ARI1_HUMAN - dbPTM
ARI1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARI1_HUMAN
UniProt AC Q9Y4X5
Protein Name E3 ubiquitin-protein ligase ARIH1
Gene Name ARIH1 {ECO:0000312|HGNC:HGNC:689}
Organism Homo sapiens (Human).
Sequence Length 557
Subcellular Localization Cytoplasm . Nucleus . Nucleus, Cajal body . Mainly cytoplasmic (PubMed:11278816). Present in Lewy body (PubMed:21590270).
Protein Description E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. [PubMed: 15236971]
Protein Sequence MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDGLLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
50UbiquitinationGEVELVEPGLGVGGE
CEEEEECCCCCCCCC		35.5121963094
52UbiquitinationVELVEPGLGVGGERD
EEEECCCCCCCCCCC		8.0127667366
64UbiquitinationERDGLLCGETGGGGG
CCCCEECCCCCCCCC		35.1621890473
97UbiquitinationGPGHEQEEDYRYEVL
CCCCCCCHHHHHEEE		61.1021890473
1422-HydroxyisobutyrylationLSHFNWDKEKLMERY
HHHCCCCHHHHHHHH		48.65-
142AcetylationLSHFNWDKEKLMERY
HHHCCCCHHHHHHHH		48.6519608861
142UbiquitinationLSHFNWDKEKLMERY
HHHCCCCHHHHHHHH		48.6521906983
144NeddylationHFNWDKEKLMERYFD
HCCCCHHHHHHHHCC		59.9032015554
144UbiquitinationHFNWDKEKLMERYFD
HCCCCHHHHHHHHCC		59.9021906983
156UbiquitinationYFDGNLEKLFAECHV
HCCCCHHHHHHHCEE		52.6621906983
161UbiquitinationLEKLFAECHVINPSK
HHHHHHHCEECCCCH		2.5222817900
163UbiquitinationKLFAECHVINPSKKS
HHHHHCEECCCCHHH		7.3722817900
165UbiquitinationFAECHVINPSKKSRT
HHHCEECCCCHHHCC		33.4322817900
167PhosphorylationECHVINPSKKSRTRQ
HCEECCCCHHHCCCC		48.5028857561
1682-HydroxyisobutyrylationCHVINPSKKSRTRQM
CEECCCCHHHCCCCC		56.90-
168UbiquitinationCHVINPSKKSRTRQM
CEECCCCHHHCCCCC		56.9032015554
179PhosphorylationTRQMNTRSSAQDMPC
CCCCCCCCCCCCCCC		28.1727251275
180PhosphorylationRQMNTRSSAQDMPCQ
CCCCCCCCCCCCCCE		27.0227251275
194UbiquitinationQICYLNYPNSYFTGL
EEEECCCCCCCEECC		23.4021890473
196UbiquitinationCYLNYPNSYFTGLEC
EECCCCCCCEECCCC		19.6722817900
196PhosphorylationCYLNYPNSYFTGLEC
EECCCCCCCEECCCC		19.67-
197PhosphorylationYLNYPNSYFTGLECG
ECCCCCCCEECCCCH		16.29-
198UbiquitinationLNYPNSYFTGLECGH
CCCCCCCEECCCCHH		4.3622817900
199PhosphorylationNYPNSYFTGLECGHK
CCCCCCEECCCCHHH		32.40-
201UbiquitinationPNSYFTGLECGHKFC
CCCCEECCCCHHHHH		4.4622817900
206UbiquitinationTGLECGHKFCMQCWS
ECCCCHHHHHHHHHH		26.0822817900
224UbiquitinationTTKIMEEGMGQTISC
HHHHHHHCCCCEECC		16.5323000965
226UbiquitinationKIMEEGMGQTISCPA
HHHHHCCCCEECCCC		32.1323000965
227UbiquitinationIMEEGMGQTISCPAH
HHHHCCCCEECCCCC		27.1121890473
229UbiquitinationEEGMGQTISCPAHGC
HHCCCCEECCCCCCC		2.8323000965
230UbiquitinationEGMGQTISCPAHGCD
HCCCCEECCCCCCCC		19.8923000965
233UbiquitinationGQTISCPAHGCDILV
CCEECCCCCCCCEEE		18.9422817900
234UbiquitinationQTISCPAHGCDILVD
CEECCCCCCCCEEEC		23.6622817900
239UbiquitinationPAHGCDILVDDNTVM
CCCCCCEEECCCCEE		1.8922817900
253UbiquitinationMRLITDSKVKLKYQH
EEHHHCCCCHHHHHH		46.3121906983
253AcetylationMRLITDSKVKLKYQH
EEHHHCCCCHHHHHH		46.3125953088
255UbiquitinationLITDSKVKLKYQHLI
HHHCCCCHHHHHHHH		42.8922817900
257UbiquitinationTDSKVKLKYQHLITN
HCCCCHHHHHHHHCC		36.8323000965
259UbiquitinationSKVKLKYQHLITNSF
CCCHHHHHHHHCCCH		24.2723000965
262UbiquitinationKLKYQHLITNSFVEC
HHHHHHHHCCCHHHH		3.0023000965
263UbiquitinationLKYQHLITNSFVECN
HHHHHHHCCCHHHHH		31.0423000965
266UbiquitinationQHLITNSFVECNRLL
HHHHCCCHHHHHHHH		6.1022817900
267UbiquitinationHLITNSFVECNRLLK
HHHCCCHHHHHHHHH		9.1122817900
274UbiquitinationVECNRLLKWCPAPDC
HHHHHHHHCCCCCCC		51.8732015554
276UbiquitinationCNRLLKWCPAPDCHH
HHHHHHCCCCCCCCE		1.6521963094
286UbiquitinationPDCHHVVKVQYPDAK
CCCCEEEEECCCCCC		23.6421906983
293UbiquitinationKVQYPDAKPVRCKCG
EECCCCCCCEEECCC		51.9621906983
298UbiquitinationDAKPVRCKCGRQFCF
CCCCEEECCCCEEEE		29.2022817900
306UbiquitinationCGRQFCFNCGENWHD
CCCEEEECCCCCCCC		33.7822817900
309UbiquitinationQFCFNCGENWHDPVK
EEEECCCCCCCCHHH		60.3921963094
316UbiquitinationENWHDPVKCKWLKKW
CCCCCHHHHHHHHHH		35.1723000965
316NeddylationENWHDPVKCKWLKKW
CCCCCHHHHHHHHHH		35.1732015554
318UbiquitinationWHDPVKCKWLKKWIK
CCCHHHHHHHHHHHH		50.2523000965
321UbiquitinationPVKCKWLKKWIKKCD
HHHHHHHHHHHHHCC		44.9723000965
322UbiquitinationVKCKWLKKWIKKCDD
HHHHHHHHHHHHCCC		52.5623000965
325UbiquitinationKWLKKWIKKCDDDSE
HHHHHHHHHCCCCCH		46.3522817900
326UbiquitinationWLKKWIKKCDDDSET
HHHHHHHHCCCCCHH		33.4921906983
331PhosphorylationIKKCDDDSETSNWIA
HHHCCCCCHHHCCCC		50.17-
339UbiquitinationETSNWIAANTKECPK
HHHCCCCCCCCCCCC		18.3222817900
342UbiquitinationNWIAANTKECPKCHV
CCCCCCCCCCCCCEE		58.0627565346PubMed
346UbiquitinationANTKECPKCHVTIEK
CCCCCCCCCEEEEEE		48.9432015554
347UbiquitinationNTKECPKCHVTIEKD
CCCCCCCCEEEEEEC		1.5622817900
349UbiquitinationKECPKCHVTIEKDGG
CCCCCCEEEEEECCC		8.9322817900
360SulfoxidationKDGGCNHMVCRNQNC
ECCCCCCEEECCCCC		1.5730846556
368UbiquitinationVCRNQNCKAEFCWVC
EECCCCCCCEEEEEE		59.5121963094
380UbiquitinationWVCLGPWEPHGSAWY
EEECCCCCCCCCCCC		30.4722817900
382UbiquitinationCLGPWEPHGSAWYNC
ECCCCCCCCCCCCCC		31.1822817900
391UbiquitinationSAWYNCNRYNEDDAK
CCCCCCCCCCHHHHH		37.5422817900
392UbiquitinationAWYNCNRYNEDDAKA
CCCCCCCCCHHHHHH		14.6522817900
398UbiquitinationRYNEDDAKAARDAQE
CCCHHHHHHHHHHHH		49.9621906983
407PhosphorylationARDAQERSRAALQRY
HHHHHHHHHHHHHHH		26.0622210691
414PhosphorylationSRAALQRYLFYCNRY
HHHHHHHHHHHHHHH		6.5429759185
417PhosphorylationALQRYLFYCNRYMNH
HHHHHHHHHHHHHHH		6.0429759185
421PhosphorylationYLFYCNRYMNHMQSL
HHHHHHHHHHHHHHH		6.5729759185
424UbiquitinationYCNRYMNHMQSLRFE
HHHHHHHHHHHHHHH		10.1022817900
425UbiquitinationCNRYMNHMQSLRFEH
HHHHHHHHHHHHHHH		2.1622817900
427PhosphorylationRYMNHMQSLRFEHKL
HHHHHHHHHHHHHHH		17.5924719451
430UbiquitinationNHMQSLRFEHKLYAQ
HHHHHHHHHHHHHHH		16.2922817900
432UbiquitinationMQSLRFEHKLYAQVK
HHHHHHHHHHHHHHH		23.7822817900
433UbiquitinationQSLRFEHKLYAQVKQ
HHHHHHHHHHHHHHH		35.6833845483
436UbiquitinationRFEHKLYAQVKQKME
HHHHHHHHHHHHHHH		20.3723503661
439UbiquitinationHKLYAQVKQKMEEMQ
HHHHHHHHHHHHHHH		31.9221906983
441UbiquitinationLYAQVKQKMEEMQQH
HHHHHHHHHHHHHHC		42.4322817900
460AcetylationIEVQFLKKAVDVLCQ
HHHHHHHHHHHHHHH		56.6526051181
463UbiquitinationQFLKKAVDVLCQCRA
HHHHHHHHHHHHHHH		32.3122817900
465UbiquitinationLKKAVDVLCQCRATL
HHHHHHHHHHHHHHH		1.1222817900
469UbiquitinationVDVLCQCRATLMYTY
HHHHHHHHHHHHHHH		12.5323503661
471PhosphorylationVLCQCRATLMYTYVF
HHHHHHHHHHHHHHH		7.8428450419
474PhosphorylationQCRATLMYTYVFAFY
HHHHHHHHHHHHEEE		9.6828450419
475PhosphorylationCRATLMYTYVFAFYL
HHHHHHHHHHHEEEE		10.1528450419
476PhosphorylationRATLMYTYVFAFYLK
HHHHHHHHHHEEEEH		3.9828450419
481PhosphorylationYTYVFAFYLKKNNQS
HHHHHEEEEHHCCEE		17.7428450419
483UbiquitinationYVFAFYLKKNNQSII
HHHEEEEHHCCEEEE		41.9222817900
484UbiquitinationVFAFYLKKNNQSIIF
HHEEEEHHCCEEEEE		59.5421906983
514PhosphorylationGYLERDISQDSLQDI
HHHHCCCCHHHHHHH		32.0229255136
517PhosphorylationERDISQDSLQDIKQK
HCCCCHHHHHHHHHH		21.9429255136
522UbiquitinationQDSLQDIKQKVQDKY
HHHHHHHHHHHHHHH		52.9721906983
522AcetylationQDSLQDIKQKVQDKY
HHHHHHHHHHHHHHH		52.9725953088
524UbiquitinationSLQDIKQKVQDKYRY
HHHHHHHHHHHHHHH		36.5422817900
528UbiquitinationIKQKVQDKYRYCESR
HHHHHHHHHHHHHHH		17.9723503661
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ARI1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARI1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARI1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UB2L3_HUMANUBE2L3physical
14623119
IF4E2_HUMANEIF4E2physical
14623119
UB2L3_HUMANUBE2L3physical
10521492
UB2L3_HUMANUBE2L3physical
11278816
SIM2_HUMANSIM2physical
15963499
ARI1_HUMANARIH1physical
15236971
UB2D1_HUMANUBE2D1physical
15236971
UB2L3_HUMANUBE2L3physical
23707686
ARI1_HUMANARIH1physical
23707686
CUL1_HUMANCUL1physical
24076655
NEDD8_HUMANNEDD8physical
24076655
ARI1_HUMANARIH1physical
24076655
UB2L3_HUMANUBE2L3physical
24076655
NC2B_HUMANDR1physical
22863883
SAE2_HUMANUBA2physical
22863883
XPO5_HUMANXPO5physical
22863883
ARI1_HUMANARIH1physical
21532592
UB2L3_HUMANUBE2L3physical
21532592
UB2D3_HUMANUBE2D3physical
21532592
UB2E2_HUMANUBE2E2physical
10521492
CUL2_HUMANCUL2physical
24076655
CUL3_HUMANCUL3physical
24076655
CUL4A_HUMANCUL4Aphysical
24076655
FBXW2_HUMANFBXW2physical
28514442
SELH_HUMANC11orf31physical
28514442
CREB5_HUMANCREB5physical
28514442
CRML_HUMANCRAMP1Lphysical
28514442
HXC9_HUMANHOXC9physical
28514442
JUND_HUMANJUNDphysical
28514442
ZN852_HUMANZNF852physical
28514442
BACD1_HUMANKCTD13physical
28514442
ISL2_HUMANISL2physical
28514442
PUS7L_HUMANPUS7Lphysical
28514442
BACD2_HUMANTNFAIP1physical
28514442
SPOP_HUMANSPOPphysical
28514442
JUN_HUMANJUNphysical
28514442
ECT2_HUMANECT2physical
28514442
KBTB7_HUMANKBTBD7physical
28514442
UHRF1_HUMANUHRF1physical
28514442
KLHL7_HUMANKLHL7physical
28514442
ATF7_HUMANATF7physical
28514442
KCTD9_HUMANKCTD9physical
28514442
PLCD3_HUMANPLCD3physical
28514442
KTNA1_HUMANKATNA1physical
28514442
ISL1_HUMANISL1physical
28514442
HXB9_HUMANHOXB9physical
28514442
DDX47_HUMANDDX47physical
28514442
TEFM_HUMANTEFMphysical
28514442
BACD3_HUMANKCTD10physical
28514442
ZN687_HUMANZNF687physical
28514442
PI51A_HUMANPIP5K1Aphysical
28514442
CREB1_HUMANCREB1physical
28514442
PDD2L_HUMANPDCD2Lphysical
28514442
CUL1_HUMANCUL1physical
28514442
BBX_HUMANBBXphysical
28514442
CAMKV_HUMANCAMKVphysical
28514442
KBTB6_HUMANKBTBD6physical
28514442
THYN1_HUMANTHYN1physical
28514442
HXA10_HUMANHOXA10physical
28514442
KCTD3_HUMANKCTD3physical
28514442
ATF1_HUMANATF1physical
28514442
RN138_HUMANRNF138physical
28514442
RBM42_HUMANRBM42physical
28514442
UB2L3_HUMANUBE2L3physical
28514442
SRBD1_HUMANSRBD1physical
28514442
SHKB1_HUMANSHKBP1physical
28514442
SETD7_HUMANSETD7physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARI1_HUMAN

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