PTN13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PTN13_HUMAN
• UniProt AC: Q12923
• Protein Name: Tyrosine-protein phosphatase non-receptor type 13
• Gene Name: PTPN13
• Organism: Homo sapiens (Human).
• Sequence Length: 2485
• Subcellular Localization: Cytoplasm, cytoskeleton . Nucleus . Cell projection, lamellipodium . Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191).
• Protein Description: Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. [PubMed: 15611135 May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2]
• Protein Sequence: MHVSLAEALEVRGGPLQEEEIWAVLNQSAESLQELFRKVSLADPAALGFIISPWSLLLLPSGSVSFTDENISNQDLRAFTAPEVLQNQSLTSLSDVEKIHIYSLGMTLYWGADYEVPQSQPIKLGDHLNSILLGMCEDVIYARVSVRTVLDACSAHIRNSNCAPSFSYVKHLVKLVLGNLSGTDQLSCNSEQKPDRSQAIRDRLRGKGLPTGRSSTSDVLDIQKPPLSHQTFLNKGLSKSMGFLSIKDTQDENYFKDILSDNSGREDSENTFSPYQFKTSGPEKKPIPGIDVLSKKKIWASSMDLLCTADRDFSSGETATYRRCHPEAVTVRTSTTPRKKEARYSDGSIALDIFGPQKMDPIYHTRELPTSSAISSALDRIRERQKKLQVLREAMNVEEPVRRYKTYHGDVFSTSSESPSIISSESDFRQVRRSEASKRFESSSGLPGVDETLSQGQSQRPSRQYETPFEGNLINQEIMLKRQEEELMQLQAKMALRQSRLSLYPGDTIKASMLDITRDPLREIALETAMTQRKLRNFFGPEFVKMTIEPFISLDLPRSILTKKGKNEDNRRKVNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATLKDNEYFFVDPDLKLTKVAPEGWKEEPKKKTKATVNFTLFFRIKFFMDDVSLIQHTLTCHQYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLSYIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQPLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTLKMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGDEGGYINASFIKIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQAEEEQKQQPQLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
89	Phosphorylation	PEVLQNQSLTSLSDV HHHHCCCCCCCHHHC	40.96	26471730
102	Phosphorylation	DVEKIHIYSLGMTLY HCEEEEEEEECCEEE	5.44	-
103	Phosphorylation	VEKIHIYSLGMTLYW CEEEEEEEECCEEEE	20.17	-
130	Phosphorylation	KLGDHLNSILLGMCE CCHHHHHHHHHHCCC	22.45	-
181	Phosphorylation	KLVLGNLSGTDQLSC HHHHCCCCCCCCCCC	43.58	29214152
183	Phosphorylation	VLGNLSGTDQLSCNS HHCCCCCCCCCCCCC	19.73	29449344
187	Phosphorylation	LSGTDQLSCNSEQKP CCCCCCCCCCCCCCC	12.96	28555341
211	Phosphorylation	LRGKGLPTGRSSTSD HCCCCCCCCCCCCCC	50.71	23898821
214	Phosphorylation	KGLPTGRSSTSDVLD CCCCCCCCCCCCCCC	39.03	23927012
215	Phosphorylation	GLPTGRSSTSDVLDI CCCCCCCCCCCCCCC	30.48	23927012
216	Phosphorylation	LPTGRSSTSDVLDIQ CCCCCCCCCCCCCCC	30.14	25394399
217	Phosphorylation	PTGRSSTSDVLDIQK CCCCCCCCCCCCCCC	27.89	23927012
231	Phosphorylation	KPPLSHQTFLNKGLS CCCCCCHHHHHHHHC	25.35	28857561
240	Phosphorylation	LNKGLSKSMGFLSIK HHHHHCCCCCCEEEC	22.29	30266825
245	Phosphorylation	SKSMGFLSIKDTQDE CCCCCCEEECCCCCC	25.90	23186163
254	Phosphorylation	KDTQDENYFKDILSD CCCCCCHHHHHHHCC	15.23	25159151
256	Ubiquitination	TQDENYFKDILSDNS CCCCHHHHHHHCCCC	33.24	29967540
260	Phosphorylation	NYFKDILSDNSGRED HHHHHHHCCCCCCCC	34.77	29978859
263	Phosphorylation	KDILSDNSGREDSEN HHHHCCCCCCCCCCC	44.19	29978859
268	Phosphorylation	DNSGREDSENTFSPY CCCCCCCCCCCCCCC	28.17	22199227
271	Phosphorylation	GREDSENTFSPYQFK CCCCCCCCCCCCCCC	22.80	22199227
273	Phosphorylation	EDSENTFSPYQFKTS CCCCCCCCCCCCCCC	22.21	22199227
275	Phosphorylation	SENTFSPYQFKTSGP CCCCCCCCCCCCCCC	25.94	22199227
294	Phosphorylation	IPGIDVLSKKKIWAS CCCCCCCCCCCEEHH	42.13	32142685
301	Phosphorylation	SKKKIWASSMDLLCT CCCCEEHHHCCEEEE	15.93	25850435
302	Phosphorylation	KKKIWASSMDLLCTA CCCEEHHHCCEEEEC	14.47	25850435
314	Phosphorylation	CTADRDFSSGETATY EECCCCCCCCCCEEE	41.54	27732954
315	Phosphorylation	TADRDFSSGETATYR ECCCCCCCCCCEEEE	40.41	27732954
318	Phosphorylation	RDFSSGETATYRRCH CCCCCCCCEEEECCC	28.02	29978859
320	Phosphorylation	FSSGETATYRRCHPE CCCCCCEEEECCCCC	25.61	29978859
321	Phosphorylation	SSGETATYRRCHPEA CCCCCEEEECCCCCC	8.13	29978859
335	Phosphorylation	AVTVRTSTTPRKKEA CEEEECCCCCCCCCC	39.96	-
344	Phosphorylation	PRKKEARYSDGSIAL CCCCCCCCCCCCEEE	20.40	28387310
345	Phosphorylation	RKKEARYSDGSIALD CCCCCCCCCCCEEEE	29.91	30278072
348	Phosphorylation	EARYSDGSIALDIFG CCCCCCCCEEEEECC	15.07	30278072
363	Phosphorylation	PQKMDPIYHTRELPT CCCCCCCCCCCCCCC	11.52	25884760
372	Phosphorylation	TRELPTSSAISSALD CCCCCCHHHHHHHHH	31.90	28555341
376	Phosphorylation	PTSSAISSALDRIRE CCHHHHHHHHHHHHH	27.09	28787133
404	Phosphorylation	VEEPVRRYKTYHGDV CCHHHHHHCCCCCCC	9.34	-
415	Phosphorylation	HGDVFSTSSESPSII CCCCCCCCCCCCCEE	30.80	21712546
416	Phosphorylation	GDVFSTSSESPSIIS CCCCCCCCCCCCEEC	42.03	23898821
418	Phosphorylation	VFSTSSESPSIISSE CCCCCCCCCCEECCH	26.37	21712546
420	Phosphorylation	STSSESPSIISSESD CCCCCCCCEECCHHH	41.66	21712546
442	Phosphorylation	EASKRFESSSGLPGV HHHHHHHHCCCCCCH	27.39	27050516
443	Phosphorylation	ASKRFESSSGLPGVD HHHHHHHCCCCCCHH	22.64	29978859
444	Phosphorylation	SKRFESSSGLPGVDE HHHHHHCCCCCCHHH	54.34	29978859
452	Phosphorylation	GLPGVDETLSQGQSQ CCCCHHHHHHCCCCC	27.52	28348404
454	Phosphorylation	PGVDETLSQGQSQRP CCHHHHHHCCCCCCC	39.42	28348404
458	Phosphorylation	ETLSQGQSQRPSRQY HHHHCCCCCCCCCCC	34.67	28348404
462	Phosphorylation	QGQSQRPSRQYETPF CCCCCCCCCCCCCCC	33.92	30622161
465	Phosphorylation	SQRPSRQYETPFEGN CCCCCCCCCCCCCCC	22.21	25106551
467	Phosphorylation	RPSRQYETPFEGNLI CCCCCCCCCCCCCCC	28.48	30622161
479	Oxidation	NLINQEIMLKRQEEE CCCCHHHHHHHHHHH	3.38	17322306
499	Phosphorylation	AKMALRQSRLSLYPG HHHHHHHHCCCCCCC	28.84	22496350
502	Phosphorylation	ALRQSRLSLYPGDTI HHHHHCCCCCCCCCC	25.42	22496350
504	Phosphorylation	RQSRLSLYPGDTIKA HHHCCCCCCCCCCCH	11.20	23312004
508	Phosphorylation	LSLYPGDTIKASMLD CCCCCCCCCCHHHHH	30.23	29449344
512	Phosphorylation	PGDTIKASMLDITRD CCCCCCHHHHHCCCC	18.18	29255136
528	Phosphorylation	LREIALETAMTQRKL HHHHHHHHHHHHHHH	23.68	-
559	Phosphorylation	ISLDLPRSILTKKGK CCCCCCHHHHCCCCC	21.73	24719451
631	Ubiquitination	FFVDPDLKLTKVAPE EEECCCCCEEECCCC	62.58	29967540
744	Ubiquitination	KLDLSYIKEELPKLH HCCHHHHHHHCHHHC	36.58	29967540
753	Phosphorylation	ELPKLHNTYVGASEK HCHHHCCCCCCCCCC	14.61	30622161
754	Phosphorylation	LPKLHNTYVGASEKE CHHHCCCCCCCCCCH	11.38	30622161
758	Phosphorylation	HNTYVGASEKETELE CCCCCCCCCCHHHHH	43.18	30622161
813	Phosphorylation	EVHNGVRTLVLRFPW EEECCEEEEEEEECC	20.86	25106551
827	Phosphorylation	WRETKKISFSKKKIT CCCCEEEECCCCEEE	32.14	24719451
829	Phosphorylation	ETKKISFSKKKITLQ CCEEEECCCCEEEEE	36.45	-
831	Acetylation	KKISFSKKKITLQNT EEEECCCCEEEEEEC	48.48	7674045
838	Phosphorylation	KKITLQNTSDGIKHG CEEEEEECCCCCCCC	18.42	-
839	Phosphorylation	KITLQNTSDGIKHGF EEEEEECCCCCCCCC	41.19	-
887	Phosphorylation	AQDIERASFRSLNLQ HHHHHHHHHHHCCCC	27.67	29978859
890	Phosphorylation	IERASFRSLNLQAES HHHHHHHHCCCCCEE	21.43	19664994
891	Phosphorylation	ERASFRSLNLQAESV HHHHHHHCCCCCEEC	6.90	32142685
897	Phosphorylation	SLNLQAESVRGFNMG HCCCCCEECCCCCCC	21.82	29255136
908	Phosphorylation	FNMGRAISTGSLASS CCCCCCCCCCCCCHH	26.23	30266825
909	Phosphorylation	NMGRAISTGSLASST CCCCCCCCCCCCHHH	25.36	30266825
911	Phosphorylation	GRAISTGSLASSTLN CCCCCCCCCCHHHHH	22.35	30266825
914	Phosphorylation	ISTGSLASSTLNKLA CCCCCCCHHHHHHHC	29.20	30266825
915	Phosphorylation	STGSLASSTLNKLAV CCCCCCHHHHHHHCC	31.16	30266825
916	Phosphorylation	TGSLASSTLNKLAVR CCCCCHHHHHHHCCC	31.67	30266825
926	Phosphorylation	KLAVRPLSVQAEILK HHCCCCHHHHHHHHH	18.18	25159151
936	Phosphorylation	AEILKRLSCSELSLY HHHHHHCCCCHHHCC	21.45	21945579
938	Phosphorylation	ILKRLSCSELSLYQP HHHHCCCCHHHCCCC	37.89	21945579
941	Phosphorylation	RLSCSELSLYQPLQN HCCCCHHHCCCCCCC	22.45	21945579
943	Phosphorylation	SCSELSLYQPLQNSS CCCHHHCCCCCCCCC	12.52	21945579
949	Phosphorylation	LYQPLQNSSKEKNDK CCCCCCCCCCCCCCC	29.81	29888752
950	Phosphorylation	YQPLQNSSKEKNDKA CCCCCCCCCCCCCCC	53.00	29888752
956	Acetylation	SSKEKNDKASWEEKP CCCCCCCCCCHHHCC	54.43	19818639
967	Phosphorylation	EEKPREMSKSYHDLS HHCCHHHHHHHHCHH	17.44	28857561
968	Acetylation	EKPREMSKSYHDLSQ HCCHHHHHHHHCHHH	54.44	30591669
969	Phosphorylation	KPREMSKSYHDLSQA CCHHHHHHHHCHHHH	22.01	25159151
970	Phosphorylation	PREMSKSYHDLSQAS CHHHHHHHHCHHHHH	11.77	20873877
974	Phosphorylation	SKSYHDLSQASLYPH HHHHHCHHHHHCCCC	29.74	20873877
977	Phosphorylation	YHDLSQASLYPHRKN HHCHHHHHCCCCCCC	22.31	29978859
979	Phosphorylation	DLSQASLYPHRKNVI CHHHHHCCCCCCCEE	8.42	29978859
983	Acetylation	ASLYPHRKNVIVNME HHCCCCCCCEEEECC	53.16	30591657
1002	Acetylation	TVAELVGKPSHQMSR HHHHHHCCCCCCCCH	35.55	30591663
1004	Phosphorylation	AELVGKPSHQMSRSD HHHHCCCCCCCCHHH	29.82	29449344
1008	Phosphorylation	GKPSHQMSRSDAESL CCCCCCCCHHHHHHH	23.28	29449344
1010	Phosphorylation	PSHQMSRSDAESLAG CCCCCCHHHHHHHHC	33.59	29255136
1014	Phosphorylation	MSRSDAESLAGVTKL CCHHHHHHHHCHHHC	25.82	29255136
1024	Phosphorylation	GVTKLNNSKSVASLN CHHHCCCCCCHHHCC	25.82	-
1026	Phosphorylation	TKLNNSKSVASLNRS HHCCCCCCHHHCCCC	23.80	23927012
1029	Phosphorylation	NNSKSVASLNRSPER CCCCCHHHCCCCHHH	24.83	25159151
1033	Phosphorylation	SVASLNRSPERRKHE CHHHCCCCHHHHCCC	30.00	25159151
1041	Phosphorylation	PERRKHESDSSSIED HHHHCCCCCCCCCCC	42.38	22496350
1041 (in isoform 3)	Phosphorylation	-	42.38	21406692
1043 (in isoform 3)	Phosphorylation	-	34.95	21406692
1044	Phosphorylation	RKHESDSSSIEDPGQ HCCCCCCCCCCCCCH	40.08	-
1044 (in isoform 3)	Phosphorylation	-	40.08	21406692
1045	Phosphorylation	KHESDSSSIEDPGQA CCCCCCCCCCCCCHH	33.67	-
1045 (in isoform 3)	Phosphorylation	-	33.67	25159151
1053	Phosphorylation	IEDPGQAYVLGMTMH CCCCCHHEEEEEEEE	6.58	30576142
1053 (in isoform 3)	Phosphorylation	-	6.58	21406692
1061	Phosphorylation	VLGMTMHSSGNSSSQ EEEEEEECCCCCCCC	29.17	30576142
1063	Phosphorylation	GMTMHSSGNSSSQVP EEEEECCCCCCCCCC	40.84	32142685
1063 (in isoform 3)	Phosphorylation	-	40.84	25159151
1066 (in isoform 3)	Phosphorylation	-	28.87	25159151
1067	Phosphorylation	HSSGNSSSQVPLKEN ECCCCCCCCCCCCCC	34.71	19664994
1067 (in isoform 3)	Phosphorylation	-	34.71	25159151
1082	Phosphorylation	DVLHKRWSIVSSPER CCCHHCCEECCCCCC	19.69	30266825
1085	Phosphorylation	HKRWSIVSSPEREIT HHCCEECCCCCCEEE	38.21	23927012
1086	Phosphorylation	KRWSIVSSPEREITL HCCEECCCCCCEEEE	21.64	19664994
1092	Phosphorylation	SSPEREITLVNLKKD CCCCCEEEEEEECCC	21.65	29514088
1102	Phosphorylation	NLKKDAKYGLGFQII EECCCCCCCCEEEEE	21.21	-
1187	Phosphorylation	EKISKVPSTPVHLTN HHHCCCCCCCCCCHH	48.62	28857561
1188	Phosphorylation	KISKVPSTPVHLTNE HHCCCCCCCCCCHHH	24.22	28857561
1213	Phosphorylation	MQDSAIDSSSKDHHW CCCCCCCCCCCCCCC	30.33	25627689
1224	Phosphorylation	DHHWSRGTLRHISEN CCCCCHHHHHHHCCC	21.36	28188228
1229	Phosphorylation	RGTLRHISENSFGPS HHHHHHHCCCCCCCC	25.30	20873877
1232	Phosphorylation	LRHISENSFGPSGGL HHHHCCCCCCCCCCC	27.77	20873877
1236	Phosphorylation	SENSFGPSGGLREGS CCCCCCCCCCCCCCC	45.96	29978859
1267	Phosphorylation	QVNGFFASHLGDQTW HHCHHHHHHHCCCCC	17.68	28348404
1295	Phosphorylation	SKATEKETFTDSNQS CHHHCCCCCCCCCCC	42.79	25002506
1297	Phosphorylation	ATEKETFTDSNQSKT HHCCCCCCCCCCCCC	46.03	25002506
1299	Phosphorylation	EKETFTDSNQSKTKK CCCCCCCCCCCCCCC	33.44	25002506
1302	Phosphorylation	TFTDSNQSKTKKPGI CCCCCCCCCCCCCCC	46.68	25002506
1304	Phosphorylation	TDSNQSKTKKPGISD CCCCCCCCCCCCCCC	49.93	21406692
1310	Phosphorylation	KTKKPGISDVTDYSD CCCCCCCCCCCCCCC	31.76	20363803
1313	Phosphorylation	KPGISDVTDYSDRGD CCCCCCCCCCCCCCC	33.92	22496350
1315	Phosphorylation	GISDVTDYSDRGDSD CCCCCCCCCCCCCCC	11.78	23927012
1316	Phosphorylation	ISDVTDYSDRGDSDM CCCCCCCCCCCCCCC	24.52	23927012
1321	Phosphorylation	DYSDRGDSDMDEATY CCCCCCCCCCCHHHC	37.34	23927012
1327	Phosphorylation	DSDMDEATYSSSQDH CCCCCHHHCCCCCCC	23.14	23927012
1328	Phosphorylation	SDMDEATYSSSQDHQ CCCCHHHCCCCCCCC	17.38	25884760
1329	Phosphorylation	DMDEATYSSSQDHQT CCCHHHCCCCCCCCC	21.11	23927012
1330	Phosphorylation	MDEATYSSSQDHQTP CCHHHCCCCCCCCCC	22.93	23927012
1331	Phosphorylation	DEATYSSSQDHQTPK CHHHCCCCCCCCCCC	33.42	23927012
1336	Phosphorylation	SSSQDHQTPKQESSS CCCCCCCCCCCCCCC	29.09	30576142
1343	Phosphorylation	TPKQESSSSVNTSNK CCCCCCCCCCCCCCC	47.81	-
1355	Phosphorylation	SNKMNFKTFSSSPPK CCCCCEEECCCCCCC	25.31	30266825
1357	Phosphorylation	KMNFKTFSSSPPKPG CCCEEECCCCCCCCC	34.83	30266825
1358	Phosphorylation	MNFKTFSSSPPKPGD CCEEECCCCCCCCCC	42.55	30266825
1359	Phosphorylation	NFKTFSSSPPKPGDI CEEECCCCCCCCCCE	43.98	30266825
1377 (in isoform 4)	Phosphorylation	-	30.73	22210691
1381 (in isoform 4)	Phosphorylation	-	16.30	22210691
1383 (in isoform 4)	Phosphorylation	-	22.79	22210691
1437	Phosphorylation	THKQAVETLRNTGQV CHHHHHHHHHHHCHH	25.15	22210691
1441	Phosphorylation	AVETLRNTGQVVHLL HHHHHHHHCHHHHHH	23.66	22210691
1454	Phosphorylation	LLLEKGQSPTSKEHV HHHHCCCCCCCCCCC	38.52	-
1464	Phosphorylation	SKEHVPVTPQCTLSD CCCCCCCCCCCCCCC	11.11	29496963
1468	Phosphorylation	VPVTPQCTLSDQNAQ CCCCCCCCCCCCCCC	24.85	25850435
1470	Phosphorylation	VTPQCTLSDQNAQGQ CCCCCCCCCCCCCCC	20.99	28348404
1508	Phosphorylation	EVKLFKNSSGLGFSF EEEEEECCCCCCCCC	26.77	28857561
1509	Phosphorylation	VKLFKNSSGLGFSFS EEEEECCCCCCCCCC	47.64	28857561
1514	Phosphorylation	NSSGLGFSFSREDNL CCCCCCCCCCCCCCC	22.10	19664994
1516	Phosphorylation	SGLGFSFSREDNLIP CCCCCCCCCCCCCCH	33.30	22496350
1535	Malonylation	ASIVRVKKLFPGQPA CCEEEEHHCCCCCCC	53.13	26320211
1561	Phosphorylation	ILKVNGASLKGLSQQ EEEECCCCCCCCCHH	31.82	27251275
1566	Phosphorylation	GASLKGLSQQEVISA CCCCCCCCHHHHHHH	38.19	-
1577	Phosphorylation	VISALRGTAPEVFLL HHHHHCCCCCCEEEE	32.38	-
1602	Phosphorylation	EIDTALLTPLQSPAQ CCCCHHCCCCCCCCC	23.85	24173317
1622	Phosphorylation	SKDSSQPSCVEQSTS CCCCCCCCHHCCCCC	24.13	23090842
1627	Phosphorylation	QPSCVEQSTSSDENE CCCHHCCCCCCCHHH	19.42	28450419
1628	Phosphorylation	PSCVEQSTSSDENEM CCHHCCCCCCCHHHC	31.76	28450419
1629	Phosphorylation	SCVEQSTSSDENEMS CHHCCCCCCCHHHCC	40.83	28450419
1630	Phosphorylation	CVEQSTSSDENEMSD HHCCCCCCCHHHCCH	49.37	28450419
1636	Phosphorylation	SSDENEMSDKSKKQC CCCHHHCCHHHHHHC	35.39	23090842
1645	Ubiquitination	KSKKQCKSPSRRDSY HHHHHCCCCCCCCCC	35.42	29967540
1699	Phosphorylation	SHHEAPKSQEDTICT HHCCCCCCCCCCEEE	37.43	21945579
1703	Phosphorylation	APKSQEDTICTMFYY CCCCCCCCEEEEEEC	19.73	21945579
1706	Phosphorylation	SQEDTICTMFYYPQK CCCCCEEEEEECCCC	13.38	21945579
1709	Phosphorylation	DTICTMFYYPQKIPN CCEEEEEECCCCCCC	11.92	23663014
1710	Phosphorylation	TICTMFYYPQKIPNK CEEEEEECCCCCCCC	6.47	23663014
1753	Phosphorylation	SSSSMDKYHIHHISE CCCCCCCEEEECCCC	11.18	28674419
1798	Phosphorylation	LIKSEKGSLGFTVTK HHHCCCCCEEEEEEE	36.07	28857561
1817	Ubiquitination	IGCYVHDVIQDPAKS EEEEEEEEECCCCCC	2.27	29967540
1824	Phosphorylation	VIQDPAKSDGRLKPG EECCCCCCCCCCCCC	47.61	-
1836	Ubiquitination	KPGDRLIKVNDTDVT CCCCEEEEECCCCCC	39.31	29967540
1840	Phosphorylation	RLIKVNDTDVTNMTH EEEEECCCCCCCCCH	27.45	24719451
1841	Ubiquitination	LIKVNDTDVTNMTHT EEEECCCCCCCCCHH	48.37	29967540
1954	O-linked_Glycosylation	VNRALDMSLPSLVLK HHHHHCCCCCHHHHH	36.47	29237092
1957	O-linked_Glycosylation	ALDMSLPSLVLKATR HHCCCCCHHHHHHHC	36.08	29237092
1963	Phosphorylation	PSLVLKATRNDLPVV CHHHHHHHCCCCCCC	28.55	22210691
1972	Phosphorylation	NDLPVVPSSKRSAVS CCCCCCCCCCCCCCC	36.56	21406692
1973	Phosphorylation	DLPVVPSSKRSAVSA CCCCCCCCCCCCCCC	26.47	21406692
1979	Phosphorylation	SSKRSAVSAPKSTKG CCCCCCCCCCCCCCC	38.27	22210691
2001	Phosphorylation	SCSQPALTPNDSFST CCCCCCCCCCCCCCC	23.35	28348404
2005	Phosphorylation	PALTPNDSFSTVAGE CCCCCCCCCCCCCCC	27.95	28348404
2007	Phosphorylation	LTPNDSFSTVAGEEI CCCCCCCCCCCCCEE	26.39	28348404
2008	Phosphorylation	TPNDSFSTVAGEEIN CCCCCCCCCCCCEEC	16.62	28348404
2018	Phosphorylation	GEEINEISYPKGKCS CCEECCCCCCCCCCC	29.24	24719451
2032	Phosphorylation	STYQIKGSPNLTLPK CCEECCCCCCCCCCC	12.95	25159151
2036	Phosphorylation	IKGSPNLTLPKESYI CCCCCCCCCCCHHHC	47.88	30266825
2095	Phosphorylation	LKMNGKLSEERTEDT CCCCCEECCCCCCCC	40.68	26471730
2099	Phosphorylation	GKLSEERTEDTDCDG CEECCCCCCCCCCCC	41.30	29449344
2102	Phosphorylation	SEERTEDTDCDGSPL CCCCCCCCCCCCCCC	32.09	27251275
2107	Phosphorylation	EDTDCDGSPLPEYFT CCCCCCCCCCHHHHH	15.26	27966365
2112	Phosphorylation	DGSPLPEYFTEATKM CCCCCHHHHHHHHCC	17.54	29978859
2114	Phosphorylation	SPLPEYFTEATKMNG CCCHHHHHHHHCCCC	24.65	29978859
2117	Phosphorylation	PEYFTEATKMNGCEE HHHHHHHHCCCCCHH	25.29	29978859
2132	Phosphorylation	YCEEKVKSESLIQKP HHHHHHHCCHHCCCC	35.09	25002506
2134	Phosphorylation	EEKVKSESLIQKPQE HHHHHCCHHCCCCCC	37.55	25002506
2171	Phosphorylation	EDSDKDHSFLTNDEL CCCCCCCCCCCCHHE	31.89	22199227
2174	Phosphorylation	DKDHSFLTNDELAVL CCCCCCCCCHHEEEE	38.32	22199227
2189	Phosphorylation	PVVKVLPSGKYTGAN EEEEECCCCCCCCCC	43.70	24719451
2205	Methylation	KSVIRVLRGLLDQGI HHHHHHHHHHHHCCC	30.75	115489629
2214	Phosphorylation	LLDQGIPSKELENLQ HHHCCCCHHHHCHHH	36.52	24719451
2243	Phosphorylation	ENRRKNRYKNILPYD HHHHHHCCCCCCCCC	20.13	28152594
2249	Phosphorylation	RYKNILPYDATRVPL CCCCCCCCCCCCCCC	18.11	-
2266	Phosphorylation	EGGYINASFIKIPVG CCCEEEEEEEEEECC	24.02	24719451
2330	Phosphorylation	WPNILGKTTMVSNRL CCCCCCCHHHHCHHH	20.51	-
2331	Phosphorylation	PNILGKTTMVSNRLR CCCCCCHHHHCHHHH	21.04	24670416
2334	Phosphorylation	LGKTTMVSNRLRLAL CCCHHHHCHHHHHHH	12.86	24670416
2383	Phosphorylation	WPDHDTPSQPDDLLT CCCCCCCCCCHHHHH	57.34	18452278
2393	Phosphorylation	DDLLTFISYMRHIHR HHHHHHHHHHHHHHH	14.53	18452278
2394	Phosphorylation	DLLTFISYMRHIHRS HHHHHHHHHHHHHHH	8.05	18452278
2453	Phosphorylation	QRHGMVQTEDQYIFC HHCCCCCCCCHHHHH	30.07	24043423
2457	Phosphorylation	MVQTEDQYIFCYQVI CCCCCCHHHHHHHHH	14.32	24043423
2461	Phosphorylation	EDQYIFCYQVILYVL CCHHHHHHHHHHHHH	8.61	24043423
2466	Phosphorylation	FCYQVILYVLTRLQA HHHHHHHHHHHHHHH	5.14	24043423
2469	Phosphorylation	QVILYVLTRLQAEEE HHHHHHHHHHHHHHH	21.20	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PTN13_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PTN13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PTN13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC_RAT	Apc	physical	10951583
IKBA_HUMAN	NFKBIA	physical	9882613
RHG29_HUMAN	ARHGAP29	physical	9305890
PKN2_HUMAN	PKN2	physical	11356191
TNFL6_HUMAN	FASLG	physical	9261095
CTNB1_HUMAN	CTNNB1	physical	10951583
PKHA1_HUMAN	PLEKHA1	physical	27880917
STXB4_HUMAN	STXBP4	physical	27880917
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
CING_HUMAN	CGN	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LPIN3_HUMAN	LPIN3	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
RTKN_HUMAN	RTKN	physical	27173435
MAST3_HUMAN	MAST3	physical	27173435
DEN1A_HUMAN	DENND1A	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
PPM1H_HUMAN	PPM1H	physical	27173435
TANC2_HUMAN	TANC2	physical	27173435
RGPS2_HUMAN	RALGPS2	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
NF1_HUMAN	NF1	physical	27173435
MPIP3_HUMAN	CDC25C	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
INP5E_HUMAN	INPP5E	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-908; SER-911 ANDSER-1629, AND MASS SPECTROMETRY.
PubMed: 19413330