dbPTM

MPIP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPIP2_HUMAN
UniProt AC	P30305
Protein Name	M-phase inducer phosphatase 2
Gene Name	CDC25B
Organism	Homo sapiens (Human).
Sequence Length	580
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole .
Protein Description	Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity..
Protein Sequence	MEVPQPEPAPGSALSPAGVCGGAQRPGHLPGLLLGSHGLLGSPVRAAASSPVTTLTQTMHDLAGLGSETPKSQVGTLLFRSRSRLTHLSLSRRASESSLSSESSESSDAGLCMDSPSPMDPHMAEQTFEQAIQAASRIIRNEQFAIRRFQSMPVRLLGHSPVLRNITNSQAPDGRRKSEAGSGAASSSGEDKENDGFVFKMPWKPTHPSSTHALAEWASRREAFAQRPSSAPDLMCLSPDRKMEVEELSPLALGRFSLTPAEGDTEEDDGFVDILESDLKDDDAVPPGMESLISAPLVKTLEKEEEKDLVMYSKCQRLFRSPSMPCSVIRPILKRLERPQDRDTPVQNKRRRSVTPPEEQQEAEEPKARVLRSKSLCHDEIENLLDSDHRELIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVDKFVIVDCRYPYEYEGGHIKTAVNLPLERDAESFLLKSPIAPCSLDKRVILIFHCEFSSERGPRMCRFIRERDRAVNDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFKDELKTFRLKTRSWAGERSRRELCSRLQDQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	QPEPAPGSALSPAGV CCCCCCCCCCCCCCC	25.61	23898821
15	Phosphorylation	PAPGSALSPAGVCGG CCCCCCCCCCCCCCC	16.66	28348404
36	Phosphorylation	LPGLLLGSHGLLGSP CCCCCCCCCCCCCCC	17.85	23898821
42	Phosphorylation	GSHGLLGSPVRAAAS CCCCCCCCCHHHHHC	21.86	17001009
49	Phosphorylation	SPVRAAASSPVTTLT CCHHHHHCCCCCHHH	30.37	22199227
49 (in isoform 2)	Phosphorylation	-	30.37	22210691
49 (in isoform 4)	Phosphorylation	-	30.37	22210691
50	Phosphorylation	PVRAAASSPVTTLTQ CHHHHHCCCCCHHHH	20.75	25850435
53	Phosphorylation	AAASSPVTTLTQTMH HHHCCCCCHHHHHHH	21.33	25850435
54	Phosphorylation	AASSPVTTLTQTMHD HHCCCCCHHHHHHHH	28.21	22199227
56	Phosphorylation	SSPVTTLTQTMHDLA CCCCCHHHHHHHHHC	21.65	22199227
58	Phosphorylation	PVTTLTQTMHDLAGL CCCHHHHHHHHHCCC	15.96	22199227
67	Phosphorylation	HDLAGLGSETPKSQV HHHCCCCCCCCHHHH	43.25	27080861
67 (in isoform 2)	Phosphorylation	-	43.25	22210691
67 (in isoform 4)	Phosphorylation	-	43.25	22210691
69	Phosphorylation	LAGLGSETPKSQVGT HCCCCCCCCHHHHHH	37.40	22199227
69 (in isoform 2)	Phosphorylation	-	37.40	22210691
69 (in isoform 4)	Phosphorylation	-	37.40	22210691
71	Ubiquitination	GLGSETPKSQVGTLL CCCCCCCHHHHHHHH	62.02	-
81	Phosphorylation	VGTLLFRSRSRLTHL HHHHHHCCCCCCHHH	27.55	23898821
86	Phosphorylation	FRSRSRLTHLSLSRR HCCCCCCHHHHHHHH	21.47	23927012
89	Phosphorylation	RSRLTHLSLSRRASE CCCCHHHHHHHHHCC	19.39	23927012
91	Phosphorylation	RLTHLSLSRRASESS CCHHHHHHHHHCCCC	19.15	23927012
97	Phosphorylation	LSRRASESSLSSESS HHHHHCCCCCCCCCC	33.80	-
115	Phosphorylation	DAGLCMDSPSPMDPH CCCCCCCCCCCCCHH	10.61	-
117	Phosphorylation	GLCMDSPSPMDPHMA CCCCCCCCCCCHHHH	36.49	-
127	Phosphorylation	DPHMAEQTFEQAIQA CHHHHHHHHHHHHHH	22.20	21640712
151	Phosphorylation	FAIRRFQSMPVRLLG HHHHHHHHCCCHHHC	23.49	30266825
151 (in isoform 3)	Phosphorylation	-	23.49	25850435
160	Phosphorylation	PVRLLGHSPVLRNIT CCHHHCCCHHHHHCC	18.20	30266825
167	Phosphorylation	SPVLRNITNSQAPDG CHHHHHCCCCCCCCC	32.16	21640712
169	Phosphorylation	VLRNITNSQAPDGRR HHHHCCCCCCCCCCC	21.04	22817900
177	Ubiquitination	QAPDGRRKSEAGSGA CCCCCCCCCCCCCCC	51.81	-
178	Phosphorylation	APDGRRKSEAGSGAA CCCCCCCCCCCCCCC	30.76	25849741
182	Phosphorylation	RRKSEAGSGAASSSG CCCCCCCCCCCCCCC	32.10	29214152
186	Phosphorylation	EAGSGAASSSGEDKE CCCCCCCCCCCCCCC	25.22	12527891
187	Phosphorylation	AGSGAASSSGEDKEN CCCCCCCCCCCCCCC	37.32	12527891
188	Phosphorylation	GSGAASSSGEDKEND CCCCCCCCCCCCCCC	43.64	-
190 (in isoform 2)	Ubiquitination	-	68.78	-
192	Ubiquitination	ASSSGEDKENDGFVF CCCCCCCCCCCCEEE	54.86	-
200	Ubiquitination	ENDGFVFKMPWKPTH CCCCEEEEECCCCCC	38.46	-
201 (in isoform 3)	Ubiquitination	-	3.04	21890473
204	Ubiquitination	FVFKMPWKPTHPSST EEEEECCCCCCCCHH	33.88	-
209	Phosphorylation	PWKPTHPSSTHALAE CCCCCCCCHHHHHHH	40.02	21640712
228 (in isoform 2)	Ubiquitination	-	22.13	21890473
229	Phosphorylation	EAFAQRPSSAPDLMC HHHHHCCCCCCCCEE	41.12	23927012
230	Phosphorylation	AFAQRPSSAPDLMCL HHHHCCCCCCCCEEE	46.64	23927012
238	Phosphorylation	APDLMCLSPDRKMEV CCCCEEECCCCCCCH	21.59	23401153
242	Sumoylation	MCLSPDRKMEVEELS EEECCCCCCCHHHHC	46.95	-
242	Sumoylation	MCLSPDRKMEVEELS EEECCCCCCCHHHHC	46.95	-
242	Ubiquitination	MCLSPDRKMEVEELS EEECCCCCCCHHHHC	46.95	21906983
242 (in isoform 1)	Ubiquitination	-	46.95	21890473
249	Phosphorylation	KMEVEELSPLALGRF CCCHHHHCHHHCCEE	22.58	29255136
258 (in isoform 3)	Ubiquitination	-	6.47	21890473
262 (in isoform 3)	Ubiquitination	-	59.82	21890473
263 (in isoform 4)	Ubiquitination	-	49.61	21890473
265	Phosphorylation	LTPAEGDTEEDDGFV CCCCCCCCCCCCCCC	52.73	21640712
266 (in isoform 3)	Ubiquitination	-	65.26	21890473
285 (in isoform 2)	Ubiquitination	-	8.27	21890473
289 (in isoform 2)	Ubiquitination	-	3.79	21890473
291	Phosphorylation	AVPPGMESLISAPLV CCCCCHHHHHCCCHH	23.31	21640712
293 (in isoform 2)	Ubiquitination	-	4.61	21890473
299	Ubiquitination	LISAPLVKTLEKEEE HHCCCHHHHCCHHHH	55.89	-
299 (in isoform 1)	Ubiquitination	-	55.89	21890473
303	Ubiquitination	PLVKTLEKEEEKDLV CHHHHCCHHHHHHHH	73.81	21906983
303 (in isoform 1)	Ubiquitination	-	73.81	21890473
307	Ubiquitination	TLEKEEEKDLVMYSK HCCHHHHHHHHHHHH	60.69	21906983
307 (in isoform 1)	Ubiquitination	-	60.69	21890473
312	Phosphorylation	EEKDLVMYSKCQRLF HHHHHHHHHHHHHHH	9.48	-
313	Phosphorylation	EKDLVMYSKCQRLFR HHHHHHHHHHHHHHC	14.62	24719451
320 (in isoform 4)	Ubiquitination	-	52.85	21890473
321	Phosphorylation	KCQRLFRSPSMPCSV HHHHHHCCCCCCHHH	17.62	23927012
323	Phosphorylation	QRLFRSPSMPCSVIR HHHHCCCCCCHHHHH	36.28	23927012
324 (in isoform 4)	Ubiquitination	-	4.38	21890473
327	Phosphorylation	RSPSMPCSVIRPILK CCCCCCHHHHHHHHH	18.08	30576142
328 (in isoform 4)	Ubiquitination	-	5.69	21890473
334	Ubiquitination	SVIRPILKRLERPQD HHHHHHHHHCCCCCC	56.51	-
344	Phosphorylation	ERPQDRDTPVQNKRR CCCCCCCCCCCCCCC	26.67	30576142
349	Ubiquitination	RDTPVQNKRRRSVTP CCCCCCCCCCCCCCC	30.14	-
353	Phosphorylation	VQNKRRRSVTPPEEQ CCCCCCCCCCCHHHH	28.65	25159151
355	Phosphorylation	NKRRRSVTPPEEQQE CCCCCCCCCHHHHHH	34.08	30278072
357 (in isoform 3)	Ubiquitination	-	48.68	21890473
367	Sumoylation	QQEAEEPKARVLRSK HHHHHCHHHHHHHHH	52.70	-
367	Sumoylation	QQEAEEPKARVLRSK HHHHHCHHHHHHHHH	52.70	-
367	Ubiquitination	QQEAEEPKARVLRSK HHHHHCHHHHHHHHH	52.70	-
367 (in isoform 3)	Ubiquitination	-	52.70	21890473
372 (in isoform 3)	Ubiquitination	-	38.90	21890473
373	Phosphorylation	PKARVLRSKSLCHDE HHHHHHHHHHHCHHH	23.57	23927012
374	Ubiquitination	KARVLRSKSLCHDEI HHHHHHHHHHCHHHH	40.80	-
375	Phosphorylation	ARVLRSKSLCHDEIE HHHHHHHHHCHHHHH	37.16	29255136
384 (in isoform 2)	Ubiquitination	-	3.49	21890473
387	Phosphorylation	EIENLLDSDHRELIG HHHHHHCCCHHHHHC	34.97	23927012
394 (in isoform 2)	Ubiquitination	-	40.19	21890473
396	Phosphorylation	HRELIGDYSKAFLLQ HHHHHCHHHHEEEEE	13.57	21406692
397	Phosphorylation	RELIGDYSKAFLLQT HHHHCHHHHEEEEEE	23.42	21406692
398	Ubiquitination	ELIGDYSKAFLLQTV HHHCHHHHEEEEEEC	36.61	21906983
398 (in isoform 1)	Ubiquitination	-	36.61	21890473
399 (in isoform 2)	Ubiquitination	-	8.38	21890473
404	Phosphorylation	SKAFLLQTVDGKHQD HHEEEEEECCCCCCC	22.12	21640712
408	Ubiquitination	LLQTVDGKHQDLKYI EEEECCCCCCCCCCC	33.36	21906983
408 (in isoform 1)	Ubiquitination	-	33.36	21890473
411 (in isoform 3)	Ubiquitination	-	44.86	21890473
413	Ubiquitination	DGKHQDLKYISPETM CCCCCCCCCCCHHHH	49.15	21906983
413 (in isoform 1)	Ubiquitination	-	49.15	21890473
414	Phosphorylation	GKHQDLKYISPETMV CCCCCCCCCCHHHHH	17.58	29496907
416	Phosphorylation	HQDLKYISPETMVAL CCCCCCCCHHHHHHH	17.37	22210691
419	Phosphorylation	LKYISPETMVALLTG CCCCCHHHHHHHHHC	21.96	24114839
419 (in isoform 4)	Ubiquitination	-	21.96	21890473
425	Phosphorylation	ETMVALLTGKFSNIV HHHHHHHHCCCCCCC	38.89	22210691
427	Ubiquitination	MVALLTGKFSNIVDK HHHHHHCCCCCCCCE	40.14	-
429	Phosphorylation	ALLTGKFSNIVDKFV HHHHCCCCCCCCEEE	29.18	22210691
429 (in isoform 4)	Ubiquitination	-	29.18	21890473
434	Ubiquitination	KFSNIVDKFVIVDCR CCCCCCCEEEEEECC	30.54	-
434 (in isoform 4)	Ubiquitination	-	30.54	21890473
438 (in isoform 2)	Ubiquitination	-	4.83	21890473
452	Ubiquitination	EYEGGHIKTAVNLPL EECCCEEEEEEECCC	25.43	21906983
452 (in isoform 1)	Ubiquitination	-	25.43	21890473
465	Phosphorylation	PLERDAESFLLKSPI CCCCCHHHHHHCCCC	23.94	26552605
469	Ubiquitination	DAESFLLKSPIAPCS CHHHHHHCCCCCCCC	57.23	-
470	Phosphorylation	AESFLLKSPIAPCSL HHHHHHCCCCCCCCC	22.85	25159151
473 (in isoform 4)	Ubiquitination	-	11.48	21890473
476	Phosphorylation	KSPIAPCSLDKRVIL CCCCCCCCCCCCEEE	38.25	23312004
479	Ubiquitination	IAPCSLDKRVILIFH CCCCCCCCCEEEEEE	54.58	-
482 (in isoform 3)	Ubiquitination	-	2.57	21890473
509 (in isoform 2)	Ubiquitination	-	41.96	21890473
513	Phosphorylation	RAVNDYPSLYYPEMY HHHCCCCHHHCCCEE	23.83	21640712
523	Ubiquitination	YPEMYILKGGYKEFF CCCEEEECCCHHHHC	40.51	2190698
523 (in isoform 1)	Ubiquitination	-	40.51	21890473
527	Ubiquitination	YILKGGYKEFFPQHP EEECCCHHHHCCCCC	51.85	-
544 (in isoform 4)	Ubiquitination	-	23.00	21890473
551	Ubiquitination	PMNHEAFKDELKTFR CCCHHHHHHHHHHHC	58.29	-
555	Ubiquitination	EAFKDELKTFRLKTR HHHHHHHHHHCHHCC	43.50	-
556	Phosphorylation	AFKDELKTFRLKTRS HHHHHHHHHCHHCCC	26.98	-
561	Phosphorylation	LKTFRLKTRSWAGER HHHHCHHCCCCCCHH	34.23	18237113
563	Phosphorylation	TFRLKTRSWAGERSR HHCHHCCCCCCHHHH	26.89	23898821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
50	S	Phosphorylation	Kinase	PLK1	P53350	PSP
50	S	Phosphorylation	Kinase	CDK1	P06493	PSP
58	T	Phosphorylation	Kinase	PLK1	P53350	PSP
101	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
103	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
127	T	Phosphorylation	Kinase	PLK1	P53350	PSP
146	S	Phosphorylation	Kinase	CDK1	P06493	PSP
160	S	Phosphorylation	Kinase	CDK1	P06493	PhosphoELM
167	T	Phosphorylation	Kinase	PLK1	P53350	PSP
169	S	Phosphorylation	Kinase	MELK	Q14680	Uniprot
169	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
186	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
186	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
186	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
187	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
187	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
187	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
209	S	Phosphorylation	Kinase	PLK1	P53350	PSP
230	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
249	S	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
249	S	Phosphorylation	Kinase	MAPK11	Q15759	GPS
253	S	Phosphorylation	Kinase	AURKA	O14965	GPS
265	T	Phosphorylation	Kinase	PLK1	P53350	PSP
291	S	Phosphorylation	Kinase	PLK1	P53350	PSP
307	S	Phosphorylation	Kinase	CDK1	P06493	PSP
321	S	Phosphorylation	Kinase	CDK1	P06493	PSP
323	S	Phosphorylation	Kinase	MELK	Q14680	Uniprot
323	S	Phosphorylation	Kinase	MAPK14	Q16539	Uniprot
323	S	Phosphorylation	Kinase	MAPK2	P49137	PhosphoELM
353	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
353	S	Phosphorylation	Kinase	AURA	O14965	PSP
353	S	Phosphorylation	Kinase	PLK1	P53350	PSP
353	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
353	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
355	T	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
375	S	Phosphorylation	Kinase	BRSK1	Q8TDC3-2	GPS
375	S	Phosphorylation	Kinase	BRSK1	Q8TDC3	Uniprot
375	S	Phosphorylation	Kinase	PLK1	P53350	PSP
375	S	Phosphorylation	Kinase	MAPK14	Q16539	Uniprot
375	S	Phosphorylation	Kinase	MAPKAPK2	P49137	PSP
397	S	Phosphorylation	Kinase	PLK1	P53350	PSP
404	T	Phosphorylation	Kinase	PLK1	P53350	PSP
465	S	Phosphorylation	Kinase	PLK1	P53350	PSP
513	S	Phosphorylation	Kinase	PLK1	P53350	PSP
563	S	Phosphorylation	Kinase	CHEK1	O14757	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:21807946
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW11	Q9UKB1	PMID:21807946

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
169	S	Phosphorylation	15908796
Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis.
323	S	Phosphorylation	11333986
Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.
353	S	Phosphorylation	15128871
Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis.
375	S	Phosphorylation	11333986
Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPIP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRT85_HUMAN	KRT85	physical	17353931
PHB2_HUMAN	PHB2	physical	17353931
K1H1_HUMAN	KRT31	physical	17353931
KRT35_HUMAN	KRT35	physical	17353931
ESR1_HUMAN	ESR1	physical	11689696
KAT2B_HUMAN	KAT2B	physical	11689696
CHK1_HUMAN	CHEK1	physical	9278511
MK14_HUMAN	MAPK14	physical	11333986
1433F_HUMAN	YWHAH	physical	10713667
1433Z_HUMAN	YWHAZ	physical	10713667
1433B_HUMAN	YWHAB	physical	10713667
1433B_HUMAN	YWHAB	physical	7644510
1433E_HUMAN	YWHAE	physical	7644510
ANDR_HUMAN	AR	physical	12569365
FOXM1_HUMAN	FOXM1	physical	15024056
FBW1A_HUMAN	BTRC	physical	15845771
CDK1_HUMAN	CDK1	physical	11516829
CDK5_HUMAN	CDK5	physical	11516829
CDC5L_HUMAN	CDC5L	physical	26496610
CENPB_HUMAN	CENPB	physical	26496610
IF4B_HUMAN	EIF4B	physical	26496610
1433B_HUMAN	YWHAB	physical	26496610
1433G_HUMAN	YWHAG	physical	26496610
1433F_HUMAN	YWHAH	physical	26496610
1433Z_HUMAN	YWHAZ	physical	26496610
FBW1A_HUMAN	BTRC	physical	26496610
1433T_HUMAN	YWHAQ	physical	26496610
WDR6_HUMAN	WDR6	physical	26496610
FBW1B_HUMAN	FBXW11	physical	26496610
FBW1A_HUMAN	BTRC	physical	27880917
FBW1B_HUMAN	FBXW11	physical	27880917
PPM1F_HUMAN	PPM1F	physical	27880917
1433E_HUMAN	YWHAE	physical	27880917
MPIP2_HUMAN	CDC25B	physical	27432908
FBW1B_HUMAN	FBXW11	physical	27432908
CC28A_HUMAN	CCDC28A	physical	27432908
1433F_HUMAN	YWHAH	physical	27432908
ANM1_HUMAN	PRMT1	physical	27432908
CCNB1_HUMAN	CCNB1	physical	27432908
CDC20_HUMAN	CDC20	physical	27432908
1433G_HUMAN	YWHAG	physical	27432908
MISSL_HUMAN	MAPK1IP1L	physical	27432908
CALU_HUMAN	CALU	physical	27432908
STK39_HUMAN	STK39	physical	27432908
1433B_HUMAN	YWHAB	physical	27432908
RCN1_HUMAN	RCN1	physical	27432908
1433Z_HUMAN	YWHAZ	physical	27432908
SKP1_HUMAN	SKP1	physical	27432908
PSME3_HUMAN	PSME3	physical	27432908
1433E_HUMAN	YWHAE	physical	27432908
CUL1_HUMAN	CUL1	physical	27432908
CDK3_HUMAN	CDK3	physical	27432908
FBW1B_HUMAN	FBXW11	physical	28514442
1433Z_HUMAN	YWHAZ	physical	28514442
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
DEN1A_HUMAN	DENND1A	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
ZN638_HUMAN	ZNF638	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
CDK16_HUMAN	CDK16	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
AN34A_HUMAN	ANKRD34A	physical	27173435
FA53C_HUMAN	FAM53C	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
TBC25_HUMAN	TBC1D25	physical	27173435
MAST3_HUMAN	MAST3	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
RAB3I_HUMAN	RAB3IP	physical	27173435
TIAM1_HUMAN	TIAM1	physical	27173435
NADK_HUMAN	NADK	physical	27173435
M3K21_HUMAN	KIAA1804	physical	27173435
NF1_HUMAN	NF1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
MELK_HUMAN	MELK	physical	27173435
CING_HUMAN	CGN	physical	27173435
PKHA7_HUMAN	PLEKHA7	physical	27173435
AFAD_HUMAN	MLLT4	physical	27173435
DEP1B_HUMAN	DEPDC1B	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
SH3B4_HUMAN	SH3BP4	physical	27173435
CAMP2_HUMAN	CAMSAP2	physical	27173435
PKHA5_HUMAN	PLEKHA5	physical	27173435
NAV1_HUMAN	NAV1	physical	27173435

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPIP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates theG2/M transition and S phase progression in response to UVirradiation."; Manke I.A., Nguyen A., Lim D., Stewart M.Q., Elia A.E., Yaffe M.B.; Mol. Cell 17:37-48(2005). Cited for: PHOSPHORYLATION AT SER-323 BY MAPKAPK2.	15629715 [Abstract]
"CDC25B phosphorylated by pEg3 localizes to the centrosome and thespindle poles at mitosis."; Mirey G., Chartrain I., Froment C., Quaranta M., Bouche J.P.,Monsarrat B., Tassan J.P., Ducommun B.; Cell Cycle 4:806-811(2005). Cited for: PHOSPHORYLATION AT SER-169, AND SUBCELLULAR LOCATION.	15908796 [Abstract]
"Phosphorylation of CDC25B by Aurora-A at the centrosome contributesto the G2-M transition."; Dutertre S., Cazales M., Quaranta M., Froment C., Trabut V.,Dozier C., Mirey G., Bouche J.P., Theis-Febvre N., Schmitt E.,Monsarrat B., Prigent C., Ducommun B.; J. Cell Sci. 117:2523-2531(2004). Cited for: SUBCELLULAR LOCATION, AND PHOSPHORYLATION AT SER-353 BY AURKA.	15128871 [Abstract]
"Human pEg3 kinase associates with and phosphorylates CDC25Bphosphatase: a potential role for pEg3 in cell cycle regulation."; Davezac N., Baldin V., Blot J., Ducommun B., Tassan J.P.; Oncogene 21:7630-7641(2002). Cited for: PHOSPHORYLATION AT SER-323.	12400006 [Abstract]
"Initiation of a G2/M checkpoint after ultraviolet radiation requiresp38 kinase."; Bulavin D.V., Higashimoto Y., Popoff I.J., Gaarde W.A., Basrur V.,Potapova O., Appella E., Fornace A.J. Jr.; Nature 411:102-107(2001). Cited for: PHOSPHORYLATION AT SER-323 AND SER-375, AND INTERACTION WITH MAPK14AND 14-3-3 PROTEINS.	11333986 [Abstract]

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