UniProt ID | FBW1B_HUMAN | |
---|---|---|
UniProt AC | Q9UKB1 | |
Protein Name | F-box/WD repeat-containing protein 11 | |
Gene Name | FBXW11 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 542 | |
Subcellular Localization | Cytoplasm. Nucleus. | |
Protein Description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. [PubMed: 25503564 Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2] | |
Protein Sequence | MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
11 (in isoform 3) | Phosphorylation | - | 31.82 | 22115753 | |
17 (in isoform 3) | Phosphorylation | - | 22.61 | 22199227 | |
18 (in isoform 3) | Phosphorylation | - | 3.78 | 22199227 | |
21 (in isoform 2) | Phosphorylation | - | 20.16 | 29116813 | |
26 (in isoform 2) | Phosphorylation | - | 1.81 | 29116813 | |
28 (in isoform 3) | Phosphorylation | - | 49.01 | 22199227 | |
33 (in isoform 3) | Phosphorylation | - | 0.70 | 29083192 | |
38 (in isoform 3) | Phosphorylation | - | 4.11 | 29083192 | |
41 (in isoform 3) | Phosphorylation | - | 21.51 | 29083192 | |
42 (in isoform 3) | Phosphorylation | - | 1.52 | 29083192 | |
43 (in isoform 3) | Phosphorylation | - | 34.61 | 29083192 | |
65 | Phosphorylation | IVSRKRPSEGNYQKE EEECCCCCCCCCHHH | 63.27 | 29496963 | |
69 | Phosphorylation | KRPSEGNYQKEKDLC CCCCCCCCHHHHHEH | 31.64 | 29116813 | |
145 (in isoform 2) | Ubiquitination | - | 3.39 | 21890473 | |
159 | Phosphorylation | KEWQRVISEGMLWKK HHHHHHHHHCHHHHH | 25.82 | 26074081 | |
166 (in isoform 3) | Ubiquitination | - | 43.02 | 21890473 | |
174 | Phosphorylation | LIERMVRTDPLWKGL HHHHHHHHCCHHHHH | 30.47 | 26074081 | |
179 | "N6,N6-dimethyllysine" | VRTDPLWKGLSERRG HHHCCHHHHHHHHCC | 58.62 | - | |
179 | Methylation | VRTDPLWKGLSERRG HHHCCHHHHHHHHCC | 58.62 | 23644510 | |
179 | Ubiquitination | VRTDPLWKGLSERRG HHHCCHHHHHHHHCC | 58.62 | 21890473 | |
179 (in isoform 1) | Ubiquitination | - | 58.62 | 21890473 | |
241 | Ubiquitination | QCRSENSKGVYCLQY EECCCCCCCEEEEEE | 65.07 | - | |
252 | Ubiquitination | CLQYDDEKIISGLRD EEEECCHHHHHCCCC | 52.94 | - | |
255 | Phosphorylation | YDDEKIISGLRDNSI ECCHHHHHCCCCCCE | 34.94 | 24719451 | |
263 | Ubiquitination | GLRDNSIKIWDKTSL CCCCCCEEEEECCHH | 37.25 | - | |
267 | Ubiquitination | NSIKIWDKTSLECLK CCEEEEECCHHHHHH | 25.64 | - | |
374 | Ubiquitination | NVVDFDDKYIVSASG EEEECCCCEEEECCC | 38.43 | - | |
403 | Ubiquitination | VRTLNGHKRGIACLQ HHHHCCCCCEEEEEE | 54.43 | - | |
411 | Phosphorylation | RGIACLQYRDRLVVS CEEEEEEECCEEEEE | 11.09 | 22817900 | |
464 | Ubiquitination | VSGAYDGKIKVWDLQ ECCCCCCCEEEEEEH | 36.13 | - | |
466 | Ubiquitination | GAYDGKIKVWDLQAA CCCCCCEEEEEEHHH | 40.53 | - | |
492 | Phosphorylation | LRTLVEHSGRVFRLQ HHHHHHHCCEEEEEE | 18.13 | - | |
532 | Phosphorylation | SAQNETRSPSRTYTY CCCCCCCCCCCCEEE | 34.35 | 21945579 | |
534 | Phosphorylation | QNETRSPSRTYTYIS CCCCCCCCCCEEEEC | 38.20 | 21945579 | |
536 | Phosphorylation | ETRSPSRTYTYISR- CCCCCCCCEEEECC- | 25.26 | 21945579 | |
537 | Phosphorylation | TRSPSRTYTYISR-- CCCCCCCEEEECC-- | 9.09 | 21945579 | |
538 | Phosphorylation | RSPSRTYTYISR--- CCCCCCEEEECC--- | 17.48 | 21945579 | |
539 | Phosphorylation | SPSRTYTYISR---- CCCCCEEEECC---- | 6.10 | 21945579 | |
541 | Phosphorylation | SRTYTYISR------ CCCEEEECC------ | 22.86 | 21945579 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBW1B_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBW1B_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
loading...