RCAN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCAN1_HUMAN
• UniProt AC: P53805
• Protein Name: Calcipressin-1
• Gene Name: RCAN1
• Organism: Homo sapiens (Human).
• Sequence Length: 252
• Protein Description: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. [PubMed: 12809556 Could play a role during central nervous system development (By similarity]
• Protein Sequence: MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28 (in isoform 4)	Phosphorylation	-	5.16	-
32 (in isoform 4)	Phosphorylation	-	32.63	-
86	Ubiquitination	VDGLCRAKFESLFRT CCHHHHHHHHHHHHH	30.25	-
93 (in isoform 2)	Phosphorylation	-	28.83	-
94	Phosphorylation	FESLFRTYDKDITFQ HHHHHHHCCCCCCHH	19.42	22817900
96	Neddylation	SLFRTYDKDITFQYF HHHHHCCCCCCHHHH	40.39	-
104	Neddylation	DITFQYFKSFKRVRI CCCHHHHHCCCEEEE	50.47	-
107	Neddylation	FQYFKSFKRVRINFS HHHHHCCCEEEEECC	58.01	-
108	Phosphorylation	QYFKSFKRVRINFSN HHHHCCCEEEEECCC	22.42	12063245
108 (in isoform 2)	Phosphorylation	-	22.42	-
112	Phosphorylation	SFKRVRINFSNPFSA CCCEEEEECCCCCCH	24.59	12063245
112 (in isoform 2)	Phosphorylation	-	24.59	-
128	Ubiquitination	DARLQLHKTEFLGKE HHHHHHHHHHHCCHH	59.34	-
129	Phosphorylation	ARLQLHKTEFLGKEM HHHHHHHHHHCCHHH	22.63	-
134	Ubiquitination	HKTEFLGKEMKLYFA HHHHHCCHHHHHHEE	57.70	-
148	Phosphorylation	AQTLHIGSSHLAPPN EEEEECCCCCCCCCC	17.62	-
163	Phosphorylation	PDKQFLISPPASPPV CCCCCEECCCCCCCC	27.29	12809556
163	Dephosphorylation	PDKQFLISPPASPPV CCCCCEECCCCCCCC	27.29	12063245
167	Phosphorylation	FLISPPASPPVGWKQ CEECCCCCCCCCCCC	35.19	12809556
179	Phosphorylation	WKQVEDATPVINYDL CCCCCCCCCCCCHHH	30.34	25332170
184	Phosphorylation	DATPVINYDLLYAIS CCCCCCCHHHHHHHH	9.24	28796482
188	Phosphorylation	VINYDLLYAISKLGP CCCHHHHHHHHHHCC	14.80	28796482
191	Phosphorylation	YDLLYAISKLGPGEK HHHHHHHHHHCCCCC	17.41	28796482
192	Ubiquitination	DLLYAISKLGPGEKY HHHHHHHHHCCCCCE	51.88	-
207	Phosphorylation	ELHAATDTTPSVVVH EEEEECCCCCCEEEE	35.93	27251275
208	Phosphorylation	LHAATDTTPSVVVHV EEEECCCCCCEEEEE	19.17	27251275
210	Phosphorylation	AATDTTPSVVVHVCE EECCCCCCEEEEEEC	26.00	30576142
218	Phosphorylation	VVVHVCESDQEKEEE EEEEEECCHHHHHHH	39.19	30576142
241	Phosphorylation	PKPKIIQTRRPEYTP CCCCEECCCCCCCCC	20.45	23186163
247	Phosphorylation	QTRRPEYTPIHLS-- CCCCCCCCCCCCC--	17.69	21965663
252	Phosphorylation	EYTPIHLS------- CCCCCCCC-------	24.82	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
93	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
108	S	Phosphorylation	Kinase	GSK-3_GROUP	-	PhosphoELM
112	S	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM
163	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
163	S	Phosphorylation	Kinase	MAP3K3	Q99759	GPS
163	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
167	S	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
167	S	Phosphorylation	Kinase	MAP3K3	Q99759	GPS
167	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
247	T	Phosphorylation	Kinase	DYRK1A	Q13627	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW11	Q9UKB1	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:18575781
-	K	Ubiquitination	E3 ubiquitin ligase	NEDD4L	Q96PU5	PMID:22426484

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCAN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCAN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2BA_HUMAN	PPP3CA	physical	10861295
STAT2_HUMAN	STAT2	physical	22426484
TOLIP_HUMAN	TOLLIP	physical	19716405
IRAK1_HUMAN	IRAK1	physical	19716405
TRAF6_HUMAN	TRAF6	physical	19716405
HS90A_HUMAN	HSP90AA1	physical	19716405
FBW1A_HUMAN	BTRC	physical	18575781
FBXW4_HUMAN	FBXW4	physical	18575781
FBW1B_HUMAN	FBXW11	physical	18575781
A4_HUMAN	APP	physical	21832049
PP2BA_HUMAN	PPP3CA	physical	23118980
UBP22_HUMAN	USP22	physical	25546086
PP2BC_HUMAN	PPP3CC	physical	28514442
PP2BA_HUMAN	PPP3CA	physical	28514442
GSK3A_HUMAN	GSK3A	physical	28514442
PP2BB_HUMAN	PPP3CB	physical	28514442
CANB1_HUMAN	PPP3R1	physical	28514442
ARMT1_HUMAN	C6orf211	physical	28514442
CYTT_HUMAN	CST2	physical	28514442
CYTD_HUMAN	CST5	physical	28514442
GSK3B_HUMAN	GSK3B	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
CLC3A_HUMAN	CLEC3A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.