dbPTM

RTKN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RTKN_HUMAN
UniProt AC	Q9BST9
Protein Name	Rhotekin
Gene Name	RTKN {ECO:0000312\|HGNC:HGNC:10466}
Organism	Homo sapiens (Human).
Sequence Length	563
Subcellular Localization
Protein Description	Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures..
Protein Sequence	MFSRNHRSRVTVARGSALEMEFKRGRFRLSLFSDLPEDTELQRKLDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILSYMGELQRRKEAQVLGKTSRRPSDSGPPAERSPCRGRVCISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQLGEHIQDTEMILVDRTLTDISFQSNVLFAEAGPDFELRLELYGACVEEEGALTGGPKRLATKLSSSLGRSSGRRVRASLDSAGGSGSSPILLPTPVVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLASHEENPAWLPLYGSVCCRLAAQPLCMTQPTASGTLRVQQAGEMQNWAQVHGVLKGTNLFCYRQPEDADTGEEPLLTIAVNKETRVRAGELDQALGRPFTLSISNQYGDDEVTHTLQTESREALQSWMEALWQLFFDMSQWKQCCDEIMKIETPAPRKPPQALAKQGSLYHEMAIEPLDDIAAVTDILTQREGARLETPPPWLAMFTDQPALPNPCSPASVAPAPDWTHPLPWGRPRTFSLDAVPPDHSPRARSVAPLPPQRSPRTRGLCSKGQPRTWLQSPV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MFSRNHRSRVTVAR -CCCCCCCCCEEEEE	29.70	32015554
8	Phosphorylation	MFSRNHRSRVTVARG CCCCCCCCCEEEEEC	24.45	23312004
9	Methylation	FSRNHRSRVTVARGS CCCCCCCCEEEEECC	28.25	54558925
9	Ubiquitination	FSRNHRSRVTVARGS CCCCCCCCEEEEECC	28.25	22817900
11	Phosphorylation	RNHRSRVTVARGSAL CCCCCCEEEEECCCE	13.82	22798277
11	Ubiquitination	RNHRSRVTVARGSAL CCCCCCEEEEECCCE	13.82	22817900
14	Methylation	RSRVTVARGSALEME CCCEEEEECCCEEEE	34.95	24129315
23	Ubiquitination	SALEMEFKRGRFRLS CCEEEEECCCCEEEE	40.41	27667366
30	Phosphorylation	KRGRFRLSLFSDLPE CCCCEEEEECCCCCC	24.10	22617229
33	Phosphorylation	RFRLSLFSDLPEDTE CEEEEECCCCCCCCH	43.46	28857561
39	Phosphorylation	FSDLPEDTELQRKLD CCCCCCCCHHHHHHH	36.61	23090842
43	Ubiquitination	PEDTELQRKLDHEIR CCCCHHHHHHHHHHH	54.88	22817900
44	Ubiquitination	EDTELQRKLDHEIRM CCCHHHHHHHHHHHH	45.35	32015554
50	Ubiquitination	RKLDHEIRMREGACK HHHHHHHHHHHHHHH	18.34	22817900
57	Ubiquitination	RMREGACKLLAACSQ HHHHHHHHHHHHHHH	46.10	32015554
60	Ubiquitination	EGACKLLAACSQREQ HHHHHHHHHHHHHHH	19.50	27667366
63	Phosphorylation	CKLLAACSQREQALE HHHHHHHHHHHHHHH	27.78	28857561
72	Phosphorylation	REQALEATKSLLVCN HHHHHHHHHHHHHCH	16.28	29052541
73	Ubiquitination	EQALEATKSLLVCNS HHHHHHHHHHHHCHH	46.27	27667366
80	Ubiquitination	KSLLVCNSRILSYMG HHHHHCHHHHHHHHH	18.64	22817900
80 (in isoform 2)	Ubiquitination	-	18.64	21906983
81	Ubiquitination	SLLVCNSRILSYMGE HHHHCHHHHHHHHHH	21.63	22817900
83	Ubiquitination	LVCNSRILSYMGELQ HHCHHHHHHHHHHHH	2.66	22817900
86	Ubiquitination	NSRILSYMGELQRRK HHHHHHHHHHHHHHH	2.78	22817900
87	Ubiquitination	SRILSYMGELQRRKE HHHHHHHHHHHHHHH	24.99	22817900
87 (in isoform 2)	Ubiquitination	-	24.99	21906983
89	Ubiquitination	ILSYMGELQRRKEAQ HHHHHHHHHHHHHHH	3.88	22817900
91	Ubiquitination	SYMGELQRRKEAQVL HHHHHHHHHHHHHHH	65.35	22817900
93	Ubiquitination	MGELQRRKEAQVLGK HHHHHHHHHHHHHCC	60.64	21906983
93 (in isoform 1)	Ubiquitination	-	60.64	21906983
97 (in isoform 3)	Ubiquitination	-	11.10	21906983
100	Ubiquitination	KEAQVLGKTSRRPSD HHHHHHCCCCCCCCC	38.88	21906983
100 (in isoform 1)	Ubiquitination	-	38.88	21906983
101	Phosphorylation	EAQVLGKTSRRPSDS HHHHHCCCCCCCCCC	26.18	28102081
102	Phosphorylation	AQVLGKTSRRPSDSG HHHHCCCCCCCCCCC	29.76	28102081
104 (in isoform 3)	Ubiquitination	-	34.54	21906983
106	Phosphorylation	GKTSRRPSDSGPPAE CCCCCCCCCCCCCHH	42.47	27273156
108	Phosphorylation	TSRRPSDSGPPAERS CCCCCCCCCCCHHHC	58.50	27273156
115	Phosphorylation	SGPPAERSPCRGRVC CCCCHHHCCCCCEEE	21.62	28731282
120	Ubiquitination	ERSPCRGRVCISDLR HHCCCCCEEEEECCC	10.77	22817900
120 (in isoform 2)	Ubiquitination	-	10.77	21906983
124	Phosphorylation	CRGRVCISDLRIPLM CCCEEEEECCCCEEE	26.01	24719451
126	Ubiquitination	GRVCISDLRIPLMWK CEEEEECCCCEEEEE	4.22	22817900
126 (in isoform 2)	Ubiquitination	-	4.22	21906983
128	Ubiquitination	VCISDLRIPLMWKDT EEEECCCCEEEEECC	3.90	22817900
133	Ubiquitination	LRIPLMWKDTEYFKN CCCEEEEECCHHHCC	40.58	21906983
133 (in isoform 1)	Ubiquitination	-	40.58	21906983
137 (in isoform 3)	Ubiquitination	-	23.19	21906983
139	2-Hydroxyisobutyrylation	WKDTEYFKNKGDLHR EECCHHHCCCCHHHH	57.77	-
139	Ubiquitination	WKDTEYFKNKGDLHR EECCHHHCCCCHHHH	57.77	22817900
139 (in isoform 1)	Ubiquitination	-	57.77	21906983
141	Ubiquitination	DTEYFKNKGDLHRWA CCHHHCCCCHHHHHH	55.16	22817900
143 (in isoform 3)	Ubiquitination	-	40.69	21906983
161	Ubiquitination	QLGEHIQDTEMILVD HHHHHHCCCCEEEEE	43.99	22817900
166	Ubiquitination	IQDTEMILVDRTLTD HCCCCEEEEECCCCC	2.94	22817900
170	Phosphorylation	EMILVDRTLTDISFQ CEEEEECCCCCEEHH	29.55	33259812
198	Ubiquitination	LRLELYGACVEEEGA EEEEEEEEEHHCCCC	4.80	22817900
203	Ubiquitination	YGACVEEEGALTGGP EEEEHHCCCCCCCCH	35.94	22817900
203 (in isoform 2)	Ubiquitination	-	35.94	21906983
207	Phosphorylation	VEEEGALTGGPKRLA HHCCCCCCCCHHHHH	39.29	33259812
211	Ubiquitination	GALTGGPKRLATKLS CCCCCCHHHHHHHHH	64.42	22817900
215	Phosphorylation	GGPKRLATKLSSSLG CCHHHHHHHHHHHCC	36.79	23927012
216	Ubiquitination	GPKRLATKLSSSLGR CHHHHHHHHHHHCCC	40.54	27667366
216 (in isoform 1)	Ubiquitination	-	40.54	21906983
218	Phosphorylation	KRLATKLSSSLGRSS HHHHHHHHHHCCCCC	21.31	23927012
219	Phosphorylation	RLATKLSSSLGRSSG HHHHHHHHHCCCCCC	39.76	23927012
220	Phosphorylation	LATKLSSSLGRSSGR HHHHHHHHCCCCCCC	31.31	28355574
220 (in isoform 3)	Ubiquitination	-	31.31	21906983
224	Phosphorylation	LSSSLGRSSGRRVRA HHHHCCCCCCCCCEE	35.03	27422710
225	Phosphorylation	SSSLGRSSGRRVRAS HHHCCCCCCCCCEEE	34.65	23090842
230	Asymmetric dimethylarginine	RSSGRRVRASLDSAG CCCCCCCEEEECCCC	19.35	-
230	Methylation	RSSGRRVRASLDSAG CCCCCCCEEEECCCC	19.35	-
232	Phosphorylation	SGRRVRASLDSAGGS CCCCCEEEECCCCCC	23.34	29255136
235	Phosphorylation	RVRASLDSAGGSGSS CCEEEECCCCCCCCC	33.82	29255136
239	Phosphorylation	SLDSAGGSGSSPILL EECCCCCCCCCCEEE	34.29	29255136
241	Phosphorylation	DSAGGSGSSPILLPT CCCCCCCCCCEEECC	34.34	29255136
242	Phosphorylation	SAGGSGSSPILLPTP CCCCCCCCCEEECCC	21.34	29255136
248	Phosphorylation	SSPILLPTPVVGGPR CCCEEECCCCCCCCC	28.78	22199227
308	Ubiquitination	AAQPLCMTQPTASGT HCCCCCCCCCCCCCE	30.33	27667366
313	Phosphorylation	CMTQPTASGTLRVQQ CCCCCCCCCEEEEEE	34.49	28857561
315	Phosphorylation	TQPTASGTLRVQQAG CCCCCCCEEEEEECC	14.64	28857561
388	Ubiquitination	LSISNQYGDDEVTHT EEEECCCCCCCCEEE	26.57	27667366
425	Ubiquitination	MSQWKQCCDEIMKIE HHHHHHHHHHHHCCC	4.95	27667366
433	Phosphorylation	DEIMKIETPAPRKPP HHHHCCCCCCCCCCC	28.37	21815630
438	Ubiquitination	IETPAPRKPPQALAK CCCCCCCCCCHHHHH	61.05	27667366
448	Phosphorylation	QALAKQGSLYHEMAI HHHHHCCCCCCEECC	24.22	28355574
450	Phosphorylation	LAKQGSLYHEMAIEP HHHCCCCCCEECCCC	9.46	29496963
465	Phosphorylation	LDDIAAVTDILTQRE HHHHHHHHHHHHHCC	16.76	22617229
470	Phosphorylation	AVTDILTQREGARLE HHHHHHHHCCCCCCC	37.67	32142685
493	Phosphorylation	FTDQPALPNPCSPAS CCCCCCCCCCCCCCC	44.84	32142685
497	Phosphorylation	PALPNPCSPASVAPA CCCCCCCCCCCCCCC	25.43	23898821
507	Phosphorylation	SVAPAPDWTHPLPWG CCCCCCCCCCCCCCC	8.78	32142685
518	Phosphorylation	LPWGRPRTFSLDAVP CCCCCCCEEECCCCC	21.91	30266825
520	Phosphorylation	WGRPRTFSLDAVPPD CCCCCEEECCCCCCC	25.40	29255136
529	Phosphorylation	DAVPPDHSPRARSVA CCCCCCCCCCCCCCC	24.38	29255136
530	Phosphorylation	AVPPDHSPRARSVAP CCCCCCCCCCCCCCC	30.45	32142685
531	Methylation	VPPDHSPRARSVAPL CCCCCCCCCCCCCCC	45.72	115492983
533	Methylation	PDHSPRARSVAPLPP CCCCCCCCCCCCCCC	32.70	115492991
534	Phosphorylation	DHSPRARSVAPLPPQ CCCCCCCCCCCCCCC	22.96	23927012
543	Phosphorylation	APLPPQRSPRTRGLC CCCCCCCCCCCCCCC	17.31	27461979
547	Methylation	PQRSPRTRGLCSKGQ CCCCCCCCCCCCCCC	37.05	54558931
561	Phosphorylation	QPRTWLQSPV----- CCCCCCCCCC-----	26.01	29496963

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
435	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RTKN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RTKN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHOA_HUMAN	RHOA	physical	12593858
RHOA_HUMAN	RHOA	physical	19805522
RHOA_HUMAN	RHOA	physical	15075243
A4_HUMAN	APP	physical	21832049
RHO1_YEAST	RHO1	physical	20171953
RHOA_HUMAN	RHOA	physical	19696020
AKP13_HUMAN	AKAP13	physical	19696020
MLP3A_HUMAN	MAP1LC3A	physical	19696020
RHOA_HUMAN	RHOA	physical	14749388
RHOA_HUMAN	RHOA	physical	22693251
RHOA_HUMAN	RHOA	physical	19147496
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
CING_HUMAN	CGN	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
DEN1A_HUMAN	DENND1A	physical	27173435
MAST3_HUMAN	MAST3	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
LPIN3_HUMAN	LPIN3	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
NF1_HUMAN	NF1	physical	27173435
ZN638_HUMAN	ZNF638	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
MPIP3_HUMAN	CDC25C	physical	27173435
RGPS2_HUMAN	RALGPS2	physical	27173435
SIN1_HUMAN	MAPKAP1	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
NADK_HUMAN	NADK	physical	27173435
CAMP2_HUMAN	CAMSAP2	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
MPIP2_HUMAN	CDC25B	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
CDK16_HUMAN	CDK16	physical	27173435
M3K21_HUMAN	KIAA1804	physical	27173435
TIAM1_HUMAN	TIAM1	physical	27173435
TANC2_HUMAN	TANC2	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
OSBL6_HUMAN	OSBPL6	physical	27173435
PKHA7_HUMAN	PLEKHA7	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
AN34A_HUMAN	ANKRD34A	physical	27173435
FA53C_HUMAN	FAM53C	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435
MELK_HUMAN	MELK	physical	27173435
RPTOR_HUMAN	RPTOR	physical	27173435
STA13_HUMAN	STARD13	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
HDAC7_HUMAN	HDAC7	physical	27173435
DEP1B_HUMAN	DEPDC1B	physical	27173435
INP5E_HUMAN	INPP5E	physical	27173435
LARP1_HUMAN	LARP1	physical	27173435
PKHA5_HUMAN	PLEKHA5	physical	27173435
KIF1B_HUMAN	KIF1B	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RTKN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-106, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-241 ANDSER-543, AND MASS SPECTROMETRY.	18669648 [Abstract]