SRBD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRBD1_HUMAN
• UniProt AC: Q8N5C6
• Protein Name: S1 RNA-binding domain-containing protein 1
• Gene Name: SRBD1
• Organism: Homo sapiens (Human).
• Sequence Length: 995
• Protein Sequence: MSSLPRRAKVQVQDVVLKDEFSSFSELSSASEEDDKEDSAWEPQKKVPRSRKQPPPKESKPKRMPRVKKNAPQISDGSEVVVVKEELNSSVAIADTALEDRKNKLDTVQTLKTAKTKQKCAAQPHTVRRTKKLKVEEETSKASNLEGESNSSETPSTSTVWGGTCKKEENDDDFTFGQSALKKIKTETYPQGQPVKFPANANSTKEEVEMNWDMVQVLSERTNIEPWVCANIIRLFNDDNTIPFIIRYRKELINNLDADSLREVQQTLEELRAVAKKVHSTIQKIKKEGKMSECLLKAMLNCKTFEELEHVSAPYKTGSKGTKAQRARQLGLEGAARALLEKPGELSLLSYIRPDVKGLSTLQDIEIGVQHILADMIAKDKDTLDFIRNLCQKRHVCIQSSLAKVSSKKVNEKDVDKFLLYQHFSCNIRNIHHHQILAINRGENLKVLTVKVNISDGVKDEFCRWCIQNRWRPRSFARPELMKILYNSLNDSFKRLIYPLLCREFRAKLTSDAEKESVMMFGRNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKTLLLNFNCSTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKIEPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFIRINQDYIRTFCSQQTETSGQIQGVAVTSSADVEVTNEKQGKKKSKTAVNVLLKPNPLDQTCIHPESYDIAMRFLSSIGGTLYEVGKPEMQQKINSFLEKEGMEKIAERLQTTVHTLQVIIDGLSQPESFDFRTDFDKPDFKRSIVCLEDLQIGTVLTGKVENATLFGIFVDIGVGKSGLIPIRNVTEAKLSKTKKRRSLGLGPGERVEVQVLNIDIPRSRITLDLIRVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSLPRRAK ------CCCCCCCCC	40.35	29262532
3	Phosphorylation	-----MSSLPRRAKV -----CCCCCCCCCE	40.89	24719451
9	Acetylation	SSLPRRAKVQVQDVV CCCCCCCCEEEEEEE	31.24	26051181
22	Phosphorylation	VVLKDEFSSFSELSS EEECCCCCCHHHHHC	28.55	27251275
23	Phosphorylation	VLKDEFSSFSELSSA EECCCCCCHHHHHCC	37.81	27251275
25	Phosphorylation	KDEFSSFSELSSASE CCCCCCHHHHHCCCC	39.31	27251275
28	Phosphorylation	FSSFSELSSASEEDD CCCHHHHHCCCCCCC	21.58	22617229
29	Phosphorylation	SSFSELSSASEEDDK CCHHHHHCCCCCCCC	48.73	22617229
31	Phosphorylation	FSELSSASEEDDKED HHHHHCCCCCCCCCC	43.39	22617229
39	Phosphorylation	EEDDKEDSAWEPQKK CCCCCCCCCCCCCCC	36.05	28102081
59	O-linked_Glycosylation	KQPPPKESKPKRMPR CCCCCCCCCCCCCCC	61.45	30379171
84	Sumoylation	GSEVVVVKEELNSSV CCEEEEEEECCCCCC	33.58	28112733
89	Phosphorylation	VVKEELNSSVAIADT EEEECCCCCCEEEHH	38.52	25849741
90	Phosphorylation	VKEELNSSVAIADTA EEECCCCCCEEEHHH	17.94	25849741
96	Phosphorylation	SSVAIADTALEDRKN CCCEEEHHHHHHHHH	24.91	30266825
107	Phosphorylation	DRKNKLDTVQTLKTA HHHHCCHHHHHHHHH	25.58	-
134	Sumoylation	VRRTKKLKVEEETSK CCCCCCCCCCHHHHH	57.38	-
134	Sumoylation	VRRTKKLKVEEETSK CCCCCCCCCCHHHHH	57.38	28112733
143	Phosphorylation	EEETSKASNLEGESN CHHHHHCCCCCCCCC	45.76	30108239
149	Phosphorylation	ASNLEGESNSSETPS CCCCCCCCCCCCCCC	53.52	30108239
151	Phosphorylation	NLEGESNSSETPSTS CCCCCCCCCCCCCCC	38.54	30108239
152	Phosphorylation	LEGESNSSETPSTST CCCCCCCCCCCCCCE	50.14	30108239
154	Phosphorylation	GESNSSETPSTSTVW CCCCCCCCCCCCEEE	25.20	30108239
156	Phosphorylation	SNSSETPSTSTVWGG CCCCCCCCCCEEECC	42.27	30108239
157	Phosphorylation	NSSETPSTSTVWGGT CCCCCCCCCEEECCE	29.62	30108239
158	Phosphorylation	SSETPSTSTVWGGTC CCCCCCCCEEECCEE	25.87	30108239
166	Sumoylation	TVWGGTCKKEENDDD EEECCEECCCCCCCC	64.16	-
166	Sumoylation	TVWGGTCKKEENDDD EEECCEECCCCCCCC	64.16	28112733
167	Acetylation	VWGGTCKKEENDDDF EECCEECCCCCCCCC	72.85	26051181
167	Sumoylation	VWGGTCKKEENDDDF EECCEECCCCCCCCC	72.85	28112733
179	Phosphorylation	DDFTFGQSALKKIKT CCCCCCHHHHHHHCC	35.63	25159151
182	Acetylation	TFGQSALKKIKTETY CCCHHHHHHHCCCCC	52.77	25953088
183	Sumoylation	FGQSALKKIKTETYP CCHHHHHHHCCCCCC	50.73	28112733
185	Sumoylation	QSALKKIKTETYPQG HHHHHHHCCCCCCCC	49.54	25114211
185	Sumoylation	QSALKKIKTETYPQG HHHHHHHCCCCCCCC	49.54	-
319	O-linked_Glycosylation	SAPYKTGSKGTKAQR CCCCCCCCCCHHHHH	32.89	30379171
381	Ubiquitination	ADMIAKDKDTLDFIR HHHHHCCHHHHHHHH	52.48	29967540
406	Phosphorylation	QSSLAKVSSKKVNEK HHHHHHHHCCCCCHH	35.42	-
407	Phosphorylation	SSLAKVSSKKVNEKD HHHHHHHCCCCCHHH	39.21	-
410	Ubiquitination	AKVSSKKVNEKDVDK HHHHCCCCCHHHHHH	14.90	24816145
459	Acetylation	VNISDGVKDEFCRWC EECCCCCCHHHHHHH	58.00	26051181
475	Phosphorylation	QNRWRPRSFARPELM HCCCCCHHHCCHHHH	26.41	22210691
494	Ubiquitination	NSLNDSFKRLIYPLL HHCCHHHHHHHHHHH	50.69	29967540
510	Phosphorylation	REFRAKLTSDAEKES HHHHHHCCCHHHHHH	24.69	28102081
511	Phosphorylation	EFRAKLTSDAEKESV HHHHHCCCHHHHHHH	45.30	28102081
547	Ubiquitination	MGVDPGYKHGCKLAI ECCCCCCCCCCEEEE	39.16	-
547	Malonylation	MGVDPGYKHGCKLAI ECCCCCCCCCCEEEE	39.16	26320211
616	Phosphorylation	ADLIMKNYFAPLDVV HHHHHHCCCCCCCEE	8.80	21406692
624	Phosphorylation	FAPLDVVYCIVSEAG CCCCCEEEEEECCCC	4.02	21406692
628	Phosphorylation	DVVYCIVSEAGASIY CEEEEEECCCCCEEE	11.21	21406692
633	Phosphorylation	IVSEAGASIYSVSPE EECCCCCEEEEECHH	22.57	21406692
635	Phosphorylation	SEAGASIYSVSPEAN CCCCCEEEEECHHHC	10.67	21406692
636	Phosphorylation	EAGASIYSVSPEANK CCCCEEEEECHHHCC	17.91	21406692
638	Phosphorylation	GASIYSVSPEANKEM CCEEEEECHHHCCCC	15.87	21406692
757	Acetylation	KVKGLGPKSFQQCAG HCCCCCCCHHHHHHH	63.20	90699
861	Phosphorylation	EMQQKINSFLEKEGM HHHHHHHHHHHHHHH	34.38	20068231
891	Ubiquitination	VIIDGLSQPESFDFR HHHHCCCCCCCCCCC	51.31	24816145
907	Ubiquitination	DFDKPDFKRSIVCLE CCCCCCCCCEEEEEC	53.25	24816145
955	Sumoylation	IRNVTEAKLSKTKKR CCCCCHHHCCCCCCC	47.24	-
955	Sumoylation	IRNVTEAKLSKTKKR CCCCCHHHCCCCCCC	47.24	25218447
964	Phosphorylation	SKTKKRRSLGLGPGE CCCCCCCCCCCCCCC	30.71	23401153
985	Phosphorylation	LNIDIPRSRITLDLI EECCCCCHHEEHHHH	23.76	29116813
986	Methylation	NIDIPRSRITLDLIR ECCCCCHHEEHHHHC	27.47	115917685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRBD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRBD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRBD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAOK1_HUMAN	TAOK1	physical	22939629
RCAN1_HUMAN	RCAN1	physical	28514442
GSK3A_HUMAN	GSK3A	physical	28514442
PP2BC_HUMAN	PPP3CC	physical	28514442
CANB1_HUMAN	PPP3R1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-964, AND MASSSPECTROMETRY.
PubMed: 18669648