ZNF35_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZNF35_HUMAN
• UniProt AC: P13682
• Protein Name: Zinc finger protein 35
• Gene Name: ZNF35
• Organism: Homo sapiens (Human).
• Sequence Length: 527
• Subcellular Localization: Nucleus .
• Protein Description: May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation..
• Protein Sequence: MTAELREAMALAPWGPVKVKKEEEEEENFPGQASSQQVHSENIKVWAPVQGLQTGLDGSEEEEKGQNISWDMAVVLKATQEAPAASTLGSYSLPGTLAKSEILETHGTMNFLGAETKNLQLLVPKTEICEEAEKPLIISERIQKADPQGPELGEACEKGNMLKRQRIKREKKDFRQVIVNDCHLPESFKEEENQKCKKSGGKYSLNSGAVKNPKTQLGQKPFTCSVCGKGFSQSANLVVHQRIHTGEKPFECHECGKAFIQSANLVVHQRIHTGQKPYVCSKCGKAFTQSSNLTVHQKIHSLEKTFKCNECEKAFSYSSQLARHQKVHITEKCYECNECGKTFTRSSNLIVHQRIHTGEKPFACNDCGKAFTQSANLIVHQRSHTGEKPYECKECGKAFSCFSHLIVHQRIHTAEKPYDCSECGKAFSQLSCLIVHQRIHSGDLPYVCNECGKAFTCSSYLLIHQRIHNGEKPYTCNECGKAFRQRSSLTVHQRTHTGEKPYECEKCGAAFISNSHLMRHHRTHLVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTAELREAM ------CCHHHHHHH	28.92	-
20	Sumoylation	PWGPVKVKKEEEEEE CCCCEECCCHHHHHH	49.07	28112733
21	Sumoylation	WGPVKVKKEEEEEEN CCCEECCCHHHHHHC	73.65	28112733
54	Phosphorylation	APVQGLQTGLDGSEE EECCCCCCCCCCCHH	44.76	28348404
59	Phosphorylation	LQTGLDGSEEEEKGQ CCCCCCCCHHHHCCC	41.31	25159151
99	Sumoylation	SLPGTLAKSEILETH CCCCCEEHHHHHHHH	52.30	28112733
117	Sumoylation	NFLGAETKNLQLLVP CCCCCCCCCEEEEEE	47.36	28112733
125	Sumoylation	NLQLLVPKTEICEEA CEEEEEECCHHCHHC	51.84	-
125	Sumoylation	NLQLLVPKTEICEEA CEEEEEECCHHCHHC	51.84	28112733
144	Sumoylation	IISERIQKADPQGPE EEEHHHHHCCCCCHH	53.00	28112733
158	Sumoylation	ELGEACEKGNMLKRQ HHHHHHHHCCHHHHH	56.31	28112733
189	Sumoylation	CHLPESFKEEENQKC CCCCHHHCHHHHHHC	73.77	28112733
202	Acetylation	KCKKSGGKYSLNSGA HCHHCCCCCCCCCCC	34.88	26051181
211	Ubiquitination	SLNSGAVKNPKTQLG CCCCCCCCCCCCCCC	67.98	29967540
214	Sumoylation	SGAVKNPKTQLGQKP CCCCCCCCCCCCCCC	59.29	28112733
276	Sumoylation	QRIHTGQKPYVCSKC EECCCCCCCEEECCC	39.39	28112733
276	Sumoylation	QRIHTGQKPYVCSKC EECCCCCCCEEECCC	39.39	-
357	Phosphorylation	IVHQRIHTGEKPFAC EEEEEEECCCCCCCC	44.67	21712546
390	Phosphorylation	SHTGEKPYECKECGK CCCCCCCEECCCCCC	45.05	-
393	Sumoylation	GEKPYECKECGKAFS CCCCEECCCCCCHHH	44.06	-
393	Sumoylation	GEKPYECKECGKAFS CCCCEECCCCCCHHH	44.06	-
441	Phosphorylation	IVHQRIHSGDLPYVC HEECCCCCCCCCEEE	31.47	28555341
487	Phosphorylation	GKAFRQRSSLTVHQR HHHHHHHCCCEEEEC	22.74	28555341
495	Phosphorylation	SLTVHQRTHTGEKPY CCEEEECCCCCCCCC	19.74	-
497	Phosphorylation	TVHQRTHTGEKPYEC EEEECCCCCCCCCCC	46.56	21857030

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZNF35_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZNF35_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZNF35_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
ARI1_HUMAN	ARIH1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.