
"Rsk-2 activity is necessary for epidermal growth factor-inducedphosphorylation of CREB protein and transcription of c-fos gene."; De Cesare D., Jacquot S., Hanauer A., Sassone-Corsi P.; Proc. Natl. Acad. Sci. U.S.A. 95:12202-12207(1998). Cited for: PHOSPHORYLATION AT SER-133.	9770464 [Abstract]
"CREB is a regulatory target for the protein kinase Akt/PKB."; Du K., Montminy M.; J. Biol. Chem. 273:32377-32379(1998). Cited for: PHOSPHORYLATION AT SER-133.	9829964 [Abstract]
"Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation ofcAMP response element-binding protein (CREB) on serine 133."; Lee H.-J.J., Mignacca R.C., Sakamoto K.M.; J. Biol. Chem. 270:15979-15983(1995). Cited for: PHOSPHORYLATION AT SER-133.	7608156 [Abstract]
"Calcium/calmodulin-dependent protein kinase types II and IVdifferentially regulate CREB-dependent gene expression."; Matthews R.P., Guthrie C.R., Wailes L.M., Zhao X., Means A.R.,McKnight G.S.; Mol. Cell. Biol. 14:6107-6116(1994). Cited for: PHOSPHORYLATION AT SER-133, AND MUTAGENESIS OF SER-133.	8065343 [Abstract]

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